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Cat. No.	Product Name	Target	Signaling Pathways
T19417	Urinary Incontinence-Targeting Compound 1	Others	Others
	Urinary Incontinence-Targeting Compound 1, used in the research of urinary incontinence, is a sulfonanilide derivative.
T5023	Propiverine hydrochloride	Others; Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Propiverine hydrochloride 是一种痉挛剂，具有钙拮抗和抗胆碱能特性，用于研究膀胱过度活动和尿失禁。
T10952	Dabuzalgron 达布扎琼,Ro 115-1240	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Dabuzalgron (Ro 115-1240) 是一种口服活性选择性 α-1A 肾上腺素受体激动剂，用于治疗尿失禁。它通过维持线粒体功能来预防多柔比星引起的心脏毒性。
T1049L	Oxybutynin Oxytrol,奥昔布宁,Ditropan,Oxibutyninum	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Oxybutynin (Ditropan) 是一种抗胆碱能药，抑制血管 Kv 通道，IC50为 11.51 μM，可用于治疗尿失禁和膀胱过度活动症。
T1472	Trospium chloride Spasmex,Sanctura,曲司氯铵,曲司氯胺	AChR	Neuroscience
	Trospium chloride (Spasmex) 是一种可口服的特异竞争性毒蕈碱胆碱能受体拮抗剂，可与毒蕈碱受体 M1、M2 和 M3 高亲和力结合，具有抗毒蕈碱活性。
T1049	Oxybutynin chloride Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Oxybutynin chloride (Oxybutynin HCl) 是一种抗胆碱能药物，用于缓解泌尿和膀胱困难。它抑制血管 Kv 通道，IC50为 11.51 μM。
T3126	Bethanechol chloride (±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride	AChR	Neuroscience
	Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂，是毒蕈碱型受体 (mAChR) 激动剂，通过直接刺激副交感神经系统的 mAChR 发挥作用。
T1534	Darifenacin hydrobromide 氢溴酸达非那新,Darifenacin HBr,UK-88525	AChR	Neuroscience
	Darifenacin hydrobromide (UK-88525) 是一种选择性 M3 蕈毒碱受体拮抗剂，pKi 为 8.9。
T29687	Afacifenacin Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986	AChR	Neuroscience
	Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂，可用于研究缺血性心脏病，尿失禁和膀胱炎和其他疾病。
T28257L	(-)-OPC-51803	AChR	Neuroscience
	(-)-OPC-51803 是一种抗利尿激素 V2受体激动剂，可用于夜尿症和尿失禁的治疗。
T28257	OPC-51803 SOU-003,SOU 003,SOU003,OPC51803,OPC 51803	Vasopressin Receptor	GPCR/G Protein
	OPC-51803是一种可口服的非肽加压素（AVP）V（2）受体选择性激动剂，可用于治疗尿失禁和夜尿。
T0111	Solifenacin succinate YM905,索非那新琥珀酸盐	AChR	Neuroscience
	Solifenacin succinate (YM905) 是毒蕈碱受体拮抗剂，对 M1、M2和M3受体的pKi 值分别为 7.6、6.9 和 8.0。
T1460	Dicyclomine hydrochloride	AChR	Neuroscience
	Dicyclomine hydrochloride 是口服活性毒蕈碱胆碱能受体拮抗剂。它是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。它对 M1 受体亚型和 M2 受体亚型，Ki 分别为5.1和54.6nM，在刷状缘膜和基底质膜中均表现出较高的亲和力。
T10830	CL 316243	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	CL316243 是一种高效的 β3 肾上腺素受体选择性激动剂，EC50 为 3 nM。它是一种有效的脂肪细胞脂解刺激剂，可增加棕色脂肪组织的产热和代谢率，具有治疗肥胖症、糖尿病和急迫性尿失禁的潜力。
T60536	Terodiline
	Terodiline 是一种钙通道阻滞剂和 M1 选择性毒蕈碱受体 (mAChR) 拮抗剂，在在兔输精管 (M1)、心房 (M2)、膀胱 (M3) 和回肠肌肉中的 Kb 分别为 15、160、280 和 198 nM。 Terodiline 具有治疗尿频和急迫性尿失禁的潜力 [1]。
T67956L	Litoxetine HCl litoxetine HCL(86811-09-8 Free base)	5-HT Receptor	GPCR/G Protein; Neuroscience
	Litoxetine HCl 是一种选择性5-羟色胺（5-HT）再摄取抑制剂（SSRI）和混合5-羟色胺拮抗剂，可用于治疗尿失禁。Litoxetine HCl 在没有抗毒蕈碱特性的浓度下（10 nM-1 microM）引起大鼠离体食道肌肉粘膜的浓度依赖性松弛，使卡巴胆碱张力降低达37%,更高浓度的Litoxetine HCl（3微摩-300微摩）与明显的松弛有关，直至取消卡巴胆碱张力。以前在离体豚鼠肠道中证明的利托西汀的抗心律失常活性，在浓度大于1 microM 时在大鼠离体食道肌肉粘膜中发挥了作用。 Litoxetine HCl 的5-HT 释放作用可以解释利托西汀对未处理的大鼠组织中的5-HT 诱导的松弛的效力，这种效力被pCPA 处理所逆转。
