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Dilazep dihydrochloride

产品编号 T15130 CAS 20153-98-4

Dilazep dihydrochloride 是一种腺苷摄取的抑制剂。它可抑制缺血性损伤，血小板聚集和核苷的膜转运。它能够增强腺苷的作用，进而具有脑和冠状血管舒张作用。

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Dilazep dihydrochloride Chemical Structure

Dilazep dihydrochloride, CAS 20153-98-4

规格	价格/CNY	货期
1 mg	￥ 186	现货
5 mg	￥ 398	现货
10 mg	￥ 663	现货
25 mg	￥ 1,330	现货
50 mg	￥ 2,160	现货
100 mg	￥ 3,490	现货
200 mg	￥ 4,480	现货
500 mg	￥ 7,130	现货
1 mL * 10 mM (in DMSO)	￥ 618	现货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Dilazep dihydrochloride is an adenosine uptake inhibitor. Dilazep dihydrochloride also inhibits the ischemic damage, membrane transport of nucleosides and platelet aggregation. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine.
体外活性	Dilazep, NBI and Dipyridamole have been reported to inhibit the uptake of adenosine into different cells. The uptake mechanism has been studied extensively in vitro. In these compounds, Dilazep and NBI are almost 10 times more effective than Dipyridamole. Only Dilazep is water soluble and no solubility aiding organic solvent is needed for preparing an aqueous solution[1].
体内活性	Dilazep inhibits the phospholipase activation in reperfused heart mitochondria and also inhibits the lipid peroxidation caused by cerebral ischemia and reperfusion. Dilazep may prevent ischemic cerebral injury due to an increase in cerebral blood flow and/or its protective effects on vascular endothelial cell membrane. After administration of Dilazep, even low doses (0.04-0.1 mg/kg/min) of exogenous adenosine significantly increases superior mesenteric arterial conductance (SMAC) and elevates arterial plasma adenosine concentration. The increased adenosine levels were highly correlated with the increased percentage of change of SMAC and values for Rmax and EC50 were 193.4% change of SMAC and 2.8 μM, respectively. Administration of bolus doses of 8-phenyltheophylline abolishes the ability of Dilazep to potentiate vasodilation. However, it did not affect isoproterenol-induced relaxation[1].

分子量	677.61
分子式	C31H46Cl2N2O10
CAS No.	20153-98-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 60 mg/mL (88.55 mM), Sonication is recommended.

H2O: 80 mg/mL (118.06 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO / H2O	1 mM	1.4758 mL	7.3789 mL	14.7578 mL	36.8944 mL
	5 mM	0.2952 mL	1.4758 mL	2.9516 mL	7.3789 mL
	10 mM	0.1476 mL	0.7379 mL	1.4758 mL	3.6894 mL
	20 mM	0.0738 mL	0.3689 mL	0.7379 mL	1.8447 mL
	50 mM	0.0295 mL	0.1476 mL	0.2952 mL	0.7379 mL
H2O	100 mM	0.0148 mL	0.0738 mL	0.1476 mL	0.3689 mL

计算器

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参考文献

1. Zhang Y, et al. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation. J Pharmacol Exp Ther. 1991 Sep;258(3):767-71. 2. Kawagoe J, et al. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):485-8.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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