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Cat. No. Product Name Target Signaling Pathways
T6611 NSC697923

2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

E1/E2/E3 Enzyme Ubiquitination
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ...

化合物

NSC697923
Cat.No: T6611
Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
Target: E1/E2/E3 Enzyme
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