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26

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9532	MRT-81	Others	Others
	MRT-81 是一种人和啮齿动物 smoothened 受体的有效拮抗剂，能够抑制 hedgehog 的活性，在 Shh-light2 细胞中的IC50值为 41 nM。它可用于研究癌症。
T19151	5-Chloro-2'-deoxyuridine 5-Chlorodeoxyuridine,5-氯-2-脱氧尿嘧啶核苷,CldU	Others	Others
	5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) 是胸腺嘧啶的类似物，可用于次氯酸对 DNA 和 DNA 前体的破坏作用的研究。
T1394	Ibuprofen Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID)，具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂，IC50值分别为 13 和 370 μM，导致前列腺素和血栓素前体的形成减少。
T0839	Ketoprofen 酮基布洛芬,RP-19583,酮洛芬	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Ketoprofen (RP-19583) 是一种非甾体抗炎剂，能够有效地抑制COX 的活性，在人血单核细胞中，对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。
T2403	Bromfenac sodium hydrate Bromfenac sodium,Bromfenac monosodium salt sesquihydrate,溴芬酸钠	COX	Immunology/Inflammation; Neuroscience
	Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) 是一种可口服的 COX 抑制剂，抑制 COX-1和COX-2的IC50值分别为 5.56 和 7.45 nM。它是一种溴化非甾体类抗炎药，有用于白内障的术后炎症和疼痛以及假晶状体囊状黄斑水肿的研究。
T15183	Dynarrestin	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Dynarrestin 是一种细胞质动力蛋白 1 和 2的氨基噻唑抑制剂。它能够快速的、可逆的抑制动力蛋白 1 驱动的微管在体外滑动和细胞内动力蛋白 1 和 2 依赖性过程，且不影响 ATP 水解和干扰纤毛发生。它可抑制神经元前体和肿瘤细胞的刺猬因子依赖性增殖。
T16008	Maleimido-tri(ethylene glycol)-propionic acid Mal-PEG3-acid	Others	Others
	Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-spec
T38020	O-Benzylhydroxylamine (hydrochloride)
	O-Benzylhydroxylamine is a building block.1,2It has been used in the synthesis of β-lactam inhibitor precursors and fluoroquinolone derivatives with antibiotic activity. 1.Bellettini, J.R., and Miller, M.J.A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitorsTetrahedron Lett.38(2)167-168(1997) 2.Asadipour, A., Moshafi, M.H., Khosravani, L., et al.N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluationDaru.26(2)19...
T20530	Cycloate HSDB 1712,R-2063,HSDB-1712,Etsan,R 2063,R2063
	Cycloate is a herbicide. It inhibits the biosynthesis of very-long-chain fatty acids, which is the essential constituents of plant suberin and waxes. Fatty acids also serve as precursors of aliphatic carbon chains in resorcinolic lipids.
T37322	Steryl Glucosides
	Steryl glucosides are neutral glycolipids commonly found in plant cell membranes and vegetable oils that contain a glucose moiety conjugated to a sterol lipid. They function as glucose donors in the biosynthesis of glucocerebrosides in plant microsomes and are metabolic precursors to acylated/esterified steryl glucosides. Steryl glucosides are the major component of filter- and engine-damaging precipitates formed during biodiesel production from transesterification of vegetable oils. This produ...
T40303	5-A-RU-PABC-Val-Cit-Fmoc	Others	Others
	5-A-RU-PABC-Val-Cit-Fmoc 是 5-A-RU 的前体物质之一。5-A-RU 是一种小分子粘膜相关的 MAIT 激活剂，是细菌合成核黄素的前体物质。
T36116	Concanamycin B
	Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell su...
T76176	Endo-β-N-acetylglucosaminidase	Antibiotic	Microbiology/Virology
	Endo-β-N-acetylglucosaminidase (Endo S) 是一种来自北拟杆菌的酶，可水解多支链复合物 N-聚糖，可在体内抑制抗体介导的炎症，广泛用于糖蛋白的聚糖分析和糖基化化合物前体的制备。
T37850	Chitobiose Octaacetate
	Chitobiose is a dimer of β-1,4 linked glucosamine units derived from chitin, which, in turn, is a long chain polymer of N-acetylglucosamine that is a primary component of fungal cell walls and arthropod exoskeletons. Chitobiose octaacetate is a form of chitobiose containing eight acetate groups. It is formed by the acetolysis of chitin. Chitobiose octaacetate can be used for the synthesis of chitobiose oxazoline and other chitin precursors.
T37530	Glycerophospho-N-Arachidonoyl Ethanolamine
	N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibit...
T35538	HPI-1 (hydrate) HPI-1 hydrate
	HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, prev...
T77076	Luspatercept
	Luspatercept (ACE-536) 是一种重组修饰的 ActRIIB 融合蛋白，与转化生长因子β超家族配体结合，通过与GDF11结合抑制Smad2/3信号通路，从而增加红细胞数量并促进红细胞前体成熟，用于贫血的研究。
T37954	Sphingosine (d20:1) Sphingosine (d20:1)
	Sphingosines are long-chain base precursors of cellular sphingolipids used directly in the synthesis of ceramide, which in combination with sialic acid forms ganglioside. Sphingosine can exist in four stereoisomers, however only sphingosine occurs naturally. Compared to other sphingolipids throughout the body, which are predominantly composed of C-18 sphingosine, only central nervous system (CNS) gangliosides contain significant amounts of sphingosine. The concentration of sphingosine within mam...
T37717	Galactosylcerebrosides (non-hydroxy)
	Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylcerebrosides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in ...
T37716	Galactosylcerebrosides (hydroxy)
	Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylcerebrosides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in ...
T36582	Glucocerebrosides (Gaucher's spleen)
	Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species. Glucocerebrosides are precursors in the synthesis of lactosylceramides and gangliosides. Increased levels of glucocerebrosides are associated with obesity-induced insulin resistance in mice and with neuronal deficits observed in neuronopathic Gaucher disease. This pr...
T38282	C22 Glucosylceramide (d18:1/22:0)
	C22 Glucosylceramide (d18:1/22:0) is an endogenous glucosylceramide. Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A2 (PLA2) type XIIA knockdown increases C22 glucosylceramide (d18:1/22:0) expression in rat brain. It is also increased in the brain, but not the liver or spinal cord, of mice f...
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。
T38049	Glycerophospho-N-Palmitoyl Ethanolamine
	N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). The different types of NAE are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is the metabo...
T80045	Defensin HNP-3 human	Antibiotic	Microbiology/Virology
	Defensin HNP-3 human 是一种具有抑制金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌活性的细胞毒性抗生素肽。该肽原先以94个氨基酸的preproHNP(1-94)形式合成，随后水解为proHNP(20-94)，最终通过去除阴离子前体转化为成熟形式的HNP(65-94)。
T83682	Tat-Gap 19 TFA
	Tat-Gap 19是一种针对连接蛋白43 (Cx43) 半通道的肽抑制剂，由HIV-1 Tat蛋白传导域与对应于Cx43第128-136残基的九氨基酸肽连接而成。Tat-Gap 19 (10 µM) 能够抑制初级大鼠肝细胞中由谷氨酸引发的ATP释放，这是Cx43半通道活性的标志。在通过中脑动脉堵塞(MCAO)诱导的小鼠脑缺血再灌注损伤模型中，以25 mg/kg的剂量进行给药，可减少梗死体积。腹腔内注射Tat-Gap 19 (1 mg/kg 每天) 能够减少硫代乙酰胺引起的小鼠肝损伤模型中的纤维化病灶面积及表达α-平滑肌肌动蛋白 (α-SMA) 的肝星状细胞（成纤维细胞的前体）面积，并提高同种小鼠分离的肝细胞中超氧化物歧化酶 (SOD) 活性。

