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42

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1562	Rebamipide Proamipide,OPC12759,瑞巴派特	Free radical scavengers; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。
T0081	Lafutidine 拉呋替丁,FRG-8813	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Lafutidine (FRG-8813) 是一种组胺受体 H2RA 拮抗剂，可抑制胃酸分泌，具有胃粘膜保护作用，可用于研究胃食管反流疾病。
T6665	Sertaconazole nitrate FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑	Antibiotic; Antifungal	Microbiology/Virology
	Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药，可用于治疗浅表皮肤和粘膜感染。
T27812	Leminoprazole	ATPase	Membrane transporter/Ion channel
	Leminoprazole 是一种可口服的 H+，K（+）-ATPase 抑制剂，可保护胃黏膜细胞免受各种细胞损伤，可用于治疗胃溃疡。
T10165L	5-A-RU hydrochloride 5-Amino-6-(D-ribitylamino)uracil hydrochloride	Others	Others
	5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride) 是细菌核黄素的中间体，可激活粘膜相关不变 T 细胞（MAIT）。5-A-RU 可用于研究乳腺癌和前列腺癌。
T71012	Nemazoline Free Base
	Nemazoline Free Base is a nasal decongestant. It has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than oxymetazoline on canine nasal mucosa, in-vitro and in-vivo. Upon intranasal administration to dogs, the compound was devoid of systemic effects up to a concentration 1000 times that needed for local decongestant effect (1.65 micrograms, atomized from a 1 microgram mL-1 solution) suggesting limited mucosal absorption. After nasal administration to rats for 1...
T40303	5-A-RU-PABC-Val-Cit-Fmoc	Others	Others
	5-A-RU-PABC-Val-Cit-Fmoc 是 5-A-RU 的前体物质之一。5-A-RU 是一种小分子粘膜相关的 MAIT 激活剂，是细菌合成核黄素的前体物质。
T35337L	Teduglutide acetate	Glucagon Receptor	GPCR/G Protein
	Teduglutide acetate 是一种 GLP-2 类似物，可使小肠黏膜肥大。它通过改变 claudin-10 的分布部分恢复小肠上皮功能，促进钠再循环以进行钠耦合葡萄糖转运和水吸收。
T13647	Dextran sulfate sodium salt (MW 4500-5500) DSS,Dextran sulfate sodium salt (MW 4500-5500),硫酸葡聚糖钠盐	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Dextran sulfate sodium salt (MW 4500-5500) 是一种脱水葡萄糖的聚合物，分子量范围是4500-5500。Dextran sulfate sodium salt (MW 4500-5500) 通过阻止病毒吸附到宿主细胞中来抑制人免疫缺陷病毒的复制。Dextran sulfate sodium salt (MW 4500-5500) 是常用的炎症性肠病造模药物，可通过硫酸基团引起的高负电荷破坏肠黏膜屏障完整性，从而导致肠屏障受损，巨噬细胞功能失调以及菌群紊乱等现象。
T20710	Ornoprostil OU-1308,OU 1308,OU1308,Ronoprost
	Ornoprostil, a prostaglandin E1 analogue, acts as a mucosal protectant.
TP2151	pBD-1	Antibacterial	Microbiology/Virology
	pBD-1 is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites with the contribution of mucosal and systemic host defenses in pigs.
T10391	Aspirin Aluminum Aluminum diacetylsalicylate,阿司匹林铝	Others	Others
	Aspirin Aluminum is an intermolecular compound that can inhibit gastrointestinal mucosal disorders induced by NSAIDs.
T32981	Lutenurine Alkaloid complex of nuphar luteum,Liutenurin
	Lutenurine is an alkaloid from yellow water lily; in treatment of skin and mucosal diseases.
T28156	Nepaprazole TY-11345,TY11345,TY 11345
	Nepaprazole is a proton pump inhibitor. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes, and the inhibitory effect was enhanced under weak acid conditions, the IC50 being 5.8 microM and 9.9 microM at pH 6.
T31958	Glycine-pentagastrin Glycine pentagastrin,Boc-gly-trp-met-asp-phe-NH2,Tbgtmap
	Glycine-pentagastrin can enhance gastric mucosal defence mechanisms against acid and protect the gastric mucosa from experimental injury.
TP2151L	pBD-1 TFA (206367-33-1 free base) pBD-1 TFA	Antibacterial	Microbiology/Virology
	pBD-1 TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs.
T62137	ANKRD22-IN-1
	ANKRD22-IN-1 是一种 ANKRD22 的有效抑制剂。ANKRD22-IN-1 能够促进胃肠黏膜上皮干细胞的扩增，进而可以间接激活 Wnt 经典通路，对体内受损胃肠黏膜组织的恢复有益。
T60263	Povafonidine
	Povafonidine (PGE-6201204) 是一种有效的 α-2 肾上腺素受体激动剂。Povafonidine 可以收缩血管，减轻粘膜充血，可用于鼻塞研究。
