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Cat. No.	Product Name	Target	Signaling Pathways
T15260	Evenamide NW-3509	Sodium Channel	Membrane transporter/Ion channel
	Evenamide (NW-3509) 是一种口服有效的电压门控钠通道 (sodium channel, VGSC) 阻滞剂，Ki 为 0.4 µM，在精神分裂症中有研究价值。Evenamide 在精神病，躁狂症，抑郁和攻击性的各种啮齿动物模型中具有显著功效。
T61416	Antileishmanial agent-9
	Antileishmanial agent-9 (compound 16c) exhibits potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. In addition, this compound demonstrates relatively low cytotoxicity in L-6 cells, with an IC50 value of 40.1 μM [1].
T78963	Antileishmanial agent-16	Parasite	Microbiology/Virology
	Antileishmanial agent-16 (化合物 14c) 是一种针对Leishmania的抗原虫剂，表现出针对Leishmaniamajor前鞭毛体的高效活性（IC50=0.59 µM）以及对Leishmaniamajor无鞭毛体的有效活性（IC50=0.81 µM）。此外，Antileishmanial agent-16对哺乳动物细胞（VERO 细胞）的毒性低，说明其具有较好的安全性。
T79419	Antileishmanial agent-24	Parasite	Microbiology/Virology
	Antileishmanial agent-24 (compound 33) Exhibiting an IC50 of 5.39 μM against the amastigote form.
T40117	Antileishmanial agent-1
	Antileishmanial agent-1 demonstrates activity against both L. amazonensis promastigotes (IC 50 = 15.52 μM) and intracellular amastigotes (IC 50 = 4.10 μM).
T62210	Antileishmanial agent-10
	Antileishmanial agent-10 (Compound 7h) 是一种抗原虫 (antiprotozoal) 剂。
T61100	Antileishmanial agent-4
	Antileishmanial agent-4 是一种核糖核苷类似物，作为抗黑热病试剂。
T79471	Antileishmanial agent-20	Parasite	Microbiology/Virology
	Antileishmanial agent-20 显示对利什曼原虫的选择性抑制作用，其针对L. infantum和L. braziliensis的IC50值分别为2.8 μM 和0.2 μM，适用于寄生虫研究领域。
T83045	Antileishmanial agent-25	Parasite	Microbiology/Virology
	Antileishmanial agent-25（compound 24）展现了对胞内无尾线虫的选择性抗力士曼体活性，其半抑制浓度（IC50）为6.63 μM。
TP2331	Leishmania peptide 183 Peptide 183,p183,Leishmania
	Leishmania peptide 183 is an antigen.
T79632	Antileishmanial agent-21	Parasite	Microbiology/Virology
	Antileishmanial agent-21 (compound 4e)，是靶向利什曼原虫蝶啶还原酶1 (Lm-PTR1) 的抗利什曼虫试剂。该化合物通过抗叶酸机制发挥作用，且其抗利什曼活性能被叶酸和亚叶酸逆转。Antileishmanial agent-21 还能抑制对 Chloroquine 抗性的恶性疟原虫菌株 (RKL9)，IC50 范围为0.0198-0.096 μM。
T79633	Antileishmanial agent-22	Parasite	Microbiology/Virology
	Antileishmanial agent-22 (compound 15b)是一种抗寄生虫和抗菌化合物，展示了对抗利什曼病、疟疾和结核病的活性。该化合物通过抗叶酸途径抑制利什曼原虫（IC50=0.408 μM）。在100 μM浓度时，Antileishmanial agent-22对叶酸和亚叶酸的抑制率分别达到88%和94%。在体内，以48.4 μM/kg/day剂量对伯氏疟原虫展示96.67%的抑制效果；在体外，其IC50值为0.038 μM。Antileishmanial agent-22还能抑制结核分枝杆菌，MIC值为28.44 μM。
T60638	Antileishmanial agent-8
	Antileishmanial agent-8 (compound 18) 对杜氏利什曼原虫 (L. donovani) 显示出有效的和选择性的杀伤活性(IC50 = 5.64 μM)，并且对 L-6 细胞显示相对较低的细胞毒性 (IC50=73.9 μM)。
T62574	Antileishmanial agent-6
	Antileishmanial agent-6 是一种有效的抗利什曼虫剂。Antileishmanial agent-6 对Leishmania donovani 和 L-6 具有抗利什曼虫活性 (IC50: 0.54 μM) 和细胞毒性 (IC50: 10.2 μM) 作用。
T63281	Antileishmanial agent-11
	Antileishmanial agent-11 是有效的抗利什曼原虫剂，能够作用于 Leishmania brazilensis (IC50: 28.3 μM)、Leishmania infantum (IC50: 24.8 μM) 和T. cruzi(IC50: 13.0 μM) 具有出抗原虫作用。
T61710	Antileishmanial agent-7
	Antileishmanial agent-7 (compound 23) exhibits strong antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively [1].
T79390	Antileishmanial agent-23	Parasite	Microbiology/Virology
	Antileishmanial agent-23 (compound G1/9) 作为一种选择性trypanothione reductase (TR)抑制剂效力显著，展现了2.24 ± 0.52 μM的IC50值。该化合物有效抑制了利什曼原虫、克氏锥虫和布氏锥虫的生长。
T61391	Antileishmanial agent-3