化合物

Cat.No: T9532

Target: Others

5-Chloro-2'-deoxyuridine

Cat.No: T19151

Synonym: 5-Chlorodeoxyuridine,5-氯-2-脱氧尿嘧啶核苷,CldU

Target: Others

Cat.No: T1394

Synonym: Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil

Target: COX

Cat.No: T0839

Synonym: 酮基布洛芬,RP-19583,酮洛芬

Target: Apoptosis, COX, MRP

Bromfenac sodium hydrate

Cat.No: T2403

Synonym: Bromfenac sodium,Bromfenac monosodium salt sesquihydrate,溴芬酸钠

Target: COX

Cat.No: T15183

Target: Hedgehog/Smoothened

Maleimido-tri(ethylene glycol)-propionic acid

Cat.No: T16008

Synonym: Mal-PEG3-acid

Target: Others

O-Benzylhydroxylamine (hydrochloride)

Cat.No: T38020

Cat.No: T20530

Synonym: HSDB 1712,R-2063,HSDB-1712,Etsan,R 2063,R2063

Steryl Glucosides

Cat.No: T37322

5-A-RU-PABC-Val-Cit-Fmoc

Cat.No: T40303

Target: Others

Cat.No: T36116

Endo-β-N-acetylglucosaminidase

Cat.No: T76176

Target: Antibiotic

Chitobiose Octaacetate

Cat.No: T37850

Glycerophospho-N-Arachidonoyl Ethanolamine

Cat.No: T37530

HPI-1 (hydrate)

