Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6611 |
NSC697923
2-[(4-methylphenyl)sulfonyl]-5-nitrofuran |
E1/E2/E3 Enzyme | Ubiquitination |
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ... |