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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7147	Valbenazine NBI-98854	Monoamine Transporter	Membrane transporter/Ion channel
	Valbenazine (NBI-98854) 是一种高度选择性的囊泡单胺转运蛋白 2 (VMAT2) 抑制剂，Ki 为 110-190 nM，用于治疗迟发性运动障碍。
T3280	Clodronate disodium tetrahydrate clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的，可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐，具有抗骨质疏松、抗炎作用，可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP，缓解慢性神经病理性疼痛和炎症性疼痛。
T7563	NBI-98782 (+)-α-二氢丁苯那嗪,(+)-α-Dihydrotetrabenazine,(+)-α-DHTBZ,(+)-DTBZ,[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-六氢-9,10-二甲氧基-3-异丁基-2H-苯并[a]喹嗪-2-醇	Monoamine Transporter	Membrane transporter/Ion channel
	NBI-98782 ((+)-α-DHTBZ) 是一种囊泡单胺转运蛋白 (VMAT2) 抑制剂，Ki 为0.97nM。
TP1429	VSV-G Peptide acetate(103425-05-4 free base) VSV-G Peptide	Others	Others
	VSV-G Peptide acetate(103425-05-4 free base) 是一种 11 个氨基酸的肽，来源于水疱性口炎病毒糖蛋白。
T13134	(+)-Tetrabenazine (+)-TBZ,(3R,11bR)-Tetrabenazine,(3R,11bR)-TBZ	Monoamine Transporter	Membrane transporter/Ion channel
	(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) 是一种可逆的囊泡单胺转运蛋白2 (VMAT-2)抑制剂，对 VMAT2转运的抑制作用是VMAT1的10倍。
T22486	Vesamicol hydrochloride (±)-AH5183 hydrochloride	AChR	Neuroscience
	Vesamicol hydrochloride ((±)-AH5183 hydrochloride) ((±)-AH5183 hydrochloride) 是一种有效的囊泡乙酰胆碱转运 (vesicular acetylcholine transport) 抑制剂，Ki 为 2 nM。(±)-Vesamicol hydrochloride 也对 σ1 和 σ2 受体具有高亲和力，Ki 值分别为 26 nM 和 34 nM。
T23409	FM4-64 SynaptoRedTM C2	Others	Others
	FM4-64 (SynaptoRedTM C2) 是一种苯乙烯类染料，染色效果稳定，但在在水溶液中基本不发荧光。FM4-64与质膜双层结合后不能被动扩散进入细胞内部,必须通过主动运输的方式进行跨膜运输。FM4-64 可用于研究胞吞胞吐和囊泡运输。
T3534	Tetrabenazine Racemate Nitoman,丁苯那嗪外消旋体,丁苯那嗪,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE	Monoamine Transporter	Membrane transporter/Ion channel
	Tetrabenazine Racemate (Rubigen) 是一种选择性和可逆的囊泡单胺转运蛋白 2(VMAT-2) 抑制剂。它阻断神经递质吸收到肾上腺素能储存囊泡中，并已被用作囊泡运输系统的高亲和力标记。
T7651	Rose Bengal sodium Rose Bengal,酸性红 94	Influenza Virus; Monoamine Transporter	Membrane transporter/Ion channel; Microbiology/Virology
	Rose Bengal sodium 是一种合成的荧光素衍生物，主要成分是 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo 荧光素，可以检测眼表干燥或受损的细胞，用作眼科诊断剂，具有抗病毒活性。它是一种 VGlut 和囊泡单胺转运蛋白抑制剂，VGlut 和 VMAT 的 Ki 分别为 19 和 64 nM。
T77549	Nurr1 agonist 2	Others	Others
	Nurr1 agonist 2 是一种 Nurr1 激动剂，EC50 值为 0.07 μM。Nurr1 agonist 2 增加 Nurr1 调节基因酪氨酸羟化酶 (TH) 和囊泡氨基酸转运蛋白 2 (VMAT2) 的 mRNA 表达。Nurr1 agonist 2 与重组 Nurr1 配体结合域 (LBD) 结合，Kd 值为 0.14 μM。Nurr1 agonist 2 可用于研究帕金森综合征。
T22781L	FFN 511 hydrochloride FFN 511 hydrochloride(1004548-96-2 Free base)
	FFN 511 hydrochloride 是一种针对神经元囊泡单胺转运体 2 (VMA T2) 的荧光假神经递质 (FFNs)。FFN 511 hydrochloride 可抑制 5-羟色胺与含 VMA T2 的膜结合，可用于标记活体皮质-纹状体急性切片中的多巴胺能神经末梢。激发和发射最大值分别为 406 和 501 nm。
T0313	Evans blue Direct Blue 53,C.I. 23860,伊文思蓝	GluR	Neuroscience
