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Search Results for " vasodilating "

22

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8462	Enoximone 依诺昔酮,烯氟酮	PDE	Metabolism
	Enoximone 是一种选择性的，具有口服活性的磷酸二酯酶 III 抑制剂，也是正性肌力血管舒张剂。它通过抑制 cGMP 抑制的 PDE 来诱导血管舒张并增加细胞内 cAMP 水平。它还表现出 PDE4抑制作用，对心肌 PDE4A 的 IC50为 21.1 μM。它用于充血性心力衰竭的研究，并具有支气管扩张，抗哮喘和抗炎作用。
T6551	Isosorbide Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide	Others	Others
	Isosorbide (Devicoran) 是一种血管舒张剂，也是一种高渗利尿剂，口服具有活性。可用于研究心力衰竭和心绞痛(胸痛)。
T0109	Molsidomine Morsydomine,SIN-10,吗多明,Corvaton	NOD	Immunology/Inflammation; NF-κB
	Molsidomine (Corvaton) 是一种长效的、口服活性的血管扩张药，在肝脏中代谢可被为活性代谢物Linsidomine。其中Linsidomine 是一种不稳定的化合物，能够产生NO，可用作血管舒张剂。
TNU0864	HUP30	Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	HUP30是一种强效的血管舒张剂。HUP30可以刺激可溶性鸟苷酸环化酶，激活 K+离子通道，阻断细胞外 Ca2+的内流。
T0112	Diltiazem hydrochloride CRD-401,盐酸地尔硫卓,RG 83606 HCl,Diltiazem HCl	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Diltiazem hydrochloride (RG 83606 HCl) 是一种苯并硫氮卓类钙通道阻滞剂，由于其拮抗钙离子对膜功能的作用而具有血管舒张作用。
T0903	Cinnarizine Stugeron,桂利嗪,Cinarizine,Dimitronal,Stutgin	Calcium Channel; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Cinnarizine (Stugeron) 是一种哌嗪衍生物，具有组胺 H1 受体和钙通道阻断活性，具有扩张血管和止吐的特性，可促进脑血流，用于脑中风、创伤后脑症状和脑动脉硬化的研究。
T15130	Dilazep dihydrochloride	Others	Others
	Dilazep dihydrochloride 是一种腺苷摄取的抑制剂。它可抑制缺血性损伤，血小板聚集和核苷的膜转运。它能够增强腺苷的作用，进而具有脑和冠状血管舒张作用。
T2671	Regadenoson CVT-3146,瑞加德松,Lexiscan	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Regadenoson (CVT-3146) 是一种腺苷衍生物和选择性 A2A 腺苷受体激动剂，具有冠状动脉舒张活性，对大鼠和猪腺苷 A2A 受体的Ki 分别为 290 和 1120 nM。它是血管扩张剂，可增加啮齿动物血脑屏障的通透性。
T26081	Ridazolol Ridazololum
	Ridazolol is a vasodilating and cardioselective beta adrenergic blocker.
T30586	Brefonalol
	Brefonalol is a vasodilating beta-adrenergic receptor blocker.
T26201	Sorbinicate LG10017,Sorbinicatum,LG10,017,LG-10017,LG 10017
	Sorbinicate is an antihypercholesterolaemic and vasodilating nicotinic acid ester.
T30487	BMS 180448 BMS-180448,BMS180448
	BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.
T70678	Rwj 29009
	Rwj 29009 is a potassium channel activator with prominent coronary and peripheral vasodilating actions.
T61495	Medroxalol
	Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist that effectively blocks both α- and β-adrenergic receptors, effectively producing antihypertensive and vasodilating effects [1].
T68600	Enoximone sulfoxide
	Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation of cAMP by PDE, which prolongs signal transduction and its subsequent effects. It is used in patients with congestive heart failure.
T11609	ICI 153110	Others	Others
	ICI 153110 is an orally active phosphodiesterase inhibitor with both inotropic and vasodilating properties. It is designed for the treatment of congestive cardiac failure.
T10371	Arotinolol	5-HT Receptor	GPCR/G Protein; Neuroscience
	Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. It is an antihypertensive agent.
T29213	Zelandopam free base YM-435,YM435,MYD-37,MYD37,Zelandopam
	Zelandopam is a dopamine D1 agonist. Zelandopam is a potent stimulant of pancreatic exocrine secretion by acting on DA D1 receptors of the pancreas in dogs. Intravenous administration of Zelandopam produces renal vasodilating and diuretic/natriuretic effe
T69303	Isoxsuprine Free Base
	Isoxsuprine Free Base is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
T36547	Quazinone
	Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.1,2 It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).1 Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.2 It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smoot...
T35600	NO-Losartan A
	Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodi...
T78007	Vasonatrin Peptide (VNP) TFA
	Vasonatrin Peptide (VNP) TFA 是一种由心钠素 (ANP) 和C型利钠肽 (CNP) 嵌合而成的肽类化合物。它整合了CNP的静脉扩张功能、ANP的利尿效果，并展现出与ANP或CNP无关的特有动脉扩张特性。Vasonatrin Peptide TFA 透过cGMP-PKG信号途径发挥其对内质网应激介导的糖尿病心脏缺血再灌注损害的保护作用。

化合物

Cat.No: T8462

Synonym: 依诺昔酮,烯氟酮

Target: PDE

Cat.No: T6551

Synonym: Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide

Target: Others

Cat.No: T0109

Synonym: Morsydomine,SIN-10,吗多明,Corvaton

Target: NOD

Cat.No: TNU0864

Target: Potassium Channel, Calcium Channel

Diltiazem hydrochloride

Cat.No: T0112

Synonym: CRD-401,盐酸地尔硫卓,RG 83606 HCl,Diltiazem HCl

Target: Calcium Channel

Cat.No: T0903

Synonym: Stugeron,桂利嗪,Cinarizine,Dimitronal,Stutgin

Target: Calcium Channel, Histamine Receptor

Dilazep dihydrochloride

Cat.No: T15130

Target: Others

Cat.No: T2671

Synonym: CVT-3146,瑞加德松,Lexiscan

Target: Adenosine Receptor

Cat.No: T26081

Synonym: Ridazololum

Cat.No: T30586

Cat.No: T26201

Synonym: LG10017,Sorbinicatum,LG10,017,LG-10017,LG 10017

Cat.No: T30487

Synonym: BMS-180448,BMS180448

Cat.No: T70678

Cat.No: T61495

Enoximone sulfoxide

Cat.No: T68600

Cat.No: T11609

Target: Others

Cat.No: T10371

Target: 5-HT Receptor

Zelandopam free base

Cat.No: T29213

Synonym: YM-435,YM435,MYD-37,MYD37,Zelandopam

Isoxsuprine Free Base

Cat.No: T69303

Cat.No: T36547

Cat.No: T35600

Vasonatrin Peptide (VNP) TFA

Cat.No: T78007

Cat. No.	Product Name	Target	Signaling Pathways
T21047	Apovincamine cis-Apovincamine
	Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.
T0879L	Niacin hydrochloride
	Niacin hydrochloride is a water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is needed by the body for the formation of coenzymes NAD and NADP. It possesses PELLAGRA-curative, vasodilating, and antilipemic properties.

天然产物

Cat.No: T21047

Synonym: cis-Apovincamine

Niacin hydrochloride

Cat.No: T0879L

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