Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM). It is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 557 | 5日内发货 | ||
100 mg | ¥ 5,150 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 776 | 5日内发货 |
7-Chlorokynurenic acid sodium salt 的其他形式现货产品:
产品描述 | 7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM). It is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μM). |
靶点活性 | Reuptake of glutamate:(ki)0.59 μM , Glycine B coagonist site of NMDA receptor:0.56 μM |
体内活性 | Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid sodium salt (10 nM) shows significant retardation of the development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response [3]. |
别名 | 7-CKA sodium salt |
分子量 | 246.6 |
分子式 | C10H6ClNNaO3 |
CAS No. | 1263094-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (203.59 mM), Sonication is recommended.
DMSO: 33.67 mg/mL (137.10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 4.0552 mL | 20.2758 mL | 40.5515 mL | 101.3788 mL |
5 mM | 0.811 mL | 4.0552 mL | 8.1103 mL | 20.2758 mL | |
10 mM | 0.4055 mL | 2.0276 mL | 4.0552 mL | 10.1379 mL | |
20 mM | 0.2028 mL | 1.0138 mL | 2.0276 mL | 5.0689 mL | |
50 mM | 0.0811 mL | 0.4055 mL | 0.811 mL | 2.0276 mL | |
100 mM | 0.0406 mL | 0.2028 mL | 0.4055 mL | 1.0138 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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