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Cat. No.	Product Name	Target	Signaling Pathways
T17870	cIAP1 ligand 1 E3 ligase Ligand 12	Others	Others
	cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体，可募集 IAP 泛素连接酶以降解靶蛋白，可用于和雄激素受体配体偶联开发蛋白降解剂，可用于研究前列腺癌。
T39609	cIAP1 Ligand-Linker Conjugates 16 cIAP1 Ligand-Linker Conjugates 16
	cIAP1 Ligand-Linker Conjugates 16 refers to a specific type of ligase ligand-linker conjugate, possessing the ability to engage with E3 ligases, which finds application in the synthesis of PROTACs.
T69322	cIAP1-IN-D19
	cIAP1-IN-D19 is an inhibitor of E3 ligase activity of cIAP1.
T17899	cIAP1 Ligand-Linker Conjugates 9 E3 ligase Ligand-Linker Conjugates 45	Others	Others
	cIAP1 Ligand-Linker Conjugates 9 feature an IAP ligand specifically targeting the E3 ubiquitin ligase, along with a PROTAC linker. It is valuable tools for developing SNIPERs[1].
T17890	cIAP1 Ligand-Linker Conjugates 2 Hydrochloride E3 ligase Ligand-Linker Conjugates 37 Hydrochloride,cIAP1 Ligand-Linker Conjugates 2 Hydrochloride (1312302-14-9 free base)	Others	Others
	cIAP1 Ligand-Linker Conjugates 2 Hydrochloride is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is utilized in the creation of SNIPERs[1].
T17869	cIAP1 ligand 2 E3 ligase Ligand 11	Others	Others
	cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER.
T17893	cIAP1 Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 39	Others	Others
	cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1].
T17889	cIAP1 Ligand-Linker Conjugates 14 E3 ligase Ligand-Linker Conjugates 36	Others	Others
	cIAP1 Ligand-Linker Conjugates 14 consist of an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker. These conjugates, known as cIAP1 Ligand-Linker Conjugates 14, are used in the development of SNIPERs[1].
T17896	cIAP1 Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 42	Others	Others
	cIAP1 Ligand-Linker Conjugates 4 is a chemical compound that comprises an IAP ligand specifically designed for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 4, has the potential to be utilized in the development of SNIPERs[1].
T17885	cIAP1 Ligand-Linker Conjugates 11 E3 ligase Ligand-Linker Conjugates 33	Others	Others
	cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in the development of SNIPERs[1], allowing for the targeted degradation of proteins.
T17891	cIAP1 Ligand-Linker Conjugates 2 E3 ligase Ligand-Linker Conjugates 37	Others	Others
	cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1].
T17895	cIAP1 Ligand-Linker Conjugates 1 E3 ligase Ligand-Linker Conjugates 41	Others	Others
	cIAP1 Ligand-Linker Conjugates 1 is composed of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 1, is particularly useful in the development of SNIPERs[1].
T17894	cIAP1 Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 40	Others	Others
	cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1].
T17898	cIAP1 Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 44	Others	Others
	cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1].
T17888	cIAP1 Ligand-Linker Conjugates 6 hydrochloride E3 ligase Ligand-Linker Conjugates 35 hydrochloride	Others	Others
