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Search Results for " naphthoquinone "

11

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7048	1,4-Naphthoquinone α-Naphthoquinone,Naphthalene-1,4-Dione,P-Naphthoquinone,1,4-萘醌,para-naphthoquinone	Others; MAO; Topoisomerase	DNA Damage/DNA Repair; Metabolism; Neuroscience; Others
	1,4-Naphthoquinone (P-Naphthoquinone) 被用作单胺氧化酶和 DNA 拓扑异构酶活性的潜在抑制剂，还用于抑制乙酰转移酶活性。
T7075	2-Chloronaphthoquinone 2-Chloro-1,4-naphthoquinone,2-氯-1,4-萘醌	Others	Others
	2-Chloronaphthoquinone (2-Chloro-1,4-naphthoquinone) 是一种取代的萘醌，用作杀虫剂和杀螨剂。
T20410	1,2-Naphthoquinone NSC 9831,NSC-9831,NSC9831
	1,2-Naphthoquinone is an agent of fungicide.
T22381	Antimalarial agent 14 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone	Others	Others
	Antimalarial agent 14 (NSC-102533) 是一种生物活性化学品。
T16706	Quinoclamine 灭藻醌,2-氨基-3-氯-1,4-萘醌	NF-κB	NF-κB
	Quinoclamine 是一种 NF-κB 抑制剂，是一种萘醌衍生物，具有抗肿瘤活性。
T5426	DMNQ	Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; NF-κB
	DMNQ 是氧化还原循环剂，以浓度依赖性方式在细胞内产生超氧化物和过氧化氢，能够诱导ROS 增加。
T29792	AK-135
	AK-135 is a derivative of 1,4-naphthoquinone (Menadione). AK-135 has been shown to restore the electron flow in defective respiratory chain (hypoxia or rotenone) systems more effectively than Menadione.
T26450	A 80915A A80915A,A-80915A
	A 80915A is A semi-naphthoquinone antibiotic from Streptomyces aculeolatus. It is a potent inhibitor of gastric (H(+)-K+)-ATPase. Inhibition by A80915A is dependent on the conformation of gastric (H(+)-K+)-ATPase, potassium slows the rate of inhibition by
T36207	Methylspinazarin
	Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg. \|1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gate...
T83877	2-(cyclohexylmethyl)-Plumbagin
	2-(cyclohexylmethyl)-Plumbagin是naphthoquinone plumbagin的衍生物。在模拟胰腺癌肿瘤微环境的营养匮乏条件下，与营养丰富条件下的PANC-1细胞相比，对PANC-1人类胰腺癌细胞表现出选择性的细胞毒性，50%优选细胞毒性值(PC50s)分别为0.11和47.2 µM。1 µM浓度下，还可诱导PANC-1细胞发生凋亡。此外，2-(cyclohexylmethyl)-Plumbagin在营养匮乏条件下，而非营养丰富条件下，选择性降低PANC-1细胞中Akt和哺乳动物雷帕霉素靶蛋白(mTOR)的磷酸化。在以每周五次、每次50和250 µg/动物剂量给药的MiaPaCa-2胰腺癌小鼠异种移植模型中，能减少肿瘤体积和重量。
T36645	CAY10763 CAY10763
	CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM...

化合物

1,4-Naphthoquinone

Cat.No: T7048

Synonym: α-Naphthoquinone,Naphthalene-1,4-Dione,P-Naphthoquinone,1,4-萘醌,para-naphthoquinone

