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21

抑制剂 & 化合物

22

天然产物

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Cat. No. Product Name Target Signaling Pathways
T10676 Carbodenafil

PDE Metabolism
Carbodenafil 是在健康食品中发现的 Sildenafil 相关化合物。其中Sildenafil 是磷酸二酯酶 5 (PDE5) 抑制剂(IC50:5.22 nM)。
T8669 3,3',4,4'-Benzophenonetetracarboxylic dianhydride

Others Others
3,3',4,4'-Benzophenonetetracarboxylic dianhydride 是一种化合物,用于生产聚酰亚胺薄膜和粘合剂的聚酰亚胺前体。它是一种无毒材料,对人体健康没有已知的不良影响。
TN2258 Tartrazine

酒石黄,FD&C Yellow No. 5,Acid Yellow 23,酸性黄 23

Others Others
Tartrazine (Acid Yellow 23) 是偶氮型酸性染料,是橙黄色粉末,溶于水中呈黄色,常用作食品着色的合成柠檬黄色偶氮染料。
T8772 Sumaresinolic Acid

Others Others
Sumaresinolic Acid 是一种天然木脂素,存在于各种植物中,如亚麻籽、芝麻和麦麸,是植物的次生代谢产物,因其潜在的健康益处而被广泛研究,包括减少炎症、改善脂质代谢和提供抗氧化保护的能力。
T29538 AC-119

AC 119,AC119

AC-119 is a bamifylline metabolite in human plasma. It has been shown to induce apoptosis in cancer cells while having no effect on health cells in humans.
T69306 Lubabegron fumarate

Lubabegron, also known as LY591281; LY488756 fumarate, is a veterinary drug used to reduce ammonia emissions from animals and their waste. Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. Lubabegron is a beta-adrenergic receptor agonist that has the effect of increasing the breakdown of fats and increasin...
T70433 Antalarmin

Antalarmin is a CRF-1 antagonist. By blocking CRF-1 activity the release of ACTH is reduced, and chronic stress is decreased in response to chronic stress. Antalarmin could be useful in reducing the adverse health consequences of chronic stress in humans, as well as treating anxiety, depression, and drug addiction.
T39259 Arzoxifene

LY353381,Arzoxifene,SERMIII

Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator (SERM) exhibiting a fixed ring structure analogous to raloxifene. This compound demonstrates potent antiestrogenic effects on breast cancer and endometrium while displaying minimal side effects. Additionally, Arzoxifene elicits favorable estrogenic effects on bone health and lipid profile.
T37371 4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic Acid

4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 . While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.
T40528 Oxytocin free acid

9-Deamidooxytocin

Oxytocin free acid, also known as 9-Deamidooxytocin, is an analog of oxytocin where the glycinamide residue at position 9 has been substituted with a glycine residue. Oxytocin, a pleiotropic peptide hormone, has wide-ranging implications for general health, adaptation, development, reproduction, and social behavior.
T69623 Tridemorph

Tridemorph is a sterol biosynthetic inhibitor. It is a fungicide used to control Erysiphe graminis. It was developed by BASF in the 1960s who use the trade name Calixin. The World Health Organization has categorized it as a Class II moderately hazardous" pesticide because it is believed harmful if swallowed and can cause irritation to skin and eyes."
T71663 FFA3 agonist 1

FFA3 agonist 1为一种FFA3(游离脂肪酸受体 3)激动剂,功能为通过激活FFA3以调节肠道微生物群的健康效应。
T77967 MS159

PROTACs PROTAC
MS159为一有效的NSD2 (核受体结合SET结构域蛋白2) PROTAC降解剂,能够抑制肿瘤细胞生长,是探究NSD2在健康与疾病中作用的重要化学工具。
T36426 Eicosapentaenoyl 1-propanol-2-amide

Monoacylglycerols (MAGs) of ω-3 polyunsaturated fatty acids have diverse physiological and health effects. In particular, MAGs containing docosahexaenoic acid or eicosapentaenoic acid have anti-proliferative properties against colon and lung cancer cell lines. Eicosapentaenoyl 1-propanol-2-amide is an EPA-containing MAG amide analog that inhibits the growth of human lung carcinoma A549 cells, producing 98.4% growth inhibition when applied at 3 μM. It is an analog of eicosapentaenoyl ethanolamide...
TMIH-0368 Naringenin-d4

Naringenin-d4 是 Naringenin 的氘代化合物。Naringenin 的 CAS 号为 480-41-1。Naringenin是葡萄柚中主要的黄烷酮,可作为抗氧化剂、自由基清除剂、抗炎剂、碳水化合物代谢促进剂、免疫系统调节剂。
T36836 (4′-Hydroxy)phenoxybenzoic Acid

