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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20625	Prochloraz 咪鲜胺,Sporgon,Prelude	Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用，由此抑制麦角固醇的生物合成，从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和雄激素受体的拮抗剂，IC50分别为25 μM 和4 μM，并激活芳烃受体，EC50为1μM。
T23549	YM 511	P450; Aromatase	Endocrinology/Hormones; Metabolism
	YM 511 是一种高度特异性的非甾体芳香酶 (aromatase) 抑制剂。YM 511 竞争性抑制大鼠卵巢和人胎盘微粒体中的芳香酶活性 (IC50 分别为 0.4 和 0.12 nM)。YM 511 轻微抑制其他类固醇激素的产生。YM 511 具有用于抑制雌激素依赖性作用研究，不会影响其他类固醇激素的血清水平的潜力。
T22774L	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物，负责将氨酰 tRNA 酶促递送至核糖体。这种亚型（α 1）在脑、胎盘、肺、肝、肾和胰腺中表达，另一种亚型（α 2）在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝，其中一些（如果不是全部）代表不同的假基因。
TP2404	Relaxin C-peptide Relaxin (79-92)
	Relaxin C-peptide, as a synthetic 14-amino acid peptide found in human decidua & placenta, can represent a partial sequence of human relaxin connecting peptide.
T39067	MAGE-3 (271-279)
	MAGE-3 (271-279) is a peptide consisting of 271-279 amino acid residues that is derived from melanoma antigens encoded by the MAGE-3 gene. It is specifically recognized by cytolytic T lymphocytes (CTLs) and binds to the human leukocyte antigen (HLA)-A2 molecule. MAGE-3 is highly expressed in various human tumor types, such as malignant melanoma, but not in normal tissues, except for the testis and placenta.
T81090	Steroid sulfatase-IN-6
	Steroid sulfatase-IN-6 (Compound 10c) 是一种针对类固醇硫酸酯酶 (STS) 的不可逆抑制剂，对人胎盘 STS 的 Ki 值达到 0.4 nM。该化合物适用于肿瘤疾病研究。
T22856	IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]	Others	Others
	IgG has four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the placenta to give passive immunity to the fetus. Eliminates pathogens in the early stages of B cell-mediated (humoral
T35460	β-Endorphin (rat)
	β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagon...
T22774	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed

化合物

Prochloraz

Cat.No: T20625

Synonym: 咪鲜胺,Sporgon,Prelude

Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal

YM 511

Cat.No: T23549

Synonym:

Target: P450, Aromatase

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)

Synonym: Relaxin (79-92)

Steroid sulfatase-IN-6

Cat.No: T81090

Synonym:

Target:

IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]

Cat.No: T22774

Synonym:

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0478	Progesterone 孕酮,Pregn-4-ene-3,20-dione	Estrogen/progestogen Receptor; Progesterone Receptor; Opioid Receptor; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience; Others
	Progesterone (Pregn-4-ene-3,20-dione) 是类固醇激素，能够调节月经周期。
T1571	Estriol NSC-12169,Oestriol,雌三醇	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; MRP; Endogenous Metabolite	Endocrinology/Hormones; Immunology/Inflammation; Metabolism
	Estriol (Oestriol) 是G 蛋白偶联雌激素受体拮抗剂，能够作用于雌激素受体阴性乳腺癌细胞。
T1009	Estrone Oestrone,雌酮,Fluoroethyl,Aquacrine	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estrone (Aquacrine) 是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。