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13

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T68102	Mitoquidone	Others	Others
	Mitoquidone 是一种新型的五环吡咯醌，是一种潜在的抗癌剂。Mitoquidone 在一系列实验性实体肿瘤模型中表现出良好的活性且不表现出明显的细胞毒性。
T37781	2,3-Indolobetulin
	2,3-Indolobetulin is a pentacyclic triterpenoid and derivative of betulin .1It has been used in the synthesis of α-glucosidase inhibitors. 1.Khusnutdinova, E.F., Smirnova, I.E., Kazakova, O.B., et al.Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitorsMed. Chem. Res.262732-2742(2017)
T38088	28-Deoxybetulin methyleneamine
	28-Deoxybetulin methyleneamine is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It has been used in the synthesis of triterpene derivatives with antiviral activity. 1.Nitz, T.J., Montalbetti, C., Mears, R., et al.Extended Triterpene Derivatives(2008)
T25000	Acetylaleuritolic acid NSC 266221,NSC-266221,NSC266221
	Acetylaleuritolic acid 是一种从小花加西亚叶中分离得到的一种五环三萜类化合物，植物代谢产物。它具有抗肿瘤特性，对P-388淋巴细胞白血病测试中显示出肿瘤抑制活性。
T32566	Lantanolic acid
	Lantanolic acid is a pentacyclic triterpenoid from the leaves of Lantana montevidensis.
T37038	Betulinic Acid propargyl ester
	Betulinic acid propargyl ester is a pentacyclic lupane triterpene and alkyne derivative of betulinic acid .1,2It has been used in click chemistry reactions for the synthesis of cytotoxic anticancer betulinic acid derivatives.
T35693	N-(2-Azidoethyl)betulonamide
	N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1 1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017)
T37782	2,3-Indolobetulonic Acid
	2,3-Indolobetulonic acid is pentacyclic triterpenoid derivative of betulonic acid and an inhibitor of α-glucosidase (IC50= 1.8 μM).1 1.Khusnutdinova, E.F., Smirnova, I.E., Kazakova, O.B., et al.Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitorsMed. Chem. Res.262732-2742(2017)
T35678	2,3-Indolobetulinic glycine amide
	2,3-Indolobetulinic glycine amide is a pentacyclic triterpene and derivative of betulinic acid .1It has been used in the synthesis of betulinic acid derivatives with anticancer activity. 1.Kumar, V., Rani, N., Aggarwal, P., et al.Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivativesBioorg. Med. Chem. Lett.18(18)5058-5062(2008)
T37039	Betulinic Aldehyde oxime
	Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as well asL. donovaniamastigotes, when used at a concentration of 50 μM.1,2Betulinic aldehyde oxime (50 μM) is cytotoxic to Huh7 hepatocellular carcinoma cells.2
T63092	Anti-inflammatory agent 12
	Anti-inflammatory agent 12 是一种五环三萜化合物，在 LPS 诱导的炎症反应中表现出显着的偏差 (IC50: 2.22 μM)。Anti-inflammatory agent 12 具有潜力用于炎症性疾病的研究。
T63061	Anti-inflammatory agent 13
	Anti-inflammatory agent 13 是一种五环三萜化合物，对炎症模型具有明显的抑制作用。Anti-inflammatory agent 13 具有潜力进行 DAMP 或 PAMP 引发炎症的研究。
T69244	Betulonaldehyde
	Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s = 19.23 and 17.09 µg/ml, respectively). Topical application of betulonaldehyde (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice. It has also been used a precursor in t...