(4′-Hydroxy)phenoxybenzoic acid is a pyrethroid insecticide metabolite.1,2 1.Akhtar, M.H., Mahadevan, S., and Russell, F.Cleavage of 3-phenoxybenzoic acid by chicken microsomal preparationsJ. Environ. Sci. Health B.28(5)527-543(1993) 2.Maloney, S.E., Maule, A., and Smith, A.R.Microbial transformation of the pyrethroid insecticides: Permethrin, deltamethrin, fastac, fenvalerate, and fluvalinateAppl. Environ. Microbiol.54(11)2874-2876(1988)
T31194 Dalapon

Basfapon B,Dowpon M,Dawpon-Rae

Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the
T36508 trans-4,5-epoxy-2(E)-Decenal

trans-4,5-epoxy-2(E)-Decenal,3-(3-pentyloxiranyl)-2E-propenal

Polyunsaturated fatty acids such as arachidonate and linoeate, while essential to health maintenance, are subject to random peroxidation by ambient oxygen, resulting in fragmented and reactive decomposition products. One prominent autoxidation product of either trilinolein or arachidonic acid is trans-4,5-epoxy-2(E)-decenal. One prominent autoxidation product of either trilinolein or arachidonic acid is trans-4,5-epoxy-2(E)-decenal. This aldehyde is responsible for a pungent metallic flavor of d...
T80286 TP4 (Nile tilapia piscidin)

Necroptosis Apoptosis
TP4(Nile tilapia piscidin)是一种piscidin样的抗菌肽,其口服活性被证实。此化合物对多种革兰氏阳性及阴性菌株均有效(MIC: 0.03-10 μg/mL),并展现了溶血性。TP4还能增强免疫响应、提升抗氧化能力和改善肠道健康,助于防御细菌感染。除此之外,TP4显示抗肿瘤效果,并可通过激发癌细胞线粒体功能障碍导致坏死(necrosis)。
T36401 DCVC

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue p...
T35419 τ-Fluvalinate

τ-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honeybee parasitic Varroa mite (V. destructor) Nav1 channels (VdNav1) expressed inXenopusoocytes (EC50= 160 nM) with a faster tail current decay than that of AmNav1 channels. Topical application of τ-fluvalinate (2 μl) in combination with coumaphos , atrazine , 2,4-DMPF, chlorpyrifos ...

化合物

Carbodenafil
Cat.No: T10676
Synonym:
Target: PDE
3,3',4,4'-Benzophenonetetracarboxylic dianhydride
Cat.No: T8669
Synonym:
Target: Others
Tartrazine
Cat.No: TN2258
Synonym: 酒石黄,FD&C Yellow No. 5,Acid Yellow 23,酸性黄 23
Target: Others
Sumaresinolic Acid
Cat.No: T8772
Synonym:
Target: Others
AC-119
Cat.No: T29538
Synonym: AC 119,AC119
Target:
Lubabegron fumarate
Cat.No: T69306
Synonym:
Target:
Antalarmin
Cat.No: T70433
Synonym:
Target:
Arzoxifene
Cat.No: T39259
Synonym: LY353381,Arzoxifene,SERMIII
Target:
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic Acid
Cat.No: T37371
Synonym:
Target:
Oxytocin free acid
Cat.No: T40528
Synonym: 9-Deamidooxytocin
Target:
Tridemorph
Cat.No: T69623
Synonym:
Target:
FFA3 agonist 1
Cat.No: T71663
Synonym:
Target:
MS159
Cat.No: T77967
Synonym:
Target: PROTACs
Eicosapentaenoyl 1-propanol-2-amide
Cat.No: T36426
Synonym:
Target:
Naringenin-d4
Cat.No: TMIH-0368
Synonym:
Target:
(4′-Hydroxy)phenoxybenzoic Acid
Cat.No: T36836
Synonym:
Target:
Dalapon
Cat.No: T31194
Synonym: Basfapon B,Dowpon M,Dawpon-Rae
Target:
trans-4,5-epoxy-2(E)-Decenal
Cat.No: T36508
Synonym: trans-4,5-epoxy-2(E)-Decenal,3-(3-pentyloxiranyl)-2E-propenal
Target:
TP4 (Nile tilapia piscidin)
Cat.No: T80286
Synonym:
Target: Necroptosis
DCVC
Cat.No: T36401
Synonym:
Target:
τ-Fluvalinate
Cat.No: T35419
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T2S0122 D-(-)-Mandelic acid

