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抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6993	Tauroursodeoxycholate sodium 牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC)	Apoptosis; ERK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	Tauroursodeoxycholate sodium (TUDC) 是一种内质网应激抑制剂。Tauroursodeoxycholate sodium (TUDC) 抑制ERK，显著降低凋亡分子表达，如caspase-3和caspase-12。
T1933	NVP 231	Apoptosis; ERK	Apoptosis; MAPK
	NVP 231 是一种强效、特异、可逆的神经酰胺激酶抑制剂，IC50值为12 nM，可竞争性地抑制神经酰胺与 CerK 的结合。它通过增加 DNA 片段和 caspase-3 和 caspase-9 的裂解来诱导细胞凋亡。
TQ0146	Ac-DEVD-CHO	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Ac-DEVD-CHO 是一种特异性 Caspase-3 抑制剂(Ki: 230 pM)。Ac-DEVD-CHO在 SLNT 诱导的细胞凋亡中有抑制作用。
T16998	Tauroursodeoxycholate dihydrate 牛磺熊去氧胆酸二水合物,Taurolite dihydrate,TUDCA dihydrate,UR 906 dihydrate	ERK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decreases the expression of apoptosis molecules, such as caspase-3 and caspase-12.
T27330	FL3
	FL3 is a novel potent eIF4F inhibitor, it induces the death of cancer cells by an original mechanism that involves the apoptosis-inducing factor and caspase 12.
T78873	CTL-12
	CTL-12是一种Fatty Acid Synthase (FASN)抑制剂（IC50: 2.5 μM），能够诱导apoptosis。它使细胞周期在Sub-G1/S期停滞并增加caspase-9和凋亡标志物Bax的表达，同时减少抗凋亡标志物Bcl-xL的水平。CTL-12通过抑制de novo脂肪酸合成，切断了肿瘤细胞的代谢需求，是乳腺癌和结直肠癌研究中的重要工具。
T78872	CTL-06
	CTL-06是一种Fatty Acid Synthase (FASN)抑制剂，具有3 μM的IC50，能够诱发细胞凋亡。CTL-12导致细胞周期在Sub-G1/S期停滞，并增加caspase-9和凋亡标志物Bax的表达，减少抗凋亡标志物Bcl-xL的表达。此外，CTL-12通过抑制脂肪酸的从头合成，剥夺肿瘤细胞代谢所需，主要用于乳腺癌和结直肠癌的研究。
T80173	BDS-I	Potassium Channel	Membrane transporter/Ion channel
	BDS-I，又名降血物质，源自苏卡达银莲花的海洋毒素。它作为钾通道特异性抑制剂，针对Kv3.4。BDS-I能够抑制由Aβ1-42诱导的Kv3.4活性增强，减少caspase-3的激活，阻止NGF诱导的PC-12细胞分化以及异常核形态的出现，并可逆转Aβ肽引发的细胞死亡。
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...

化合物

Tauroursodeoxycholate sodium

Cat.No: T6993

Synonym: 牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC)

Target: Apoptosis, ERK, Caspase

Cat.No: T1933

Target: Apoptosis, ERK

Cat.No: TQ0146

Target: Apoptosis, Caspase

Tauroursodeoxycholate dihydrate

Cat.No: T16998

Synonym: 牛磺熊去氧胆酸二水合物,Taurolite dihydrate,TUDCA dihydrate,UR 906 dihydrate

Target: ERK, Caspase

Cat.No: T27330

Cat.No: T78873

Cat.No: T78872

Cat.No: T80173

Target: Potassium Channel

2-chloro Palmitic Acid

Cat.No: T36221

Cat.No: T37861

Cat. No.	Product Name	Target	Signaling Pathways
T2A2481	Taurochenodeoxycholic Acid Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸	Apoptosis; TNF; Caspase; Endogenous Metabolite	Apoptosis; Metabolism; Proteases/Proteasome
	Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一，可诱导细胞凋亡，具有明显的抗炎和免疫调节作用。
T2532	Tauroursodeoxycholate Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis; ERK; P450; Caspase; Endogenous Metabolite	Apoptosis; MAPK; Metabolism; Proteases/Proteasome
	Tauroursodeoxycholate (UR 906)，又称 ursodoxicoltaurine，是一种高度亲水性的三级胆汁酸，在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式，而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病，如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。
T5A2461	Bufotalin 蟾蜍他灵,Bufotaline,蟾毒它灵,蟾蜍他灵	Apoptosis; Others; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Others
	Bufotalin (Bufotaline) 是一种从蟾酥中分离的类固醇内酯，可诱导癌细胞凋亡，也诱导内质网应激的激活，具有强大的抗肿瘤活性。
TN2215	Taurochenodeoxycholic acid sodium 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
T8092	Taurohyodeoxycholic acid sodium salt Sodium taurohyodeoxycholate hydrate	Caspase	Apoptosis; Proteases/Proteasome
	Taurohyodeoxycholic acid sodium salt (Sodium taurohyodeoxycholate hydrate) 通过阻断钙介导的细胞凋亡途径以及 Caspase-12 活化来防止细胞凋亡
T75319	Taurodeoxycholic acid Taurodeoxychloic acid	Apoptosis; Calcium Channel; Caspase	Apoptosis; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Taurodeoxycholic acid (Taurodeoxychloic acid) 是脱氧胆酸的胆汁酸牛磺酸共轭物，是一种人体代谢物，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid具有神经保护活性，可用于研究 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 。
TJA2398	Taurodeoxycholic acid sodium hydrate Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt,牛磺猪去氧胆酸	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。它可用于原发性胆汁性肝硬化、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤积和肌萎缩侧索硬化症。
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Taurochenodeoxycholic Acid

Cat.No: T2A2481

Synonym: Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸

Target: Apoptosis, TNF, Caspase, Endogenous Metabolite

Tauroursodeoxycholate

Cat.No: T2532

Synonym: Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA

Target: Apoptosis, ERK, P450, Caspase, Endogenous Metabolite

Cat.No: T5A2461

Synonym: 蟾蜍他灵,Bufotaline,蟾毒它灵,蟾蜍他灵

Target: Apoptosis, Others, Reactive Oxygen Species

Taurochenodeoxycholic acid sodium

Cat.No: TN2215

Synonym: 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠

Target: Apoptosis, Endogenous Metabolite

Taurohyodeoxycholic acid sodium salt

Cat.No: T8092

Synonym: Sodium taurohyodeoxycholate hydrate

Target: Caspase

Taurodeoxycholic acid

Cat.No: T75319

Synonym: Taurodeoxychloic acid

Target: Apoptosis, Calcium Channel, Caspase

Taurodeoxycholic acid sodium hydrate

Cat.No: TJA2398

Synonym: Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt,牛磺猪去氧胆酸

Target: Apoptosis, Caspase

Cat.No: T36954

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