T10952L	Dabuzalgron HCl R1240,R-450,R450,RO-1151240,R-1240,RO1151240
	Dabuzalgron, an adrenoceptor agonist, is used potentially for the treatment of urinary incontinence.
T27401	Garomefrine HCl PNO-49B,NS-49,ABT-232,ABT232,NS49,PNO49B
	Garomefrine HCl, a α1A-adrenoceptor agonist, is potential for the treatment of urinary incontinence.
T28465	PSD-506 PSD 506,RO 3202904,RO3202904,RO-3202904
	PSD-506, a muscarinic M2/M3 antagonist, is used potentially for the treatment of overactive bladder, and urinary incontinence.
T26604	Alvameline Tartrate LU-25-109T,LU 25 109T,LU-25109T,LU 25109T
	Alvameline Tartrate, a muscarinic M1 receptor agonist and M2/M3 receptor antagonist, is used potentially for treatment of urinary incontinence.
T29667	Adosopine Adosupine
	Adosopine is a dibenzoazepine which affects urinary bladder hyperreflexia and may be suitable for treating urinary incontinence.
T71889	Esoxybutynin Chloride
	Esoxybutynin Chloride is (S)-enantiomer of oxybutynin. Esoxybutynin Chloride exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence.
T71821	Norfenefrine HCl
	Norfenefrine is an Adrenergic Agonist. It is used in the treatment of female stress incontinence.
T71268	Esoxybutynin Free Base
	Esoxybutynin Free Base is (S)-enantiomer of oxybutynin. Esoxybutynin Free Base exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence.
T31404	Dextranomer Dextranomere,Dextranomero,Debrisan,Dextranomerum
	Dextranomer, for treatment of burns; consists of three-dimensional network of dextran polymers cross-linked by epichlorohydrin; dextranomer based implants usedas a bulking agent for endoscopic treatment of pediatric structural incontinence; ingredient of
T25325	Dicyclonon LAB 145-138H,BAS 145-138
	Dicyclonon is a muscarinic antagonist utilized as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It has some local anesthetic properties and is utilized in biliary, gastrointestinal,
T61309	(R)-Oxybutynin
	(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitively antagonizes Carbachol-induced contractions. It is particularly useful in researching neurogenic bladder dysfunction-related incontinence [1] [2] [3].
T70379	PF-04479745 tartrate
	PF-04479745, also known as PF-4479745, is a potent and selective 5-HT2C agonist (EC50 = 10 nM). PF-4479745 displayed robust pharmacology in a preclinical canine model of stress urinary incontinence (SUI) and no measurable functional agonism at the key selectivity targets 5-HT2A and 5-HT2B in relevant tissue-based assay systems.
T29742	AH-9700 free base
	AH-9700 free base 用于治疗急迫性尿失禁和尿毒症。在一项放射性配体结合研究中，AH-9700 free base 对 sigma 受体表现出较高的亲和力，对膀胱功能正常的实验动物的排尿反射(即膀胱容量增加作用)有明显的抑制作用。
T73572	NS-8
	NS-8，一种吡咯衍生物，能够激活Ca2+-敏感的K+通道。通过降低盆腔传入神经活动，NS-8有助于抑制排尿反射，适用于尿频与尿失禁的研究。
T72091	ADRA1D receptor antagonist 1 free base
	ADRA1D receptor antagonist 1 (free base) (化合物 (R)-9s)，是口服高效、强效及选择性的人类α1D-肾上腺素受体（α1D-AR）拮抗剂，具有Ki值为1.6 nM。该化合物能剂量依赖性降低膀胱收缩，IC30值为15 nM，适用于膀胱过度活动症（包括尿急、尿频和尿失禁）的研究。

