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Search Results for " β-glucuronidase "

Targets Recommended: Antibacterial

18

抑制剂 & 化合物

5

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T13477	β-Glucuronidase-IN-1	Antibacterial	Microbiology/Virology
	β-Glucuronidase-IN-1 是一种 E. coli β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂，对 E. coli β-葡萄糖醛酸酶的 IC50 和 Ki 值分别为 283 nM 和 164 nM，具有强效性，选择性，非竞争性和具有口服活性。
T63250	β-Glucuronidase-IN-2
	β-Glucuronidase-IN-2 是 E. coliβ-葡萄糖醛酸酶 β-glucuronidase 的有效抑制剂(IC50: 0.24 μM, Ki: 1.09 μM)，表现出抗增殖作用，具有潜力进行抗癌和抗炎治疗的研究。
T63805	β-Glucuronidase/hCAII-IN-1
	β-Glucuronidase/hCAII-IN-2 (Compound 12e) 是一种有效的β-glucuronidase 和 hCA II 抑制剂，其 IC50分别为 440.1 μM 和 4.91 μM。
T63789	β-Glucuronidase/hCAII-IN-2
	β-Glucuronidase/hCAII-IN-2 是 β-glucuronidase 和 hCA II 的有效抑制剂，他们的IC50值分别为 670.7 μM 和 21.77 μM。
T80055	Beta-glucuronidase (bovine liver)
	Beta-glucuronidase是一种关键溶酶体酶，主要功能是参与糖胺聚糖中含有葡萄糖醛酸成分的降解过程。
T37811	6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt)	Others	Others
	6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) 是 β-glucuronidase 的显色底物。 6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) 可用于组织化学分析 β-glucuronidase 活性。
T41319	D-Saccharic acid 1,4-lactone hydrate	Others	Others
	D-Saccharic acid 1,4-lactone hydrate 是β-葡萄糖醛酸酶的有效抑制剂（IC50=48.4 μM），可用作标准药物。D-Saccharic acid 1,4-lactone hydrate 显示出抗癌、解毒和抗氧化的活性性。
T15422	GSK-626616	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	GSK-626616 是一种口服具有活力的 DYRK3抑制剂 (IC50:0.7 nM)。它以相似的效力抑制 DYRK 家族的其他成员，可用于研究贫血。
T75363	Fluorescein Di-β-D-Glucuronide
	Fluorescein Di-β-D-Glucuronide 作为一款荧光探针，以其非侵入性的优势被广泛应用于裸鼠肠道细菌β-葡萄糖醛酸酶（βG）活性成像研究中。该探针通过成像技术有效揭示了肠道细菌β-葡萄糖醛酸酶在体内外的活性，进而为特定细菌β-葡萄糖醛酸酶抑制剂的药效学评估提供了重要工具。
T19076	X-Gluc Dicyclohexylamine 5-Bromo-4-chloro-3-indolyl-beta-D-glucuronide cyclohexylammonium salt,5-溴-4-氯-3-吲哚基-beta-D-葡糖苷酸环己胺盐	Others	Others
	X-Gluc Dicyclohexylamine (5-Bromo-4-chloro-3-indolyl-beta-D-glucuronide cyclohexylammonium salt) 是一种检测β-葡萄糖醛酸酶的试剂，可用于分子生物学实验中对靶基因的表达进行标记和选择。
T63908	hCAII-IN-4
	hCAII-IN-4 (Compound 12j) 是一种有效的hCA II 抑制剂，IC50为 7.78 μM。hCAII-IN-4 也抑制β-glucuronidase，IC50为 773.9 μM。
T80692	β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE
	β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE 是一种具有选择性的抗增殖活性木耳素-葡糖苷缀合物，对β-葡萄糖醛酸酶处理和未处理的癌细胞体外显示IC50为5.7 nM - 9.7 nM。在HCT-116异种移植小鼠模型中展现出显著的抗肿瘤效果，并且未观察到副作用。
T72259	3-Chlorogentisyl alcohol
	3-Chlorogentisyl alcohol 是一种有效的 E. coliβ-葡萄糖醛酸酶β-glucuronidase 抑制剂，IC50值为 0.74 µM，Ki 值为 0.58 µM。3-Chlorogentisyl alcohol 显示出抗增殖活性。3-Chlorogentisyl alcohol 具有抗癌和抗炎治疗研究的潜力。
T78428	X-Gluc cyclohexanamine
	X-Gluc cyclohexanamine是一种用于检测β-葡萄糖醛酸酶(GUS)活性的染料，常用作基因表达的标记，可用于检测目的基因的表达。
T36623	Antileukinate
	Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 μM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.
T36367	RK-682 (calcium salt)
	Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the...
T15204	EHT 1610 EHT 5372	GSK-3; NF-κB; Tyrosinase; DYRK; CDK	Cell Cycle/Checkpoint; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	EHT 1610 (EHT 5372) 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂，对 DYRK1A 和 DYRK1B 有抑制作用，的 IC50 分别为 0.36 nM 和 0.59 nM。EHT 1610 对白血病具有抑制效应，可调节细胞周期，诱导细胞凋亡。
T7390	DMAT Casein kinase II Inhibitor,2-二甲基氨基-4,5,6,7-四溴苯并咪唑,CK2 Inhibitor	Casein Kinase	Metabolism; Stem Cells
	DMAT (Casein kinase II Inhibitor) 是一种特异性 CK2抑制剂，IC50值为 130 nM。

