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Cat. No. | Product Name | Target | Signaling Pathways |
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T8702 |
SKF-83566
|
Dopamine Receptor; 5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂,Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂,可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。 | |||
T7180 |
Sultopride hydrochloride
LIN-1418 hydrochloride,盐酸舒托必利,盐酸舒必利 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Sultopride hydrochloride (LIN-1418 hydrochloride) 是一种多巴胺 D2受体的选择性拮抗剂。 | |||
T27252 |
ELB-139
ELB139 |
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ELB-139 is a GABA A receptor agonist. ELB139 increases 5-HT in the striatum and prefrontal cortex of rats. | |||
T14083 |
Abaperidone
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Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Abaperidone 是一种有效的 5-HT2A 受体和多巴胺 D2 受体拮抗剂,对 5-HT2A 受体的 IC50 为 6.2 nM,对多巴胺 D2 受体的IC50 为 17 nM。Abaperidone是一种潜在的非典型抗精神化合物,可降低大鼠纹状体和前额叶皮层中的基础hsp70 mRNA表达。 | |||
T12483 |
Piperidine-MO-1
|
Others | Others |
Piperidine-MO-1是多巴胺受体 (dopamine receptor) 调节剂,在大鼠纹状体中增加DOPAC 的 ED50 值为68 μmol/kg。 | |||
TP1597L |
Secretoneurin, rat acetate
Secretoneurin, rat acetate(149146-12-3 Free base) |
Others | Others |
Secretoneurin, rat acetate 是一种 33 个氨基酸的多肽,由分泌粒蛋白 II (SgII) 的蛋白水解加工产生。它在体内和体外诱导大鼠纹状体中的多巴胺释放,它对单核细胞和嗜酸性粒细胞有很强的趋化作用,但对粒细胞没有。 | |||
T22781L |
FFN 511 hydrochloride
FFN 511 hydrochloride(1004548-96-2 Free base) |
||
FFN 511 hydrochloride 是一种针对神经元囊泡单胺转运体 2 (VMA T2) 的荧光假神经递质 (FFNs)。FFN 511 hydrochloride 可抑制 5-羟色胺与含 VMA T2 的膜结合,可用于标记活体皮质-纹状体急性切片中的多巴胺能神经末梢。激发和发射最大值分别为 406 和 501 nm。 | |||
T6951 |
Pramipexole dihydrochloride hydrate
Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Pramipexole dihydrochloride hydrate (Mirapex) 是选择性的,具有血脑屏障 (BBB) 渗透性的 D2 型多巴胺受体激动剂,对 D2 型受体、D2、D3、D4亚型受体的 Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM,可用于研究帕金森综合症和腿多动综合征。 | |||
TP1920L1 |
Acein acetate
|
RAAS | Endocrinology/Hormones |
Acein acetate 是高亲和力血管紧张素转换酶 (ACE) 配体 (Kd = 2.79 nM)。浓度高达 500 nM 时对 ACE 酶活性没有显着影响。增强 NMDA + D-丝氨酸诱导的多巴胺从体外纹状体切片和体内纹状体的释放。 | |||
T23265 |
RS 67333 hydrochloride
RS 67333 (hydrochloride),RS 67333 HCl,盐酸RS67333 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
RS 67333 hydrochloride (RO5203648) 是一种有效的、选择性的5-HT4 受体 (5-HT4R) 部分激动剂,在豚鼠纹状体中的 pKi 为 8.7。RS 67333 hydrochloride 对其他几种受体的亲和力较低,包括 5-HT1A、5-HT1D、5-HT2A、5-HT2C、多巴胺 D1、D2 和毒蕈碱 M1-M3 受体。RS 67333 hydrochloride 具有神经保护作用,可用于阿尔茨海默病研究。 | |||
T37190 |
L-Allylglycine
|
Dehydrogenase; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Allylglycine 是 GABA 合成酶(谷氨酸脱羧酶)的有效抑制剂。 | |||
T33656 |
Neurotensin (1-6)
|
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Neurotensin (1-6) affects dopamine release from striatum. | |||
T26993 |
CGP 56999A
CGP56999A,CGP-56999A |
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CGP 56999A is an antagonist of GABA(B) receptor, it enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum. | |||
T23722 |
AMG-7980
AMG7980 |
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AMG-7980 is a highly specific phosphodiesterase 10A ligand. It shows a good uptake in the striatum. | |||
T10542 |
Bifeprunox
|
Others | Others |
Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schizophrenia. | |||
T69449 | Cyclindole | ||
Cyclindole is an antipsychotic with a tricyclic structure that was never marketed. It displaces spiperone binding in vitro and elevates dopamine levels in the striatum, indicating it acts as a D₂ receptor antagonist. | |||
T28336 |
PD 142505-0028
CI 1017,CI1017,CI-1017,PD-142505-0028,PD42505-0028 |
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PD 142505-0028, a functionally M1-selective muscarinic agonist, rapidly increases glutamate but not aspartate concentrations in the striatum of anesthetized rats. Additionally, it inhibited production of amyloidogenic A beta and increased secretion of sol | |||
T36233 |
Dicrotalic anhydride
3-hydroxy-3-Methylglutaric anhydride |
Others | Others |
Dicrotalic anhydride(3-hydroxy-3-Methylglutaric anhydride) 可诱导大鼠纹状体DNA损伤。 | |||
T38221 |
