18
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Cat. No. | Product Name | Target | Signaling Pathways |
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T7837 |
SR8278
|
Others | Others |
SR8278 是竞争性核血红素受体REV-ERB 合成拮抗剂,能够抑制 REV-ERBα 转录活性(EC50:0.47 μM)。它可用于调节生物体内的代谢和研究生物节律。 | |||
TP1264 |
Prolylleucine
((Benzyloxy)carbonyl)-L-prolyl-D-leucine |
Others | Others |
Prolylleucine (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) 是一种二肽,含有支链氨基酸,可以影响动物的昼夜节律和行为。 | |||
T13573 |
Arrhythmias-Targeting Compound 1
|
Others | Others |
Arrhythmias-Targeting Compound 1 is a compound. It is used in the research of arrhythmias. | |||
T72323 |
Antiarrhythmic agent-1
|
||
Antiarrhythmic agent-1 (示例 I) 是一种抗心律失常试剂,也是IKr 钾离子通道抑制剂 (IC50<1 μM)。 | |||
T83102 |
Antiarrhythmic peptide (cattle atrium)
|
||
Antiarrhythmic peptide (cattle atrium)是一种具有保护作用的六肽,能对抗活性分子诱导的心律不齐。 | |||
T13900 |
Arrhythmic-Targeting Compound 1
|
Others | Others |
Arrhythmic-Targeting Compound 1 is used for arrhythmic disease, with nitrogen-containing spirocycles. | |||
T73573 |
CLK8
|
Others | Others |
CLK8 是一种具有选择性的 CLOCK 抑制剂,可结合并干扰 CLOCK 活性,破坏 CLOCK 和 BMAL1 之间的相互作用,可调节昼夜节律振幅。CLK8 可用于研究与昼夜节律相关的疾病。 | |||
T60005 |
CK1-IN-3
|
Casein Kinase | Metabolism; Stem Cells |
CK1-IN-3 是酪蛋白激酶 1 抑制剂,可用于治疗或预防与 circadiantiazol 节律相关的疾病、炎症性疾病的研究。 | |||
T1012 |
Acebutolol hydrochloride
盐酸醋丁洛尔,Acebutolol HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂,用于研究高血压、心绞痛和心律失常。 | |||
T6476 |
Dofetilide
UK 68789,UK-68798,Tikosyn,多非利特 |
Potassium Channel | Membrane transporter/Ion channel |
Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂,作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。 | |||
T16127 |
Moricizine
Moracizine,莫雷西嗪 |
Others | Others |
Moricizine is an antiarrhythmia agent which is used primarily for ventricular rhythm disturbances. | |||
T17095 |
TIK-301
PD-6735,LY-156735 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment. | |||
TP1980 |
Neuromedin S(rat)
Neuromedin S (rat) |
||
Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide. | |||
T78351 |
Phosphoenolpyruvate carboxylase
PEPC |
||
Phosphoenolpyruvate carboxylase (PEPC) 是将磷酸烯醇丙酮酸同碳酸氢盐在 Mg2+ 存在下以不可逆的过程转变成草酰乙酸和无机磷的二氧化碳固定酶。该酶在催化景天酸代谢植物中二氧化碳(CO(2))的初级同化过程中发挥关键作用,并在植物代谢的昼夜模式设定中扮演主要角色。 | |||
T81275 |
Riboxin
IDP |
||
Riboxin (IDP) 是一种抗缺氧及抗高血压活性的口服有效嘌呤衍生物次黄苷。该化合物对心律失常也具有治疗作用,能够干预Ouabain诱导的猫、兔子、小鼠的心脏节律障碍模型。此外,Riboxin还能保护动物不受γ辐射的损害。 | |||
TP2194 |
Neuropeptide Y (scrambled)
|
Others | Others |
Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous systems. It modulates a variety of physiological processes, e.g. the central reg | |||
T70070 |
Cisapride tartrate
|
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Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports o... | |||
T35993 |
Epitalon (acetate)
|
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Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S2215 |
Crebanine
|
Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 | |||
T71896 |
Brevicompanine B
|
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Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various genes involved in the regulation of plant circadian rhythm. It is active against P. falciparum. | |||
TN1812 |
Jujuboside B1
酸枣仁皂苷 B1 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides, jujubosides may be good source of lead compounds for novel hypnotics. |