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Search Results for " pancreatitis "

23

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2391	Camostat mesylate FOY-S980,甲磺酸卡莫司他,FOY305,Camostat mesilate	Serine/threonin kinase; SARS-CoV; Sodium Channel	Cell Cycle/Checkpoint; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Camostat mesylate (FOY-S980) 是口服活性合成的丝氨酸蛋白酶抑制剂，用于慢性胰腺炎。它是TMPRSS2的抑制剂，对SARS-CoV-2具有抗病毒活性。它抑制前列腺素、胰蛋白酶和苦参多糖的活性。
T34123	Pranazepide FR120480,FK 480,FR-120480	cholecystokinin	GPCR/G Protein
	Pranazepide (FK 480) 是一种小分子胆囊收缩素受体拮抗剂，可用于研究消化系统疾病和胰腺炎。
T28248	Ono-3307 mesylate Ono-3307,Ono3307,Ono 3307	Protease	Proteases/Proteasome
	Ono-3307 mesylate 是一种蛋白酶抑制剂，对多种蛋白酶均具有抑制作用。Ono-3307 mesylate 对大鼠的肝损伤具有显着的保护作用，抑制放射性纤维蛋白在肾脏和肺部的沉积，可用于研究胰腺炎。
T0372	Gabexate mesylate 甲磺酸加贝酯,FOY	Factor Xa; Serine Protease; Proteasome	Metabolism; Proteases/Proteasome; Ubiquitination
	Gabexate mesylate (FOY) 是一种非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。
T74140	β-D-Glucan	Others	Others
	β-D-Glucan 是一种靶向肿瘤相关巨噬细胞的化合物，具有抗肿瘤活性，可调节坏死性胰腺炎中的免疫反应
T9670L	Patamostat HCl Patamostat HCl（114568-26-2 Free base）	Serine Protease; Protease	Proteases/Proteasome
	Patamostat HCl 是一种具有高效性和选择性的小分子蛋白酶 (protease) 抑制剂，对胰蛋白酶，纤溶酶和凝血酶有抑制作用，IC50 值分别为 39 nM，950 nM 和 1.9 μM。Patamostat HCl 可用于研究急性胰腺炎。
T67749	Fuzapladib IS-741	Phospholipase	Metabolism
	Fuzapladib (IS-741) (IS-741)是一种磷脂酶A2抑制剂，可以抑制细胞粘附分子Mac-1的表达。fuzpladib 阻断炎症细胞表面表达的粘附分子(integrin)的激活，阻止炎症细胞粘附血管内皮细胞和浸润组织，控制胰腺炎的恶化。
T25275	Crambene NSC 321802,NSC-321802,NSC321802
	Crambene results in the induction of apoptosis by protects mice against acute pancreatitis via anti-inflammatory pathways.
T13662	Diarylalkane derivative 1	Others	Others
	Diarylalkane derivative 1 is used for the research of pancreatitis.
T78376	Rimtoregtide
	Rimtoregtide为一多肽化合物，能显著下调急性胰腺炎致血液淀粉酶与脂肪酶水平升高。该化合物在胰腺炎及急性胰腺炎研究中具备潜力。
T37771	Taurolithocholic Acid 3-sulfate (sodium salt)
	Taurolithocholic acid 3-sulfate (TLCA3S) is a metabolite of the conjugated bile acid taurolithocholic acid . TLCA3S has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis.
T31569	DP-b99 DP-b-99,DP-BAPTA-99,DPb-99,DPBAPTA-99,DP-b 99
	DP-B 99 (DP-B 99, DP-BAPTA-99, DPB-99, DP-BAPTA-99) is a potential chelating agent for the treatment of acute pancreatitis.
T28933	TCV-309 TCV309
	TCV-309 is an inhibitor of platelet activating factor (PAF). TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. TCV-309 attenuates the priming effects of bronchoalveolar macrophages
T10055	(Iso)-FK-480 CHEMBL333994	cholecystokinin	GPCR/G Protein
	(Iso)-FK-480 是一种新型可口服的胆囊收缩素 A（CCK-A）拮抗剂，可用于研究治疗慢性胰腺炎。
T22506	3,4-DAA	NOS	Immunology/Inflammation
	3,4-DAA 具有抗炎活性，可改善急性肝同种异体移植损伤，通过抑制肠道屏障功能障碍和 NF-κB 活化来缓解严重的急性胰腺炎。3,4-DAA 抑制由 IFN-γ 和脂多糖诱导的 EOC20 细胞诱导型一氧化氮合酶 (iNOS) 发挥作用。
T33314	Methantheline Bromide Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide
	Methantheline Bromide is a synthetic spasmolytic used to relieve cramps or spasms of the stomach, bowel, and bladder. It is also useful for intestinal or gastric ulcers (peptic ulcer disease), intestinal problems, pancreatitis, gastritis, biliary dysmotil
T79258	sEH inhibitor-16	Epoxide Hydrolase	Metabolism
	sEH inhibitor-16，作为一种可溶性环氧化物水解酶（sEH）抑制剂，具有2 nM的IC50值。它能够降低小鼠Cerulein诱导的急性胰腺炎（AP）的炎症损伤，适用于免疫炎症研究。
T71955	C3001a
	C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous system to reduce the excitability of nociceptive neurons. In neuropathic pain, C3001a alleviated spontaneous pain and cold hyperalgesia. In a mouse model of acute pancreatitis, C3001a alleviated mechanical allodynia and inflammation. C3001a represents a lead compound which could a...
T36623	Antileukinate
	Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 μM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.
T38521	Patamostat mesylate E-3123 mesylate
	Patamostat mesylate (E-3123) is a highly potent protease inhibitor, displaying strong inhibitory activity against trypsin, plasmin, and thrombin, with IC 50 values of 39 nM, 950 nM, and 1.9 μM, respectively. This compound, Patamostat mesylate, shows promising potential in suppressing the pathogenesis and development of acute pancreatitis.
T69035	Camostat free base
	Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). Inhibition of TMPRSS2 partially blocked infection by SARS-CoV and Human coronavirus NL63 in HeLa cell cultures. In vitro study showed that camostat significantly reduces...
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
T9670	Patamostat
	Patamostat (E-3123)是一种有效的蛋白酶抑制剂，对胰蛋白酶、纤溶酶和凝血酶具有显著抑制效果，其IC50值分别为39 nM、950 nM和1.9 μM。Patamostat可能在急性胰腺炎的发病机制和发展中发挥抑制作用。

