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Search Results for " glycine site "

26

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22517	5,7-Dichlorokynurenic acid 5,7-二氯犬尿喹啉酸,5,7-dichlorokynurenic acid sodium,5,7-DCKA	NMDAR	Neuroscience
	5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) 是一种专门针对于NMDA 受体甘氨酸位点的竞争性拮抗剂(KB:65 nM)。它是犬尿酸的衍生物，可降低大鼠皮质细胞培养物中 NMDA 诱导的神经元损伤程度。
T1909	L-701324 7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉,L701324	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	L-701324 是一种 NMDA 受体，对甘氨酸位点具有高亲和力和选择性，用作口服活性和长效抗惊厥药。
T16797	RPR104632	NMDAR	Neuroscience
	RPR104632 是一种新型有效的位于 NMDA 甘氨酸位点的拮抗剂，具有神经保护活性。
T26686	AV-101 L-4-Cl-KYN,L-4-chlorokynurenine,4-Cl-KYN,4ClKYN,4-Chlorokynurenine,(S)-4-Chlorokynurenine	NMDAR	Neuroscience
	AV-101 (4-Cl-KYN) 是 NMDA 受体甘氨酸位点的前药拮抗剂，具有抗抑郁活性，可减少 MPTP 猴子中左旋多巴诱导的运动障碍。
T11516	GV-196771A	NMDAR	Neuroscience
	GV-196771A 一种新型的NMDA受体甘氨酸位点拮抗剂，具有强大的抗痛觉过敏活性。
T22542	1-Aminocyclobutanecarboxylic acid ACBC,1-氨基环丁烷羧酸	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	1-Aminocyclobutanecarboxylic acid (ACBC) 是一种NMDA 受体部分激动剂，作用于 NR1 甘氨酸位点。
T5819	Rapastinel Trifluoroacetate Thr-Pro-Pro-Thr-NH2 Trifluoroacetate,GLYX-13 Trifluoroacetate	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) 是一种 NMDA 受体调节剂，具有甘氨酸位点部分激动剂性质，有研究抑郁症的潜力。
T10781	CGP 78608 hydrochloride PAMQX	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	CGP 78608 hydrochloride 是 NMDA 受体甘氨酸结合位点的特异性拮抗剂 (IC50 = 6 nM)。 CGP 78608 hydrochloride 具有抗惊厥活性。 CGP 78608 hydrochloride 增强 GluN1/GluN3A 介导的甘氨酸电流（估计 EC50 = 26.3 nM）。
T3407L	Rapastinel acetate Rapastinel acetate (117928-94-6 Free base)	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Rapastinel acetate 是 N-甲基-D-天冬氨酸 (NMDA) 受体的调节剂和甘氨酸位点的部分激动剂，具有长效抗抑郁作用。
T22900	L-701252 L-701,252	NMDAR	Neuroscience
	L-701252 是一种有效的甘氨酸位点 NMDA 受体拮抗剂，IC50 值为 420 nM。L-701252 对全脑缺血提供小范围的神经保护。
T60612	Neboglamine hydrochloride
	Neboglamine (CR-2249, XY-2401) hydrochloride 是NMDA 受体甘氨酸位点的正向调节剂，具有口服活性，可用于研究精神分裂症。
T22798	Gavestinel GV 150526,Gavestinel sodium salt	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Gavestinel (GV 150526) 是一种非竞争性的 NMDA 受体拮抗剂，具有有效性、选择性和口服活性。Gavestinel 可与 NMDA 受体的甘氨酸位点结合，其结合亲和力(pKi 值)为 8.5。Gavestinel 可用于急性缺血性脑卒中研究。
T69263	HA-966 HCl
	HA-966 HCl is an NMDA receptor complex glycine site antagonist.
T27504	GV-196771
	GV-196771 selectively antagonize the glycine-binding site of the NMDA ionophore.
T10191	7-Chlorokynurenic acid sodium salt 7-CKA sodium salt	Others	Others
	7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM). It is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μ
T71018	MDL 100748
	MDL 100748 is a glycine site antagonist of NMDA receptor.
T23603	ACEA1011 ACEA-1011,ACEA 1011
	ACEA1011 is a glycine site NMDA receptor antagonist. It may have analgesic effects.
T68750	HA-966 trihydrate
	HA-966 trihydrate is an NMDA receptor complex glycine site antagonist.
T69211	GW-468816
	GW-468816 is a glycine site NMDA receptor antagonist.
T69949	CGP-78608
	CGP-78608 is a glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia.
T79273	NMDA receptor antagonist 6	iGluR	Membrane transporter/Ion channel; Neuroscience
	NMDA receptor antagonist6 (compound 13b) 为针对甘氨酸结合位点的NMDA 受体拮抗剂，其展现出对PC12 细胞的神经保护功能，能够抵御NMDA引起的细胞损伤及细胞凋亡。
T15684	L-689560	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	L-689560 是 N-甲基-D-天冬氨酸受体（NMDA）的有效拮抗剂，抑制 NMDA 甘氨酸结合位点。它用于研究 NMDA 受体在正常神经系统过程以及疾病中的作用，也广泛用作结合研究中的放射性标记配体，也。
T35787	Obestatin (human) (trifluoroacetate salt)
	Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide.1It binds to the orphan receptor GPR39 (Kd= 1 nM) and stimulates cAMP production in CHO and HEK293 cells overexpressing human GPR39. Obestatin inhibits contraction of isolated mouse jejunum muscle strips induced by ghrelin .In vivo, obestatin (12.5-1,000 nmol/kg) suppresses food intake in a time- and dose-dependent manne...
T35582	H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)
	H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50values of 320 and 35 μM, respectively.2Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.3H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection ...
T76378	RGD-4C
	RGD-4C（ACDCRGDCFC）是一种携带Arg-Gly-Asp（RGD）序列的肽，具备与αv整合素结合的能力，用于模拟细胞外基质蛋白的整合素识别特性。作为αv整合素的配体，它能够与生物活性分子进行偶联，进而在动物模型中展现出抗肿瘤活性。
T82379	FN-A208 fusion peptide
	FN-A208 是源自鼠层粘连蛋白 a1 的 A208 与纤连蛋白 (GRGDS) 活性位点和甘氨酸间隔区融合形成的生物活性肽。该肽能形成淀粉样原纤维，并有助于促进肌动蛋白应力纤维的形成，进而介导成纤维细胞附着，显示出其在组织再生和工程生物粘合剂方面的应用潜力。FN-A208 与 IKVAV 受体和整合素发生相互作用，而在 EDTA 存在下，其活性则会被破坏。