	cIAP1 Ligand-Linker Conjugates 6 hydrochloride is a compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized for the purpose of designing SNIPERs[1].
T17892	cIAP1 Ligand-Linker Conjugates 12 E3 ligase Ligand-Linker Conjugates 38	Others	Others
	cIAP1 Ligand-Linker Conjugates 12 is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 12, is valuable for creating SNIPERs[1].
T17887	cIAP1 Ligand-Linker Conjugates 15 E3 ligase Ligand-Linker Conjugates 34	Others	Others
	cIAP1 Ligand-Linker Conjugates 15 consists of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 15, is suitable for the development of SNIPERs[1].
T17901	cIAP1 Ligand-Linker Conjugates 10 E3 ligase Ligand-Linker Conjugates 47	Others	Others
	cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10.
T17897	cIAP1 Ligand-Linker Conjugates 13 E3 ligase Ligand-Linker Conjugates 43	Others	Others
	cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1].
T17900	cIAP1 Ligand-Linker Conjugates 8 E3 ligase Ligand-Linker Conjugates 46	Others	Others
	cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1].
T17886	cIAP1 Ligand-Linker Conjugates 15 hydrochloride E3 ligase Ligand-Linker Conjugates 34 hydrochloride	Others	Others
	cIAP1 Ligand-Linker Conjugates 15 hydrochloride is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is useful in the development of SNIPERs[1].
T17884	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride E3 ligase Ligand-Linker Conjugates 33 Hydrochloride	Others	Others
	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1].
T64302	XIAP/cIAP1 antagonist-1
	XIAP/cIAP1 antagonist-1 是一种有效的、口服具有活力的 XIAP/cIAP1 拮抗剂，能够作用于 XIAP (EC50: 5.1 nM) 和 cIAP1 (EC50: 0.32 nM)。XIAP/cIAP1 antagonist-1 能够剂量依赖性地抑制体内肿瘤生长。
T13410	ZLDI-8	Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells
	ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂，可抑制 Notch 蛋白裂解，并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂，以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。
T8931L	ICCB-19 hydrochloride ICCB-19 HCl（750621-52-4 free base）	Apoptosis; Others; Autophagy; RIP kinase	Apoptosis; Autophagy; NF-κB; Others
	ICCB-19 hydrochloride (ICCB-19 HCl) 是RIPK1激酶活性的间接抑制剂。它是一种 TRADD 抑制剂，可与 TRADD 的 N 端结构域结合，破坏其与 TRADD-C 和 TRAF2 的结合，诱导自噬和长寿命蛋白质的降解。
T36201L	AZD5582 TFA AZD5582 TFA（1258392-53-8 free base）	Apoptosis; IAP	Apoptosis
	AZD5582 TFA 是一种有效的 IAP 拮抗剂，可与 cIAP1，cIAP2 和 XIAP 的 BIR3 结构域结合, IC50 值分别为 15，21，15 nM。AZD5582 TFA可诱导细胞凋亡。
T6763	Xevinapant ARRY-334543,SM-406,AT406,Debio-1143	IAP	Apoptosis
	Xevinapant (Debio-1143) 是一种有效的 Smac 模拟物和 IAP 的拮抗剂，能够抑制 XIAP，cIAP1 和 cIAP2 蛋白，Ki 值分别为 66.4，1.9 和 5.1 nM。
T14378L	AZD5582 acetate (1258392-53-8 free base)	IAP	Apoptosis
	AZD5582 acetate (1258392-53-8 free base) 是一种 IAP 抑制剂，与 BIR3 结构域 cIAP1、cIAP2 和 XIAP 结合，IC50 分别为 15、21 和 15 nM。 AZD5582 诱导细胞凋亡。
T6299	GDC-0152 GDC0152	IAP	Apoptosis
	GDC-0152 是一种 IAP 抑制剂，可以与 XIAP、cIAP1和cIAP2的 BIR3 结合域，以及ML-IAP 的 BIR 结合域结合，Ki 值分别为 28 nM、17 nM、43 nM 和 14 nM。
T2080	LCL161	IAP	Apoptosis
	LCL161 是一种 SMAC 模拟物，可有效结合并抑制多种 IAP。它抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1的 IC50分别为 35 和 0.4 nM。