Target: Others, MAO, Topoisomerase

2-Chloronaphthoquinone

Cat.No: T7075

Synonym: 2-Chloro-1,4-naphthoquinone,2-氯-1,4-萘醌

Target: Others

1,2-Naphthoquinone

Cat.No: T20410

Synonym: NSC 9831,NSC-9831,NSC9831

Antimalarial agent 14

Cat.No: T22381

Synonym: 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone

Target: Others

Cat.No: T16706

Synonym: 灭藻醌,2-氨基-3-氯-1,4-萘醌

Target: NF-κB

Cat.No: T5426

Target: Reactive Oxygen Species, ROS

Cat.No: T29792

Cat.No: T26450

Synonym: A80915A,A-80915A

Methylspinazarin

Cat.No: T36207

2-(cyclohexylmethyl)-Plumbagin

Cat.No: T83877

Cat.No: T36645

Synonym: CAY10763

Cat. No.	Product Name	Target	Signaling Pathways
T3008	Lawsone methyl ether 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌	Apoptosis; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和Swertia calycina 中分离出的，有抗真菌和抗菌活性。
T4010	Juglone 5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin	DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料，有抗菌作用。
T2969	Lawsone Hennotannic acid,指甲花醌,2-hydroxy-1,4-naphthoquinone	Others; Antifungal	Microbiology/Virology; Others
	Lawsone (Hennotannic acid) 是一种从Lawsonia inermis 的叶片中分离得到的萘醌染料，具有抗菌和抗氧化活性。
T8678	Naphthazarin 萘茜,5,8-Dihydroxy-1,4-naphthoquinone,DHNQ	Apoptosis	Apoptosis
	Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) 是来自毛紫草的一种天然产物，通过氧化应激、线粒体凋亡诱导因子的激活、微管的解聚、干扰溶酶体功能和 p53 依赖性 p21 激活，可触发细胞凋亡并具有抗肿瘤作用。
TN1208	2-Amino-3-carboxy-1,4-naphthoquinone	NADPH-oxidase	Immunology/Inflammation
	2-Amino-3-carboxy-1,4-naphthoquinone 是电子转移介质，可改变同型发酵乳酸菌的葡萄糖代谢，可作为双歧杆菌生长刺激剂，它通过NAD(P)H 介导的氧化作用影响双歧杆菌的终产物形态。
TN5790	2-Carbamoyl-3-hydroxy-1,4-naphthoquinone
	2-Carbamoyl-3-hydroxy-1,4-naphthoquinone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5790，CAS号为 103646-20-4。
TN5795	Chimaphilin 梅笠草素,2,7-Dimethyl-1,4-naphthoquinone
	Chimaphilin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5795，CAS号为 482-70-2。
T5S2350	Beta-Acetoxyisovalerylshikonin 乙酰氧基异戊酰阿卡宁,Acetoxyisovalerylalkannin,β-乙酰氧基异戊酰阿卡宁	Others	Others
	Acetoxyisovalerylshikonin 是一种萘醌衍生物，提取自Arnebia euchroma 中。
T0449	Menadione 维生素K3,Vitamin K3,甲萘醌	Thrombin; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	Menadione (Vitamin K3) 是合成的萘醌，能够在体内转化成活性维生素 K2。
T2841	Plumbagin Plumbagone,Plumbagine,白花丹素,Plumbaein,2-Methyljuglone	ROS	Immunology/Inflammation
	Plumbagin (Plumbaein) 是一种萘醌类物质，从Plumbago zeylanica L 中获得，具有抗肿瘤、抗增殖作用。
T2897	(Rac)-Shikonin (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid	Others	Others
	(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。
T4958	(-)-Alkannin Alkannin,左旋紫草素,紫草素,Shikonin	Apoptosis; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	(-)-Alkannin (Shikonin) 是从紫朱草中发现的一种天然产物，具有抗癌活性，可抑制细胞周期，诱导细胞凋亡，用作食品着色剂，在 Rho 激酶途径中可改善肝脏炎症。
T36914	2-Hydroxyanthraquinone	Others	Others
	2-Hydroxyanthraquinone 是一种天然产物，显示出抗肿瘤和免疫抑制活性。
T30449	Biflorin
	Biflorin is an o-naphthoquinone of clinical significance.

天然产物

Lawsone methyl ether

Cat.No: T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌

Target: Apoptosis, Antibacterial, Antifungal

Cat.No: T4010

Synonym: 5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin

Target: DNA/RNA Synthesis, Antibacterial

Cat.No: T2969

Synonym: Hennotannic acid,指甲花醌,2-hydroxy-1,4-naphthoquinone

Target: Others, Antifungal

Cat.No: T8678

Synonym: 萘茜,5,8-Dihydroxy-1,4-naphthoquinone,DHNQ

Target: Apoptosis

2-Amino-3-carboxy-1,4-naphthoquinone

Cat.No: TN1208

Target: NADPH-oxidase

2-Carbamoyl-3-hydroxy-1,4-naphthoquinone

Cat.No: TN5790

Cat.No: TN5795

Synonym: 梅笠草素,2,7-Dimethyl-1,4-naphthoquinone

Beta-Acetoxyisovalerylshikonin

Cat.No: T5S2350

Synonym: 乙酰氧基异戊酰阿卡宁,Acetoxyisovalerylalkannin,β-乙酰氧基异戊酰阿卡宁

Target: Others

Cat.No: T0449

Synonym: 维生素K3,Vitamin K3,甲萘醌

Target: Thrombin, Endogenous Metabolite

Cat.No: T2841

Synonym: Plumbagone,Plumbagine,白花丹素,Plumbaein,2-Methyljuglone

Target: ROS

Cat.No: T2897

Synonym: (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid

Target: Others

Cat.No: T4958

Synonym: Alkannin,左旋紫草素,紫草素,Shikonin

Target: Apoptosis, PI3K

2-Hydroxyanthraquinone

Cat.No: T36914

Target: Others

Cat.No: T30449

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