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Search Results for " genotoxic "

27

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38003	Levofloxacin N-oxide	Others	Others
	Levofloxacin N-oxide 是从左氧氟沙星中分离出来的杂质。
T31532	Disperse Red 1 Celliton Scarlet B,Neosetile Scarlet B,Diacelliton Scarlet B,Fenacet Scarlet B,分散红 1,Celliton Red B	Others	Others
	Disperse Red 1 (Celliton Scarlet B) 是偶氮苯衍生物，是偶氮纺织品染料，普遍用于纺织工业中的聚酯织物染色。
T22309	2,5-Dimethyl-3(2H)-furanone 2,5-二甲基-3(2H)-呋喃酮,2,5-Dimethyl-2,3-dihydrofuran-3-one	Others	Others
	2,5-Dimethyl-3(2H)-furanone (2,5-Dimethyl-2,3-dihydrofuran-3-one) 是一种调味物质，无遗传毒性。
TN2258	Tartrazine 酒石黄,FD&C Yellow No. 5,Acid Yellow 23,酸性黄 23	Others	Others
	Tartrazine (Acid Yellow 23) 是偶氮型酸性染料，是橙黄色粉末，溶于水中呈黄色，常用作食品着色的合成柠檬黄色偶氮染料。
T1887	Inauhzin INZ	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Inauhzin (INZ) 是一种新型小分子，通过抑制 SIRT1 活性有效地重新激活 p53，促进人 Y 细胞的 p53 依赖性凋亡，在 A549 细胞中的IC50为3 uM。
T2204	Diaveridine 二氨藜芦啶,EGIS-5645,敌菌净,CCRIS-3784,AI3-23935	DHFR; Antifolate; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Diaveridine (AI3-23935) 是二氢叶酸还原酶的抑制剂，对于野生型 DHFR 的Ki 值为 11.5 nM。它也是一种抗菌剂。
T19051	Reactive Blue 4 活性艳蓝X-ARL,活性蓝4	Others	Others
	Reactive Blue 4 是蒽醌类染料，具有植物毒性、细胞毒性和基因毒性。它可作为单一的比色化学传感器，用于在水介质中连续测定具有不同光学响应的多种分析物。
T69840	MX106
	MX106 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.
T36952	N-Nitroso Fluoxetine
	N-Nitroso fluoxetine is a derivative of fluoxetine.1It is genotoxic toS. typhimuriumwhen used at concentrations ranging from 0.06 to 0.12 mg/ml.
T40740	Dibromochloroacetaldehyde
	Dibromochloroacetaldehyde, a trihalogenated acetaldehyde compound, is present as a byproduct in drinking water. It exhibits genotoxic properties.
T69845	MX107
	MX107 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.
T39657	Cyanazine
	Cyanazine, a triazine herbicide, is utilized for effective control of a diverse range of grass and broadleaf weeds. It has been scientifically validated as non-genotoxic.
T28117	MSN-50 MSN50,MSN 50
	MSN-50, an inhibitor of Bax and Bak oligomerization, inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
T32272	Jatropham
	Jatropham 是一种天然化合物，从百合花中分离得到。它被证明具有调节和降低 zeocin 的细胞毒性和遗传毒性/致裂作用的潜力。
T41127	Bromochloroacetaldehyde
	Bromochloroacetaldehyde is a dihalogenated acetaldehyde compound that is commonly found as a byproduct in drinking water. It exhibits genotoxic properties.
T69434	Methapyrilene fumarate
	Methapyrilene fumarate is a histamine H1 antagonist with sedative action used as a hypnotic and in allergies. It is a hepatocarcinogen in sufficiently high doses, inducing mutations through an indirect genotoxic mechanism; e.g., via an oxidative mechanism or interaction with chromosomal proteins.
T74465	Colibactin
	Colibactin 是一种复杂的次级代谢产物，由一些具有遗传毒性的肠道大肠杆菌菌株产生。Colibactin 具有研究结直肠癌的潜力。
T81748	MRV03-069
	MRV03-069（化合物3）为一种选择性ClbP抑制剂，具备阻止Colibactin对真核细胞基因毒性的能力，适用于结直肠癌的研究。
T74985	MRV03-037
	MRV03-037 是一种选择性的大肠杆菌素活化肽酶 (ClbP) 抑制剂，能阻断Colibactin 对真核细胞的基因毒性作用。MRV03-037 可以防止肠道细菌基因毒素的产生。
T78549	Ethylene glycol dimethacrylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Ethylene glycol dimethacrylate 是一种具有细胞毒性和基因毒性作用的甲基丙烯酸酯单体。它可增加人牙龈成纤维细胞 (HGF) 内的活性氧 (ROS) 产生，引发 DNA 损伤和细胞凋亡 (apoptosis)，并使细胞周期在 G1/G0 期停滞。
T81749	MRV03-068
	MRV03-068（化合物2）作为一种选择性的ClbP抑制剂，有效抑制Colibactin对真核细胞的基因毒性。该化合物在结直肠癌研究中具有潜在应用价值。
T73517	RK-701
	RK-701 是一种G9a 高选择性且非遗传毒性的抑制剂，IC50值为 23-27 nM。RK-701 选择性的上调 HbF、γ- Globin、BGLT3 的表达，下调 H3K9me2 的表达。RK-701 也对 BCL11A 和 ZBTB7A 有抑制作用。
T60888	NiCur
	NiCur 可阻断CBP HAT 活性并在基因毒性应激时下调 p53 的激活。NiCur 是CBP 组蛋白乙酰转移酶 (HAT)的有效选择性抑制剂，IC50值为 0.35 μΜ。 NiCur 可用于机制研究，不影响目标蛋白的表达。
T63337	CYP2C19-IN-1
	CYP2C19-IN-1 是强效的，无遗传毒性的、无肝脏毒性的 CYP2C19 抑制剂。 CYP2C19-IN-1 能够抑制 RNA 依赖的 RNA 聚合酶 (RdRP) (Ki: 6.16 μM)，能够用于研究寨卡病毒 (ZIKV) 感染。
T36235	5-Chlorouracil
	5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. ...
T69908	Pidnarulex HCl
	Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. T...
T36241	Arecaidine propargyl ester (hydrobromide)
	Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecai...