T15642	KAG-308	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing,
T76062	pBD-1 TFA
	pBD-1 TFA 是一种来源于猪组织的内源性组成型表达的抗菌肽 (AMP)，尤其在猪黏膜上皮部位表达。pBD-1 TFA 具有抗菌作用，并且有助于猪黏膜和系统宿主防御。
T38619	GSK1795091 CRX-601
	GSK1795091 (CRX-601) is a synthetic TLR4 agonist and immunologic stimulator with demonstrated antitumor activity. It serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines.
T64866	Glycyl-L-phenylalanine Gly-Phe,(S)-2-(2-Aminoacetamido)-3-phenylpropanoic acid
	Glycyl-L-phenylalanine (Gly-L-Phe）是一种二肽，常当作气管上皮细胞肽转运的模型肽，在粘膜液中会立即降解，可用于皮肤衰老和保湿。
T10165	5-A-RU 5-Amino-6-(D-ribitylamino)uracil	Others	Others
	5-A-RU (5-Amino-6-(D-ribitylamino)uracil), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules that are derived from
T80340	ROAD-1
	ROAD-1是一种α-防御素，源于恒河猴口腔粘膜。该化合物展现出对金黄色葡萄球菌、大肠杆菌和白色念珠菌的抗菌活性。
T75823	GLP-2(rat) TFA
	GLP-2(rat) TFA为肠道生长因子，能刺激细胞增殖、抑制凋亡，且在大肠小肠切除术(MSBR)后，可提升残留小肠粘膜的品质与功能。
T26090	Rioprostil TR 4698,TR4698,Rioprostilum,TR-4698
	Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection against NSAID-induced gastric muco
T78510	Zolimidine	Others	Others
	Zolimidine是一种咪唑并吡啶衍生物，可作为口服抗溃疡剂。它能刺激肠粘膜细胞分泌粘液，增强肠壁的抗溃疡能力，并在十二指肠溃疡研究中显示出胃保护效果。
T64314	OxyMetazoline
	OxyMetazoline 是一种 α-肾上腺素受体 (α-adrenoceptor) 激动剂，能够作用于 α1A (IC50: 0.02 μM)、α1B (IC50: 0.25 μM)、α2A (IC50: 0.58 μM) 和 α2C (IC50: 0.13 μM)。OxyMetazoline 能够用于研究缓解鼻黏膜充血。
T76172	Neuraminidase
	Neuraminidase（Exo-α-sialidase）为一种常用于生化研究的外唾液酸酶，能够在唾液酸（N-acetylneuraminic）与临近糖残基间切断α-酮甙键（α-ketosidic）。该酶源自黏膜病原体，作为一种调整宿主感染反应的毒力因子。
T11042	Dihydrocytochalasin B	Others	Others
	Dihydrocytochalasin B (H2CB) is a cell division inhibitor that changes the morphology of cells, similar to cytochalasin B. Does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the structure of actin and inhibits the ability of growth
T5499	gardiquimod TFA salt
	Gardiquimod diTFA，咪唑啉类似物TLR7/8激动剂，可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs)的HIV-1感染。在浓度低于10 μM时，该化合物特异性激活TLR7。
T70428	Nepaprazole sodium
	Nepaprazole Na is the salt form of Nepaprazole Free Base, also known as TY-11345, is a proton pump inhibitor potentially for treatment of gastric ulcer. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes; and the inhibitory effect was enhanced under weak acid conditions, the IC50 (concentrations that inhibit the enzyme activity by 50%) being 5.8 microM and 9.9 microM at pH 6.0 and pH 7.4, respectively. TY-11345 should be useful for the clinical tre...
T27092	CS-526 R-105266,R 105266,R105266
	CS-526 is a proton pump inhibitor. The inhibitory mechanism of CS-526 on H+,K+-ATPase was a competitive antagonism to the K+ binding site of H+,K+-ATPase, and it was also a reversible inhibition. CS-526 has a potent antisecretory effect on gastric acid se
T80362	Human α-Defensin 6
	Human α-Defensin 6，含32个半胱氨酸残基的抗菌肽，能够阻止细菌入侵，促进粘膜免疫。该肽通过自组装形成有序的原纤维和纳米网，能随机结合细菌表面蛋白，进而围绕并缠绕细菌。此外，Human α-Defensin 6抑制C. albicans生物膜的形成。
T37265	15(R)-Lipoxin A4 15(R)-Lipoxin A4,AT-Lipoxin A4
	Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
T36984	Cyclic di-IMP (sodium salt)
	Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p...
T73873	c-di-AMP disodium
	c-di-AMP (Cyclic diadenylate) sodium 作为一种STING 激动剂，通过结合STING 激活TBK3-IRF3 信号途径，引发I 型 IFN 和 TNF 产生，兼具细菌第二信使功能，在革兰氏阳性细菌中调控细胞生长、存活及毒力，并影响宿主免疫反应。此外，作为有效的粘膜佐剂，它能刺激体液和细胞反应。
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T35426	β-Defensin-1 (human) (trifluoroacetate salt)
	β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but no...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro...
T38042	Resolvin D4 Resolvin D4,RvD4
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosi...

