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47

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0322	Fipexide	Dopamine Receptor; AChR	GPCR/G Protein; Neuroscience
	Fipexide 是对氯苯乙酸衍生物，是哌嗪化学类的精神活性药物，作为促智药物，有用于老年痴呆的研究潜力。它可降低了纹状体腺苷酸环化酶的活性，通过多巴胺能神经传递对认知表现出积极的作用。
T10492	BD-AcAc 2 Ketone Ester	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	BD-AcAc 2 (Ketone Ester) 是一种酮单酯，是口服营养酮的来源。小鼠口服 BD-AcAc 2 后可提高血浆乙酰乙酸和β-羟基丁酸水平、血液钠离子、血糖水平和血肌酐水平。BD-AcAc 2 可以一定程度预防脓毒症小鼠的肌无力。BD-AcAc 2 显示出提高动物机体耐力和运动能力的潜力。BD-AcAc 2 还可用于研究糖尿病或帕金森病。
T70793	Parogrelil Free Base
	Parogrelil Free Base is a phosphodiesterase inhibitor, improves claudication-limited exercise performance in patients with peripheral arterial disease.
T16728	Reldesemtiv CK-2127107	Others	Others
	Reldesemtiv (CK-2127107) 是一种快速骨骼肌肌钙蛋白的选择性激活剂，EC50 为 3.4 μM。 Reldesemtiv 提高了心力衰竭模型中的运动表现。
T12950	Sodium laureth sulfate Sodium lauryl polyoxyethylene ether sulfate,月桂醇聚氧乙烯醚硫酸酯钠盐	Others	Others
	Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate) 是一种阴离子活性剂，具有优良的去污，分散，乳化，润湿等性能。
T19205	Benzophenonetetracarboxylic acid 4,4'-Carbonyldiphthalic acid,3,3',4,4'-Benzophenonetetracarboxylic acid	Others	Others
	Benzophenonetetracarboxylic acid (3,3',4,4'-Benzophenonetetracarboxylic acid) 可用于制备高性能聚酰亚胺，也可用作环氧树脂的固化剂。
T7352	Pridopidine ACR16,ASP2314,FR310826,4-[3-(甲磺酰基)苯基]-1-丙基哌啶	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Pridopidine (FR310826) 是多巴胺稳定剂，是一种低亲和力的多巴胺 D2 受体拮抗剂。它高亲和力作用于 sigma 1受体，Ki=70-80 nM，比其对 D2R 的亲和力高约 100 倍。
T13101	TC-MCH 7c	Melanin-concentrating Hormone Receptor (MCHR)	GPCR/G Protein
	TC-MCH 7c 是一种可口服的、可选择的、可穿透血脑屏障的MCH1R 拮抗剂，其对hMCH1R 的IC50表现为5.6 nM，TC-MCH 7c 是一种苯基吡啶酮衍生物，其对人的MCH1R Ki 分别为 3.4 nM ，对小鼠 MCH1R Ki 为 3.0 nM。
T19337	GBR 12783 dihydrochloride GBR12783 2HCl	Others	Others
	GBR 12783 dihydrochloride (GBR12783 2HCl) 是一种特异性，有效且选择性的多巴胺摄取抑制剂，可抑制大鼠和小鼠纹状体突触小体对 [3H] 多巴胺 ([3H]dopamine) 的摄取，IC50值分别为 1.8 nM 和 1.2 nM。GBR 12783 dihydrochloride 还可改善大鼠记忆力并增加海马通路乙酰胆碱的释放。
T11371	GBR 12783	Others	Others
	GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats. GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.
T75003	Antidepressant agent 4
	Antidepressant agent 4为一种口服活性抗抑郁剂，具备抗抑郁、抗焦虑、性能增强以及促智活性。
T26799	Bibn 99 Bibn99,Bibn-99
	Bibn 99, a lipophilic and selective muscarinic M2 receptor antagonist, has applications in cognitive performance and Alzheimer's Disease.
T34653	SK1071
	SK1071 is a novel migrastatin analogs, which demonstrated improved performance over migrastatin, with nanomolar IC50 values in chamber cell migration assays with tumor cells and human umbilical vein endothelial cells (HUVECs), and in wound healing assays.
T71835	Otamixaban HCl
	Otamixaban HCl is an experimental injectable anticoagulant direct factor Xa inhibitor, that was investigated for the treatment for acute coronary syndrome. In 2013, Sanofi announced that it had ended development of the drug candidate after poor performance in a Phase III clinical trial.
T35243	YD2 YD-2,YD 2
	YD2 is a porphyrin sensitizer. YD2 is a useful material for making solar cell. Cosensitization of YD2-o-C8 with another organic dye enhances the performance of the device, leading to a measured power conversion efficiency of 12.3% under simulated air mass
T70618	SK609
	SK609 is a selective dopamine D3 receptor agonist which significantly improves the performance of the impaired paw and normalizes the bilateral asymmetry associated with the hemiparkinson rat.
T75002	Antidepressant agent 3
	Antidepressant agent 3, 一种具有口服活性的抗抑郁剂，具备抗抑郁、抗焦虑、性能增强及促智活性。
T78515	Follicle-stimulating hormone	Others	Others
	卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白，其参与调控动物的生殖能力与繁殖效率。
T22734	DL-AP7	Others	Others
	DL-AP7 是一种竞争性NMDA 拮抗剂和抗惊厥剂。DL-AP7 阻断 NMDA 诱导的惊厥,并导致小鼠在被动回避任务中的学习表现受损。
T36809	UoS 12258
