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22

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19235	CHAPS	Others	Others
	CHAPS 是一种两性离子洗涤剂，是一种 Cholic acid 的衍生物，可溶解膜蛋白。它用于稳定各种蛋白质-DNA 复合物，并可以保留溶液中蛋白质的生化活性。
T65355	Zwittergent 3-12 Detergent
	Zwittergent 3-12 Detergent 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65355，CAS号为 14933-08-5。
T65361	ZWITTERGENT 3-16 Detergent
	ZWITTERGENT 3-16 Detergent 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65361，CAS号为 2281-11-0。
T37885	1-Dodecylimidazole	Antifungal	Microbiology/Virology
	1-Dodecylimidazole 是溶酶体活性洗涤剂。1-Dodecylimidazole 通过在溶酶体中的酸依赖性积累、溶酶体膜的破坏和半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。它显示出降胆固醇和广谱抗真菌活性。
T19729	Dodecylphosphocholine FOS-维生素B-12,DPC,n C12PC,Foscholine-12,DDPPC,nC12PC,n-C12PC	Others	Others
	Dodecylphosphocholine (DPC) 是一种去污剂，普遍用于膜蛋白核磁共振的研究。
T20992	MEGA-9 Nonanoyl-N-Methylglucamide	Serine Protease	Proteases/Proteasome
	MEGA-9 (Nonanoyl-N-Methylglucamide) 可溶解膜蛋白，可用作非离子去污剂。
T20331	Sodium lauroyl glutamate Hostapon CLG,Amisoft LS 11,Sodium N-lauroylglutamate,月桂酰谷氨酸钠,Acylglutamate LS-11	Others	Others
	Sodium lauroyl glutamate (Acylglutamate LS-11) 是一种氨基酸去污剂，可增加长链没食子酸烷基酯(如没食子酸烷基酯)的溶解度。
T9620	Sodium Tetradecyl Sulfate	Others	Others
	Sodium Tetradecyl Sulfate 是洗涤剂硬化剂，常用于静脉曲张及食管静脉的治疗。
T64321	Octyl-beta-D-glucopyranoside Octyl glucoside,11β-HSD1-IN-11	Others	Others
	Octyl-beta-D-glucopyranoside (11β-HSD1-IN-11) 是一种非离子洗涤剂，广泛应用于生物技术，生化应用，膜蛋白的增溶和结晶的研究中。
T16335	Nonaethylene glycol monododecyl ether Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇	Others	Others
	Nonaethylene glycol monododecyl ether (Polidocanol) 是一种非离子表面活性剂和聚乙二醇清洁剂，可用于蛋白质分离和纯化，以及用于形成初始聚结的 O/W 乳剂液滴。
T38651	Lauryl maltose neopentyl glycol LMNG
	Lauryl maltose neopentyl glycol (LMNG) 是一种能溶解和稳定膜蛋白的洗涤剂。Lauryl maltose neopentyl glycol 能从膜上提取完整的膜蛋白，从而改善G 蛋白偶联受体和呼吸系统复合物等膜蛋白的稳定性。Lauryl maltose neopentyl glycol 具有增溶作用。
T64297	Triton X-100
	Triton X-100 是一种溶解脂膜的非变性洗涤剂。Triton X-100 通常用于实验室，并在生产过程的不同阶段应用于疫苗。Triton X-100 被列为某些疫苗,包括裂解病毒流感疫苗的赋形剂。Triton X-100 是一种非离子表面活性剂。
T35879	Octyl glucose neopentyl glycol
	Octyl glucose neopentyl glycol (OGNG) is a detergent derived from neopentyl glycol, intended for stabilizing membrane proteins [1].
T32797	Lithocholenic acid
	Lithocholenic acid is a bile acid that acts as a detergent to solubilize fats for absorption.
T20417	Benzenesulfonic acid AI3 15297,AI315297,AI3-15297
	Benzensulfonic acid is commonly used as the active ingredient in laundry detergent. It is used in clothes washing machines.
T34119	PPS Silent Surfactant PPS
	PPS Silent Surfactant is a cleavable detergent used in biochemistry, and especially in proteomics, to enhance protein denaturation and solubility.
T39438	Lithium dodecyl sulfate
	Lithium dodecyl sulfate is an anionic detergent and surfactant, suitable as a substitute for sodium dodecyl sulfate (SDS) in electrophoresis applications performed under lower temperatures. Lithium dodecyl sulfate is also applicable in the synthesis of nanomaterials and chromatography processes.
T38652	Decyl maltose neopentyl glycol DMNG
	Decyl maltose neopentyl glycol (DMNG) is a neopentyl glycol detergent known for its ability to maintain the integrity of the AlkB oligomeric state. AlkB, a nonheme di-iron alkane hydroxylase, is unaffected by DMNG, making it a suitable choice for preserving the functionality of this enzyme.
T38825	Glyco-diosgenin
	Glyco-diosgenin serves as a synthetic surfactant and detergent utilized in the extraction of proteins from membranes. This compound finds application in studies related to the structure and function of proteins, as well as in single-particle cryo-electron microscopy (cryoEM) studies specifically targeted at membrane proteins.
T36450	1,2-Dimyristoyl-rac-glycerol
	1,2-Dimyristoyl-rac-glycerol 可促进蛋白质和脂质之间的相互作用，可用作洗涤剂或试剂。可用于甘油脂的代谢和代谢途径的细胞生物学实验等。
T83921	IMCTA-C14 TFA
	IMCTA-C14是一种洗涤剂且是微生物代谢产物4-糖腺苷的衍生物。其临界胶束浓度(CMC)为0.11 mM，亲水亲油平衡(HLB)值为9.72。IMCTA-C14（0.05%和0.5%）能从OVK18卵巢癌细胞提取蛋白质，包括膜蛋白。它对几种不同菌株具有活性（MICs = 8-128 µg/ml），并对52种癌细胞系具有细胞毒性（IC50s = 2.9-29.2 µg/ml）。IMCTA-C14（50 µM）诱导OVK18细胞的自噬。
T38286	C26 Sphingomyelin (d18:1/26:0) C26 Sphingomyelin (d18:1/26:0)
	C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.] 1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphi...

