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Search Results for " less active enantiomer "

46

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10480	Bay 41-4109 (less active enantiomer)	HBV	Microbiology/Virology
	Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
T12814	(S)-Tenofovir (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF	Others	Others
	(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体，Tenofovir 是一种核苷酸逆转录酶抑制剂。
T12831	SAR405 R enantiomer	Others	Others
	SAR405 R enantiomer 是一种 PIK3C3/Vps34 抑制剂，也是活性低于 SAR405 的对映体。
T11129L	Duvelisib (R enantiomer) hydrochloride IPI-145 R enantiomer HCl,Duvelisib (R enantiomer) hydrochloride(1261590-48-0 Free base),INK1197 R enantiomer HCl	PI3K	PI3K/Akt/mTOR signaling
	Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) 是 PI3K 抑制剂。Duvelisib (R enantiomer) hydrochloride 是 Duvelisib 的活性较低的对映体。
T22450	Tyrphostin B44, (+) enantiomer 酪氨酸磷酸化抑制剂AG 835	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin B44, (+) enantiomer 是一种表皮生长因子受体 (EGFR) 激酶抑制剂，IC50 为 0.86 μM，活性低于 (-) 对映体。
T10376	ARS-1630	Ras	GPCR/G Protein; MAPK
	ARS-1630 是一种突变型 K-ras G12C 抑制剂。它是 ARS-1620 的活性较低的对映异构体。
T13140	Umbralisib R-enantiomer TGR-1202 R-enantiomer,RP5264 R-enantiomer	PI3K	PI3K/Akt/mTOR signaling
	Umbralisib R-enantiomer (RP5264 R-enantiomer) 是 PI3K 的δ型抑制剂，是 TGR-1202 活性较低的对映体。Umbralisib R-enantiomer 对δ型 pi3激酶的 IC50，至少比抑制剂对其他 PI3K 亚型(A， β和γ)的 IC50低20倍。
T20898	(R)-Propranolol hydrochloride Dexpropranolol hydrochloride,(R)-(+)-Propranolol,盐酸普奈洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) 是一种抗肾上腺素受体拮抗剂，是一种普萘洛尔的活性较低的对映体。Dexpropranolol 是一种非选择性的β-adrenergic receptor 拮抗剂，对 β1AR 和 β2AR 具有高亲和力。
T13438	(R,S)-Ivosidenib (R,S)-AG-120	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	(R,S)-Ivosidenib is the less active enantiomer of Ivosidenib .
T13450	(S)-GNE-140	Others	Others
	(S)-GNE-140 is the less active enantiomer of GNE-140.
T13426L	(3S,4S)-Tofacitinib (3S,4S)-托法替尼	Others	Others
	(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.
T11156	Nazartinib S-enantiomer EGF816 (S-enantiomer)	Others	Others
	Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.
T10856	Cobimetinib (R-enantiomer) 考比替尼 (R 型对映体),XL-518 R-enantiomer,Cobimetinib R-enantiomer,GDC-0973 R-enantiomer	Others	Others
	Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.
T11801	l-Atabrine dihydrochloride	Others	Others
	l-Atabrine dihydrochloride displays antiprion activity. l-Atabrine dihydrochloride is a less active enantiomer of quinacrine.
T10564	(8R,9S)-Talazoparib (8R,9S)-BMN-673,他拉唑帕利 (8R,9S)	Others	Others
	(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).
T12200	Firsocostat S enantiomer ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer	Others	Others
	Firsocostat S enantiomer is the less active S enantiomer of Firsocostat.
T11334	Fulvestrant (R enantiomer) ICI 182780 R enantiomer,ZD 9238 R enantiomer,ZM 182780 R enantiomer,Fulvestrant R enantiomer	Others	Others
	Fulvestrant R enantiomer is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.
T11335	Fulvestrant (S enantiomer) ZM 182780 S enantiomer,ICI 182780 S enantiomer,Fulvestrant S enantiomer,ZD 9238 S enantiomer	Others	Others
	Fulvestrant S enantiomer is the less active S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.
T26371	(2S,3R)-LP99
	(2S,3R)-LP99 is a less active enantiomer of LP99.
T12636	(R)-(+)-Anatabine	Others	Others
	(R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent agonist of α4β2 nAChR.
T6493L	(R)-Citalopram oxalate
	(R)-Citalopram oxalate is a less active enantiomer of Escitalopram Oxalate. Escitalopram Oxalate is a potent and selective serotonin reuptake inhibitor.
T12635	(R)-Plevitrexed (R)-ZD 9331,(R)-BGC9331,(R)-普来曲塞	Others	Others
	(R)-Plevitrexed is a less active enantiomer of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).
T13426	(3R,4S)-Tofacitinib	Others	Others
	(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).
T12633	(R)-Nicardipine (R)-YC-93 free base	Others	Others
	(R)-Nicardipine is the less active R enantiomer of Nicardipine. Nicardipine is a blocker of calcium channel(IC50 of 1 μM for blocking cardiac calcium channels).