化合物

Levofloxacin N-oxide

Cat.No: T38003

Target: Others

Cat.No: T31532

Synonym: Celliton Scarlet B,Neosetile Scarlet B,Diacelliton Scarlet B,Fenacet Scarlet B,分散红 1,Celliton Red B

Target: Others

2,5-Dimethyl-3(2H)-furanone

Cat.No: T22309

Synonym: 2,5-二甲基-3(2H)-呋喃酮,2,5-Dimethyl-2,3-dihydrofuran-3-one

Target: Others

Cat.No: TN2258

Synonym: 酒石黄,FD&C Yellow No. 5,Acid Yellow 23,酸性黄 23

Target: Others

Cat.No: T1887

Synonym: INZ

Target: Sirtuin

Cat.No: T2204

Synonym: 二氨藜芦啶,EGIS-5645,敌菌净,CCRIS-3784,AI3-23935

Target: DHFR, Antifolate, Antibacterial

Reactive Blue 4

Cat.No: T19051

Synonym: 活性艳蓝X-ARL,活性蓝4

Target: Others

Cat.No: T69840

N-Nitroso Fluoxetine

Cat.No: T36952

Dibromochloroacetaldehyde

Cat.No: T40740

Cat.No: T69845

Cat.No: T39657

Cat.No: T28117

Synonym: MSN50,MSN 50

Cat.No: T32272

Bromochloroacetaldehyde

Cat.No: T41127

Methapyrilene fumarate

Cat.No: T69434

Cat.No: T74465

Cat.No: T81748

Cat.No: T74985

Ethylene glycol dimethacrylate

Cat.No: T78549

Target: Reactive Oxygen Species

Cat.No: T81749

Cat.No: T73517

Cat.No: T60888

Cat.No: T63337

Cat.No: T36235

Cat.No: T69908

Arecaidine propargyl ester (hydrobromide)