化合物

Cat.No: T19235

Target: Others

Zwittergent 3-12 Detergent

Cat.No: T65355

ZWITTERGENT 3-16 Detergent

Cat.No: T65361

1-Dodecylimidazole

Cat.No: T37885

Target: Antifungal

Dodecylphosphocholine

Cat.No: T19729

Synonym: FOS-维生素B-12,DPC,n C12PC,Foscholine-12,DDPPC,nC12PC,n-C12PC

Target: Others

Cat.No: T20992

Synonym: Nonanoyl-N-Methylglucamide

Target: Serine Protease

Sodium lauroyl glutamate

Cat.No: T20331

Synonym: Hostapon CLG,Amisoft LS 11,Sodium N-lauroylglutamate,月桂酰谷氨酸钠,Acylglutamate LS-11

Target: Others

Sodium Tetradecyl Sulfate

Cat.No: T9620

Target: Others

Octyl-beta-D-glucopyranoside

Cat.No: T64321

Synonym: Octyl glucoside,11β-HSD1-IN-11

Target: Others

Nonaethylene glycol monododecyl ether

Cat.No: T16335

Synonym: Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇

Target: Others

Lauryl maltose neopentyl glycol

Cat.No: T38651

Synonym: LMNG

Cat.No: T64297

Octyl glucose neopentyl glycol

Cat.No: T35879

Lithocholenic acid

Cat.No: T32797

Benzenesulfonic acid

Cat.No: T20417

Synonym: AI3 15297,AI315297,AI3-15297

PPS Silent Surfactant

Cat.No: T34119

Synonym: PPS

Lithium dodecyl sulfate

Cat.No: T39438

Decyl maltose neopentyl glycol

Cat.No: T38652

Synonym: DMNG

Glyco-diosgenin

Cat.No: T38825

1,2-Dimyristoyl-rac-glycerol

Cat.No: T36450

Cat.No: T83921

C26 Sphingomyelin (d18:1/26:0)

Cat.No: T38286

Synonym: C26 Sphingomyelin (d18:1/26:0)