Mandelic acid,(R)-(-)-Mandelic acid,D-(−)-Mandelic Acid,R-(−)-Mandelic Acid,D-(-)-扁桃酸,扁桃酸;D-扁桃酸;R-扁桃酸;D-苦杏仁酸;苯基乙醇酸

Others Others
D-(-)-Mandelic acid ((R)-(-)-Mandelic acid) 是一种提取自苦杏仁中的天然产物。
T8071 L-Lysine hydrochloride

赖氨酸盐酸盐,Lysine hydrochloride,L-赖氨酸盐酸盐

Virus Protease Microbiology/Virology
L-Lysine hydrochloride 是一种人类必需氨基酸,能增加钙吸收,减少糖尿病相关疾病和改善肠道健康,可用于疱疹的研究。
T3909 Pulsatilla saponin D

白头翁皂苷D,Hederacolchiside A,SB365

Apoptosis; Others Apoptosis; Others
Pulsatilla saponin D (Hederacolchiside A) 是从朝鲜白头翁根部分离得到的一种天然产物,具有抗癌活性。
T3328 Angelic Acid

2-Methylisocrotonic acid,(Z)-2-Methylbut-2-enoic acid,当归酸,cis-2-Methyl-2-butenoic acid

Others Others
Angelic Acid ((Z)-2-Methylbut-2-enoic acid) 是一种存在于Anthemis nobilis 精油中的酯,能够促进伤口愈合,具有促进安定和精神药物的作用。
T6S0270 Ononin

Formononetin 7-O-β-D-glucopyranoside,Formononetin glucoside,Ononoside,芒柄花苷,Formononetin 7-O-glucoside

Antibacterial Microbiology/Virology
Ononin (Formononetin 7-O-glucoside) 是一种能够抑制土壤中杂 Pluchea lanceolata 生长的异黄酮。
T2994 (E)-Cardamonin

Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明

Apoptosis; TRP/TRPV Channel Apoptosis; Membrane transporter/Ion channel
(E)-Cardamonin (Alpinetin chalcone) 是一种新型hTRPA1阳离子通道拮抗剂,IC50值为454 nM。
T7913 2-Bromobiphenyl

Others Others
2-Bromobiphenyl 是一种持久性有机污染物,主要存在于土壤和水中。它是一种已知的人类致癌物,与生殖和发育毒性等多种健康影响有关。
T2838 Naringenin

柚皮素,Naringetol,S-Dihydrogenistein,Pelargidanon,Salipurol,NSC 11855,NSC 34875

P450; Influenza Virus; Reactive Oxygen Species; Endogenous Metabolite; PPAR DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Naringenin (NSC-11855) 是葡萄柚中主要的黄烷酮,可作为抗氧化剂、自由基清除剂、抗炎剂、碳水化合物代谢促进剂、免疫系统调节剂。
T0433 Artesunate

WR-256283,青蒿琥酯

Virus Protease; Ferroptosis; STAT; Parasite Apoptosis; JAK/STAT signaling; Microbiology/Virology; Stem Cells
Artesunate (WR-256283) 是治疗疟疾的青蒿素组药物的一部分。 它是青蒿素的半合成衍生物,具有水溶性。
T2S0490 Eugenol acetate

Acetyleugenol,乙酰丁香酚,Aceteugenol,乙酸丁香酚酯,Eugenyl acetate,1,3,4-Eugenol acetate

Others; Antibacterial; Antifungal Microbiology/Virology; Others
Eugenol acetate (Aceteugenol) 是来自丁香植物 Syzygiumaromaticum 的一种化学成分,具有抗菌、抗毒和抗氧化活性。
TN1011 Rhodionin

P450; AChE Metabolism; Neuroscience
Rhodionin 是从红景天的根中分离的特异性非竞争性细胞色素 P450 2D6 抑制剂,IC50=0.761 μM,Ki=0.769 μM。它有 DPPH 自由基清除活性,IC50为 19.49 μM。它抑制乙酰胆碱酯酶,IC50范围为 57.50 至 2.43 μg/mL。
T4723 D-Tagatose

塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Others; Endogenous Metabolite Metabolism; Others
D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖,具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物,也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品,也是口香糖、果汁和饮料等食品中的低热量甜味剂。
TN1713 Graveobioside A

木犀草素 7-芹糖(1-2)-葡萄糖苷,木犀草素7-芹糖(1-2)-葡萄糖苷

Others Others
Graveobioside A can be used in hyperuricemia and gout-resistant drugs or health foods.
T34536 Satratoxin H

Satratoxin-H

Satratoxin H is an air- and food-borne mycotoxin, which has been implicated in human health damage.
TMA0925 Wilforlide A acetate

