首页工具

登录

搜索结果

Search Results for " mglur2 "

35

抑制剂 & 化合物

1

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T38910	mGluR2 antagonist 1
	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, with an IC50 value of 9 nM. Furthermore, it exhibits excellent permeability across the blood-brain barrier, making it a promising candidate for central nervous system-related studies or therapies.
T61277	mGluR2 modulator 4
	mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1].
T60882	mGluR2 modulator 2
	mGluR2 modulator 2 (compound 2) 可用于抗精神病药物研究。mGluR2 modulator 2 是一种有效的、选择性和口服生物可利用的mGluR2正变构调节剂，EC50值为 0.13 μM。
T62202	mGluR2 modulator 1
	mGluR2 modulator 1 (compound 95) 是一种有效的、具有血脑屏障通透性的 mGluR2 (代谢型谷氨酸受体-2)正向变构调节剂 (EC50: 0.03 μM)。mGluR2 modulator 1 能够用于研究精神病。
T15090	Decoglurant RO4995819	GluR	Neuroscience
	Decoglurant (RO4995819) 是 mGluR2和 mGluR3的负变构调制器，有抗抑郁作用。
T10432L	AZD-8529 mesylate	GluR	Neuroscience
	AZD-8529 mesylate 是高度选择性的可口服mGluR2正向调节剂，EC50值为 285 nM。它在 20-25 M 时，对 mGluR1、3、4、5、6、7 和 8 亚型没有显示正变构调节剂反应。
T3479	(RS)-MCPG alpha-MCPG,(±)-MCPG	GluR	Neuroscience
	(RS)-MCPG ((±)-MCPG) 是一种竞争性和选择性 I/II 组代谢型谷氨酸受体 (mGluR) 拮抗剂，可阻断 TBS 诱导的幼年和新生大鼠海马神经元的转变。
T15812	LY2979165 mGlu2 agonist	GluR	Neuroscience
	LY2979165 (mGlu2 agonist) 是 mGluR2 的正构激动剂，可用于作为抗抑郁药的研究。
T3484	trans-ACPD Trans-(±)-ACP,1-amino-1,3-dicarboxycyclopentane,(±)-trans-ACPD	GluR	Neuroscience
	trans-ACPD ((±)-trans-ACPD) 是代谢型受体激动剂，可促进钙离子活动及产生内向电流。
T27932	LY-2300559 LY2300559	GluR	Neuroscience
	LY-2300559 是代谢型谷氨酸受体 2 (mGluR2) 的激动剂，可用于偏头痛治疗的研究。
T6022	LY404039 pomaglumetad	Glucocorticoid Receptor; GluR	Endocrinology/Hormones; Neuroscience
	LY404039 (pomaglumetad) 是可口服的mGluR2和mGluR3选择性激动剂，有抗精神病和抗焦虑的作用。它对重组人mGluR2和mGluR3的Ki 分别为 149 和 92 nM，比对其他受体/转运蛋白的抑制性高 100 倍以上。
T41301	L-Cysteinesulfinic acid monohydrate	GluR	Neuroscience
	L-Cysteinesulfinic acid monohydrate 是代谢型谷氨酸受体 (mGluRs) 的有效激动剂，可以作用于 mGluR1，mGluR2，mGluR5，mGluR4，mGluR6 和 mGluR8，pEC50分别为 3.92，3.9，4.6，2.7，4.0，和 3.94。
T3464	PHCCC (-) PHCCC	GluR	Neuroscience
	PHCCC ((-) PHCCC) 是 I 组代谢型谷氨酸受体拮抗剂和 mGluR4 的正变构调节剂。它对 mGluR2 和 mGluR8 也有很强的拮抗作用，具有抗帕金森病作用。
T27448	GSK1331258 GSK 1331258,GSK-1331258
	GSK1331258 is a selective, orally bioavailable positive modulators of mGluR2.
T10432	AZD-8529	Others	Others
	AZD-8529 is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
T23294	(S)-4C3HPG	Others	Others
	group I mGlu1a/1a receptor antagonist and mGluR2 agonist
T27449	GSK1331268 GSK 1331268,GSK-1331268
	GSK1331268 is a selective, orally bioavailable positive modulators of mGluR2.
T27942	LY307452 LY 307452,LY-307452
	LY307452 is a selective antagonist of mGluR2/3.
T14615	Biphenylindanone A BINA	GluR	Neuroscience
	Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.
T28600	Ro4491533 Ro 4491533,Ro-4491533
	Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3).
T79302	MK-8768
	MK-8768为口服生效且能穿越血脑屏障的选择性mGluR2负向变构调节剂，其IC50为9 nM。
T28034	MGS-0039 BCI 632,BCI-632,MGS0039,BCI632
	MGS-0039 is a group II metabotropic glutamate receptor (mgluR2/3) antagonist. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor seems to play a key role in the an
T60611	Talaglumetad hydrochloride
	Talaglumetad (hydrochloride) 是Eglumegad 的前药，Eglumegad 是II 型代谢型谷氨酸受体(mGluR2/3)有效选择性的激动剂，用于治疗焦虑等精神疾病。
T62756	LY487379
	LY487379是一种选择性的人类 mGluR2 阳性异生调节剂（PAM）。LY487379 可提高谷氨酸刺激的 [35 S] GTPγS 结合，作用于 mGlu2 受体 (EC50: 1.7 μM) 和 mGlu3 受体 (EC50>10 μM)。LY487379 在大鼠模型中促使认知的灵活性，并诱导行为抑制。LY487379 能够用于研究精神分裂症。
T9353	OXOMEMAZINE	AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Oxomemazine 是毒菌碱 M1 受体的选择性拮抗剂，具有明显的抗毒蕈碱活性。它是基于吩噻嗪的组胺 H1 受体阻滞剂，是抗组胺和抗胆碱能试剂，可用于咳嗽相关研究。
T15816	LY341495	GluR	Neuroscience
	LY341495 是高效的代谢型谷氨酸受体拮抗剂，对多种谷氨酸受体的亚型表现除很高的活性，可用于研究神经系统疾病。
T23515	VU-29 VU 29	GluR	Neuroscience
	VU-29 是代谢型谷氨酸 5(mGlu5)受体的正变构调节剂，对 rmGluR5 的 EC50为 9 nM，Ki 为 244 nM。相对于其他亚型，它对 mGluR5 具有选择性，对 rmGluR1/rmGluR2和 hmGluR4的 EC50分别为557 nM/1.5 μM 和 154 nM。
T3486	3-MATIDA	GluR; NMDAR	Neuroscience
	3-MATIDA 是一种有效的 mGluR-1 拮抗剂（IC50：6.3 μM，大鼠 mGluR-1a）。显示出 ≥ 40 倍于其他受体的选择性：mGluR-5、mGluR-2、mGluR-4 (mGluR-4a) (IC50 > 300 μM)、NMDA 和 GluR (AMPA) (IC50 = 250 μM)。 3-MATIDA 在体外培养的鼠皮质细胞和大鼠海马切片培养物中充当神经保护剂。
T15618	JNJ-46281222	GluR	Neuroscience
	JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).
T11165	EGLU (2S)-α-EGLU,(2S)-α-Ethylglutamic acid	Others	Others
	EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent.EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist.
T15807	LY2794193	SGLT	GPCR/G Protein
	LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
T11906	LY 541850	GluR	Neuroscience
	LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells.
T15809	LY2812223	LIM Kinase	Cell Cycle/Checkpoint
	LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).
T11911	LY3020371 hydrochloride	GluR	Neuroscience
	LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.
T38791	LY3020371
	LY3020371 is a highly potent and selective antagonist targeting the glutamate (mGlu) 2/3 receptor, showcasing excellent inhibition at Ki values of 5.26 nM and 2.50 nM for hmGluR2 and hmGluR3, respectively. With its remarkable affinity and specificity, LY3020371 serves as a valuable tool in depression research.

化合物

mGluR2 antagonist 1

Cat.No: T38910

mGluR2 modulator 4

Cat.No: T61277

mGluR2 modulator 2

Cat.No: T60882

mGluR2 modulator 1

Cat.No: T62202

Cat.No: T15090

Synonym: RO4995819

Target: GluR

AZD-8529 mesylate

Cat.No: T10432L

Target: GluR

Cat.No: T3479

Synonym: alpha-MCPG,(±)-MCPG

Target: GluR

Cat.No: T15812

Synonym: mGlu2 agonist

Target: GluR

Cat.No: T3484

Synonym: Trans-(±)-ACP,1-amino-1,3-dicarboxycyclopentane,(±)-trans-ACPD

Target: GluR

Cat.No: T27932

Synonym: LY2300559

Target: GluR

Cat.No: T6022

Synonym: pomaglumetad

Target: Glucocorticoid Receptor, GluR

L-Cysteinesulfinic acid monohydrate

Cat.No: T41301

Target: GluR

Cat.No: T3464

Synonym: (-) PHCCC

Target: GluR

Cat.No: T27448

Synonym: GSK 1331258,GSK-1331258

Cat.No: T10432

Target: Others

Cat.No: T23294

Target: Others

Cat.No: T27449

Synonym: GSK 1331268,GSK-1331268

Cat.No: T27942

Synonym: LY 307452,LY-307452

Biphenylindanone A

Cat.No: T14615

Synonym: BINA

Target: GluR

Cat.No: T28600

Synonym: Ro 4491533,Ro-4491533

Cat.No: T79302

Cat.No: T28034

Synonym: BCI 632,BCI-632,MGS0039,BCI632

Talaglumetad hydrochloride

Cat.No: T60611

Cat.No: T62756

Cat.No: T9353

Target: AChR, Histamine Receptor

Cat.No: T15816

Target: GluR

Cat.No: T23515

Synonym: VU 29

Target: GluR

Cat.No: T3486

Target: GluR, NMDAR

Cat.No: T15618

Target: GluR

Cat.No: T11165

Synonym: (2S)-α-EGLU,(2S)-α-Ethylglutamic acid

Target: Others

Cat.No: T15807

Target: SGLT

Cat.No: T11906

Target: GluR

Cat.No: T15809

Target: LIM Kinase

LY3020371 hydrochloride

Cat.No: T11911

Target: GluR

Cat.No: T38791

Cat. No.	Product Name	Target	Signaling Pathways
T11803	L-Cysteinesulfinic acid	Others	Others
	L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs, pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively).

天然产物

L-Cysteinesulfinic acid

Cat.No: T11803

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