Cat. No.	Product Name	Target	Signaling Pathways
T2721	Digitonin	Others	Others
	Digitonin 属于糖苷类天然产物，是一种去垢剂。Digitonin 具有抗肿瘤活性，可以与胆固醇分子结合从而增加细胞膜的通透性，对多种细胞的细胞膜具有裂解活性。
T2965	Deoxycholic acid Cholorebic,去氧胆酸,脱氧胆酸,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic	Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Deoxycholic acid (Cholanoic Acid) 是 G 蛋白偶联胆汁酸受体 TGR5的激活剂。
T4070	Glycocholic Acid Sodium Salt Glycocholate Sodium,Sodium Glycocholate,甘氨胆酸钠盐	Others	Others
	Glycocholic Acid Sodium Salt (Sodium Glycocholate) 是一种结合胆汁盐和离子生物去污剂。它参与脂肪的乳化。
TN2349	Taurodeoxycholate sodium salt Sodium taurodeoxylate,牛磺脱氧胆酸钠	Endogenous Metabolite	Metabolism
	Taurodeoxycholate sodium salt (Sodium taurodeoxylate) 是胆盐相关的阴离子洗涤剂，用于分离膜蛋白，包括线粒体内膜蛋白。它还可以抑制各种炎症反应。
T1100	Polymyxin B Sulfate Aerosporin,硫酸多粘菌素 B,PMB,Polymyxin B sulphate,硫酸多粘菌素B,Polymyxin B sulfate (1404-26-8 free base),Poly-RX	Antibacterial; Antibiotic	Microbiology/Virology
	Polymyxin B Sulfate (Poly-RX) 是一个阳离子型表面活性剂抗生素剂，能够提高细胞膜的渗透性。
T1138	Taurocholic acid sodium salt hydrate 牛胆酸钠,牛磺胆酸钠水合物,Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate	Others; Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Others
	Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) 是一种胆汁酸钠盐水合物，作用是参与脂肪的乳化。
T0847	Chenodeoxycholic acid CDCA,鹅去氧胆酸,Chenodiol	Potassium Channel; FXR; Endogenous Metabolite; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Chenodeoxycholic acid (CDCA) 是一种胆汁酸，通常与甘氨酸或牛磺酸结合。它作为清洁剂溶解脂肪以供肠道吸收，并被小肠重新吸收。它被用作利胆剂、利胆泻药，以及预防或溶解胆结石。
T2202	Lithocholic acid 3α-Hydroxy-5β-cholanic acid,石胆酸	Apoptosis; Others; FXR; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism; Others
	Lithocholic acid (3α-Hydroxy-5β-cholanic acid) 是由鹅去氧胆酸盐通过细菌作用形成的胆汁酸，通常与甘氨酸或牛磺酸结合，被用作利胆剂。它作为清洁剂溶解脂肪以供吸收，并且本身被吸收。
T16223	N-Dodecyl-β-D-maltoside 十二烷基-β-D-麦芽糖苷,Lauryl Maltoside	Others	Others
	N-Dodecyl-β-D-maltoside (Lauryl Maltoside) 是一种芘 (Py) 的衍生物。它可用作烷基吡喃麦芽糖苷清洁剂，尤其是在转运蛋白和呼吸复合物中。它已用于诸如 RNA 聚合酶的纯化和稳定化，以及蛋白质-脂质相互作用的检测的应用中。
T36585	Isodeoxycholic Acid isoDCA	Chloride channel; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Isodeoxycholic Acid 是一种胆汁酸，由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚，这表明它的去污活性降低了，而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid（0.1%）能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发，并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中，血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。

天然产物

Cat.No: T2721

Target: Others

Deoxycholic acid

Cat.No: T2965

Synonym: Cholorebic,去氧胆酸,脱氧胆酸,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic

Target: Endogenous Metabolite, GPCR19

Glycocholic Acid Sodium Salt

Cat.No: T4070

Synonym: Glycocholate Sodium,Sodium Glycocholate,甘氨胆酸钠盐

Target: Others

Taurodeoxycholate sodium salt

Cat.No: TN2349

Synonym: Sodium taurodeoxylate,牛磺脱氧胆酸钠

Target: Endogenous Metabolite

Polymyxin B Sulfate

Cat.No: T1100

Synonym: Aerosporin,硫酸多粘菌素 B,PMB,Polymyxin B sulphate,硫酸多粘菌素B,Polymyxin B sulfate (1404-26-8 free base),Poly-RX

Target: Antibacterial, Antibiotic

Taurocholic acid sodium salt hydrate

Cat.No: T1138

Synonym: 牛胆酸钠,牛磺胆酸钠水合物,Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate

Target: Others, Potassium Channel, Endogenous Metabolite

Chenodeoxycholic acid

Cat.No: T0847

Synonym: CDCA,鹅去氧胆酸,Chenodiol

Target: Potassium Channel, FXR, Endogenous Metabolite, Autophagy

Lithocholic acid

Cat.No: T2202

Synonym: 3α-Hydroxy-5β-cholanic acid,石胆酸

Target: Apoptosis, Others, FXR, Endogenous Metabolite, Autophagy

N-Dodecyl-β-D-maltoside

Cat.No: T16223

Synonym: 十二烷基-β-D-麦芽糖苷,Lauryl Maltoside

Target: Others

Isodeoxycholic Acid

Cat.No: T36585

Synonym: isoDCA

Target: Chloride channel, Antibacterial

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