	Positive allosteric modulator of AMPA receptors (pEC50 = 5.2 for potentiation of AMPA-mediated currents in vitro). Also potentiates AMPA-mediated synaptic responses in vivo. Improves performance of rats in various learning and memory paradigms Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID:20614889 \|Ward et al (2017) Pharmacological characterization of N-[...
T80554	Myoregulin MLN peptide	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Myoregulin（MLN peptide）为调节蛋白家族成员，作用于肌肉性能调控，通过影响细胞内钙处理机制实现其功能。它直接与SERCA相互作用，抑制Ca2+进入肌浆网。
T76757	Ponezumab
	Ponezumab (PF-04360365) 是一种人源化抗淀粉样蛋白 IgG2单克隆抗体。Ponezumab 可降低中枢神经系统的 Aβ水平，并改善小鼠在各种学习和记忆模型中的表现。Ponezumab 可用于阿尔茨海默症的研究。
T70951	ELND006
	ELND006 is a novel gamma secretase inhibitor previously under investigation for the oral treatment of Alzheimer's disease. ELND006 shows poor solubility and has moderate to high permeability. The in vivo performance of the ELND006 nanosuspension was tested in fed and fasted beagle dogs and compared with a gelatin capsule containing reference API. The results show that nanosizing ELND006 profoundly improved the oral bioavailability and virtually eliminated variation resulting from food intake.
T83816	Cytidine-5'-O-(2-thiodiphosphate) sodium CDP-β-S
	Cytidine-5’-O-(2-thiodiphosphate) (CDP-β-S) 是一种不可水解的CDP衍生物，具有抗氧化活性。在Trolox等效吸收能力(TEAC)测定中，该化合物在5至20 µM的浓度范围内清除自由基。
T80555	Myoregulin TFA MLN peptide TFA	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Myoregulin (MLN peptide) TFA，作为调节蛋白家族成员，通过干预细胞内钙处理机制来调控肌肉功能。该化合物直接作用于肌浆网 Ca2+-ATPase (SERCA)，抑制其将Ca2+传输至肌浆网。
T35584	Hydroxydehydro Nifedipine Carboxylate
	Hydroxydehydro nifedipine carboxylate is a metabolite of nifedipine .1 1.Roosemalen, M.C.M., Soons, P.A., Funaki, T., et al.High-performance liquid chromatographic determination of the polar metabolites of nifedipine in plasma, blood and urineJ. Chromatogr.565(1-2)516-522(1991)
T35840	4-Amino-6-chloro-1,3-benzenedisulfonamide
	4-Amino-6-chloro-1,3-benzenedisulfonamide is a carbonic anhydrase inhibitor.1 Formulations containing this compound are diuretics.2 4-Amino-6-chloro-1,3-benzenedisulfonamide is detected as a hydrolysis product of chlorothiazide in the urine.2 Diuretics, including chlorothiazide, have been abused as performance-enhancing drugs and masking agents in sports doping.3References1. Nishimori, I., Vullo, D., Minakuchi, T., et al. Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies ...
T81087	Stick Insect Hypertrehalosaemic Factor II
	Stick Insect Hypertrehalosaemic Factor II为合成肽，展现出与天然样品一致的FAB光谱、反相高效液相色谱特性以及生物活性，适用于高海藻糖效应的研究。
T35699	Fosetyl-aluminum
	0 [1]. Fan Z, Jia S, Ding N, et al. Determination of Fosetyl-Aluminium by Ion-Pair Reversed Phase-High Performance Liquid Chromatography With Evaporative Light Scattering Detection. Se Pu. 2009;27(6):849‐851. [2]. TüRK LMEZ , et al. Activity of metalaxyl-M+mancozeb, fosetyl-Al, and phosphorous acid against Phytophthora crown and root rot of apricot and cherry caused by Phytophthora palmivora. Plant Protect. Sci., 53: 216-225.
T76252L	WLSEAGPVVTVRALRGTGSW TFA
	WLSEAGPVVTVTVRALGTGSW TFA 为心肌细胞特异性肽。该化合物通过表达外泌体，提高心肌细胞的特定摄取能力，降低心肌细胞凋亡率，并在体内心肌内注射后提升心脏潴留能力。
T78971	AMPA receptor modulator-4	iGluR	Membrane transporter/Ion channel; Neuroscience
	AMPA receptor modulator-4 是一种口服有效的 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD) 类 AMPA 受体正变构调节剂 (AMPAR PAM)。该化合物能穿透血脑屏障，能够增强小鼠的认知能力并改善其工作记忆。
T38279	C2-8 C2-8
	C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2...
T62531	TRK-IN-12
	TRK-IN-12 (Compound 9e) 是一种大环衍生的有效TRK抑制剂，具有显著的TRKG595R抑制活性 (IC50= 13.1 nM)。在Ba/F3-LMNA-NTRK1细胞系中具有出色的抗增殖效果 (IC50= 0.080 μM)，并且在Ba/F3-LMNA-NTRK1-G595R细胞系中展示了超过对照活性分子LOXO-101的抑制能力 (IC50= 0.646 μM)。
T36444	Sildenafil Chlorosulfonyl
	Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor sildenafil .1It is also a potential impurity found in commercial preparations of sildenafil. 1.Nagaraju, V., Sreenath, D., Rao, J.T., et al.Separation and determination of synthetic impurities of sildenafil (Viagra) by reversed-phase high-performance liquid chromatographyAnal. Sci.19(7)1007-1011(2003)