化合物

Cat.No: T1562

Synonym: Proamipide,OPC12759,瑞巴派特

Target: Free radical scavengers, COX, Prostaglandin Receptor

Cat.No: T0081

Synonym: 拉呋替丁,FRG-8813

Target: 5-HT Receptor, Histamine Receptor

Sertaconazole nitrate

Cat.No: T6665

Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑

Target: Antibiotic, Antifungal

Cat.No: T27812

Target: ATPase

5-A-RU hydrochloride

Cat.No: T10165L

Synonym: 5-Amino-6-(D-ribitylamino)uracil hydrochloride

Target: Others

Nemazoline Free Base

Cat.No: T71012

5-A-RU-PABC-Val-Cit-Fmoc

Cat.No: T40303

Target: Others

Teduglutide acetate

Cat.No: T35337L

Target: Glucagon Receptor

Dextran sulfate sodium salt (MW 4500-5500)

Cat.No: T13647

Synonym: DSS,Dextran sulfate sodium salt (MW 4500-5500),硫酸葡聚糖钠盐

Target: Apoptosis, HIV Protease

Cat.No: T20710

Synonym: OU-1308,OU 1308,OU1308,Ronoprost

Cat.No: TP2151

Target: Antibacterial

Aspirin Aluminum

Cat.No: T10391

Synonym: Aluminum diacetylsalicylate,阿司匹林铝

Target: Others

Cat.No: T32981

Synonym: Alkaloid complex of nuphar luteum,Liutenurin

Cat.No: T28156

Synonym: TY-11345,TY11345,TY 11345

Glycine-pentagastrin

Cat.No: T31958

Synonym: Glycine pentagastrin,Boc-gly-trp-met-asp-phe-NH2,Tbgtmap

pBD-1 TFA (206367-33-1 free base)

Cat.No: TP2151L

Synonym: pBD-1 TFA

Target: Antibacterial

Cat.No: T62137

Cat.No: T60263

Cat.No: T15642

Target: Prostaglandin Receptor

Cat.No: T76062

Cat.No: T38619

Synonym: CRX-601

Glycyl-L-phenylalanine

Cat.No: T64866

Synonym: Gly-Phe,(S)-2-(2-Aminoacetamido)-3-phenylpropanoic acid

Cat.No: T10165

Synonym: 5-Amino-6-(D-ribitylamino)uracil

Target: Others

Cat.No: T80340

Cat.No: T75823

Cat.No: T26090

Synonym: TR 4698,TR4698,Rioprostilum,TR-4698

Cat.No: T78510

Target: Others

Cat.No: T64314

Cat.No: T76172

Dihydrocytochalasin B

Cat.No: T11042

Target: Others

gardiquimod TFA salt

Cat.No: T5499

Nepaprazole sodium

Cat.No: T70428

Cat.No: T27092

Synonym: R-105266,R 105266,R105266

Human α-Defensin 6

Cat.No: T80362

15(R)-Lipoxin A4

Cat.No: T37265

Synonym: 15(R)-Lipoxin A4,AT-Lipoxin A4

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

Cyclic di-IMP (sodium salt)

Cat.No: T36984

c-di-AMP disodium

Cat.No: T73873

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

β-Defensin-1 (human) (trifluoroacetate salt)

Cat.No: T35426

β-Defensin-4 (human) (trifluoroacetate salt)

Cat.No: T35453

Cat.No: T38042

Synonym: Resolvin D4,RvD4

Cat. No.	Product Name	Target	Signaling Pathways
T40615	N,N'-Dimethylthiourea N,N-二甲基硫脲,DMTU	Antioxidant	oxidation-reduction
	N,N'-Dimethylthiourea (DMTU) 是一种分离自黑蒜的化合物。N,N'-Dimethylthiourea 具有口服活性的羟基自由基 (•OH) 的清除剂，通过活化的中性粒细胞在体外阻止 •OH 的产生。N,N'-Dimethylthiourea 通过发挥 •OH 清除和抗炎作用，防止水浸限制应激诱导的大鼠胃粘膜损伤。
TN1913	Marmin	Calcium Channel; Antifection; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine.

天然产物

N,N'-Dimethylthiourea

Cat.No: T40615

Synonym: N,N-二甲基硫脲,DMTU

Target: Antioxidant

Cat.No: TN1913

Target: Calcium Channel, Antifection, Histamine Receptor

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