keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Cysteinesulfinic acid monohydrate 是代谢型谷氨酸受体 (mGluRs) 的有效激动剂,可以作用于 mGluR1,mGluR2,mGluR5,mGluR4,mGluR6 和 mGluR8,pEC50分别为 3.92,3.9,4.6,2.7,4.0,和 3.94。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 289 | 现货 | ||
10 mg | ¥ 413 | 现货 | ||
25 mg | ¥ 813 | 现货 | ||
50 mg | ¥ 1,230 | 现货 | ||
100 mg | ¥ 1,850 | 现货 | ||
200 mg | ¥ 2,750 | 现货 |
产品描述 | L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1]. |
体外活性 | L-Cysteinesulfinic acid (monohydrate) is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA (monohydrate) is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA (monohydrate) selectively activates the PLD-coupled receptor. 1 mM L-CSA (monohydrate) induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA (monohydrate) elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA (monohydrate) is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA (monohydrate)-induced increases in cell firing[1]. |
分子量 | 183.18 |
分子式 | C9H10FNO2 |
CAS No. | 207121-48-0 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 120 mg/mL (701.06 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 5.4591 mL | 27.2956 mL | 54.5911 mL | 136.4778 mL |
5 mM | 1.0918 mL | 5.4591 mL | 10.9182 mL | 27.2956 mL | |
10 mM | 0.5459 mL | 2.7296 mL | 5.4591 mL | 13.6478 mL | |
20 mM | 0.273 mL | 1.3648 mL | 2.7296 mL | 6.8239 mL | |
50 mM | 0.1092 mL | 0.5459 mL | 1.0918 mL | 2.7296 mL | |
100 mM | 0.0546 mL | 0.273 mL | 0.5459 mL | 1.3648 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
L-Cysteinesulfinic acid monohydrate 207121-48-0 Neuroscience GluR L Cysteinesulfinic acid monohydrate LCysteinesulfinic acid monohydrate Metabotropic glutamate receptors Inhibitor inhibit L-Cysteinesulfinic acid Monohydrate L-Cysteinesulfinic acid mGluR inhibitor