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17

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0112L	Diltiazem Diltiazem free base,Dilticard,地尔硫卓,CRD-401,CRD401,Dilzen,CRD 401
	Diltiazem is a non-dihydropyridine (non-DHP) calcium channel blocker that relaxes the smooth muscle in arterial walls, thus opening (dilating) arteries, allowing easier blood flow, and lowering blood pressure, and is used to treat hypertension, angina pec
T8390	Cefazolin 头孢唑林,头孢唑啉	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Cefazolin 是一种头孢类抗生素, 用于多种细菌感染的研究。
T38041	(R)-3-hydroxy Myristic Acid
	Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria. LPS is composed of polysaccharides and lipid A, where lipid A is a phosphoglycolipid containing acyl chains composed of 10 to 16 carbons. The lipid A component of LPS is detected by Toll-like receptor 4 of mammalian leukocytes and, thus, is a key determinant in immune response. (R)-3-Hydroxymyristic Acid is a form of the 14:0 lipid myristic acid that is found in the lipid A component of some Gram-negative bacte...
T0197	Terazosin hydrochloride 盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Terazosin hydrochloride (Hytrin) 是一种竞争性和口服活性的 α1-肾上腺素受体拮抗剂，是一种喹唑啉衍生物。它通过舒张血管和打开膀胱来起作用。它可用于良性前列腺增生和高血压的研究。
T1215	Nicardipine hydrochloride 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。
T30025	AMOR 6-O-(4-O-Methyl-β-D-glucuronosyl)-D-galactose,GlcA[4Me]β(1-6)Gal
	AMOR is unique to plant cell walls and enhances plant fertilization efficiency and capacity
T38317	Ac-muramic acid
	A component of bacterial cell walls. For a protected derivative of MurNAc see Q-1005.
T31785	Feruloyl arabinobiose
	Feruloyl arabinobiose is a bioactive chemical extracted from the cell walls of spinach cells.
T31735	Exeporfinium chloride XF 73,XF73,XF-73
	Exeporfinium chloride(XF-73) is an antimicrobial agent that can weaken bacterial cell walls.
T71881	Bromophenol red
	Bromophenol red (BPR) is a chemical indicator. It has been shown to bind to lysozymes and inhibits their activity against bacterial cell walls, but not against the polysaccharide component of peptidoglycan.
T78213	MurA-IN-4
	MurA-IN-4是一种具有抗细菌活性的MurA抑制剂，能够抑制细菌细胞壁的合成。
T74775	Antibacterial agent 138
	Antibacterial agent 138 对多重耐药菌具有优异的抗菌活性。Antibacterial agent 138 抑制细菌蛋白质合成和细菌细胞壁。
T37850	Chitobiose Octaacetate
	Chitobiose is a dimer of β-1,4 linked glucosamine units derived from chitin, which, in turn, is a long chain polymer of N-acetylglucosamine that is a primary component of fungal cell walls and arthropod exoskeletons. Chitobiose octaacetate is a form of chitobiose containing eight acetate groups. It is formed by the acetolysis of chitin. Chitobiose octaacetate can be used for the synthesis of chitobiose oxazoline and other chitin precursors.
TP2244	egg white lysozyme (19-36) [Gallus gallus]	Others	Others
	Hen egg-white lysozyme has a molecular weight of about 14,600 and each molecule comprises 129 amino acid residues1. The activity of lysozyme in promoting the dissolution of bacterial cell walls is now known to depend upon its ability to catalyze the hydro
T73956	Amoxicillin trihydrate mixture with potassium clavulanate (4:1)
	Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) 是一种抗生素 (antibiotic)，具有优良的口服吸收性及广谱抗菌作用。该化合物通过抑制细胞壁内多肽的生物合成来阻止细胞生长。
T74555	EDA-DA
	EDA-DA 是一种 N 末端标记的二肽探针，可用于标记细菌的肽聚糖 (PG)。肽聚糖 (PG) 是绝大多数细菌细胞壁中的一种基本结构，对于分裂和维持细胞形状和静水压力至关重要。
T63632	Anti-MRSA agent 3
	Anti-MRSA agent 3 能够明显的抑制耐甲氧西林金黄色葡萄球菌 (MRSA) 的活性 (MIC: 0.098 μg/ml)，并且对正常细胞毒性较低。Anti-MRSA agent 3 对细菌基因组 DNA 具有较高的结合亲和力，对细菌细胞壁和细胞膜具有较强的破坏能力。

