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41

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39816	Ceftaroline fosamil inner salt TAK-599 free acid,PPI0903freeacid
	Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection.
T65053	(Methoxycarbonylsulfamoyl)triethylammonium hydroxide, inner salt
	(Methoxycarbonylsulfamoyl)triethylammonium hydroxide, inner salt 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65053，CAS号为 29684-56-8。
T9133	Caroverine hydrochloride Caroverine HCL	GluR; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Caroverine hydrochloride (Caroverine HCL) 是竞争性可逆的NMDA 和AMPA 谷氨酸受体拮抗剂。它也是抗氧化和钙阻滞剂，具有血管舒张作用，可用于内耳耳鸣的研究。
T15947	MAC13243 HCl	Antibacterial	Microbiology/Virology
	MAC13243 HCl 是一种将脂蛋白从内膜运输到外膜的周质伴侣LolA的抑制剂，是一种具有特异性的抗菌剂，对革兰氏阴性菌抑制作用显著。
T68055	Devapamil Devapamilo,Devapamilum	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Devapamil (Devapamilo) 是一种苯烷基胺，以使用依赖性方式阻断来自膜细胞内侧的 L 型钙电流。
T1223	Ceftriaxone sodium hydrate Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Ceftriaxone sodium hydrate 是一种头孢菌素类抗生素，对革兰氏阳性和革兰氏阴性菌均有活性。它具有抗炎和抗氧化作用。
T11348	G907	Antibiotic	Microbiology/Virology
	G907 是一种具有选择性和有效性的小分子ATP 结合盒 (ABC) 转运蛋白 MsbA 的拮抗剂，具有杀菌活性，可将 MsbA 捕获在朝内的脂多糖中。 G907 对大肠杆菌 MsbA 有抑制作用， IC50 值为 18 nM。
T8644	Elamipretide Triacetate Elamipretide TriTFA	Others	Others
	Elamipretide Triacetate (Elamipretide TriTFA) 是一种芳香族阳离子四肽，可轻松穿透细胞膜并短暂定位于线粒体内膜，在此与心磷脂结合。它已用于研究 Leber 遗传性视神经病变治疗的试验。
T1005L	Amoxicillin trihydrate Amoxycillin trihydrate,Amoxil trihydrate,Amoxipen trihydrate,阿莫西林三水物,Moxaline trihydrate	Antibacterial; Antibiotic	Microbiology/Virology
	Amoxicillin trihydrate (Moxaline trihydrate) 是一种中谱β内酰胺抗菌素。
T6437	Cefoperazone 头孢哌酮,Cefob,Medocef	Antibacterial; Antibiotic	Microbiology/Virology
	Cefoperazone (Medocef) 是一种半合成的头孢菌素，有抗菌活性。
T0953	Cefazolin sodium Ancef,头孢唑啉钠,头孢唑林钠,Cefazolin sodium salt,Sodium cephazolin,cephazolin sodium,cefazoline sodium,Sodium cefazolin	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Cefazolin sodium (cephazolin sodium) salt 是一种头孢类抗生素, 可研究多种细菌感染。
T1005	Amoxicillin Amoxycillin,阿莫西林	Antibacterial; Antibiotic	Microbiology/Virology
	Amoxicillin (Amoxycillin) 是一种具有广谱抗菌活性和良好口服吸收的抗生素。
T1228	Cefonicid sodium Monocid sodium,头孢尼西钠,Cefonicid disodium salt	Antibacterial; Antibiotic	Microbiology/Virology
	Cefonicid sodium (Monocid sodium) 是一种广谱头孢类抗生素, 能抑制细菌细胞壁的形成。
T27417L	Glutathione arsenoxide hydrochloride GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)	Apoptosis; AChR	Apoptosis; Neuroscience
	Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) 是一种潜在的抗癌活性分子和肿瘤代谢抑制剂。Glutathione arsenoxide hydrochloride 靶向线粒体内膜腺嘌呤核苷酸转移酶 (ANT)，对细胞增殖有抑制作用，促进细胞凋亡。Glutathione arsenoxide hydrochloride 可用于识别如蛋白质二硫异构酶一样的细胞表面蛋白质。
T1213	Piperacillin sodium 哌拉西林钠,Sodium piperacillin,CL227193,Piperacillin sodium salt	Antibacterial; Antibiotic	Microbiology/Virology
	Piperacillin sodium salt(CL227193) )是一种β-内酰胺类广谱抗生素。
