Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nelociguat (BAY60-4552) 是一种一氧化氮敏感的可溶性鸟苷酸环化酶刺激剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 295 | 现货 | ||
2 mg | ¥ 433 | 现货 | ||
5 mg | ¥ 712 | 现货 | ||
10 mg | ¥ 1,090 | 现货 | ||
25 mg | ¥ 1,630 | 现货 | ||
50 mg | ¥ 2,220 | 现货 | ||
100 mg | ¥ 3,580 | 现货 | ||
200 mg | ¥ 4,530 | 现货 | ||
500 mg | ¥ 6,130 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 783 | 现货 |
产品描述 | Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. |
体内活性 | Bilateral CN crush injury followed by a 3-wk recovery period decreased erectile responses to ES CN by about 50%. In CN-crushed rats, IV vardenafil 0.03 mg/kg and BAY 60-4552 (0.03 or 0.3 mg/kg) increased erectile responses to ES CN to the same extent: intracavernosal pressure/mean arterial pressure (ICP/MAP) at 10 Hz ES CN was 21±1% after vehicle, 25±3% (p<0.001) after vardenafil, and 26±5% and 27±5% after BAY 60-4552 0.03 mg/kg (p<0.01) and 0.3 mg/kg (p<0.001), respectively. The combination of vardenafil with BAY 60-4552 in CN-crushed rats totally restored erectile responses to ES CN equivalent to sham rats (ICP/MAP at 10 Hz ES CN: 34±4% after BAY 60-4552/vardenafil combination vs 39±4% in sham rats; not significant)[1]. |
动物实验 | The acute effects of intravenous (IV) injection of vehicle, vardenafil 0.03 mg/kg, BAY 60-4552 0.03 mg/kg or 0.3 mg/kg, or a BAY 60-4552 0.03 mg/kg plus vardenafil 0.03 mg/kg combination were evaluated in CN-crushed rats[1]. |
别名 | N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯, BAY60-4552 |
分子量 | 408.39 |
分子式 | C19H17FN8O2 |
CAS No. | 625115-52-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 105 mg/mL (257.11 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4486 mL | 12.2432 mL | 24.4864 mL | 61.216 mL |
5 mM | 0.4897 mL | 2.4486 mL | 4.8973 mL | 12.2432 mL | |
10 mM | 0.2449 mL | 1.2243 mL | 2.4486 mL | 6.1216 mL | |
20 mM | 0.1224 mL | 0.6122 mL | 1.2243 mL | 3.0608 mL | |
50 mM | 0.049 mL | 0.2449 mL | 0.4897 mL | 1.2243 mL | |
100 mM | 0.0245 mL | 0.1224 mL | 0.2449 mL | 0.6122 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nelociguat 625115-52-8 GPCR/G Protein Guanylate cyclase inhibit Inhibitor N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯 Guanylate Cyclase BAY60-4552 inhibitor