T13427	(3S,4R)-Tofacitinib	Others	Others
	(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).
T12629	(R)-MIK665	Others	Others
	(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).
T28489	R-(-)-Niguldipine hydrochloride
	R-(-)-Niguldipine hydrochloride is a L-type Ca2+ channel blocker; potassium agonist that activates Ca2+-activated maxi K-channel; alpha1A-adrenoceptor antagonist; antihypertensive agent; Less active enantiomer.
T10252L	ADU-S100 enantiomer ammonium salt MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt	Others	Others
	ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100. ADU-S100 is an activator of the stimulator of interferon genes (STING).
T12641	(R)-SCH 42495	Others	Others
	(R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active inhibitor of neutral metalloendopeptidase (NEP), with antihypertensive effect.
T12807	(S)-Nicardipine (S)-YC-93 free base	Others	Others
	(S)-Nicardipine is the less active S enantiomer of Nicardipine. Nicardipine is a blocker of calcium channel(IC50 of 1 μM for blocking cardiac calcium channels).
T40930	(S)-Sitagliptin phosphate (S)-Sitagliptin phosphate,(S)-MK-0431 phosphate
	(S)-Sitagliptin phosphate, the less active S-enantiomer of Sitagliptin phosphate, is a high-potency inhibitor of DPP4. It exhibits an IC50 of 19 nM in Caco-2 cell extracts.
T13444	(R)-Nedisertib (R)-M3814	Others	Others
	(R)-Nedisertib is a less active R-enantiomer of Nedisertib(IC50 in the range of 7-30 nM for DNA-PK).
T75251	Firsocostat (S enantiomer)
	Firsocostat S enantiomer (ND-630 S enantiomer) 是 Firsocostat 的低活性的 S 型异构体。Firsocostat 是乙酰辅酶 A 羧化酶抑制剂。
T35844	(R)-Pirtobrutinib
	(R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib, and Pirtobrutinib is a highly selective and non-covalent next generation BTK inhibitor. Pirtobrutinib (LOXO-305) effectively inhibits diverse BTK C481 substitution mutations[1].
T12378	PD-1-IN-20	Others	Others
	PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.
T13445	(R)-Q-VD-OPh (R)-Quinoline-Val-Asp-Difluorophenoxymethylketone,(R)-QVD-OPH	Others	Others
	(R)-Q-VD-OPh is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible inhibitor of pan-caspase, with potent antiapoptotic properties.
T12613	(R)-BAY-85-8501	Others	Others
	(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent Human Neutrophil Elastase (HNE)inhibitor(IC50 of 65 pM).
T72657	(3S,4S)-A2-32-01
	(3S,4S)-A2-32-01 ，A2-32-01 的活性较低的 (S,S)-对映异构体。A2-32-01 是一种有效的酪蛋白分解蛋白蛋白酶 (ClpP) 抑制剂。
T39299	(3S,4S)-PF-06459988
	(3S, 4S)-PF-06459988 is the less active S enantiomer of PF-06459988, which is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 exhibits excellent selectivity against EGFR wild-type due to its minimally reactive electrophile, which reduces the likelihood of off-target labeling.
T75250	(R)-Funapide
	(R)-Funapide ((R)-TV 45070)为Funapide中活性较低的R-对映异构体，是一种高效的Nav1.7钠通道阻滞剂，应用于疼痛研究。
T72913	(R)-MLN-4760
	(R)-MLN-4760 是 MLN-4760 的活性较低的 R 型异构体，是一种ACE2抑制剂，IC50值为 8.4 μM。
T72746	(R)-eIF4A3-IN-2
	'(R)-eIF4A3-IN-2'为eIF4A3-IN-2的一种活性较弱异构体。eIF4A3-IN-2是一款具高度选择性且为非竞争性的真核起始因子4A-3(eIF4A3)抑制剂，其半抑制浓度(IC50)为110 nM。
T74185	(S,S)-BMS-984923
	(S,S)-BMS-984923，BMS-984923的(S,S)-对映体，相较于其它对映体展现了较低的活性。(S,S)-BMS-984923对mGluR5受体的EC50值超过1μM，标明其在这一受体上的活性较弱。BMS-984923本身为一种高效的mGluR5沉默变构调节剂。
T36719	D-NAME (hydrochloride)
	N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester . D-NAME was initially thought to be inactive and was often used as a negative control for L-NAME. Later studies showed that D-NAME (40 mg/kg/day in rats) can have similar but less pronounced effects as L-NAME (40 mg/kg/day in rats) in the cardiovascular system, particularly at long-term timepoints. D-NAME (3-10 &#181g/mouse) had no effect on no...
T73682	(R)-Lanicemine
	(R)-Lanicemine ((R)-AZD6765) 是 Lanicemine 的低活性的 R 型异构体。Lanicemine (AZD6765) 是一种低捕获的NMDA 受体拮抗剂，Ki 为 0.56-2.1 μM。CHO 和爪蟾卵母细胞中，IC50分别为 4-7 μM 和 6.4 μM。具有抗抑郁作用。
T36400	para-amino-Blebbistatin
	para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks ap...

