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Search Results for " cardiac arrhythmias "

23

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8391	Cesium chloride 氯化铯,CsCl	Potassium Channel	Membrane transporter/Ion channel
	Cesium chloride (CsCl) 是一种钾通道抑制剂，可以防止 Alloxan 引起的 Na+转运减少。Cesium chloride 可以诱发心律失常。
T20898	(R)-Propranolol hydrochloride Dexpropranolol hydrochloride,(R)-(+)-Propranolol,盐酸普奈洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) 是一种抗肾上腺素受体拮抗剂，是一种普萘洛尔的活性较低的对映体。Dexpropranolol 是一种非选择性的β-adrenergic receptor 拮抗剂，对 β1AR 和 β2AR 具有高亲和力。
T15207	Eleclazine hydrochloride GS 6615 hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Eleclazine hydrochloride (GS 6615 hydrochloride) 是新型 Na+电流抑制剂，IC50是0.7 uM。
T11239	Ethacizine hydrochloride NIK-244,Ethacizin,NIK-244 hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Ethacizine hydrochloride (NIK-244) 具有抗心律失常活性，其作用于心脏活动有关，可用于研究心律失常和心肌梗死。
T29050	UK 66914 UK66914,UK-66914	Potassium Channel	Membrane transporter/Ion channel
	UK 66914 是一种 K（+）通道阻断剂，可用于研究心律失常。
T28686	SB-237376 HCl SB-237376 hydrochloride	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	SB-237376 HCl (SB-237376 hydrochloride) 是一种钙和钾通道拮抗剂，可用于治疗心律失常。
T28686L	SB-237376	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	SB-237376 是一种钙和钾通道拮抗剂，可用于治疗心律失常。
T27630	Isbogrel CV4151,CV-4151,CV 4151	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Isbogrel (CV4151)是一种小分子血栓素A2合成酶(TXA2 synthase)抑制剂，可用来研究心律失常、短暂性脑缺血发作和血栓形成。
T25701	Levosemotiadil SD 3212,SA 3212	LDL; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Levosemotiadil（SA 3212）是一种新型钙拮抗剂，是一种非常有效的低密度脂蛋白氧化抑制剂。Levosemotiadil 可用于预防致死性心律失常。
T23536	Xamoterol hemifumarate ICI 118587 hemifumarate,Corwin hemifumarate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Xamoterol hemifumarate 是一种具有强效性和选择性的β1-肾上腺素受体激动剂。Xamoterol hemifumarate 是研究心律失常和 β1-肾上腺素能刺激与 IKr 之间关系的潜在化合物。
T77550	O-Desmethyl Quinidine	Others	Others
	O-Desmethyl Quinidine 是一种新型的奎尼丁类似物，具有显着的抗心律失常活性和较低的急性毒性，可能有助于治疗心律失常。
T68164	Tolamolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tolamolol 是一种选择性 β肾上腺素能阻滞剂，能显著降低运动诱导的S-T段抑制程度，可用于治疗心律失常。
T1012	Acebutolol hydrochloride 盐酸醋丁洛尔,Acebutolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂，用于研究高血压、心绞痛和心律失常。
T69472	Edrophonium
	Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
T19887	Teflurane Abbott-16900,Tefluranum,Abbott 16900,Teflurano
	Teflurane is a halocarbon drug, Teflurane was investigated as an inhalational anesthetic, a high incidence of cardiac arrhythmias in patients, similarly to the cases of halopropane and norflurane.
T26875	BN 50739 BN50739,BN-50739
	BN 50739 is an antagonist of platelet-activating factor (PAF). BN 50739 suppresses certain cardiac arrhythmias. PAF is released from ischaemic myocardium and may contribute to initiation of ischaemia-induced ventricular fibrillation (VF)
T63330	Clamikalant sodium
	Clamikalant sodium 是非选择性的、 ATP 敏感性的钾 (KATP) 通道阻滞剂，能够用于研究心律不齐。
T21391	Flecainide Tambocor,Apocard,Flecainida,Flecainidum
	Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of
T10229	Acebutolol D7	Others	Others
	Acebutolol D7 is a deuterium-labeled Acebutolol. Acebutolol is a selective antagonist of the β1 adrenergic receptor used in the treatment of angina pectoris, hypertension, and cardiac arrhythmias.
T72323	Antiarrhythmic agent-1
	Antiarrhythmic agent-1 (示例 I) 是一种抗心律失常试剂，也是IKr 钾离子通道抑制剂 (IC50<1 μM)。
T33579	Nafazatrom Nafazatromum
	Nafazatrom is a pyrazolinone derivative and lipoxygenase inhibitor that increases endogenous prostacyclin (PGI2) and has experimental anticancer activity. Nafazatrom is also an antithrombotic drug that increases prostacyclin levels and reduces the inciden
T71945	Eleclazine free base
	Eleclazine, also known as GS-6615, is a selective late sodium current inhibitor. Eleclazine is potentially useful for treatment of coronary vasodilators, antiarrhythmics and vasodilators. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the T-wave in the heart’s electrical cycle) in patients with long QT-3 (LQT3) syndrome. LQT3 is a genetic disorder that prolongs the heart’s QTc interval and can cause life-threatening cardiac arrhyth...
T37297	Ru360
	Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial ce...