T35755	Avermectin B1a aglycone
	Avermectin B1a aglycone is an aglycone form of the anthelmintic and insecticide avermectin B1a . It hyperpolarizes P. crassipes muscle fibers with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a aglycone decreases survival of C. elegans (MAC = 0.1 μM). In vivo, avermectin B1a aglycone prevents seizures induced by pentylenetetrazole in mice (ED50 = 43.9 mg/kg) without inducing deficits in rotarod performance.
T75137	BAY-747
	BAY-747 (BAY 1165747) 为一种通过口服生效且具有脑渗透性的sGC刺激剂。它能可逆地逆转L-NAME所诱导的记忆障碍并在大鼠中增强认知功能。BAY-747还可在有意识状态下降低正常血压及自发性高血压大鼠(SHR)的血压。此外，BAY-747在mdx/mTRG2小鼠模型中改善了与Duchenne肌营养不良症(DMD)相关的骨骼肌功能。
T38075	ThioFluor 623
	The rapid, selective, and sensitive sensing of thiols is important in diverse areas of research. This thiofluor 623 responds upon exposure to thiols with an increase in fluorescence intensity of up to 120-fold. The response is selective for thiols and occurs in aqueous media. In the absence of thiols, the probe is essentially non-fluorescent; thiols cause cleavage of the probe, generating a fluorophore with an absorption maximum of 563 nm and emission at 623 nm. The fluorescence quantum yield of...
T37403	O-desmethyl Brinzolamide (hydrochloride)
	O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1 1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tand...
T38357	1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)
	1,3,6,8-Pyrenetetrasulfonic acid is an intermediate in the synthesis of the color additive pyranine.1It has been used to stabilize intermolecular interactions for the crystallization ofL. mexicanapyruvate kinase.2 1.Jitian, S., White, S.R., Yang, H.-H.W., et al.Conventional high-performance liquid chromatography versus derivative spectrophotometry for the determination of 1,3,6-pyrenetrisulfonic acid trisodium salt and 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt in the color additive D&C G...
T36989	N-3-hydroxydecanoyl-DL-Homoserine lactone
	N-3-hydroxydecanoyl-DL-Homoserine lactone is a bacterial quorum-sensing molecule.1It activates SdiA (EC50= 0.6 μM), a transcription factor that detects N-acyl homoserine lactones (AHLs), in the 14028/pJNS25 strain ofS. enterica.2 1.Fekete, A., Frommberger, M., Rothballer, M., et al.Identification of bacterial N-acylhomoserine lactones (AHLs) with a combination of ultra-performance liquid chromatography (UPLC), ultra-high-resolution mass spectrometry, and in-situ biosensorsAnal. Bioanal. Chem.387...
T83727	Tat-NTS Peptide TFA Tat-Nuclear Translocation Signal Peptide
	Tat-NTS肽是一种能穿透细胞的肽，由HIV-1 Tat蛋白的转导域与对应于脂联素A1重复III域残基228-237的10个氨基酸肽链接而成，扮演核转运信号（NTS）的角色。它通过阻断脂联素A1与进口素β之间的蛋白质-蛋白质相互作用，阻止脂联素A1在初级鼠海马神经元中的核内转运。Tat-NTS抑制初级鼠海马神经元在葡萄糖-氧剥夺及再灌注诱导的细胞凋亡。在体内，Tat-NTS（10 mg/kg）有效减少了由中脑动脉闭塞（MCAO）引起的缺血-再灌注损伤模型小鼠的梗塞体积和神经元凋亡，并缩短了在Morris水迷宫测试中达到平台的时间。
T36006	Olmesartan medoxomil impurity C
	Olmesartan medoxomil impurity C is an Olmesartan medoxomil impurity. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. [1]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. [2]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Phar...
T35836	PMX-205 (trifluoroacetate salt)
	PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela...
T35504	(±)10-HDHA
	(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. Reference：[1]. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984).[2]. Reynaud, ...
T38286	C26 Sphingomyelin (d18:1/26:0) C26 Sphingomyelin (d18:1/26:0)
	C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.] 1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphi...
T37800	PF-04449613
	PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-0444...
T35892	Q134R Q134R
	Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo...