T6007	Birinapant TL32711,比瑞那帕	Apoptosis; IAP; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Birinapant (TL32711) 是一种二价 Smac 模拟物，是 XIAP 和 cIAP1的强效拮抗剂，Kd 值分别为 45 nM 和小于 1 nM。它靶向与 TRAF2 相关的 cIAP，并消除 TNF 诱导的 NF-κB 活化。
T12932L	SM-164	Apoptosis; IAP	Apoptosis
	SM-164 是细胞渗透性 Smac 类似物，与含有 BIR2 和 BIR3 结构域的 XIAP 蛋白结合，IC50值为 1.39 nM，它用作XIAP 的强效拮抗剂。
T14378	AZD5582	Apoptosis; IAP	Apoptosis
	AZD5582 是一种 IAP 拮抗剂，可诱导凋亡，可与 cIAP1、cIAP2 和 XIAP 的 BIR3 结构域结合，IC50值分别为 15、21和15 nM。
T36201	AZD5582 dihydrochloride AZD 5582 dihydrochloride
	Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice. Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP...
T18596	PROTAC AR Degrader-4	Others	Others
	PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
T23760	AT-IAP
	AT-IAP is an effective dual antagonist of XIAP and cIAP1.
T17706	BzNH-BS	Others	Others
	BzNH-BS is a chemical compound comprising two distinct ligands: methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide. The ligands are interconnected through linkers. MeBS functions as a ligand for cIAP1, a ubiquitin ligase involved in cellular inhibition of apoptosis processes [1].
T69840	MX106
	MX106 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.
T18635	PROTAC RAR Degrader-1	Others	Others
	PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
T18690	SNIPER(ABL)-039	Others	Others
	SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].
T18605	PROTAC ERα Degrader-2	Others	Others
	PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
T18650	Ch55-O-C3-NH2 RAR ligand 1	Others	Others
	Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR. Through a linker, Ch55-O-C3-NH2 interacts with cIAP1 ligand Bestatin to form SNIPER[1].
T17545	Biotin-BS	Others	Others
	Biotin-BS is a chemical compound composed of two distinct ligands: methyl-bestatin (MeBS) for cIAP1 and biotin. These ligands are interconnected through linkers. MeBS serves as a ligand specifically for the cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].
T16905	SNIPER(BRD)-1	Others	Others
	SNIPER(BRD)-1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+)-JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway and effectively degrades cIAP1, cIAP2, and XIAP with IC50 values of 6.8 nM, 17 nM, and 49nM, respectively[1].
T79247	Anticancer agent 127	IAP	Apoptosis
	Anticanceragent 127 (142D6) 是一种共价靶向 XIAP、cIAP1 以及 cIAP2 的 BIR3 结构域的IAP抑制剂，其对 XIAP、cIAP1 和 cIAP2 的 BIR3 结构域的 IC50 值分别为 12 nM、14 nM 和 9 nM，显示出抗癌活性。
T69845	MX107
	MX107 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.
T14288	Androstanolone acetate	Others	Others
	Androstanolone acetate is a compound that functions as an androgen ligand, specifically targeting the androgen receptor (AR). It binds to the cIAP1 ligand Bestatin through a linker, resulting in the formation of PROTACs[1].
T78947	CST626	PROTACs	PROTAC
	CST626 (Compound 9) 为一种pan-IAP PROTAC降解剂，其在MM.1S细胞中对XIAP、cIAP1以及cIAP2的DC50分别为0.7 nM、2.4 nM和6.2 nM。
T13837	PROTAC CRABP-II Degrader-2	Others	Others
	PROTAC CRABP-II Degrader-2 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on cIAp1.
T73726	PROTAC AR Degrader-4 TFA
	PROTACAR Degrader-4 包含IAP 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于cIAP1的降解剂也被称为SNIPER。