	Evans blue (C.I. 23860) 是一种突触泡谷氨酸吸收的有效抑制剂，同时也是一种AMPA/kainate 受体拮抗剂。
T25750	Lobelane Hydrochloride
	Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.
T36949	Niaprazine	5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Niaprazine 是有效的组胺 H1 受体拮抗剂，具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。
T70322	Valbenazine dihydrochloride
	Valbenazine dihydrochloride inhibits vesicular monoamine transporter 2 (VMAT2); used to treat tardive dyskinesia.
T31790	FFN200 dihydrochloride FFN200 HCl,FFN200,FFN 200,FFN-200
	FFN200 is a vesicular monoamine transporter 2 (VMAT2) substrate that selectively traces monoamine exocytosis in both neuronal cell culture and brain tissue.
T31791	FFN246 HCl FFN 246,FFN246 hydrochloride,FFN246,FFN-246
	FFN246 is a fluorescent substrate for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2).
T24941	VMAT2-IN-I HCl VMAT2 IN I Hydrochloride,VMAT2-IN-I Hydrochloride,VMAT2INI Hydrochloride
	VMAT2-IN-I HCl is an inhibitor of vesicular monoamine transporter-2. It also has 15- fold greater affinity than GZ- 793A.
T12190	Trans (2,3)-Dihydrotetrabenazine (2R,3R,11bR)-rel-DHTBZ,(2R,3R,11bR)-rel-Dihydrotetrabenazine	Others	Others
	Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).
T22452	Valbenazine tosylate 結苯那嗪,NBI-98854	Monoamine Transporter	Membrane transporter/Ion channel
	Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).
T75768	VSV-G tag Peptide
	VSV-G Peptide 是一种源于水泡性口炎病毒糖蛋白的由 11 个氨基酸残基组成的多肽。
TP2191	VSV-G Peptide	Others	Others
	VSV-G is a vesicular stomatitis virus G (VSV-G) protein fragment. VSV-G protein is commonly used in biomedical research to pseudotype retroviral and lentiviral vectors, conveying the ability to transduce a broad range of mammalian cell types with genes of
T39878	FFN270 hydrochloride FFN270 hydrochloride
	FFN270 hydrochloride, a fluorescent tracer for norepinephrine and vesicular monoamine transporters, features dual resolved absorption/excitation peaks that vary with solvent pH (FFN270 ex: 320 nm or 365 nm, em: 475 nm). It serves as a ratiometric fluorescent pH-sensor, highlighting its utility in monitoring norepinephrine.
T9300	DiPT
	DiPT 是5HT2A 受体的激动剂和5HT1A 受体的部分激动剂, 抑制 5-羟色胺转运体和泡状单胺转运体 2 的转运。
T78684	FFN246	5-HT Receptor	GPCR/G Protein; Neuroscience
	FFN246作为serotonin transporter (SERT) 和 vesicular monoamine transporter2 (VMAT2) 的荧光双底物探针，具有392/427 nm的激发和发射光谱。该化合物能够通过SERT依赖性积累，标记小鼠脑组织中的5-羟色胺能神经元。
T79758	BQZ-485	Apoptosis	Apoptosis
	BQZ-485是一种有效的GDI2抑制剂，它通过与Tyr245相互作用以破坏GDI2-Rab1A之间的内在相互作用，阻断了从内质网(ER)至高尔基体的囊泡转运，并触发了随后的凋亡事件。
T36045	1a,1b-dihomo Prostaglandin E2 1a,1b-dihomo Prostaglandin E2
	1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid . This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
T36887	8(E),10(E),12(Z)-Octadecatrienoic Acid
	8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland...