化合物

Cat.No: T0322

Target: Dopamine Receptor, AChR

Cat.No: T10492

Synonym: Ketone Ester

Target: Reactive Oxygen Species

Parogrelil Free Base

Cat.No: T70793

Cat.No: T16728

Synonym: CK-2127107

Target: Others

Sodium laureth sulfate

Cat.No: T12950

Synonym: Sodium lauryl polyoxyethylene ether sulfate,月桂醇聚氧乙烯醚硫酸酯钠盐

Target: Others

Benzophenonetetracarboxylic acid

Cat.No: T19205

Synonym: 4,4'-Carbonyldiphthalic acid,3,3',4,4'-Benzophenonetetracarboxylic acid

Target: Others

Cat.No: T7352

Synonym: ACR16,ASP2314,FR310826,4-[3-(甲磺酰基)苯基]-1-丙基哌啶

Target: Dopamine Receptor

Cat.No: T13101

Target: Melanin-concentrating Hormone Receptor (MCHR)

GBR 12783 dihydrochloride

Cat.No: T19337

Synonym: GBR12783 2HCl

Target: Others

Cat.No: T11371

Target: Others

Antidepressant agent 4

Cat.No: T75003

Cat.No: T26799

Synonym: Bibn99,Bibn-99

Cat.No: T34653

Cat.No: T71835

Cat.No: T35243

Synonym: YD-2,YD 2

Cat.No: T70618

Antidepressant agent 3

Cat.No: T75002

Follicle-stimulating hormone

Cat.No: T78515

Target: Others

Cat.No: T22734

Target: Others

Cat.No: T36809

Cat.No: T80554

Synonym: MLN peptide

Target: Calcium Channel

Cat.No: T76757

Cat.No: T70951

Cytidine-5'-O-(2-thiodiphosphate) sodium

Cat.No: T83816

Synonym: CDP-β-S

Cat.No: T80555

Synonym: MLN peptide TFA

Target: Calcium Channel

Hydroxydehydro Nifedipine Carboxylate

Cat.No: T35584

4-Amino-6-chloro-1,3-benzenedisulfonamide

Cat.No: T35840

Stick Insect Hypertrehalosaemic Factor II

Cat.No: T81087

Fosetyl-aluminum

Cat.No: T35699

WLSEAGPVVTVRALRGTGSW TFA

Cat.No: T76252L

AMPA receptor modulator-4

Cat.No: T78971

Target: iGluR

Cat.No: T38279

Synonym: C2-8

Cat.No: T62531

Sildenafil Chlorosulfonyl

Cat.No: T36444

Avermectin B1a aglycone

Cat.No: T35755

Cat.No: T75137

Cat.No: T38075

O-desmethyl Brinzolamide (hydrochloride)