化合物

Urinary Incontinence-Targeting Compound 1

Cat.No: T19417

Target: Others

Propiverine hydrochloride

Cat.No: T5023

Target: Others, Calcium Channel, AChR

Cat.No: T10952

Synonym: 达布扎琼,Ro 115-1240

Target: Apoptosis, Adrenergic Receptor

Cat.No: T1049L

Synonym: Oxytrol,奥昔布宁,Ditropan,Oxibutyninum

Target: Potassium Channel, AChR

Trospium chloride

Cat.No: T1472

Synonym: Spasmex,Sanctura,曲司氯铵,曲司氯胺

Target: AChR

Oxybutynin chloride

Cat.No: T1049

Synonym: Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl

Target: Potassium Channel, AChR

Bethanechol chloride

Cat.No: T3126

Synonym: (±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride

Target: AChR

Darifenacin hydrobromide

Cat.No: T1534

Synonym: 氢溴酸达非那新,Darifenacin HBr,UK-88525

Target: AChR

Cat.No: T29687

Synonym: Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986

Target: AChR

Cat.No: T28257L

Target: AChR

Cat.No: T28257

Synonym: SOU-003,SOU 003,SOU003,OPC51803,OPC 51803

Target: Vasopressin Receptor

Solifenacin succinate

Cat.No: T0111

Synonym: YM905,索非那新琥珀酸盐

Target: AChR

Dicyclomine hydrochloride

Cat.No: T1460

Target: AChR

Cat.No: T10830

Target: Adrenergic Receptor

Cat.No: T60536

Cat.No: T67956L

Synonym: litoxetine HCL(86811-09-8 Free base)

Target: 5-HT Receptor

Dabuzalgron HCl

Cat.No: T10952L

Synonym: R1240,R-450,R450,RO-1151240,R-1240,RO1151240

Garomefrine HCl

Cat.No: T27401

Synonym: PNO-49B,NS-49,ABT-232,ABT232,NS49,PNO49B

Cat.No: T28465

Synonym: PSD 506,RO 3202904,RO3202904,RO-3202904

Alvameline Tartrate

Cat.No: T26604

Synonym: LU-25-109T,LU 25 109T,LU-25109T,LU 25109T

Cat.No: T29667

Synonym: Adosupine

Esoxybutynin Chloride

Cat.No: T71889

Norfenefrine HCl

Cat.No: T71821

Esoxybutynin Free Base

Cat.No: T71268

Cat.No: T31404

Synonym: Dextranomere,Dextranomero,Debrisan,Dextranomerum

Cat.No: T25325

Synonym: LAB 145-138H,BAS 145-138

Cat.No: T61309

PF-04479745 tartrate

Cat.No: T70379

AH-9700 free base

Cat.No: T29742

Cat.No: T73572

ADRA1D receptor antagonist 1 free base

Cat.No: T72091

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