T1122	Cephalothin sodium 头孢噻吩钠,Cefalotin sodium,Cephalothin,Cefalotin	Antibacterial; Antibiotic	Microbiology/Virology
	Cephalothin sodium (Cefalotin) 是一种头孢类抗生素, 具有广泛的抗菌活性，抑制革兰氏阳性和阴性菌。
T20897	Cefepime dihydrochloride Cefepime hydrochloride anhydrous,BMY-28142 dihydrochloride,Cepimax,Axepim,Cefepime HCl
	Cefepime dihydrochloride, a broad-spectrum fourth-generation cephalosporin, binds and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.
T4995L	Cefpirome Cefpiromum,HR 810,HR810,Cefpiroma,HR-810
	Cefpirome is a broad-spectrum, fourth-generation cephalosporin. It binds to and inactivates penicillin-binding proteins located on the inner membrane of the bacterial cell wall.
TP2237	Cytochrome c fragment (93-108)	Others	Others
	Cytochrome c is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, including plants and fungi but not higher animals, contains methylated lysine residues at specific positions
TP2238	Cytochrome P450 CYP1B1 (190-198) [Homo sapiens]	Others	Others
	Cytochrome c is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, including plants and fungi but not higher animals, contains methylated lysine residues at specific positions
T69012	Cinnarizine clofibrate
	Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion sickness. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus
T25104	Aprofene aprophen,Aprofenum
	Aprofene (Aprophen) is an antagonist of muscarinic and nicotinic acetylcholine receptors. It may be used in the therapy of peptic ulcers, endarteritis (inflammation of the inner shell of the artery), cholecystitis (inflammation of the gallbladder), and sp
T35948	4-carboxy TEMPO
	4-carboxy TEMPO is a nitroxide and spin label. Nitroxides such as 4-carboxy TEMPO react with reactive oxygen species (ROS) and can be used with electron spin resonance (ESR) spectroscopy to monitor ROS production in vivo., It has also been used to study flavin-photosensitized damage in inner mitochondrial membranes.
T78042	JB-95 acetate
	JB-95 acetate 是一种 β-发夹大环肽，对大肠杆菌具有有效抗菌活性。该化合物能选择性破坏大肠杆菌外膜，而不影响其内膜。
T37407	Arachidonoyl-L-carnitine (chloride) C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride)
	Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alte...
T36861	Ganglioside GD1b Mixture (sodium salt) Ganglioside GD1b Mixture (sodium salt)
	Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside ...
T78932	hDHODH-IN-12	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	hDHODH-IN-12是一种有效的DHODH抑制剂，IC50值为0.421 μM，DHODH作为嘧啶从头合成的限速酶，在(DNA/RNA Synthesis)DNA与RNA生成中扮演重要角色。hDHODH-IN-12位于人类线粒体内膜，展示了研究肺癌的潜力。
T35985	CAY10487
	The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits....
T73337	Articaine Hoe-045 free base
	Articaine (Hoe-045 free base) 是一种含酯基的酰胺类麻醉剂，可逆地与神经内腔内电压门控钠通道的α亚基结合，能有效缓解疼痛。Articaine 通过抑制NF-ĸB 的激活和NLRP3炎症小体通路改善脂多糖 (LPS) 诱导的急性肾损伤。
T35553	Ganglioside GQ1b Mixture (sodium salt)
	Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit. It stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO human neuroblastoma cells when used at a concentration of 5 nM. Ganglioside GQ1b promotes differentiation of murine embryonic stem cells (mESCs) to neuronal precursor and glial cells via activation of the ERK1/2 pathway. It also induces differentiation of murine keratinocytes throu...
T63148	DHODH-IN-20
	DHODH-IN-20 (Compound 133) 是一种 DHODH 的有效抑制剂。其中 DHODH 是一种含铁的黄素依赖性酶，存在于人类线粒体的内膜中。DHODH-IN-20 对肿瘤的生长具有抑制作用。DHODH-IN-20 具有潜力进行急性髓细胞白血病的研究。
TP2254	GTP-Binding Protein Fragment, G alpha	Others	Others
	Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a si
T73935	MsbA-IN-6	Antibiotic	Microbiology/Virology
	MsbA-IN-6作为一种高效的抑制剂，针对革兰氏阴性ATP结合盒(ABC)转运蛋白MsbA具有抗生素作用。MsbA是关键的内膜蛋白，负责将脂多糖从内叶转运至内膜的周质面。MsbA-IN-6通过抑制大肠杆菌MsbA的ATP酶与转运活性实现其杀菌效果，并对多种临床上常见的多药耐药菌株保持有效活性。
T69266	Cefcanel free acid
	Cefcanel is a semisynthetic third-generation cephalosporin with antibacterial activity. Cefcanel is active against the species E. coli, K. aerogenes and Proteus mirabilis; H. influenzae and M. catarrhalis has reasonable susceptibility. Cefcanel inhibits 90% of S. aureus strains at 2 µg/ml, irrespective of the presence of a β-lactamase. Cefcanel binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the te...
T36862	Ganglioside GT1b Mixture (sodium salt) Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture
	Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCP...
T82546	DiSBAC10
	DiSBAC10是一种电压敏感荧光探针，用于FRET检测中研究细胞膜的电活动。在静息极化的细胞中，DiSBAC10位于膜的外leaflet，从激发的荧光素标记蛋白那里接收光子，并以更高的波长重新发射光子。当细胞去极化时，DiSBAC10迅速转移到膜的内leaflet，从而增加了荧光团之间的距离并减少FRET信号。
TP2182	Lamin fragment	Others	Others
	Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amin
T78451	Patent Blue V Acid blue 1
	Patent Blue V（Acid blue 1）是一款应用于眼科的新型生物染料，特别是在进行视网膜切除手术时，用以染色以便去除内限制膜（ILM）。该染料在玻璃体视网膜手术中确保了对视网膜结构的有效标记，从而实现精确去除。光谱分析揭示，Patent Blue V在450 nm以下和600 nm以上具有强烈的吸收特性，展现蓝绿色。此外，它亦作为淋巴管造影术中的追踪剂，在染色活检手术中使用以助于淋巴结的切除。
T37498	Antimycin A4
	Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The antimycin A complex is a mixture of antimycins A1, A2, A3, and A4 that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties. It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial elect...
T35578	Phosphatidylserines (sodium salt) Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum (ER) and can be reversibly converted back by the same enzymes. It can also be irre...
T83706	BMAP 28 (bovine) TFA Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28
	BMAP 28是一种合成抗菌肽，对应牛防御素-5的132-158氨基酸。对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)、耐甲氧西林金黄色葡萄球菌(MRSA)、表皮葡萄球菌(S. epidermidis)及白色念珠菌(C. albicans)具有活性(MICs分别为2、2、4、1和8 µM)。在200 nM浓度下，BMAP 28能够使大肠杆菌的内膜渗透。在5 µM浓度下，减少Vero 76细胞中单纯疱疹病毒1型(HSV-1)的复制。在30 µM浓度下，对分离的人类红细胞引起溶血，并对分离的人类嗜中性粒细胞具有细胞毒性。BMAP 28 (0.8 mg/kg)可提高大肠杆菌或MRSA感染的小鼠的生存率，但对铜绿假单胞菌(P. aeruginosa)感染的小鼠无效。

