Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CLEFMA 是一种姜黄素,抑制肿瘤生长与 NF-κB 调节的抗炎和抗转移作用有关,具有抗肿瘤活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,300 | 现货 | ||
5 mg | ¥ 2,920 | 现货 | ||
10 mg | ¥ 4,320 | 现货 | ||
25 mg | ¥ 6,880 | 现货 | ||
50 mg | ¥ 9,330 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
500 mg | ¥ 25,200 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,190 | 现货 |
产品描述 | CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects. |
靶点活性 | H441 cells:6.4 μM, A549 cells:8.9 μM |
体外活性 | CLEFMA induces autophagic death in H441 cells[1]. CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2]. CLEFMA induces apoptosis and reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2]. |
体内活性 | Daily intraperitoneal injection of 0.2-0.4 mg/kg CLEFMA for 4 weeks, CLEFMA inhibits tumor growth and FDG uptake in tumor tissue in a xenograft mouse model [2]. In addition, CLEFMA downregulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2, and survivin, and induces the cleavage and expression of the pro-apoptotic protein BID [2]. |
分子量 | 442.29 |
分子式 | C23H17Cl2NO4 |
CAS No. | 1246964-32-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (135.66 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.261 mL | 11.3048 mL | 22.6096 mL | 56.524 mL |
5 mM | 0.4522 mL | 2.261 mL | 4.5219 mL | 11.3048 mL | |
10 mM | 0.2261 mL | 1.1305 mL | 2.261 mL | 5.6524 mL | |
20 mM | 0.113 mL | 0.5652 mL | 1.1305 mL | 2.8262 mL | |
50 mM | 0.0452 mL | 0.2261 mL | 0.4522 mL | 1.1305 mL | |
100 mM | 0.0226 mL | 0.113 mL | 0.2261 mL | 0.5652 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CLEFMA 1246964-32-8 NF-Κb NF-κB cancer Inhibitor anti-metastatic Apoptosis antitumor curcuminoid anti-inflammatory inhibit inhibitor