Others Others
Wilforlide A (T1) serves as a quality control standard of Tripterygium Glycosides that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. T1 has anti-inflammatory effects.
TN4346 Jaconine

Others Others
Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.
T81507 Petunidin 3-rutinoside

Petunidin 3-rutinoside,一种可从Sambucus canadensis分离的天然产物。
T83588 (±)-Coclaurine

(±)-Coclaurine,Roemeria refracta 中的天然产物,具备抗氧化活性及对心血管系统的效应。
T81907 Lucenin 3

Lucenin 3,一种生物活性类黄酮,具备生物医学领域内的功能性特性。
T81960 Lacto-N-difucohexaose II

LNDFH II,Lacto-N-fucohexaose

Lacto-N-difucohexaose II (LNDFH II) 为人乳中的一种重要低聚糖,对婴儿健康具有显著作用。
TN2060 Petunidin-3-O-glucoside chloride

Others Others
Petunidin-3-O-glucoside chloride has significantly higher antioxidant activity than the Fe2+ control. Petunidin-3-O-glucoside causes problems in digestibility, may be important dietary supplements with beneficial health effects.
TN1938 Mogroside VI

罗汉果甜苷 VI,罗汉果甜苷VI

Antifection Microbiology/Virology
Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga

天然产物

D-(-)-Mandelic acid
Cat.No: T2S0122
Synonym: Mandelic acid,(R)-(-)-Mandelic acid,D-(−)-Mandelic Acid,R-(−)-Mandelic Acid,D-(-)-扁桃酸,扁桃酸;D-扁桃酸;R-扁桃酸;D-苦杏仁酸;苯基乙醇酸
Target: Others
L-Lysine hydrochloride
Cat.No: T8071
Synonym: 赖氨酸盐酸盐,Lysine hydrochloride,L-赖氨酸盐酸盐
Target: Virus Protease
Pulsatilla saponin D
Cat.No: T3909
Synonym: 白头翁皂苷D,Hederacolchiside A,SB365
Target: Apoptosis, Others
Angelic Acid
Cat.No: T3328
Synonym: 2-Methylisocrotonic acid,(Z)-2-Methylbut-2-enoic acid,当归酸,cis-2-Methyl-2-butenoic acid
Target: Others
Ononin
Cat.No: T6S0270
Synonym: Formononetin 7-O-β-D-glucopyranoside,Formononetin glucoside,Ononoside,芒柄花苷,Formononetin 7-O-glucoside
Target: Antibacterial
(E)-Cardamonin
Cat.No: T2994
Synonym: Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明
Target: Apoptosis, TRP/TRPV Channel
2-Bromobiphenyl
Cat.No: T7913
Synonym:
Target: Others
Naringenin
Cat.No: T2838
Synonym: 柚皮素,Naringetol,S-Dihydrogenistein,Pelargidanon,Salipurol,NSC 11855,NSC 34875
Target: P450, Influenza Virus, Reactive Oxygen Species, Endogenous Metabolite, PPAR
Artesunate
Cat.No: T0433
Synonym: WR-256283,青蒿琥酯
Target: Virus Protease, Ferroptosis, STAT, Parasite
Eugenol acetate
Cat.No: T2S0490
Synonym: Acetyleugenol,乙酰丁香酚,Aceteugenol,乙酸丁香酚酯,Eugenyl acetate,1,3,4-Eugenol acetate
Target: Others, Antibacterial, Antifungal
Rhodionin
Cat.No: TN1011
Synonym:
Target: P450, AChE
D-Tagatose
Cat.No: T4723
Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos
Target: Others, Endogenous Metabolite
Graveobioside A
Cat.No: TN1713
Synonym: 木犀草素 7-芹糖(1-2)-葡萄糖苷,木犀草素7-芹糖(1-2)-葡萄糖苷
Target: Others
Satratoxin H
Cat.No: T34536
Synonym: Satratoxin-H
Target:
Wilforlide A acetate
Cat.No: TMA0925
Synonym:
Target: Others
Jaconine
Cat.No: TN4346
Synonym:
Target: Others
Petunidin 3-rutinoside
Cat.No: T81507
Synonym:
Target:
(±)-Coclaurine
Cat.No: T83588
Synonym:
Target:
Lucenin 3
Cat.No: T81907
Synonym:
Target:
Lacto-N-difucohexaose II
Cat.No: T81960
Synonym: LNDFH II,Lacto-N-fucohexaose
Target:
Petunidin-3-O-glucoside chloride
Cat.No: TN2060
Synonym:
Target: Others
Mogroside VI
Cat.No: TN1938
Synonym: 罗汉果甜苷 VI,罗汉果甜苷VI
Target: Antifection
TargetMol Loading
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