化合物

cIAP1 ligand 1

Cat.No: T17870

Synonym: E3 ligase Ligand 12

Target: Others

cIAP1 Ligand-Linker Conjugates 16

Cat.No: T39609

Synonym: cIAP1 Ligand-Linker Conjugates 16

Cat.No: T69322

cIAP1 Ligand-Linker Conjugates 9

Cat.No: T17899

Synonym: E3 ligase Ligand-Linker Conjugates 45

Target: Others

cIAP1 Ligand-Linker Conjugates 2 Hydrochloride

Cat.No: T17890

Synonym: E3 ligase Ligand-Linker Conjugates 37 Hydrochloride,cIAP1 Ligand-Linker Conjugates 2 Hydrochloride (1312302-14-9 free base)

Target: Others

cIAP1 ligand 2

Cat.No: T17869

Synonym: E3 ligase Ligand 11

Target: Others

cIAP1 Ligand-Linker Conjugates 5

Cat.No: T17893

Synonym: E3 ligase Ligand-Linker Conjugates 39

Target: Others

cIAP1 Ligand-Linker Conjugates 14

Cat.No: T17889

Synonym: E3 ligase Ligand-Linker Conjugates 36

Target: Others

cIAP1 Ligand-Linker Conjugates 4

Cat.No: T17896

Synonym: E3 ligase Ligand-Linker Conjugates 42

Target: Others

cIAP1 Ligand-Linker Conjugates 11

Cat.No: T17885

Synonym: E3 ligase Ligand-Linker Conjugates 33

Target: Others

cIAP1 Ligand-Linker Conjugates 2

Cat.No: T17891

Synonym: E3 ligase Ligand-Linker Conjugates 37

Target: Others

cIAP1 Ligand-Linker Conjugates 1

Cat.No: T17895

Synonym: E3 ligase Ligand-Linker Conjugates 41

Target: Others

cIAP1 Ligand-Linker Conjugates 3

Cat.No: T17894

Synonym: E3 ligase Ligand-Linker Conjugates 40

Target: Others

cIAP1 Ligand-Linker Conjugates 7

Cat.No: T17898

Synonym: E3 ligase Ligand-Linker Conjugates 44

Target: Others

cIAP1 Ligand-Linker Conjugates 6 hydrochloride

Cat.No: T17888

Synonym: E3 ligase Ligand-Linker Conjugates 35 hydrochloride

Target: Others

cIAP1 Ligand-Linker Conjugates 12

Cat.No: T17892

Synonym: E3 ligase Ligand-Linker Conjugates 38

Target: Others

cIAP1 Ligand-Linker Conjugates 15

Cat.No: T17887

Synonym: E3 ligase Ligand-Linker Conjugates 34

Target: Others

cIAP1 Ligand-Linker Conjugates 10

Cat.No: T17901

Synonym: E3 ligase Ligand-Linker Conjugates 47

Target: Others

cIAP1 Ligand-Linker Conjugates 13

Cat.No: T17897

Synonym: E3 ligase Ligand-Linker Conjugates 43

Target: Others

cIAP1 Ligand-Linker Conjugates 8

Cat.No: T17900

Synonym: E3 ligase Ligand-Linker Conjugates 46

Target: Others

cIAP1 Ligand-Linker Conjugates 15 hydrochloride

Cat.No: T17886

Synonym: E3 ligase Ligand-Linker Conjugates 34 hydrochloride

Target: Others

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride

Cat.No: T17884

Synonym: E3 ligase Ligand-Linker Conjugates 33 Hydrochloride

Target: Others

XIAP/cIAP1 antagonist-1

Cat.No: T64302

Cat.No: T13410

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

ICCB-19 hydrochloride

Cat.No: T8931L

Synonym: ICCB-19 HCl（750621-52-4 free base）

Target: Apoptosis, Others, Autophagy, RIP kinase

Cat.No: T36201L

Synonym: AZD5582 TFA（1258392-53-8 free base）

Target: Apoptosis, IAP

Cat.No: T6763

Synonym: ARRY-334543,SM-406,AT406,Debio-1143

Target: IAP

AZD5582 acetate (1258392-53-8 free base)

Cat.No: T14378L

Target: IAP

Cat.No: T6299

Synonym: GDC0152

Target: IAP

Cat.No: T2080

Target: IAP

Cat.No: T6007

Synonym: TL32711,比瑞那帕

Target: Apoptosis, IAP, HIV Protease

Cat.No: T12932L

Target: Apoptosis, IAP

Cat.No: T14378

Target: Apoptosis, IAP

AZD5582 dihydrochloride

Cat.No: T36201

Synonym: AZD 5582 dihydrochloride

PROTAC AR Degrader-4

Cat.No: T18596

Target: Others

Cat.No: T23760

Cat.No: T17706

Target: Others

Cat.No: T69840

PROTAC RAR Degrader-1

Cat.No: T18635

Target: Others

SNIPER(ABL)-039

Cat.No: T18690

Target: Others

PROTAC ERα Degrader-2

Cat.No: T18605

Target: Others

Cat.No: T18650

Synonym: RAR ligand 1

Target: Others

Cat.No: T17545

Target: Others

Cat.No: T16905

Target: Others

Anticancer agent 127

Cat.No: T79247

Target: IAP

Cat.No: T69845

Androstanolone acetate

Cat.No: T14288

Target: Others

Cat.No: T78947

Target: PROTACs

PROTAC CRABP-II Degrader-2

Cat.No: T13837

Target: Others

PROTAC AR Degrader-4 TFA

Cat.No: T73726

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