化合物

β-Glucuronidase-IN-1

Cat.No: T13477

Target: Antibacterial

β-Glucuronidase-IN-2

Cat.No: T63250

β-Glucuronidase/hCAII-IN-1

Cat.No: T63805

β-Glucuronidase/hCAII-IN-2

Cat.No: T63789

Beta-glucuronidase (bovine liver)

Cat.No: T80055

6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt)

Cat.No: T37811

Target: Others

D-Saccharic acid 1,4-lactone hydrate

Cat.No: T41319

Target: Others

Cat.No: T15422

Target: DYRK

Fluorescein Di-β-D-Glucuronide

Cat.No: T75363

X-Gluc Dicyclohexylamine

Cat.No: T19076

Synonym: 5-Bromo-4-chloro-3-indolyl-beta-D-glucuronide cyclohexylammonium salt,5-溴-4-氯-3-吲哚基-beta-D-葡糖苷酸环己胺盐

Target: Others

Cat.No: T63908

β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE

Cat.No: T80692

3-Chlorogentisyl alcohol

Cat.No: T72259

X-Gluc cyclohexanamine

Cat.No: T78428

Cat.No: T36623

RK-682 (calcium salt)

Cat.No: T36367

Cat.No: T15204

Synonym: EHT 5372

Target: GSK-3, NF-κB, Tyrosinase, DYRK, CDK

Cat.No: T7390

Synonym: Casein kinase II Inhibitor,2-二甲基氨基-4,5,6,7-四溴苯并咪唑,CK2 Inhibitor

Target: Casein Kinase

Cat. No.	Product Name	Target	Signaling Pathways
TN1818	Kaempferol 3-O-β-D-glucuronide Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,山奈酚葡萄糖醛酸苷,Kaempferol-3-glucuronide	IL Receptor	Immunology/Inflammation
	Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide) 具有抗氧化活性。类黄酮葡糖苷酸可以被来自各种人体细胞的微粒体 α2-葡糖苷酸酶解偶联。
TN7224	2,2'-Dihydroxy chalcone	Antibacterial; Autophagy	Autophagy; Microbiology/Virology
	2,2'-Dihydroxy chalcone 是一种用 fMLP/CB 刺激的大鼠中性粒细胞释放β-葡糖醛酸酶（IC50=1.6±0.2μM）和溶菌酶（IC50=1.4±0.2μM）的有效抑制剂。2,2'-Dihydroxy chalcone 对大肠杆菌、福氏志贺氏菌、白葡萄球菌和金黄色葡萄球菌有抑菌活性。
T13716	(+)-Guaiacin	Others	Others
	(+)-Guaiacin is a compound isolated from the bark of Machilus wangchiana Chun. It shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF).
TN2766	2'-Hydroxydaidzein	Cannabinoid Receptor; Antioxidant	GPCR/G Protein; oxidation-reduction
	2'-Hydroxydaidzein 是一种在植物中发现的异黄酮类植物素，是一种天然化合物。2'-Hydroxydaidzein 具有抗氧化活性，主要由o -氢键解离焓(BDE)和氢原子转移(HAT)机制驱动。2'-Hydroxydaidzein 抑制炎症细胞中的化学介质，可能对治疗和预防与化学介质产生过多有关的中枢和外周炎症性疾病有作用。2'-Hydroxydaidzein 对大鼠中性粒细胞和formyl-Met-Leu-Phe/cytochalasin B（fMLP/CB）的释放具有抑制作用，IC（50）值分别为2.8+/-0.1和5.9+/-1.4 microM。
TN1847	Kushenol X 苦参醇X	Others	Others
	Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).

天然产物

Kaempferol 3-O-β-D-glucuronide

Cat.No: TN1818

Synonym: Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,山奈酚葡萄糖醛酸苷,Kaempferol-3-glucuronide

Target: IL Receptor

2,2'-Dihydroxy chalcone

Cat.No: TN7224

Target: Antibacterial, Autophagy

Cat.No: T13716

Target: Others

2'-Hydroxydaidzein

Cat.No: TN2766

Target: Cannabinoid Receptor, Antioxidant

Cat.No: TN1847

Synonym: 苦参醇X

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00787	GUSB Protein, E. coli, Recombinant (His) uidA,β-glucuronidase,Beta-glucuronidas...	E. coli	E. coli
	Beta-D-glucuronidase from E.coli is a highly specific enzyme in hydrolyzing glucuronides. Beta-D-glucuronidase (GLUase) activity can be measured as the rate of production of fluorescent methylumbelliferone (MU), resulting from the hydrolysis of the substrate 4-methylumbelliferyl-β-d-glucuronide (MUGLU), which is an effective and rapid method for detection and verification of E. coli in food, water, and environmental samples. High purity recombinant beta-Glucuronidase is used in research, bioche...

重组蛋白

GUSB Protein, E. coli, Recombinant (His)

Cat.No: TMPJ-00787

Species: E. coli

Expression System: E. coli

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