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Cat. No. | Product Name | Target | Signaling Pathways |
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T21024 |
Ornithine-α-ketoglutarate
L-Ornithine-α-ketoglutarate,Ornithine α ketoglutarate,L Ornithine α ketoglutarate,Ornithine α-ketoglutarate,OKG,鸟氨酸α-酮戊二酸 |
Others | Others |
Ornithine-α-ketoglutarate (L-Ornithine-α-ketoglutarate) 是由 2 个鸟氨酸分子和 1 个 α-酮戊二酸分子形成的盐。 Ornithine-α-ketoglutarate (L-Ornithine-α-ketoglutarate) 可改善慢性营养不良(例如老年人)和急性营养不良患者(尤其是烧伤和创伤患者)的营养状况。 | |||
T9259 |
Alpha-calcium ketoglutarate monohydrate
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Others | Others |
Alpha-calcium ketoglutarate monohydrate 是 α-酮戊二酸的钙盐形式,参与生物体内的三羧酸循环。 | |||
T36871 |
5-Octyl-α-ketoglutarate
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In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases. It is used in experiments to increase levels of intracellular α-ketoglutarate. 5-Octyl-α-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathway... | |||
T71961 |
TUN-92046
DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate |
Others | Others |
TUN-92046 (Dimethyl 2-oxoglutarate)是一种膜渗透性α酮戊二酸类似物,抑制压力过载诱导的心肌病中适应不良的自噬。 | |||
T32080 |
Histidine oxoglurate
Histidine alpha-ketoglutarate |
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Histidine oxoglurate is a bioactive chemical. | |||
T71960 | Aminogenistein | ||
Aminogenistein inhibits protein-tyrosine kinase activity of p56lck. | |||
T6820 |
D-α-Hydroxyglutaric acid disodium
D-alpha-Hydroxyglutaric acid disodium salt,(R)-2-羟基戊二酸二钠盐,Disodium (R)-2-Hydroxyglutarate |
ATPase; Others; Reactive Oxygen Species; Endogenous Metabolite; mTOR | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others; PI3K/Akt/mTOR signaling |
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) 是神经代谢疾病 D-2-羟基戊二酸尿症中积累的主要代谢产物,可增加活性氧的产生。它是 α-酮戊二酸 (α-KG) 的弱竞争拮抗剂,可抑制多种α-KG 依赖性双加氧酶,Ki 为 10.87 mM。 | |||
T21634 |
N-Oxalylglycine
N-草酰<乙二酰>甘氨酸,Oxalylglycine |
Others | Others |
N-Oxalylglycine (Oxalylglycine) 是一种可渗透细胞的 α-酮戊二酸依赖性酶抑制剂。 | |||
T1939 |
DMOG
Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine,二甲基草酰甘氨酸 |
HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism |
DMOG (Dimethyloxalylglycine) 是 α-酮戊二酸辅因子的拮抗剂,是一种 HIF 脯氨酰羟化酶抑制剂,可导致蛋白HIF-1α的积聚和稳定,诱导细胞自噬。它是一种促血管生成剂,在结肠炎和腹泻动物模型中起保护作用。 | |||
T36624L |
α-Hydroxyglutaric Acid Lithium
α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base) |
Decarboxylase; Endogenous Metabolite; mTOR | Metabolism; Others; PI3K/Akt/mTOR signaling |
α-Hydroxyglutaric Acid Lithium 在微生物和动物体内有谷氨酸转化而来,是 α-酮戊二酸依赖性双加氧酶和 5-甲基胞嘧啶羟化酶抑制剂,对 ATP 合酶和 mTOR 信号传导有抑制作用。 | |||
T13019 |
Succinyl phosphonate trisodium salt
琥珀酰膦酸盐 |
Dehydrogenase; Reactive Oxygen Species; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB |
Succinyl phosphonate trisodium salt 是 α-酮戊二酸脱氢酶(KGDHC)抑制剂,能够有效抑制肌肉,脑,人成纤维细胞,细菌中的 KGDHC。Succinyl phosphonate trisodium salt 抑制 2-氧代戊二酸脱氢酶,以细胞特异性代谢依赖性方式抑制癌细胞的活力。Succinyl phosphonate trisodium salt 抑制谷氨酸诱导的海马神经元中ROS 的产生。 | |||
T6157 |
Devimistat
CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid |
Apoptosis; Dehydrogenase; Mitochondrial Metabolism | Apoptosis; Metabolism |
Devimistat (6,8-Bis(benzylthio)octanoic acid) 是一种线粒体代谢抑制剂,还是一种lipoic acid 拮抗剂,能阻断线粒体能量代谢,诱导多种癌细胞凋亡。 | |||
TP1777L |
p2Ca acetate(142606-55-1 free base)
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Others | Others |
p2Ca acetate(142606-55-1 free base) 是一种天然加工的肽,来源于普遍存在的酶 α-酮戊二酸脱氢酶,并被 CTL 克隆 (2C) 识别为与 I 类 MHC 蛋白 Ld 结合。 | |||
T13020 |
Succinyl phosphonate
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Others | Others |
Succinyl phosphonate is a α-ketoglutarate dehydrogenase inhibitor . | |||
T77217 | Saccharopine hydrochloride | ||
Saccharopine hydrochloride(L-Saccharopine hydrochloride)是赖氨酸降解的中间体,兼具线粒体毒性。该化合物由赖氨酸-酮戊二酸还原酶催化赖氨酸与α-酮戊二酸生成。继而,糖精脱氢酶作用于Saccharopine hydrochloride,生成α-氨基己酸酯半醛和谷氨酸。其通过干扰线粒体的稳态平衡,对生物体的发育造成损害。 | |||
T38473 |
Malonyl Coenzyme A lithium
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Malonyl Coenzyme A (lithium) is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl Coenzyme A (lithium) is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl Coenzyme A (lithium) is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides. | |||
T73616 |
Glutamate dehydrogenase (NAD(P))
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Glutamate dehydrogenase NAD(P) (GLDH)(谷氨酸脱氢酶 NAD(P))是一种存在于肝细胞、肾组织、脑、肌肉和肠细胞的线粒体酶,主要应用于生化研究。作为尿素循环的一环,该酶催化谷氨酸的逆向氧化脱氨反应,生成α-酮戊二酸(α-KG)。 | |||
T76174 |
Isocitrate dehydrogenase
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Isocitrate dehydrogenase(ICDH) 异柠檬酸脱氢酶是一种柠檬酸或三羧酸循环酶,常用于生化研究。Isocitrate dehydrogenase 催化异柠檬酸氧化脱羧生成 α-酮戊二酸,并将 NAD(P)+还原为 NAD(P)H,在细胞代谢中起重要作用。 | |||
T76178 |
Aspartate aminotransferase
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Aspartate aminotransferase (AST) 是一种转氨酶,常用于生化研究。Aspartate aminotransferase 催化天冬氨酸和 α-酮戊二酸转化为草酰乙酸和谷氨酸。Aspartate aminotransferase 可存在于在脑脊液、渗出液和渗出物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T0200 |
α-Lipoic Acid
Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸 |
Apoptosis; NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子,是一种抗氧化剂,可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。 |