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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T12643	(R)-Terazosin (R)-特拉唑嗪,盐酸特拉唑嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(R)-Terazosin 是一种 Terazosin 的活性 R 型对映体, 是 α1-肾上腺素受体拮抗剂，对 α1a，α1b 和α1d-肾上腺素受体的Ki 分别为 6.51 nM，1.01 nM 和 1.97 nM。
T25339	Dipiproverine
	Dipiproverine 是α-氨基酸酯类化合物，是一种解痉化合物。它被用作抗胆碱能药物。
T25339L	Dipiproverine hydrochloride L.D. 935,LD 935
	Dipiproverine 是 Dipiproverine 的盐酸盐形式。Dipiproverine 是α-氨基酸酯类化合物，一种解痉化合物，它被用作抗胆碱能药物。
T18924	Benzenepentacarboxylic Acid 苯五甲酸,Pentacarboxybenzene	Others	Others
	Benzenepentacarboxylic Acid (Pentacarboxybenzene) 是具有发现和清除HO 自由基作用的荧光染料。
T27868	LY 113174 LY-113174,LY113174
	LY 113174, a novel nonsteroidal aromatase inhibitor, may prove useful in the treatment of estrogen-dependent diseases.
TP1502	MAGE-A3 (195-203) MAGE-A3 195-203
	This peptide MAGE-3-encoded HLA-A24 epitope is a high MHC binder.The identification of this MAGE-3/HLA-A24 peptide may as a result effectiveially offer the opportunities to design peptide-based immunotherapeutic approaches that might prove to be potent in
T27507	GW-3333 GW 3333,GW3333
	GW-3333 is an matrix metalloproteinase inhibitor. It is also a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. The efficacy of GW3333 suggests that dual inhibitors of matrix metalloproteinases and TACE may prove therapeutic as antiar
T69479	CGC 11093
	CGC 11093 is a polyamine analog; inhibits growth of human prostate tumor xenografts in nude mice. It may prove useful in promoting regression of choroidal neovascularization.
T71011	Perfluorinated SAHA
	Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-like enzyme from P. aeruginosa, as well as other HDACs, which may prove beneficial for developing novel chemotherapeutic treatments for cancer.
T71622	Duartin
	Duartin is an anti-rickettsial compound. These small molecules and the workflow, featuring a high-throughput phenotypic screen for growth inhibitors of intracellular Rickettsia spp. and machine learning models for the prediction of growth inhibition of an obligate intracellular Gram-negative bacterium, should prove useful in the search for new therapeutic strategies to treat infections from Rickettsia spp. and other obligate intracellular bacteria.

化合物

(R)-Terazosin

Cat.No: T12643

Synonym: (R)-特拉唑嗪,盐酸特拉唑嗪

Target: Adrenergic Receptor

Dipiproverine hydrochloride

Cat.No: T25339L

Synonym: L.D. 935,LD 935

Target:

Benzenepentacarboxylic Acid

Cat.No: T18924

Synonym: 苯五甲酸,Pentacarboxybenzene

Target: Others

LY 113174

Cat.No: T27868

Synonym: LY-113174,LY113174

Target:

MAGE-A3 (195-203)

Cat.No: TP1502

Synonym: MAGE-A3 195-203

Target:

GW-3333

Cat.No: T27507

Synonym: GW 3333,GW3333

Cat. No.	Product Name	Target	Signaling Pathways
T5654	Musk ketone	Others	Others
	Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性，因此可能被证明是有用的癌症化学保护剂。
TL0014	Pinusolide	ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK	Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.

天然产物

Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK

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