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Cat. No. | Product Name | Target | Signaling Pathways |
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T8982 |
RH01687
|
Others | Others |
RH01687 是可以保护胰腺 β 细胞免受内质网应激诱导的细胞死亡的化合物。它对糖尿病具有潜在的研究价值。 | |||
T2055 |
WS3
|
EGFR; IκB/IKK | Angiogenesis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors |
WS3 是一种可促进鼠和人原代胰岛的胰腺 β 细胞增殖的增殖分子。它可用于研究 I 型糖尿病。 | |||
T15159 |
Dorzagliatin
HMS5552 |
Glucokinase | Metabolism |
Dorzagliatin (HMS5552) 是双重作用的葡萄糖激酶 (glucokinase;GK) 激活剂,可改善 2 型糖尿病的血糖控制,提高胰腺 β 细胞功能。 | |||
TP1125 |
Insulin(cattle)
牛胰岛素,Insulin from bovine pancreas,胰岛素 |
IGF-1R | Tyrosine Kinase/Adaptors |
Insulin cattle (Insulin from bovine pancreas) 是一种在胰腺 β 细胞中产生的两链多肽激素,在很多哺乳动物细胞培养体系中用作生长因子。 | |||
T6961 |
PX-478
PX-478 2HCl |
HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism |
PX-478 是一种 HIF-1α 抑制剂,具有选择性、口服活性和血脑屏障渗透性。PX-478 具有抗肿瘤活性,还可以保护糖尿病中的胰腺 β 细胞功能,用于 2 型糖尿病的研究。 | |||
T4400 |
DIM-C-pPhOH
CDIM8 |
Apoptosis; Others | Apoptosis; Others |
DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂,可降低细胞增殖,对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导,诱导细胞凋亡和细胞应激。 | |||
T27736 |
KM10103
KM-10103,KM 10103 |
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KM10103 exhibits β-cell-protective activities against ER stress, which plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes. | |||
T26895 |
BRD0476
BRD-0476,ML 187,ML187,ML-187,BRD 0476 |
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BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT | |||
T28157 |
Nephrin
|
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Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highl | |||
T29154 |
WB403
WB-403,WB 403 |
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WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α- | |||
T35627 |
Amylin (human) (trifluoroacetate salt)
|
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Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes. Amylin forms fibrils that react to thioflavin T and are organized in a cro... | |||
T60743 | Vin-C01 | ||
Vin-C01 可用于研究Ⅱ型糖尿病,是胰腺 β 细胞的有效保护剂 (EC 50 = 0.22 μM)。Vin-C01 保护 β 细胞免受 STZ 诱导的细胞凋亡,并有效促进 β 细胞存活。 | |||
T38764 |
Amylin (8-37), human
|
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Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type II diabetes mellitus. | |||
T61040 |
Vin-F03
|
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Vin-F03 可用于研究2型糖尿病,它是胰腺 β 细胞的有效保护剂 (EC50 = 0.27 μM)。Vin-F03 有效促进 β 细胞存活并且保护 β 细胞免受 STZ 诱导的细胞凋亡。 | |||
T35625 |
Aminoacetone (hydrochloride)
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Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases. It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes patients. As a pro-oxidant, 0.10-5 mM aminoacetone can induce cell death in RINm5f pancreatic β-cells. Aminoacetone is used as a growth substrate for Pseudomonas. | |||
T71981 |
Gliclazide-d4
|
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Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin... | |||
T68976 | Piragliatin | ||
Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus. Piragliatin has an acute glucose-lowering action in patients with mild type 2 diabetes, mainly mediated through a generalized enhancement of β-cell function and through fasting restricted changes in ... | |||
T69380 | Cinnamic acid, hydrazide | ||
Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various mechanism of actions including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibiti... | |||
T36408 |
Rhein-13C4
Rhein-13C4 |
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Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i... | |||
T38764L |
Amylin (8-37), human acetate(135702-23-7 free base)
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Amylin (8-37), human acetate(135702-23-7 free base) 源自人 Amylin,对大鼠离体肠系膜阻力动脉具有直接血管舒张作用。 Amylin (8-37), human acetate,是一种小型胰腺 β 细胞激素,在没有胰岛素的情况下会形成聚集体,是 II 型糖尿病的一个关键病理特征。 | |||
T76480 |
Amylin (1-37) (human)
|
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Amylin (1-37) (human) (hIAPP (1-37)) 为胰岛β细胞分泌颗粒中的肽类激素,其C端经酰胺化处理,第2和第7个半胱氨酸残基间形成二硫键。 | |||
T63019 | GKA50 quarterhydrate | ||
GKA50 quarterhydrate 是一种有效的葡萄糖激酶激活剂,其 EC50 值为 33 nM。GKA50 quarterhydrate 是一种啮齿动物和人类胰岛中 β 细胞代谢的葡萄糖样激活剂,也是一种 Ca2+依赖性胰岛素分泌调节剂。GKA50 quarterhydrate 能够刺激小鼠胰岛分泌胰岛素,可以显著降低高脂喂养的雌性大鼠血糖。 | |||
T25739 |
Linogliride
McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida |
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Linogliride 是一种基于胍的胰岛素分泌抑制剂,也是 pirogliride 的结构类似物,具有降血糖活性。它可以阻断胰腺β细胞膜上对 ATP 敏感的钾通道,从而刺激胰岛素分泌并改善葡萄糖耐受性。 | |||
T82317 |
GIP, rat
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GIP, rat 是一种由十二指肠和空肠 K 细胞在食物摄入后分泌的具有生物活性的肽,由 42 个氨基酸组成。作为肠促胰岛素激素肽家族的一员,GIP 与另一激素 GLP 共同负责刺激胰岛 β 细胞分泌胰岛素,并促进 β 细胞的增殖与存活。近期研究显示GIP 在调控脂质平衡及肥胖发病机制中发挥重要作用。 | |||
T82907 |
BDC2.5 Mimotope 1040-63
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BDC2.5 Mimotope 1040-63是具有生物活性的肽,广泛应用于1型糖尿病(T1D)研究中的TCR转基因模型(BDC2.5)模拟表位。T1D是一种涉及自身免疫系统对胰岛β细胞的T细胞介导损害的自身免疫性疾病。BDC2.5模拟表位在研究胰岛素产生细胞遭到自身反应性T细胞破坏的过程中,对支持抗原肽实现向胰岛自身抗原特异性T细胞的抗原呈递具有重要作用。 | |||
T83928 |
DA ZP1
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DA ZP1(diacetylated Zinpyr1)是一种荧光性的Zn(II)传感器(KdZn2+= 0.6 nM),可用于体外成像和分离胰腺β细胞及类似β细胞,并用于纯化源自干细胞的活体类似β细胞。该传感器亦可用于体内成像移植的岛细胞移植物和内源性小鼠岛细胞。在没有Zn(II)离子存在时,DA ZP1不发光,但其与Zn(II)的结合促进乙酰基的水解裂解,产生强烈的荧光信号。其激发和发射最大波长(λ)分别为490 nm和522 nm。 | |||
T25739L |
Linogliride fumarate
McN 3935,McN-3935,McN3935 |
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Linogliride fumarate 是Linogliride 的富马酸盐。Linogliride 是一种基于胍的胰岛素分泌抑制剂,也是pirogliride 的结构类似物,具有降血糖活性。它可以阻断胰腺β细胞膜上对ATP 敏感的钾通道,从而刺激胰岛素分泌并改善葡萄糖耐受性。 | |||
T82316 |
GIP, rat TFA
|
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GIP, rat TFA 是一种源自大鼠的生物活性肽。GIP(Glucose-dependent Insulinotropic Polypeptide,又名 Gastric Inhibitory Polypeptide)是由十二指肠与空肠中的K细胞在摄食后释放的一种含42个氨基酸的多肽。作为肠促胰岛素激素肽家族的一部分,GIP和GLP(Glucagon-Like Peptide)共同调控胰岛β细胞的胰岛素分泌,并可能促进β细胞扩增及存活。此外,近期研究显示GIP参与调节脂质平衡,并可能在肥胖的病理生理中扮演角色。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN4383 |
Kazinol U
|
IL Receptor; IκB/IKK; NOS; NF-κB | Immunology/Inflammation; NF-κB |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. |