Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
产品描述 | PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cells at a concentration of 30 μM. Degradation inducers that utilize cIAP1 are referred to as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1]. |
分子量 | 763.96 |
分子式 | C42H61N5O8 |
CAS No. | 1351169-29-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (261.79 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.309 mL | 6.5448 mL | 13.0897 mL | 32.7242 mL |
5 mM | 0.2618 mL | 1.309 mL | 2.6179 mL | 6.5448 mL | |
10 mM | 0.1309 mL | 0.6545 mL | 1.309 mL | 3.2724 mL | |
20 mM | 0.0654 mL | 0.3272 mL | 0.6545 mL | 1.6362 mL | |
50 mM | 0.0262 mL | 0.1309 mL | 0.2618 mL | 0.6545 mL | |
100 mM | 0.0131 mL | 0.0654 mL | 0.1309 mL | 0.3272 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PROTAC ERα Degrader-2 1351169-29-3 Others PROTAC ERα Degrader 2 PROTAC ERalpha Degrader-2 PROTAC ERa Degrader-2 PROTAC ERα Degrader2 Inhibitor inhibitor inhibit