化合物

Cat.No: T7147

Synonym: NBI-98854

Target: Monoamine Transporter

Clodronate disodium tetrahydrate

Cat.No: T3280

Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium

Target: IL Receptor, TNF

Cat.No: T7563

Synonym: (+)-α-二氢丁苯那嗪,(+)-α-Dihydrotetrabenazine,(+)-α-DHTBZ,(+)-DTBZ,[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-六氢-9,10-二甲氧基-3-异丁基-2H-苯并[a]喹嗪-2-醇

Target: Monoamine Transporter

VSV-G Peptide acetate(103425-05-4 free base)

Cat.No: TP1429

Synonym: VSV-G Peptide

Target: Others

(+)-Tetrabenazine

Cat.No: T13134

Synonym: (+)-TBZ,(3R,11bR)-Tetrabenazine,(3R,11bR)-TBZ

Target: Monoamine Transporter

Vesamicol hydrochloride

Cat.No: T22486

Synonym: (±)-AH5183 hydrochloride

Target: AChR

Cat.No: T23409

Synonym: SynaptoRedTM C2

Target: Others

Tetrabenazine Racemate

Cat.No: T3534

Synonym: Nitoman,丁苯那嗪外消旋体,丁苯那嗪,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE

Target: Monoamine Transporter

Rose Bengal sodium

Cat.No: T7651

Synonym: Rose Bengal,酸性红 94

Target: Influenza Virus, Monoamine Transporter

Nurr1 agonist 2

Cat.No: T77549

Target: Others

FFN 511 hydrochloride

Cat.No: T22781L

Synonym: FFN 511 hydrochloride(1004548-96-2 Free base)

Cat.No: T0313

Synonym: Direct Blue 53,C.I. 23860,伊文思蓝

Target: GluR

Lobelane Hydrochloride

Cat.No: T25750

Cat.No: T36949

Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Valbenazine dihydrochloride

Cat.No: T70322

FFN200 dihydrochloride

Cat.No: T31790

Synonym: FFN200 HCl,FFN200,FFN 200,FFN-200

Cat.No: T31791

Synonym: FFN 246,FFN246 hydrochloride,FFN246,FFN-246

Cat.No: T24941

Synonym: VMAT2 IN I Hydrochloride,VMAT2-IN-I Hydrochloride,VMAT2INI Hydrochloride

Trans (2,3)-Dihydrotetrabenazine

Cat.No: T12190

Synonym: (2R,3R,11bR)-rel-DHTBZ,(2R,3R,11bR)-rel-Dihydrotetrabenazine

Target: Others

Valbenazine tosylate

Cat.No: T22452

Synonym: 結苯那嗪,NBI-98854

Target: Monoamine Transporter

VSV-G tag Peptide

Cat.No: T75768

Cat.No: TP2191

Target: Others

FFN270 hydrochloride

Cat.No: T39878

Synonym: FFN270 hydrochloride

Cat.No: T9300

Cat.No: T78684

Target: 5-HT Receptor

Cat.No: T79758

Target: Apoptosis

1a,1b-dihomo Prostaglandin E2

Cat.No: T36045

Synonym: 1a,1b-dihomo Prostaglandin E2

8(E),10(E),12(Z)-Octadecatrienoic Acid

Cat.No: T36887

Cat. No.	Product Name	Target	Signaling Pathways
T75570	Justicidin C
	Justicidin C 是一种抗病毒木脂素，对水泡性口炎病毒展现了较强的抗病毒活性，同时在兔肺细胞(RL-33)中显示较低的细胞毒性。

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Cat.No: T75570

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