化合物

Cat.No: T68102

Target: Others

2,3-Indolobetulin

Cat.No: T37781

28-Deoxybetulin methyleneamine

Cat.No: T38088

Acetylaleuritolic acid

Cat.No: T25000

Synonym: NSC 266221,NSC-266221,NSC266221

Lantanolic acid

Cat.No: T32566

Betulinic Acid propargyl ester

Cat.No: T37038

N-(2-Azidoethyl)betulonamide

Cat.No: T35693

2,3-Indolobetulonic Acid

Cat.No: T37782

2,3-Indolobetulinic glycine amide

Cat.No: T35678

Betulinic Aldehyde oxime

Cat.No: T37039

Anti-inflammatory agent 12

Cat.No: T63092

Anti-inflammatory agent 13

Cat.No: T63061

Betulonaldehyde

Cat.No: T69244

Cat. No.	Product Name	Target	Signaling Pathways
T2S0501	Ilexgenin A	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Ilexgenin A 是一种五环三萜类化合物，提取自海南冬青，可用于研究炎症及癌症。
TN2097	Pomolic acid 坡模酸	Apoptosis; Caspase; HIV Protease; AMPK	Apoptosis; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pomolic acid 是从野鸦椿中分离出来的一种五环三萜烯。它抑制肿瘤细胞的生长，诱导细胞凋亡，有用于前列腺癌的潜力。
TN6722	Terminolic acid 2α,6β,23-trihydroxyl oleanolic acid	Antibacterial	Microbiology/Virology
	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) 是一种从 Combretum racemosum 中分离得到的五环三萜糖苷，可通过与 IL-1β 和 IL-6 的受体活性位点结合抑制促炎细胞因子，并通过与 IL-4 受体结合位点结合增强抗炎细胞因子。它还表现出适度的抗菌活性。
T21820	Resistomycin Geliomycin,Heliomycin	Antibiotic	Microbiology/Virology
	Resistomycin（Geliomycin），一种五环多酮类抗生素，通过触发凋亡展现出强大的抗癌特性。
TN1866	Licoricesaponin G2 甘草皂苷G2
	Licoricesaponin G2 是一种从 Glycyrrhiza aspera 中提取出的五环三萜类化合物，可用于区分粗甘草和蜂蜜加工甘草。
T0722	Ursolic acid Malol,熊果酸,Urson,NSC 167406,NSC-4060,Prunol	Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Ursolic acid (Prunol) 是从毛喉杜鹃中提取的一种五环三萜羧酸，具有预防和抗癌活性。
T3323	Ursonic Acid CCRIS 7123,NSC4060,熊果酮酸,Prunol,3-Ketoursolic acid,Malol,TOS-BB-0966	Apoptosis; HIV Protease; Endogenous Metabolite	Apoptosis; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Ursonic Acid (TOS-BB-0966) 是一种天然三萜酸，属于熊果烷三萜类，其结构基于五环熊果烷骨架。它具有作为 HIV-1 蛋白酶抑制剂的潜力。
T2813	Madecassoside Asiaticoside A,羟基积雪草苷	Apoptosis; Antioxidant; Endogenous Metabolite	Apoptosis; Metabolism; oxidation-reduction
	Madecassoside (Asiaticoside A) 是从崩大碗中分离出来的一种五环三萜，有抗炎症，抗氧化和抗衰老的作用。
T3368	Alpha-Hederin α常春藤皂甙,Helixin,Tauroside E,α-Hederin,Hederoside C	Apoptosis; Others	Apoptosis; Others
	Alpha-Hederin (Tauroside E) 是存在于黑种草种子中的一种单桥糖三萜皂苷，具有抗肿瘤作用。它可通过激活线粒体依赖性途径抑制胃癌细胞增殖，诱导凋亡，并有活性氧生成和谷胱甘肽减少。
TN1111	Arnidiol	Immunology/Inflammation related	Immunology/Inflammation
	Arnidiol 是一种五环三萜烯，从Barleria Longiflora LinnF. 中提取得到。
T3248	alpha-Boswellic acid α-Boswellic acid,α-乳香酸	Others	Others
	alpha-Boswellic acid (α-Boswellic acid) 是一种从乳香中提取得到的五环三萜类天然产物，具有抗惊厥和抗癌作用。在动物体内，它是预防和减少阿尔茨海默病标志物，可用于阿尔茨海默病的研究。
T2830	Betulinic acid 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid	Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。
T13964	Waltonitone	Others	Others
	Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.
T24884	Tingenone Maytenin,Maitenin,Tingenin A,Tingenon
	Tingenone is a pentacyclic triterpene. It induces peripheral antinociception due to opioidergic activation.
T72867	Fusarisetin A
	Fusarisetin A 是一种五环真菌代谢物，是一种腺泡形态发生抑制剂。
T19880	Friedelinol Friedelan-3alpha-ol,Friedelan-3-ol,NSC 407041,epi-Friedelinol,Epifriedelanol
	Friedelinol is a pentacyclic trierpene plant as the free acid or the aglycone for many saponins. Friedelinol can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.
T82747	Centellasaponin A
	Centellasaponin A (compound 10)为五环三萜皂苷类化合物，可通过积雪草甲醇提取物进行分离提取。
T82431	Eupenifeldin
	Eupenifeldin为五环双酚酮类化合物，源自Eupenicillium brefeldianum ATCC 74184培养物分离得到。该化合物对HCT-116细胞系展现细胞毒性，具有潜在的白血病研究价值。
T82042	Isoasiaticoside
	Isoasiaticoside为五环三萜皂苷类化合物，可从积雪草(Centella asiatica)提取。该化合物在6-OHDA诱导的PC12细胞模型中显示出潜在神经保护效应。

天然产物

Cat.No: T2S0501

Target: IL Receptor, TNF

Cat.No: TN2097

Synonym: 坡模酸

Target: Apoptosis, Caspase, HIV Protease, AMPK

Terminolic acid

Cat.No: TN6722

Synonym: 2α,6β,23-trihydroxyl oleanolic acid

Target: Antibacterial

Cat.No: T21820

Synonym: Geliomycin,Heliomycin

Target: Antibiotic

Licoricesaponin G2

Cat.No: TN1866

Synonym: 甘草皂苷G2

Cat.No: T0722

Synonym: Malol,熊果酸,Urson,NSC 167406,NSC-4060,Prunol

Target: Endogenous Metabolite, Autophagy

Cat.No: T3323

Synonym: CCRIS 7123,NSC4060,熊果酮酸,Prunol,3-Ketoursolic acid,Malol,TOS-BB-0966

Target: Apoptosis, HIV Protease, Endogenous Metabolite

Cat.No: T2813

Synonym: Asiaticoside A,羟基积雪草苷

Target: Apoptosis, Antioxidant, Endogenous Metabolite

Cat.No: T3368

Synonym: α常春藤皂甙,Helixin,Tauroside E,α-Hederin,Hederoside C

Target: Apoptosis, Others

Cat.No: TN1111

Target: Immunology/Inflammation related

alpha-Boswellic acid

Cat.No: T3248

Synonym: α-Boswellic acid,α-乳香酸

Target: Others

Cat.No: T2830

Synonym: 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid

Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy

Cat.No: T13964

Target: Others

Cat.No: T24884

Synonym: Maytenin,Maitenin,Tingenin A,Tingenon

Cat.No: T72867

Cat.No: T19880

Synonym: Friedelan-3alpha-ol,Friedelan-3-ol,NSC 407041,epi-Friedelinol,Epifriedelanol

Centellasaponin A

Cat.No: T82747

Cat.No: T82431

Isoasiaticoside

Cat.No: T82042

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