	Antileishmanial agent-3 (Compound 13) 是一种很有前景的Leishmania major 的生长抑制剂。
T61560	Antileishmanial agent-5
	Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L.infantum and T.cruzi, having EC 50 values of 0.68 μM and 0.83 μM, respectively [1].
T62330	Antileishmanial agent-12
	Antileishmanial agent-12 (compound 5a) 是一种有效的抗利什曼原虫剂，对 Leishmania brazilensis (IC50: 14.9 μM)、Leishmania infantum (IC50: 21.3 μM) 和 T. cruzi (IC50: 9.3 μM) 具有抗原虫作用。
T78680	Antileishmanial agent-14	Parasite	Microbiology/Virology
	Antileishmanial agent-14，一种磺胺类类似物，展现了对Leishmaniadonovani promastigotes的潜在活性(IC50=4.1 μM)。该化合物同时对L. donovani amastigotes的感染也具有抑制作用(IC50=11.1 μM)。
T78962	Antileishmanial agent-15	Parasite	Microbiology/Virology
	Antileishmanial agent-15 (compound 13c) 是针对L. major前鞭毛体和无鞭毛体的高效抗利什曼原虫分子，展现出显著的抗原虫活性和细胞毒性，其IC50值分别为0.78 μM和0.99 μM。
T78964	Antileishmanial agent-17	Parasite	Microbiology/Virology
	Antileishmanial agent-17是香豆素杂化化合物，展现出优越的抗利什曼原虫活性(IC50<0.78 μM)，同时对VERO细胞具备安全性。该化合物通过抑制叶酸代谢途径发挥效用，且在对抗利什曼原虫不同生长阶段表现显著，其IC50值分别对前鞭毛体为0.40 μM，对无鞭毛体为0.68 μM。
T79449	Antileishmanial agent-19	Parasite	Microbiology/Virology
	Antileishmanial agent-19 (Compound F27)是一种有效的抗利什曼病试剂，其对L. donovani promastigotes的IC50值为3.39 μM。该化合物能够抑制L. donovani promastigotes中的脯氨酰-tRNA合成酶，并干预宿主PI3K/Akt/CREB轴，从而抑制IL-10的分泌。此外，Antileishmanial agent-19能诱导L. donovani promastigotes自噬介导的细胞凋亡(apoptosis)过程，并在感染的动物体内显著减少寄生虫负担。
T72260	Antileishmanial agent-13
	Antileishmanial agent-13 是一种喹啉-靛蓝杂交物，可作为抗利什曼病试剂，抑制L. MajorLeishmania 株系。Antileishmanial agent-13 通过抗叶酸机制获得其抗利什曼病活性。Antileishmanial agent-13 对前鞭毛体和无鞭毛体均具有较强的抑制作用，IC50分别为 0.604 μM 和 0.508 μM。
T6241	Quetiapine hemifumarate Quetiapine Fumarate,ICI-204636,富马酸喹硫平	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Quetiapine hemifumarate (ICI-204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂，对人5-HT1A 和人D2的pEC50值分别为 4.77 和 6.33，具有抗抑郁和抗焦虑作用。
T19680	Zotepine	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Zotepine 是一种抗精神病剂，是有效的5-HT2A、5-HT2C、组胺H1、α1-肾上腺素能和多巴胺D2受体拮抗剂，Kd 值分别为 2.6、3.2、3.3、7.3 和 8 nM。它在体内表现出抗抑郁和抗焦虑作用。
T15117	Didesmethyl cariprazine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Didesmethyl cariprazine 是 Cariprazine 的代谢物，是主要的循环活性部分。 Didesmethyl cariprazine 有较长的半衰期，为 1-3 周。Cariprazine 是一种有效的多巴胺D3偏好D3/D2受体部分激动剂，用于治疗精神分裂症、双相躁狂和抑郁症，对d3和d2受体具有高亲和力，对5-HT 1A 受体具有中等亲和力。
T22589	Asenapine hydrochloride	Others	Others
	Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder.
T63592	Thiothixene hydrochloride
	Thiothixene hydrochloride 是抗精神病剂，能够用于研究精神分裂症和双相性躁狂症。
T28282	Oxypertine Win-18501,Forit,Win18501,Win 18501
	Oxypertine is an indole-derivative antipsychotic with general properties similar to those of the chlorpromazine and phenothiazine. Oxypertine is used as a treatment for various psychoses including mania, schizophrenia, disturbed behaviour, and severe anx
T9540	Phenelzine Fenelzyna,苯乙肼,(2-phenylethyl)-hydrazin	Dopamine Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Phenelzine 是一种抗抑郁和躁狂症药物，是一种单胺氧化酶抑制剂。其抗抑郁作用与烟酰胺相似。可减少脑内儿茶酚胺（去甲肾上腺素、多巴胺、5-羟色胺）的降解，增加儿茶酚胺的含量。，并起到抗抑郁作用。对内源性抑郁症疗效较好，对外源性和反应性抑郁症疗效较差。
T71578	Endoxifen mesylate
	Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and other psychotic disorders. Endoxifen is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group. It is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromat...