化合物

Camostat mesylate

Cat.No: T2391

Synonym: FOY-S980,甲磺酸卡莫司他,FOY305,Camostat mesilate

Target: Serine/threonin kinase, SARS-CoV, Sodium Channel

Cat.No: T34123

Synonym: FR120480,FK 480,FR-120480

Target: cholecystokinin

Ono-3307 mesylate

Cat.No: T28248

Synonym: Ono-3307,Ono3307,Ono 3307

Target: Protease

Gabexate mesylate

Cat.No: T0372

Synonym: 甲磺酸加贝酯,FOY

Target: Factor Xa, Serine Protease, Proteasome

Cat.No: T74140

Target: Others

Cat.No: T9670L

Synonym: Patamostat HCl（114568-26-2 Free base）

Target: Serine Protease, Protease

Cat.No: T67749

Synonym: IS-741

Target: Phospholipase

Cat.No: T25275

Synonym: NSC 321802,NSC-321802,NSC321802

Diarylalkane derivative 1

Cat.No: T13662

Target: Others

Cat.No: T78376

Taurolithocholic Acid 3-sulfate (sodium salt)

Cat.No: T37771

Cat.No: T31569

Synonym: DP-b-99,DP-BAPTA-99,DPb-99,DPBAPTA-99,DP-b 99

Cat.No: T28933

Synonym: TCV309

Cat.No: T10055

Synonym: CHEMBL333994

Target: cholecystokinin

Cat.No: T22506

Target: NOS

Methantheline Bromide

Cat.No: T33314

Synonym: Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide

sEH inhibitor-16

Cat.No: T79258

Target: Epoxide Hydrolase

Cat.No: T71955

Cat.No: T36623

Patamostat mesylate

Cat.No: T38521

Synonym: E-3123 mesylate

Camostat free base

Cat.No: T69035

Cat.No: T36408

Synonym: Rhein-13C4

Cat.No: T9670

Cat. No.	Product Name	Target	Signaling Pathways
T8198	Visnagin	Others	Others
	Visnagin 是一种抗氧化剂呋喃香豆素衍生物。它具有预防Cerulein 诱导的急性胰腺炎的潜力。它在血管平滑肌中具有良好的血管扩张作用。它具有抗炎作用，可用于缓解疼痛的研究。
T5352	GLYCODEOXYCHOLIC ACID	Others; Endogenous Metabolite	Metabolism; Others
	Glycodeoxycholic Acid 是内源性代谢产物的一种。

天然产物

Cat.No: T8198

Target: Others

GLYCODEOXYCHOLIC ACID

Cat.No: T5352

Target: Others, Endogenous Metabolite

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