Cat.No: T37403

1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)

Cat.No: T38357

N-3-hydroxydecanoyl-DL-Homoserine lactone

Cat.No: T36989

Tat-NTS Peptide TFA

Cat.No: T83727

Synonym: Tat-Nuclear Translocation Signal Peptide

Olmesartan medoxomil impurity C

Cat.No: T36006

PMX-205 (trifluoroacetate salt)

Cat.No: T35836

Cat.No: T35504

C26 Sphingomyelin (d18:1/26:0)

Cat.No: T38286

Synonym: C26 Sphingomyelin (d18:1/26:0)

Cat.No: T37800

Cat.No: T35892

Synonym: Q134R

Cat. No.	Product Name	Target	Signaling Pathways
T3S0195	Nootkatone 诺卡酮,努特卡酮,诺卡酮	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Nootkatone 是一种神经保护剂，来自于Alpiniae OxyphyllaeFructus ，具有抗氧化和抗炎活性。它能够改善脂多糖诱导的阿尔茨海默氏病小鼠模型的认知障碍。
TN2496	1,4-Anthraquinone	Others	Others
	1,4-Anthraquinone 是一种抗癌药物，在体外与柔红霉素相同纳摩尔范围内阻断核苷转运、抑制大分子合成、诱导 DNA 片段化并降低 L1210 白血病细胞的生长和活力。它被提议为一种用于高效液相色谱 (HPLC) 测定药物制剂中 N-乙酰半胱氨酸 (NAC) 和卡托普利 (CAP) 的新型柱前试剂。
T4120	N-Methylsarcosine N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,N,N-二甲基甘氨酸,DMG	Endogenous Metabolite	Metabolism
	N-Methylsarcosine (Dimethylglycine) 被用作运动性能增强剂和免疫兴奋剂。它也被用于治疗自闭症、癫痫和线粒体疾病。它也被用作慢性阻塞性肺疾病(COPD)患者蛋白质降解的生物标志物。此外，它被用作鉴定、区分和表征氨基酸甲基转移酶的底物。它在甘氨酸基离子液体和乳化剂的发展中起着重要的作用。
T20868	Isophthalic acid Acide isophtalique
	Isophthalic acid is an intermediate for a modifier of polyethylene terephthalate for bottles, gel coats, high solids paints, resins for coatings, and high-performance unsaturated polyesters.
T38706	Erlose
	Erlose, a trisaccharide present in soybean aphid honeydew and composed of sucrose, acts as a sweetener substitute to inhibit dental caries formation by oral microorganisms, primarily Streptococcus mutans. Erlose can serve as a reference compound in high-performance liquid chromatography (HPLC) methods employed for the analysis of sugar content in various food samples.
T81072	Suffruticosol A
	Suffruticosol A是一种从P. lactiflora种子中分离得到的神经保护剂，能够逆转由Scopolamine诱导的细胞神经退行性损伤。该化合物还能改善海马体胆碱能缺陷并部分增强BDNF信号传导，从而在Scopolamine诱导模型中显示出改善神经功能的作用，可恢复小鼠记忆与认知行为。
T36734	Methyl brevifolincarboxylate
	Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2]. Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM. [1]. Wu QY, et al. Chromatographic fingerprint and the simultane...

天然产物

Cat.No: T3S0195

Synonym: 诺卡酮,努特卡酮,诺卡酮

Target: AMPK

1,4-Anthraquinone

Cat.No: TN2496

Target: Others

N-Methylsarcosine

Cat.No: T4120

Synonym: N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,N,N-二甲基甘氨酸,DMG

Target: Endogenous Metabolite

Isophthalic acid

Cat.No: T20868

Synonym: Acide isophtalique

Cat.No: T38706

Suffruticosol A

Cat.No: T81072

Methyl brevifolincarboxylate

Cat.No: T36734

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