Cat.No: T35538

Synonym: HPI-1 hydrate

Cat.No: T77076

Sphingosine (d20:1)

Cat.No: T37954

Synonym: Sphingosine (d20:1)

Galactosylcerebrosides (non-hydroxy)

Cat.No: T37717

Galactosylcerebrosides (hydroxy)

Cat.No: T37716

Glucocerebrosides (Gaucher's spleen)

Cat.No: T36582

C22 Glucosylceramide (d18:1/22:0)

Cat.No: T38282

Cat.No: T83848

Glycerophospho-N-Palmitoyl Ethanolamine

Cat.No: T38049

Defensin HNP-3 human

Cat.No: T80045

Target: Antibiotic

Cat.No: T83682

Cat. No.	Product Name	Target	Signaling Pathways
T7450	1-Phenylpropane-1,2-dione 1-Phenyl-1,2-propanedione,Acetyl benzoyl,1-苯基-1,2-丙二酮	Others	Others
	1-Phenylpropane-1,2-dione (Acetyl benzoyl) 是麻黄素生物碱的生物合成前体，分离自从嫩麻黄中。
TN7073	3-Feruloyl-4-caffeoylquinic acid	Others	Others
	3-Feruloyl-4-caffeoylquinic acid 是一种绿原酸异构体。绿原酸是相关的咖啡品质标志、味道和香气前体以及重要的生物活性化合物。
T21065	Artemisitene	Others	Others
	Artemisitene 是青蒿素的氧化形式，是一种抗疟药。青蒿素前体是青蒿素生物合成的重要基础物质，包括青蒿素 B、青蒿素、青蒿酸等。
TN1733	Hesperetin 7-O-glucoside	Anti-infection; Antibacterial; HMG-CoA Reductase	Metabolism; Microbiology/Virology
	Hesperetin 7-O-glucoside 是通过 Hesperidin 的酶促转化产生的一种人 HMG-CoA 还原酶抑制剂，具有降压作用，可抑制幽门螺杆菌的生长。
T65269	L-Aspartic acid potasium salt Aspartic acid potasium salt,Potassium L-aspartate	Others	Others
	L-aspartic acid potasium salt（VX-548）是一种广泛存在于动植物体内的氨基酸。L-aspartic acid potasium salt驱动氮氧化物的产生，从而促进吞噬作用，有助于提高鱼类的成活率。L-aspartic acid potasium salt 可对抗生素产生刺激，刺激作用可能与参与天冬氨酸-4-半醛生物合成的前体有关。
T4858	4-Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid	Endogenous Metabolite	Metabolism
	4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。
TN6686	Cyclo(Pro-Pro)
	Cyclo(Pro-Pro) tasted bitter.Verpacamides A-D, a sequence of C11N5 diketopiperazines relating cyclo(Pro-Pro) to cyclo(Pro-Arg), from the marine sponge Axinella vaceleti is possible biogenetic precursors of pyrrole-2-aminoimidazole alkaloids.
TN2912	3,9-Dihydroxypterocarpan	Others	Others
	3,9-Dihydroxypterocarpan and phaseollidin are all good precursors of the pterocarpan phytoalexin phaseollin.
TN4785	Picrasidine I	NF-κB; ROS; MAPK	Immunology/Inflammation; MAPK; NF-κB
	Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-ÎºB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.
T10910	Cycloartenol	Others	Others
	Cyclopentanol is a plant sterol compound and one of the key precursors for biosynthesis of various sterol compounds. Cycloartenol inhibits the migration of glioma cells and inhibits the phosphorylation of p38 MAP kinase. Cycloenol has various pharmacologi

天然产物

1-Phenylpropane-1,2-dione

Cat.No: T7450

Synonym: 1-Phenyl-1,2-propanedione,Acetyl benzoyl,1-苯基-1,2-丙二酮

Target: Others

3-Feruloyl-4-caffeoylquinic acid

Cat.No: TN7073

Target: Others

Cat.No: T21065

Target: Others

Hesperetin 7-O-glucoside

Cat.No: TN1733

Target: Anti-infection, Antibacterial, HMG-CoA Reductase

L-Aspartic acid potasium salt

Cat.No: T65269

Synonym: Aspartic acid potasium salt,Potassium L-aspartate

Target: Others

4-Hydroxyphenylpyruvic acid

Cat.No: T4858

Synonym: 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid

Target: Endogenous Metabolite

Cat.No: TN6686

3,9-Dihydroxypterocarpan

Cat.No: TN2912

Target: Others

Cat.No: TN4785

Target: NF-κB, ROS, MAPK

Cat.No: T10910

Target: Others

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