化合物

Cat.No: T0112L

Synonym: Diltiazem free base,Dilticard,地尔硫卓,CRD-401,CRD401,Dilzen,CRD 401

Cat.No: T8390

Synonym: 头孢唑林,头孢唑啉

Target: Others, Antibacterial, Antibiotic

(R)-3-hydroxy Myristic Acid

Cat.No: T38041

Terazosin hydrochloride

Cat.No: T0197

Synonym: 盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic

Target: Adrenergic Receptor

Nicardipine hydrochloride

Cat.No: T1215

Synonym: 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Cat.No: T30025

Synonym: 6-O-(4-O-Methyl-β-D-glucuronosyl)-D-galactose,GlcA[4Me]β(1-6)Gal

Ac-muramic acid

Cat.No: T38317

Feruloyl arabinobiose

Cat.No: T31785

Exeporfinium chloride

Cat.No: T31735

Synonym: XF 73,XF73,XF-73

Bromophenol red

Cat.No: T71881

Cat.No: T78213

Antibacterial agent 138

Cat.No: T74775

Chitobiose Octaacetate

Cat.No: T37850

egg white lysozyme (19-36) [Gallus gallus]

Cat.No: TP2244

Target: Others

Amoxicillin trihydrate mixture with potassium clavulanate (4:1)

Cat.No: T73956

Cat.No: T74555

Anti-MRSA agent 3

Cat.No: T63632

Cat. No.	Product Name	Target	Signaling Pathways
T19606	Xylan	Others	Others
	Xylan 是开花植物的次生植物细胞壁中的半纤维素成分，是一种由木糖单元组成的多糖，主要包含由纤维素连接的 β-D-木糖单位。
T0878	Diosmin Venosmine,Diosmil,Barosmin,地奥司明,地奥司明（7-芸香糖甙）	Aryl Hydrocarbon Receptor; Norepinephrine	Immunology/Inflammation; Neuroscience
	Diosmin (Venosmine) 是在各种柑橘类水果中发现的类黄酮，也是芳烃受体激动剂，有增强血管壁的作用。
T22291	Chitin Chitin (From shrimp and crab shells)	Others	Others
	Chitin 是一种大型的结构多糖，存在于真菌的细胞壁、昆虫的外骨骼以及鱼类和无脊椎动物的某些坚硬结构中。
T6S0920	2"-O-Galloylhyperin 2”-O-没食子酰基金丝桃苷,2''-O-Galloylhyperin,Q-100605,FT-0689359	Others	Others
	2"-O-Galloylhyperin (FT-0689359) 是一种分离自Pyrola incarnateFisch. 中的活性化合物，具有抗氧化和抗炎作用，对氧化应激诱导的肝损伤具有肝保护作用。
T5780	HYPOCRELLIN B	Apoptosis; Parasite; Antifungal	Apoptosis; Microbiology/Virology
	Hypocrellin B 是从真菌Hypocrella bambusae 和Shiraia bambusicola 中分离得到的一种感光颜料，可用于癌症光动力研究。它是一个凋亡诱导剂，还拥有抗菌和抗利什曼活性。
T20643	Cefoxitin Rephoxitin,Cefoxitinum	Cell wall; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology
	Cefoxitin (Rephoxitin) 是一种广谱的、可口服的第二代头孢霉素类抗生素。Cefoxitin 干扰细菌细胞壁的合成。其活性谱包括革兰氏阴性和革兰氏阳性菌，通常用于腹腔感染、盆腔感染和某些类型的妇科感染等腹部，对厌氧菌具有高效性。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
T4889	2,6-Diaminoheptanedioic acid	Others; Endogenous Metabolite	Metabolism; Others
	2,6-Diaminoheptanedioic acid 是内源性代谢产物的一种。
T38176	Muramic acid
	Muramic acid is a prevalent constituent found in the cell walls of Gram-positive bacteria, serving as a distinguishing marker for such bacteria[1].
T11849	Lignin 木质素,脱碱的,木质素,Lignine	Others	Others
	Lignin (Lignine) 是一种具有生物可降解性和生物相容性的天然复合生物聚合物。它是植物细胞壁的主要成分，是一种可再生的芳香族聚合物，具有显著的抗氧化作用。
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T19606

Target: Others

Cat.No: T0878

Synonym: Venosmine,Diosmil,Barosmin,地奥司明,地奥司明（7-芸香糖甙）

Target: Aryl Hydrocarbon Receptor, Norepinephrine

Cat.No: T22291

Synonym: Chitin (From shrimp and crab shells)

Target: Others

2"-O-Galloylhyperin

Cat.No: T6S0920

Synonym: 2”-O-没食子酰基金丝桃苷,2''-O-Galloylhyperin,Q-100605,FT-0689359

Target: Others

Cat.No: T5780

Target: Apoptosis, Parasite, Antifungal

Cat.No: T20643

Synonym: Rephoxitin,Cefoxitinum

Target: Cell wall, Antibacterial, Antibiotic

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

2,6-Diaminoheptanedioic acid

Cat.No: T4889

Target: Others, Endogenous Metabolite

Cat.No: T38176

Cat.No: T11849

Synonym: 木质素,脱碱的,木质素,Lignine

Target: Others

Cat.No: T35624

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