N,N-Dipropyldopamine (hydrobromide)
|
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N,N-Dipropyldopamine is a dopamine receptor agonist.1,2,3 It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 μmol/kg, respectively), as well as reduces homovanillic acid levels in rat striatum when administered at a dose of 80 μmol/kg.1 N,N-Dipropyldopamine (0.5-16 mg/kg) reduces spontaneous locomotor activity in mice, an effect that can be reversed by the antipsychotic spiroperidol.2,3 | |||
T27455 |
GSK-215083
GSK215083 |
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GSK-215083 is a PET radioligand for the 5-HT6 receptor. GSK 215083 is a quinoline based compounds and acts by antagonising the 5-HT6 receptor. GSK-215083 binds to receptors 5-hydroxytrypamine-6 (5HT6) in the striatum and 5-hydroxytryptamine-2A (5HT2A) in | |||
T16547 |
PK14105
|
Others | Others |
PK14105 has been evaluated biologically as a potential radioligand for positron emission tomography (PET) studies targeting peripheral benzodiazepine binding sites (PBBS) receptors. When administered to rats with unilaterally lesioned striata, PK14105 was observed to quickly cross the blood-brain barrier, displaying significant radioactivity retention in the lesioned striatum, in contrast to the unlesioned striatum or cerebellar vermis. Additionally, PK14105 has the capability to inhibit recepto... | |||
TP1920 |
Acein
|
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Acein is a High affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo. | |||
T76599 |
Ac-Leu-Val-Lys-Aldehyde
|
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Ac-Leu-Val-Lys-Aldehyde 是有效的组织蛋白酶 B (cathepsin B) 抑制剂,其 IC50 值为 4 nM。该化合物能显着降低喹啉酸引起的纹状体细胞死亡,并促使 LC3-II 积累。 | |||
T76403 |
[Glp5] Substance P (5-11)
|
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[Glp5] Substance P (5-11)为一八肽,为大鼠中枢神经系统(CNS)主要P物质片段之一,局部调节大鼠纹状体多巴胺释放。 | |||
T29002 |
Trazium Esilate
EGYT3615,EGYT-3615,EGYT 3615 |
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Trazium esilate is an adrenergic receptor antagonist. Trazium esilate is a weak displacer on a1-, a2- and D2-receptors, however, it induced a2-receptor desenzitization after repeated treatment. It had no influence on rat brain cortical noradrenaline and s | |||
T26564 |
ADCI
SGB-017,SGB017,SGB 017 |
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ADCI is an inhibitor of voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabolism in the prefrontal cortex and/o | |||
T82972 |
Argininosuccinic acid disodium
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Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Argininosuccinic acid disodium 在尿素循环的第四步起关键作用,由ASL(精氨酸琥珀酸裂解酶)催化裂解生成精氨酸和富马酸。此外,该化合物能够降低GSH(还原型谷胱甘肽)浓度,并提升大脑皮层与纹状体中的活性氧产生。Argininosuccinic acid disodium 还可能导致脂质过氧化和蛋白质氧化,并在发育中的大鼠脑内触发氧化应激。 | |||
T70456 |
Nolpitantium Free Base
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Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no eff... | |||
T36176 |
AMK (hydrochloride)
|
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AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7... | |||
T36521 |
Alaproclate (hydrochloride)
|
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Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio... | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
T83894 |
4A7C-301-Nurr1 Agonist
4A7C-301-Nuclear Receptor-Related 1 |
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4A7C-301-Nurr1激动剂是一种核受体相关1(Nurr1)的激动剂。它通过与Nurr1配体结合域(LBD;IC50 = 48.22 nM)结合,增加了在使用SK-N-BE(2)C人神经母细胞瘤细胞进行的报告基因测定中Nurr1-LBD和全长Nurr1的转录活性(EC50s = 6.53 和 50-70 µM,分别)。每天5 mg/kg的4A7C-301-Nurr1激动剂能减少在经MPTP神经毒素或α-突触核蛋白过表达诱导的帕金森病鼠模型中纹状体和黑质compacta部分多巴胺能细胞的死亡,并减少运动和嗅觉缺陷,而不诱发类似运动障碍的行为。 | |||
T36947 |
Pyrithiamine (hydrobromide)
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Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner.... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6S2227 |
Spinosin
斯皮诺素,Flavoayamenin |
Others | Others |
Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮,从 Zizyphus jujube 种子分离得到,能够激活 Nrf2/HO-1 通路,并抑制 Aβ1-42的产生和聚合。 |