化合物

5,7-Dichlorokynurenic acid

Cat.No: T22517

Synonym: 5,7-二氯犬尿喹啉酸,5,7-dichlorokynurenic acid sodium,5,7-DCKA

Target: NMDAR

Cat.No: T1909

Synonym: 7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉,L701324

Target: NMDAR, iGluR

Cat.No: T16797

Target: NMDAR

Cat.No: T26686

Synonym: L-4-Cl-KYN,L-4-chlorokynurenine,4-Cl-KYN,4ClKYN,4-Chlorokynurenine,(S)-4-Chlorokynurenine

Target: NMDAR

Cat.No: T11516

Target: NMDAR

1-Aminocyclobutanecarboxylic acid

Cat.No: T22542

Synonym: ACBC,1-氨基环丁烷羧酸

Target: NMDAR, iGluR

Rapastinel Trifluoroacetate

Cat.No: T5819

Synonym: Thr-Pro-Pro-Thr-NH2 Trifluoroacetate,GLYX-13 Trifluoroacetate

Target: NMDAR, iGluR

CGP 78608 hydrochloride

Cat.No: T10781

Synonym: PAMQX

Target: NMDAR, iGluR

Rapastinel acetate

Cat.No: T3407L

Synonym: Rapastinel acetate (117928-94-6 Free base)

Target: NMDAR, iGluR

Cat.No: T22900

Synonym: L-701,252

Target: NMDAR

Neboglamine hydrochloride

Cat.No: T60612

Cat.No: T22798

Synonym: GV 150526,Gavestinel sodium salt

Target: NMDAR, iGluR

Cat.No: T69263

Cat.No: T27504

7-Chlorokynurenic acid sodium salt

Cat.No: T10191

Synonym: 7-CKA sodium salt

Target: Others

Cat.No: T71018

Cat.No: T23603

Synonym: ACEA-1011,ACEA 1011

HA-966 trihydrate

Cat.No: T68750

Cat.No: T69211

Cat.No: T69949

NMDA receptor antagonist 6

Cat.No: T79273

Target: iGluR

Cat.No: T15684

Target: NMDAR, iGluR

Obestatin (human) (trifluoroacetate salt)

Cat.No: T35787

H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)

Cat.No: T35582

Cat.No: T76378

FN-A208 fusion peptide

Cat.No: T82379

Cat. No.	Product Name	Target	Signaling Pathways
T10191L	7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA	GluR; NMDAR	Neuroscience
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 激动剂位点的 IC50 为 0.56 μM。 7-Chlorokynurenic acid 抑制谷氨酸再摄取到突触小泡中，Ki 为 0.59 μM，并在神经轴输送后显示出镇痛作用。
T4752	1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite; NMDAR	Metabolism; Neuroscience
	1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。

天然产物

7-Chlorokynurenic acid

Cat.No: T10191L

Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA

Target: GluR, NMDAR

1-Aminocyclopropane-1-carboxylic acid

Cat.No: T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

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