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Fenoprofen calcium hydrate

产品编号 T6498 CAS 71720-56-4

别名: Feprona dihydrate, Fenoprofen calcium salt dihydrate, Progesic dihydrate, 非诺洛芬钙二水合物

Fenoprofen calcium hydrate (Progesic dihydrate) 是一非甾体类抗炎症化合物。

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Fenoprofen calcium hydrate Chemical Structure

Fenoprofen calcium hydrate, CAS 71720-56-4

规格	价格/CNY		货期	数量
1 g	￥ 379		现货
1 mL * 10 mM (in DMSO)	￥ 312		现货

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其他形式的 Fenoprofen calcium hydrate:

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纯度: 100%

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Fenoprofen calcium hydrate (Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).
体外活性	Fenoprofen is a more potent inhibitor of collagen-induced platelet aggregation than either aspirin or phenylbutazone. [1] Fenoprofen inhibits the formation of palmitoyl-CoA in both microsomal and peroxisomal fractions, and inhibits the beta-oxidation of lignoceric acid and cerotic acid in rat hepatocytes. [5] Fenoprofen exhibits modest antiproliferative activity against HT-29, DID-1, and SW480 cells with IC50 of 240 μM, 300 μM, and 360 μM, respectively. [6] Fenoprofen (0.1 mM) is an efficient activator of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to a degree comparable to that obtained with the PPARγ ligands BRL49653 and 15-deoxy-D12,14-PGJ2 and the peroxisome proliferator Wy14643. Fenoprofen is also an efficacious activator of PPARα, activating the receptor to a degree comparable to that obtained with the strong peroxisome proliferator Wy14643. Consistently, Fenoprofen treatment promotes lipogenesis in C3H10T1/2 cells. [7] Although Fenoprofen displays only modest antiproliferative activity, Fenoprofen amides can potently induce cell cycle arrest at the G1 phase, as well as apoptosis, probably because of a greater lipophilicity and/or better cell uptake. [9]
体内活性	Oral administration of Fenoprofen at 50 mg/kg potently inhibits thrombus formation by 47%, whereas a dose of 200 mg/kg of aspirin is required to reduce thrombus formation 21 %. [1] Similar to indomethacin, adminstration of Fenoprofen inhibits prostaglandin synthesis. [2] In rats with type II collagen-induced arthritis, Fenoprofen treatment at 40 mg/kg/day partially suppresses the paw swelling, but has no significant effect on humoral and cellular responses. [3] Administration of Fenoprofen depresses the rebound contraction, thus transforming the brisk relaxant response, elicited by vagal stimulation or ATP, into long-lasting relaxation. [4] Administration of Fenoprofen causes a strong and dose-related induction of peroxisomal palmitoyl-CoA oxidase, and of carnitine acyltransferase and acyl-CoA hydrolase activities in liver homogenates of mice fed diets. Hepatic catalase activity is significantly increased in mice fed the diet with 0.05 and 0.1% fenoprofen but not the 1% fenoprofen-containing diet. [8]
细胞实验	Cells are exposed to various concentrations of Fenoprofen for 6 days. Cell number is determined using the SRB colonimetnic protein stain assay. After 6 days of culture, cells are fixed by the addition of cold trichloroacetic acid to a final concentration of 10%. Plates are incubated at 4 °C for 1 hour, then the supernatant is aspirated and the plates are washed with deionized water. SRB solution is formulated to 0.4% w/v in 1% acetic acid; 100 μL is added to each well and the plates are incubated for 10 minutes at room temperature. Unbound SRB is removed by washing with 1% acetic acid followed by air drying. Bound stain is solubilized with 50 mM unbuffered Tris and absorbance is read by an automated spectrophotometer at a single wavelength of 540 nm.(Only for Reference)

别名	Feprona dihydrate, Fenoprofen calcium salt dihydrate, Progesic dihydrate, 非诺洛芬钙二水合物
分子量	558.63
分子式	C15H14O3·1/2Ca·H2O
CAS No.	71720-56-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 15 mg/mL (19.1 mM)

DMSO: 45 mg/mL (57.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	1.7901 mL	8.9505 mL	17.9009 mL	44.7523 mL
	5 mM	0.358 mL	1.7901 mL	3.5802 mL	8.9505 mL
	10 mM	0.179 mL	0.895 mL	1.7901 mL	4.4752 mL
DMSO	20 mM	0.0895 mL	0.4475 mL	0.895 mL	2.2376 mL
DMSO	50 mM	0.0358 mL	0.179 mL	0.358 mL	0.895 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Herrmann RG, et al. Proc Soc Exp Biol Med, 1972, 139(2), 548-552. 2. Patrono C, et al. Pharmacol Res Commun, 1974, 6(5), 509-518. 3. Phadke K, et al. Clin Exp Immunol, 1982, 47(3), 579-586. 4. Baccari MC, et al. Exp Physiol, 1990, 75(3), 415-418. 5. Lageweg W, et al. Biochem Pharmacol, 1993, 46(1), 79-85.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Fenoprofen calcium hydrate 71720-56-4 Apoptosis Immunology/Inflammation Neuroscience Others COX Feprona Dihydrate Feprona dihydrate Cyclooxygenase Fenoprofen calcium salt dihydrate inhibit Fenoprofen calcium Hydrate Progesic dihydrate Progesic Dihydrate 53746-45-5 Fenoprofen Calcium Inhibitor Progesic Fenoprofen calcium 非诺洛芬钙二水合物 Feprona Fenoprofen calcium Dihydrate inhibitor

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Fenoprofen calcium hydrate

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords