16
5
Cat. No. | Product Name | Target | Signaling Pathways |
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T67945 |
WAY-620473
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
WAY-620473是一种有效的 PARP-1抑制剂,具有抗肿瘤活性,可改变真核生物的寿命。 | |||
T62461 |
Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine
|
Others | Others |
Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine 可用于改变真核生物寿命。 | |||
T77612 |
WAY-620472
|
PPAR | DNA Damage/DNA Repair; Metabolism |
WAY-620472是一种PPAR 调节剂,可用于改变真核生物的寿命。 | |||
T77604 |
WAY-326766
|
CFTR | Membrane transporter/Ion channel |
WAY-326766通过突变型 CFTR 增加离子转运,可用于改变真核生物的寿命。WAY-326766可用于治疗囊性纤维化(CF)。 | |||
T38376 |
2-O-(α-D-Glucopyranosyl)glycerol
2-alphaGG |
Others | Others |
2-O-(α-D-Glucopyranosyl)glycerol (2-alphaGG) 存在于少数细菌和生长在恶劣环境中的植物中,可通过增加渗透压反应来延长出芽酵母的寿命和红孢子虫的寿命。 | |||
T60001 |
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) 是一种 sirtuin 调节剂,可用于延长细胞寿命,治疗和/或预防多种 疾病和障碍包括糖尿病、心血管疾病、凝血障碍、炎症、癌症等。 | |||
T15646 |
KBU2046
|
Others | Others |
KBU2046 是口服有效的,体外细胞运动和侵袭的高选择性抑制剂。它结合伴侣异源复合物,选择性地改变调节运动性的侣伴蛋白的结合,并且缺乏经典 HSP90抑制剂的所有标志。它抑制癌症转移并延长寿命。 | |||
T82638 |
Cyclohexyl [3,5-bis(methylthio)-4-isothiazolyl]carbamate
|
||
Cyclohexyl [3,5-bis(methylthio)-4-isothiazolyl]carbamate为能影响真核生物寿命的化学化合物。 | |||
T62002 |
Topoisomerase I inhibitor 7
|
||
Topoisomerase I inhibitor 7 (Compound 8) 是有效的Topoisomerase I 抑制剂。Topoisomerase I inhibitor 7 显著抑制肿瘤生长(高达 79%)。在接受 P388 淋巴瘤移植的小鼠模型中,Topoisomerase I inhibitor 7延长了小鼠寿命(153%)。 | |||
T35670 |
Miro1 Reducer
|
||
Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models. | |||
T21921 |
Valeroyl Salicylate
2-Valeryloxybenzoic acid,戊酰基水杨酸 |
Others | Others |
Valeroyl Salicylate (2-Valeryloxybenzoic acid) 具有抗炎作用,可延长寿命,延缓随年龄增长而导致的自发活动下降,并提高抗压能力。 | |||
T83861 |
Bactobolamine
|
||
Bactobolamine是一种免疫抑制剂。在200 µg/ml的浓度下,该化合物能够抑制CTLL细胞的IL-2产生。在体内实验中,Bactobolamine(200 mg/kg)能够延长MHC兼容及MHC不兼容的大鼠心脏移植物存活时间。此外,它还能在大鼠肝脏移植模型和犬类肾脏移植模型中延长存活时间。 | |||
T72483 |
Sirtuin modulator 4
|
||
Sirtuinmodulator 4 是 sirtuin 调节剂。Sirtuinmodulator 4 对 SIRTl 具有抑制效应,EC50值为 51-100 μM。Sirtuinmodulator 4 可用于延长细胞寿命以及预防各种疾病和紊乱的研究,例如:糖尿病、肥胖、神经退行性疾病、心血管疾病、炎症和癌症 。 | |||
T74743 |
M47
|
||
M47 是一种小分子,可选择性地破坏隐花色素 1 (CRY1) 的稳定性并增加细胞核中 CRY1 的降解。M47 增强Ras 转化的 P53 缺陷小鼠皮肤成纤维细胞系的细胞凋亡,并延长 p53 基因敲除小鼠的寿命。M47 可用于癌症研究。 | |||
T69600 |
Spermidine-d6
|
||
Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki... | |||
T35812 |
CAY10591
CAY10591 |
||
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This com... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S1820 |
Parishin
巴利森苷A,派立辛,Parishin A |
Others | Others |
Parishin (Parishin A) A 是一种酚类葡萄糖苷,从天麻中分离得到。Parishin 通过调节 Sir2/Uth1/TOR 信号通路而具有抗衰老作用,并延长酵母寿命。 | |||
T3333 |
Cyclogalegenin
环黄芪醇,Cyclogalegigenin,Cyclogalagenin,Astramembrangenin,Cycloastragenol |
Telomerase | DNA Damage/DNA Repair |
Cyclogalegenin (Astramembrangenin) 是一种发现于Astragalus galegiformis 中的类异戊二烯,是 Cycloastragenol 的异构体。 | |||
TN2309 |
Withanolide A
|
EGFR; TNF; NF-κB | Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors |
Withanolide A 提取于印度草药 Ashwagandha 中,在严重受损的神经元中,能再生神经元突并重建突触。它延长了人类 EGFR 驱动的癌性秀丽隐杆线虫的寿命。 | |||
TMS1461 |
Qingyangshengenin B
青阳参甙元B,青阳参苷元B,Otophylloside B |
Beta Amyloid | Neuroscience |
Qingyangshengenin B (Otophylloside B) 是一种分离自 Qingyangshen 的 C-21 甾体苷。它能够在 mRNA 水平上抑制 Aβ 的表达来减少 Aβ 的沉积,对 Aβ 的毒性有保护作用。它具有抗癫痫作用。 | |||
T38515 |
Ascr#7
|
||
Ascr#7, an ascaroside-based hormonal compound, plays a significant role in nematode physiology. It is specifically expressed throughout the various stages of nematode development. Notably, ascarosides exhibit the capability to initiate the formation of dauer larvae, which are characterized by their long lifespan and exceptional stress resistance. |