化合物

Cat.No: T15260

Synonym: NW-3509

Target: Sodium Channel

Antileishmanial agent-9

Cat.No: T61416

Antileishmanial agent-16

Cat.No: T78963

Target: Parasite

Antileishmanial agent-24

Cat.No: T79419

Target: Parasite

Antileishmanial agent-1

Cat.No: T40117

Antileishmanial agent-10

Cat.No: T62210

Antileishmanial agent-4

Cat.No: T61100

Antileishmanial agent-20

Cat.No: T79471

Target: Parasite

Antileishmanial agent-25

Cat.No: T83045

Target: Parasite

Leishmania peptide 183

Cat.No: TP2331

Synonym: Peptide 183,p183,Leishmania

Antileishmanial agent-21

Cat.No: T79632

Target: Parasite

Antileishmanial agent-22

Cat.No: T79633

Target: Parasite

Antileishmanial agent-8

Cat.No: T60638

Antileishmanial agent-6

Cat.No: T62574

Antileishmanial agent-11

Cat.No: T63281

Antileishmanial agent-7

Cat.No: T61710

Antileishmanial agent-23

Cat.No: T79390

Target: Parasite

Antileishmanial agent-3

Cat.No: T61391

Antileishmanial agent-5

Cat.No: T61560

Antileishmanial agent-12

Cat.No: T62330

Antileishmanial agent-14

Cat.No: T78680

Target: Parasite

Antileishmanial agent-15

Cat.No: T78962

Target: Parasite

Antileishmanial agent-17

Cat.No: T78964

Target: Parasite

Antileishmanial agent-19

Cat.No: T79449

Target: Parasite

Antileishmanial agent-13

Cat.No: T72260

Quetiapine hemifumarate

Cat.No: T6241

Synonym: Quetiapine Fumarate,ICI-204636,富马酸喹硫平

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T19680

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Didesmethyl cariprazine

Cat.No: T15117

Target: Dopamine Receptor, 5-HT Receptor

Asenapine hydrochloride

Cat.No: T22589

Target: Others

Thiothixene hydrochloride

Cat.No: T63592

Cat.No: T28282

Synonym: Win-18501,Forit,Win18501,Win 18501

Cat.No: T9540

Synonym: Fenelzyna,苯乙肼,(2-phenylethyl)-hydrazin

Target: Dopamine Receptor, Serotonin Transporter, Norepinephrine

Endoxifen mesylate

Cat.No: T71578

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