化合物

Bay 41-4109 (less active enantiomer)

Cat.No: T10480

Target: HBV

Cat.No: T12814

Synonym: (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF

Target: Others

SAR405 R enantiomer

Cat.No: T12831

Target: Others

Duvelisib (R enantiomer) hydrochloride

Cat.No: T11129L

Synonym: IPI-145 R enantiomer HCl,Duvelisib (R enantiomer) hydrochloride(1261590-48-0 Free base),INK1197 R enantiomer HCl

Target: PI3K

Tyrphostin B44, (+) enantiomer

Cat.No: T22450

Synonym: 酪氨酸磷酸化抑制剂AG 835

Target: EGFR

Cat.No: T10376

Target: Ras

Umbralisib R-enantiomer

Cat.No: T13140

Synonym: TGR-1202 R-enantiomer,RP5264 R-enantiomer

Target: PI3K

(R)-Propranolol hydrochloride

Cat.No: T20898

Synonym: Dexpropranolol hydrochloride,(R)-(+)-Propranolol,盐酸普奈洛尔

Target: Adrenergic Receptor

(R,S)-Ivosidenib

Cat.No: T13438

Synonym: (R,S)-AG-120

Target: Opioid Receptor

Cat.No: T13450

Target: Others

(3S,4S)-Tofacitinib

Cat.No: T13426L

Synonym: (3S,4S)-托法替尼

Target: Others

Nazartinib S-enantiomer

Cat.No: T11156

Synonym: EGF816 (S-enantiomer)

Target: Others

Cobimetinib (R-enantiomer)

Cat.No: T10856

Synonym: 考比替尼 (R 型对映体),XL-518 R-enantiomer,Cobimetinib R-enantiomer,GDC-0973 R-enantiomer

Target: Others

l-Atabrine dihydrochloride

Cat.No: T11801

Target: Others

(8R,9S)-Talazoparib

Cat.No: T10564

Synonym: (8R,9S)-BMN-673,他拉唑帕利 (8R,9S)