Cat.No: T36241

Cat. No.	Product Name	Target	Signaling Pathways
T19137	4'-Methylacetophenone	Others	Others
	4′-methylacetophenone 是一种香料，普遍存在于食品中的挥发性化合物和某些天然复合物中。
T10148	4-Hydroxynonenal 4-羟基壬烯醛,4-HNE	Dehydrogenase; Endogenous Metabolite	Metabolism
	4-Hydroxynonenal (4-HNE) 是一种 α，β 不饱和羟基烯醛，可作为氧化/亚硝化应激生物标志物。它是ALDH2的底物和抑制剂。它可以调节许多信号传导过程，主要是通过与蛋白质，核酸和膜脂质中具有亲核官能团的共价加合物形成的。它通过线粒体在癌症中起重要作用。
T19081	1,3-Dithiane 1,3-Dithian,M-DITHIANE,1,3-Dithiacyclohexane,1,3-二噻烷	Anti-infection; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	1,3-Dithiane (1,3-Dithian) 是一种受保护的甲醛阴离子等价物，可用作有用的标记合成子。它是在煮熟的牛肉提取物中发现的含硫美拉德反应产物。
TN1886	Lucidin primeveroside Lucidin 3-O-primeveroside,亮黄素3-桑色素酊	Topoisomerase	DNA Damage/DNA Repair
	Lucidin primeveroside (Lucidin 3-O-primeveroside) 是从茜草的根粉中分离得到的天然产物，可用作着色剂和食用色素。 Lucidin Primeveroside 可以在小鼠体内代谢转化为基因毒性化合物 Lucidin。
T22857	Illudin S	Apoptosis; DNA Alkylator/Crosslinker; Antifungal	Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology
	Illudin S (ILS)是一种真菌倍半萜次生代谢物，具有很强的遗传毒性和细胞毒性
TJS0405	Lucidin NSC 30546,芦西定；卢西定,卢西定,亮黄素,Henine	Others	Others
	Lucidin (NSC-30546) 是茜草中的一种天然成分，可以诱导细菌和哺乳动物细胞的突变。
T37101	1-Hydroxyanthraquinone	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	1-Hydroxyanthraquinone 是口服有效的天然产物，来源于植物 Tabebuia avellanedae，显示出致癌活性。
TN2245	Sunset Yellow FCF Food Yellow 3,Orange Yellow S,Sunset yellow,CI 15985	Androgen Receptor	Endocrinology/Hormones
	Sunset Yellow FCF (Sunset yellow) 是一种橙色偶氮染料，吸光度具有pH 依赖性。Sunset Yellow FCF 可在食品，化妆品和药品中使用，在许多食品中用作着色剂食品添加剂，它们可能具有细胞毒性和遗传毒性，因此在使用这些材料作为食品添加剂时必须小心。
TN4219	Homobaldrinal	Others	Others
	Homobaldrinal has low toxic activity. It has genotoxic activity in the Salmonella/microsome test and the SOS-chromotest.
TN4913	Riddelline	VEGFR; DNA/RNA Synthesis	Angiogenesis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
TN3403	Djalonensone 交链孢霉甲基醚,Alternariol monomethyl ether	Immunology/Inflammation related	Immunology/Inflammation
	Djalonensone (Alternariol monomethyl ether) 具有强大的 DPPH 自由基清除作用。
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...

天然产物

4'-Methylacetophenone

Cat.No: T19137

Target: Others

4-Hydroxynonenal

Cat.No: T10148

Synonym: 4-羟基壬烯醛,4-HNE

Target: Dehydrogenase, Endogenous Metabolite

Cat.No: T19081

Synonym: 1,3-Dithian,M-DITHIANE,1,3-Dithiacyclohexane,1,3-二噻烷

Target: Anti-infection, Endogenous Metabolite, Antibacterial

Lucidin primeveroside

Cat.No: TN1886

Synonym: Lucidin 3-O-primeveroside,亮黄素3-桑色素酊

Target: Topoisomerase

Cat.No: T22857

Target: Apoptosis, DNA Alkylator/Crosslinker, Antifungal

Cat.No: TJS0405

Synonym: NSC 30546,芦西定；卢西定,卢西定,亮黄素,Henine

Target: Others

1-Hydroxyanthraquinone

Cat.No: T37101

Target: DNA/RNA Synthesis

Sunset Yellow FCF

Cat.No: TN2245

Synonym: Food Yellow 3,Orange Yellow S,Sunset yellow,CI 15985

Target: Androgen Receptor

Cat.No: TN4219

Target: Others

Cat.No: TN4913

Target: VEGFR, DNA/RNA Synthesis

Cat.No: TN3403

Synonym: 交链孢霉甲基醚,Alternariol monomethyl ether

Target: Immunology/Inflammation related

Cylindrospermopsin

Cat.No: T35770

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