化合物

Cesium chloride

Cat.No: T8391

Synonym: 氯化铯,CsCl

Target: Potassium Channel

(R)-Propranolol hydrochloride

Cat.No: T20898

Synonym: Dexpropranolol hydrochloride,(R)-(+)-Propranolol,盐酸普奈洛尔

Target: Adrenergic Receptor

Eleclazine hydrochloride

Cat.No: T15207

Synonym: GS 6615 hydrochloride

Target: Sodium Channel

Ethacizine hydrochloride

Cat.No: T11239

Synonym: NIK-244,Ethacizin,NIK-244 hydrochloride

Target: Sodium Channel

Cat.No: T29050

Synonym: UK66914,UK-66914

Target: Potassium Channel

Cat.No: T28686

Synonym: SB-237376 hydrochloride

Target: Calcium Channel, Sodium Channel

Cat.No: T28686L

Target: Calcium Channel, Sodium Channel

Cat.No: T27630

Synonym: CV4151,CV-4151,CV 4151

Target: Prostaglandin Receptor

Cat.No: T25701

Synonym: SD 3212,SA 3212

Target: LDL, Calcium Channel

Xamoterol hemifumarate

Cat.No: T23536

Synonym: ICI 118587 hemifumarate,Corwin hemifumarate

Target: Adrenergic Receptor

O-Desmethyl Quinidine

Cat.No: T77550

Target: Others

Cat.No: T68164

Target: Adrenergic Receptor

Acebutolol hydrochloride

Cat.No: T1012

Synonym: 盐酸醋丁洛尔,Acebutolol HCl

Target: Adrenergic Receptor

Cat.No: T69472

Cat.No: T19887

Synonym: Abbott-16900,Tefluranum,Abbott 16900,Teflurano

Cat.No: T26875

Synonym: BN50739,BN-50739

Clamikalant sodium

Cat.No: T63330

Cat.No: T21391

Synonym: Tambocor,Apocard,Flecainida,Flecainidum

Cat.No: T10229

Target: Others

Antiarrhythmic agent-1

Cat.No: T72323

Cat.No: T33579

Synonym: Nafazatromum

Eleclazine free base

Cat.No: T71945

Cat.No: T37297

Cat. No.	Product Name	Target	Signaling Pathways
T8183	Deslanoside 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C	ATPase; Drug Metabolite	Membrane transporter/Ion channel; Metabolism
	Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷，可抑制Na-K-ATPase 膜泵，导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常，并在研究慢性心房颤动时控制心室率。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。

天然产物

Cat.No: T8183

Synonym: 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C

Target: ATPase, Drug Metabolite

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

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