Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SKA-111 是一种选择性钙离子激活的钾离子通道 (potassium phannel ) KCa3.1 激活剂,可引起猪内皮细胞膜超极化。SKA-111结合在CaM N-瓣和S4-S5接头之间的界面中,能够改善 Bradykinin 诱导的离体大鼠心脏的冠状动脉扩张,可用于研究心血管疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 636 | 现货 | ||
5 mg | ¥ 1,580 | 现货 | ||
10 mg | ¥ 2,660 | 现货 | ||
25 mg | ¥ 4,450 | 现货 | ||
50 mg | ¥ 6,350 | 现货 | ||
100 mg | ¥ 8,680 | 现货 | ||
500 mg | ¥ 17,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,680 | 现货 |
产品描述 | SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases. |
体外活性 | SKA-111 (1 μM; 5 min) causes KCa3.1 membrane hyperpolarization in porcine endothelial cells. SKA-111 induces significantly enhanced Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in porcine large coronary arteries (PCA).[1] |
体内活性 | SKA-111 (1 μM; Cardiac perfusion; Langendorff in rat hearts; ) improves Bradykinin-induced coronary artery dilation in isolated rat hearts. SKA-111 potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.[1] |
别名 | SKA 111, SKA111 |
分子量 | 214.29 |
分子式 | C12H10N2S |
CAS No. | 1369170-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.86 mg/mL (200 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.6666 mL | 23.3329 mL | 46.6657 mL | 116.6643 mL |
5 mM | 0.9333 mL | 4.6666 mL | 9.3331 mL | 23.3329 mL | |
10 mM | 0.4667 mL | 2.3333 mL | 4.6666 mL | 11.6664 mL | |
20 mM | 0.2333 mL | 1.1666 mL | 2.3333 mL | 5.8332 mL | |
50 mM | 0.0933 mL | 0.4667 mL | 0.9333 mL | 2.3333 mL | |
100 mM | 0.0467 mL | 0.2333 mL | 0.4667 mL | 1.1666 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SKA-111 1369170-24-0 Membrane transporter/Ion channel Potassium Channel SKA 111 SKA111 Inhibitor inhibitor inhibit