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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1281	Tropicamide Ro 1-7683,托吡卡胺	AChR	Neuroscience
	Tropicamide (Ro 1-7683) 是一种选择性的 M4毒蕈碱乙酰胆碱受体拮抗剂，作为滴眼剂使用时，会产生短效瞳孔扩张和睫状肌麻痹。
T24799	SKA-111 SKA 111,SKA111	Potassium Channel	Membrane transporter/Ion channel
	SKA-111 是一种选择性钙离子激活的钾离子通道 (potassium phannel ) KCa3.1 激活剂，可引起猪内皮细胞膜超极化。SKA-111结合在CaM N-瓣和S4-S5接头之间的界面中，能够改善 Bradykinin 诱导的离体大鼠心脏的冠状动脉扩张，可用于研究心血管疾病。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T22685	CP-471474 CP 471474	Others	Others
	Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
T31383	D-Epinephrine L-(+)-Adrenaline,Racepinefrine, (S)-,BRN-2938799,d-Adrenaline,BRN 2938799
	D-Epinephrine can be used as a hormone, neurotransmitter, and medication. Epinephrine can be normally obtained from the adrenal glands and certain neurons. It involves in the fight-or-flight response by increasing blood flow to muscles, output of the hear
T83868	(±)13,14-EDT (±)13,14-Epoxydocosatrienoic Acid,(±)13,14-EpDoTrE,(±)-Dihomo-13,14-EET
	(±)13,14-EDT是一种氧脂和腎上腺酸的代谢产物，通过细胞色素P450（CYP）途径形成。在50 nM的浓度下，它能激活分离的大鼠冠状小动脉平滑肌细胞中的大导电钙激活钾通道（KCa1.1/BK），并导致分离的猪小动脉扩张（EC50 = 12 pM）。(±)13,14-EDT还能使用TP受体激动剂U-46619预收缩的分离牛冠状动脉放松。
T80637	Homatropine hydrochloride
	Homatropine hydrochloride为口服抗胆碱能剂，迅速扩张瞳孔并导致睫状肌麻痹。该化合物也展现出镇咳效果，适用于眼科疾病和止咳研究。
T83869	(±)16,17-EDT (±)16,17-Epoxydocosatrienoic Acid,(±)-Dihomo-16,17-EET,(±)16,17-EpDoTrE
	(±)16,17-EDT，一种经由细胞色素P450 (CYP) 途径形成的腺苷酸代谢物和氧脂肪酸，能够诱导分离的猪小动脉舒张（EC50 = 11 pM）。此外，(±)16,17-EDT 亦能促进以TP受体激动剂U-46619 预收缩的分离牛冠状动脉的松弛。
T36152	14S(15R)-EET
	14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid .114S(15R)-EET binds to isolated guinea pig monocytes with a Kivalue of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.2It induces dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM).3Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.4 1.Daikh, B.E., Lasker, J.M., Raucy, J.L., ...
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...

化合物

Tropicamide

Cat.No: T1281

Synonym: Ro 1-7683,托吡卡胺

Target: AChR

SKA-111

Cat.No: T24799

Synonym: SKA 111,SKA111

Target: Potassium Channel

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

CP-471474

Cat.No: T22685

Synonym: CP 471474

Target: Others

D-Epinephrine

Cat.No: T31383

Synonym: L-(+)-Adrenaline,Racepinefrine, (S)-,BRN-2938799,d-Adrenaline,BRN 2938799

Target:

(±)13,14-EDT

Cat.No: T83868

Synonym: (±)13,14-Epoxydocosatrienoic Acid,(±)13,14-EpDoTrE,(±)-Dihomo-13,14-EET

Target:

Homatropine hydrochloride

Synonym: (±)16,17-Epoxydocosatrienoic Acid,(±)-Dihomo-16,17-EET,(±)16,17-EpDoTrE

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T1083	Theophylline Theo-24,1,3-Dimethylxanthine,茶碱	Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物，具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。

天然产物

Theophylline

Cat.No: T1083

Synonym: Theo-24,1,3-Dimethylxanthine,茶碱

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Drotaverine hydrochloride

Cat.No: T8787

Synonym:

Target: PDE

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