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Search Results for " irritant "

13

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11991	Mefentrifluconazole	P450; Antifungal	Metabolism; Microbiology/Virology
	Mefentrifluconazole 是一种有效的、选择性的和具有口服活性的真菌 CYP51 (Kd= 0.5 nM) 抑制剂，但对人芳香酶的抑制活性较低，IC50值为0.92 μM。它是一种新型唑类衍生物，用作农用广谱抗真菌剂。
T12489L	Pimethixene maleate Pimetixene maleate	Dopamine Receptor; 5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pimethixene maleate (Pimetixene maleate) 是一种高效的 5-HT2B 受体拮抗剂，具有镇静和镇咳活性。Pimethixene maleate 抑制 5-HT1A，5-HT2A，5-HT2B，5-HT2C，组胺 H1，多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2，可用于研究儿童干咳和刺激性咳嗽。
T20639	Lauryl benzalkonium chloride Lauralkonium chloride,NSC 85508,NSC85508,十二烷基二甲基苄基氯化铵,Benzododecinium chloride,NSC-85508	Others	Others
	Lauryl benzalkonium chloride (Benzododecinium chloride) 是阳离子表面活性剂的一种。
T20982	Sodium 3-nitrobenzenesulfonate	Others	Others
	Sodium 3-nitrobenzenesulfonate 是一种温和的氧化剂。 Sodium 3-nitrobenzenesulfonate 在轧染印花或蒸汽印花时可以保护色光，并抵消还原物质的作用。
T30756	Carvyl propioate AI3-26372,FEMA No. 2251
	Carvyl propioate is a Skin / Eye Irritant.
T33034	Lyngbyatoxin B
	Lyngbyatoxin B is an irritant form Lyngbya majuscula.
T20671	Lauramidopropyl betaine Amphitol 20AB,Amphoteric L,Anpholex LB 2
	Lauramidopropyl betaine is a very low irritant amphoteric surfactant.
T29779	AI3-16552 AI3 16552
	AI3-16552 is an herbicide with irritant effects on the eye and the gastrointestinal system.
T37948	17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
	A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As a...
T40833	ω-Hydroxy-DEET
	ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.
T70974	Cipamfylline
	Cipamfylline is a xanthine, a theophylline analogue, and is a potent and selective inhibitor of phosphodiesterase type 4 (PDE-4). Cipamfylline was tested in patients with a diagnosis of atopic dermatitis and in two human models of acute and chronic irritant contact dermatitis. The outcome of the study revealed that cipamfylline was more effective than vehicle in treating atopic dermatitis, but less effective than a group II steroid, hydrocortisone-17-butyrate both in the treatment of atopic derm...
T82551	Dinophysistoxin 1 DTX 1
	Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) 为腹泻性贝类中毒病原体，并表现出促进肿瘤活性，同时亦作为一种皮肤刺激物。
T37831	CAY10641
	Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from thesn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1CAY10641 is an inactive alcohol derivative of a highly potent (IC50= 12 nM) cPLA2α inhibitor.2The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in...

化合物

Mefentrifluconazole

Cat.No: T11991

Target: P450, Antifungal

Pimethixene maleate

Cat.No: T12489L

Synonym: Pimetixene maleate

Target: Dopamine Receptor, 5-HT Receptor, AChR, Histamine Receptor

Lauryl benzalkonium chloride

Cat.No: T20639

Synonym: Lauralkonium chloride,NSC 85508,NSC85508,十二烷基二甲基苄基氯化铵,Benzododecinium chloride,NSC-85508

Target: Others

Sodium 3-nitrobenzenesulfonate

Cat.No: T20982

Target: Others

Carvyl propioate

Cat.No: T30756

Synonym: AI3-26372,FEMA No. 2251

Cat.No: T33034

Lauramidopropyl betaine

Cat.No: T20671

Synonym: Amphitol 20AB,Amphoteric L,Anpholex LB 2

Cat.No: T29779

Synonym: AI3 16552

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

Cat.No: T37948

Synonym: 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

ω-Hydroxy-DEET

Cat.No: T40833

Cat.No: T70974

Dinophysistoxin 1

Cat.No: T82551

Synonym: DTX 1

Cat.No: T37831

Cat. No.	Product Name	Target	Signaling Pathways
T40712	Diethyl fumarate	Others	Others
	Diethyl fumarate 是农药马拉硫磷的分解产物。 Diethyl fumarate 会在皮肤上引起非免疫性接触性荨麻疹。
T0966	Sennoside A 番泻苷A,NSC 112929,番泻苷 A	MAO; HIV Protease	Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Sennoside A (NSC-112929) 是在番泻叶的叶子和豆荚中大量发现的蒽醌苷，抑制 HIV-1 复制。
T8096	Diethyl succinate	Others	Others
	Diethyl succinate 能够在生理 pH 下使用并穿过生物膜，掺入组织培养物中的细胞中，通过 TCA 循环进行代谢。它不具有毒性，可用于香料和调味剂中。
T0729	Benzyl benzoate Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester	Parasite	Microbiology/Virology
	Benzyl benzoate (Benzoic acid benzyl ester) 是化妆品中的香料成分，可研究疥疮和蠕形螨相关的炎症性皮肤病。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。
TN4253	Ingenol 3-palmitate	Others	Others
	Ingenol-3-palmitate shows irritant and cocarcinogenic activity on mouse ear and on mice back skin.
T2S2363	Corydine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant and CNS depressant activities. Injected intravenously in rabbits corydine produced an initial

天然产物

Diethyl fumarate

Cat.No: T40712

Target: Others

Cat.No: T0966

Synonym: 番泻苷A,NSC 112929,番泻苷 A

Target: MAO, HIV Protease

Diethyl succinate

Cat.No: T8096

Target: Others

Benzyl benzoate

Cat.No: T0729

Synonym: Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester

Target: Parasite

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Ingenol 3-palmitate

Cat.No: TN4253

Target: Others

Cat.No: T2S2363

Target: IL Receptor, Antifection

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