化合物

Ceftaroline fosamil inner salt

Cat.No: T39816

Synonym: TAK-599 free acid,PPI0903freeacid

(Methoxycarbonylsulfamoyl)triethylammonium hydroxide, inner salt

Cat.No: T65053

Caroverine hydrochloride

Cat.No: T9133

Synonym: Caroverine HCL

Target: GluR, NMDAR, iGluR

Cat.No: T15947

Target: Antibacterial

Cat.No: T68055

Synonym: Devapamilo,Devapamilum

Target: Calcium Channel

Ceftriaxone sodium hydrate

Cat.No: T1223

Synonym: Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium

Target: Others, Antibacterial, Antibiotic

Cat.No: T11348

Target: Antibiotic

Elamipretide Triacetate

Cat.No: T8644

Synonym: Elamipretide TriTFA

Target: Others

Amoxicillin trihydrate

Cat.No: T1005L

Synonym: Amoxycillin trihydrate,Amoxil trihydrate,Amoxipen trihydrate,阿莫西林三水物,Moxaline trihydrate

Target: Antibacterial, Antibiotic

Cat.No: T6437

Synonym: 头孢哌酮,Cefob,Medocef

Target: Antibacterial, Antibiotic

Cefazolin sodium

Cat.No: T0953

Synonym: Ancef,头孢唑啉钠,头孢唑林钠,Cefazolin sodium salt,Sodium cephazolin,cephazolin sodium,cefazoline sodium,Sodium cefazolin

Target: Others, Antibacterial, Antibiotic

Cat.No: T1005

Synonym: Amoxycillin,阿莫西林

Target: Antibacterial, Antibiotic

Cefonicid sodium

Cat.No: T1228

Synonym: Monocid sodium,头孢尼西钠,Cefonicid disodium salt

Target: Antibacterial, Antibiotic

Glutathione arsenoxide hydrochloride

Cat.No: T27417L

Synonym: GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)

Target: Apoptosis, AChR

Piperacillin sodium

Cat.No: T1213

Synonym: 哌拉西林钠,Sodium piperacillin,CL227193,Piperacillin sodium salt

Target: Antibacterial, Antibiotic

Cephalothin sodium

Cat.No: T1122

Synonym: 头孢噻吩钠,Cefalotin sodium,Cephalothin,Cefalotin

Target: Antibacterial, Antibiotic

Cefepime dihydrochloride

Cat.No: T20897

Synonym: Cefepime hydrochloride anhydrous,BMY-28142 dihydrochloride,Cepimax,Axepim,Cefepime HCl

Cat.No: T4995L

Synonym: Cefpiromum,HR 810,HR810,Cefpiroma,HR-810

Cytochrome c fragment (93-108)

Cat.No: TP2237

Target: Others

Cytochrome P450 CYP1B1 (190-198) [Homo sapiens]

Cat.No: TP2238

Target: Others

Cinnarizine clofibrate

Cat.No: T69012

Cat.No: T25104

Synonym: aprophen,Aprofenum

4-carboxy TEMPO

Cat.No: T35948

Cat.No: T78042

Arachidonoyl-L-carnitine (chloride)

Cat.No: T37407

Synonym: C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride)

Ganglioside GD1b Mixture (sodium salt)

Cat.No: T36861

Synonym: Ganglioside GD1b Mixture (sodium salt)

Cat.No: T78932

Target: DNA/RNA Synthesis

Cat.No: T35985

Cat.No: T73337

Synonym: Hoe-045 free base

Ganglioside GQ1b Mixture (sodium salt)

Cat.No: T35553

Cat.No: T63148

GTP-Binding Protein Fragment, G alpha

Cat.No: TP2254

Target: Others

Cat.No: T73935

Target: Antibiotic

Cefcanel free acid

Cat.No: T69266

Ganglioside GT1b Mixture (sodium salt)

Cat.No: T36862

Synonym: Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture

Cat.No: T82546

Cat.No: TP2182

Target: Others

Cat.No: T78451

Synonym: Acid blue 1

Cat.No: T37498

Phosphatidylserines (sodium salt)

Cat.No: T35578

Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine

BMAP 28 (bovine) TFA

Cat.No: T83706

Synonym: Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28

Cat. No.	Product Name	Target	Signaling Pathways
TN2349	Taurodeoxycholate sodium salt Sodium taurodeoxylate,牛磺脱氧胆酸钠	Endogenous Metabolite	Metabolism
	Taurodeoxycholate sodium salt (Sodium taurodeoxylate) 是胆盐相关的阴离子洗涤剂，用于分离膜蛋白，包括线粒体内膜蛋白。它还可以抑制各种炎症反应。
T35577	Phosphatidylserines (bovine)
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi...

天然产物

Taurodeoxycholate sodium salt

Cat.No: TN2349

Synonym: Sodium taurodeoxylate,牛磺脱氧胆酸钠

Target: Endogenous Metabolite

Phosphatidylserines (bovine)

Cat.No: T35577

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