Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MSU-42011 是一种具有口服活性的类视黄醇 X 受体 (RXR) 激动剂。MSU-42011 有效抑制iNOS,低SREBP 诱导和激活RXR 以及 p-ERK 蛋白水平的表达。MSU-42011在kras 驱动的肺癌小鼠模型中表现出抗肿瘤活性。MSU-42011可有效治疗临床前Krasdriven 肺癌且具有免疫调节活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 333 | 现货 | ||
5 mg | ¥ 797 | 现货 | ||
10 mg | ¥ 1,260 | 现货 | ||
25 mg | ¥ 2,320 | 现货 | ||
50 mg | ¥ 3,720 | 现货 | ||
100 mg | ¥ 5,390 | 现货 | ||
500 mg | ¥ 10,900 | 现货 |
产品描述 | MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level.MSU-42011 has demonstrated antitumor activity in a kras-driven mouse model of lung cancer.MSU-42011 is an effective therapy for the treatment of preclinical krasdriven lung cancer and has immunomodulatory activity. |
靶点活性 | iNOS:158 nM |
体外活性 |
MSU-42011 (300 nM; 8 h) showed a low induction effect on SREBP in HepG2 cells.[1] MSU-42011 (0-5000 nM; 24 h) can activate RXR in HepG2 cells.[1] |
体内活性 |
MSU-42011 (25 mg/kg; oral; for 12 weeks) significantly reduced the number, size, and overall tumor burden of tumors in the A/J mouse lung cancer model. Compared with the control group, there were fewer cells with active proliferation and showed a significant decrease in p-ERK [1]. MSU-42011 (25 mg/kg; oral; single dose) is most effective in reducing the number, size, and overall tumor burden of the A/J mouse lung cancer model in combination with C/P. Reduced macrophages in the lungs and increased activation markers of CD8+T cells [1]. MSU42011 (100 mg/kg; PO; single dose) reduces tumor burden in a mouse lung tumor model [2]. |
分子量 | 382.54 |
分子式 | C24H34N2O2 |
CAS No. | 2456434-36-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MSU-42011 2456434-36-7 Apoptosis Immunology/Inflammation Metabolism NOS Retinoid Receptor NO Synthase PERK Lipid MSU42011 6((3,5ditertbutylphenyl)(isobutyl)amino)nicotinicacid MSU 42011 Inhibitor inhibitor inhibit