Target: Others

Firsocostat S enantiomer

Cat.No: T12200

Synonym: ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer

Target: Others

Fulvestrant (R enantiomer)

Cat.No: T11334

Synonym: ICI 182780 R enantiomer,ZD 9238 R enantiomer,ZM 182780 R enantiomer,Fulvestrant R enantiomer

Target: Others

Fulvestrant (S enantiomer)

Cat.No: T11335

Synonym: ZM 182780 S enantiomer,ICI 182780 S enantiomer,Fulvestrant S enantiomer,ZD 9238 S enantiomer

Target: Others

Cat.No: T26371

(R)-(+)-Anatabine

Cat.No: T12636

Target: Others

(R)-Citalopram oxalate

Cat.No: T6493L

(R)-Plevitrexed

Cat.No: T12635

Synonym: (R)-ZD 9331,(R)-BGC9331,(R)-普来曲塞

Target: Others

(3R,4S)-Tofacitinib

Cat.No: T13426

Target: Others

(R)-Nicardipine

Cat.No: T12633

Synonym: (R)-YC-93 free base

Target: Others

(3S,4R)-Tofacitinib

Cat.No: T13427

Target: Others

Cat.No: T12629

Target: Others

R-(-)-Niguldipine hydrochloride

Cat.No: T28489

ADU-S100 enantiomer ammonium salt

Cat.No: T10252L

Synonym: MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt

Target: Others

Cat.No: T12641

Target: Others

(S)-Nicardipine

Cat.No: T12807

Synonym: (S)-YC-93 free base

Target: Others

(S)-Sitagliptin phosphate

Cat.No: T40930

Synonym: (S)-Sitagliptin phosphate,(S)-MK-0431 phosphate

Cat.No: T13444

Synonym: (R)-M3814

Target: Others

Firsocostat (S enantiomer)

Cat.No: T75251

(R)-Pirtobrutinib

Cat.No: T35844

Cat.No: T12378

Target: Others

Cat.No: T13445

Synonym: (R)-Quinoline-Val-Asp-Difluorophenoxymethylketone,(R)-QVD-OPH

Target: Others

(R)-BAY-85-8501

Cat.No: T12613

Target: Others

(3S,4S)-A2-32-01

Cat.No: T72657

(3S,4S)-PF-06459988

Cat.No: T39299

Cat.No: T75250

Cat.No: T72913

(R)-eIF4A3-IN-2

Cat.No: T72746

(S,S)-BMS-984923

Cat.No: T74185

D-NAME (hydrochloride)

Cat.No: T36719

Cat.No: T73682

para-amino-Blebbistatin

Cat.No: T36400

Cat. No.	Product Name	Target	Signaling Pathways
T20191	(-)-Camphoric acid (-)-樟脑酸,L-Camphoric acid,Camphoric acid, (-)-	GluR	Neuroscience
	(-)-Camphoric acid (L-Camphoric acid) 是一种活性较低的樟脑酸对映异构体，樟脑酸可诱导 GluR 表达。
TN1448	(-)-Bornyl acetate L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯	p38 MAPK; NF-κB; JNK; Antifungal	MAPK; Microbiology/Virology; NF-κB
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。
T38497	(-)-Taxifolin (-)-二氢槲皮素,(-)-Dihydroquercetin
	(-)-Taxifolin is the less active enantiomer of Taxifolin, demonstrating vital anti-tyrosinase activity and notable inhibition against collagenase (IC50 = 193.3 μM). It is valued as an essential natural compound showing antifibrotic potential, while also acting as a capable free radical scavenger and possessing antioxidant capacity.

天然产物

(-)-Camphoric acid

Cat.No: T20191

Synonym: (-)-樟脑酸,L-Camphoric acid,Camphoric acid, (-)-

Target: GluR

(-)-Bornyl acetate

Cat.No: TN1448

Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

Target: p38 MAPK, NF-κB, JNK, Antifungal

Cat.No: T38497

Synonym: (-)-二氢槲皮素,(-)-Dihydroquercetin

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