Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Darodipine (PY-108068) 是钙离子通道的有效拮抗剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 465 | 现货 | ||
2 mg | ¥ 672 | 现货 | ||
5 mg | ¥ 959 | 现货 | ||
10 mg | ¥ 1,360 | 现货 | ||
25 mg | ¥ 2,460 | 现货 | ||
50 mg | ¥ 3,670 | 现货 | ||
100 mg | ¥ 5,290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 995 | 现货 |
产品描述 | Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist. |
体内活性 | Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. Darodipine (10 mg/kg; 6-month (from the 18th to the 24th month of life); p.o.) treatment restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex [2]. Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon's horn is the most sensitive to treatment with darodipine [1]. |
别名 | 达罗地平, PY-108068, PY 108-068 |
分子量 | 371.39 |
分子式 | C19H21N3O5 |
CAS No. | 72803-02-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (161.56 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6926 mL | 13.4629 mL | 26.9259 mL | 67.3147 mL |
5 mM | 0.5385 mL | 2.6926 mL | 5.3852 mL | 13.4629 mL | |
10 mM | 0.2693 mL | 1.3463 mL | 2.6926 mL | 6.7315 mL | |
20 mM | 0.1346 mL | 0.6731 mL | 1.3463 mL | 3.3657 mL | |
50 mM | 0.0539 mL | 0.2693 mL | 0.5385 mL | 1.3463 mL | |
100 mM | 0.0269 mL | 0.1346 mL | 0.2693 mL | 0.6731 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Darodipine 72803-02-2 Membrane transporter/Ion channel Metabolism Calcium Channel Ca channels 达罗地平 PY 108068 PY-108068 PY 108-068 PY108068 Ca2+ channels Inhibitor inhibit inhibitor