Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD5582 acetate (1258392-53-8 free base) 是一种 IAP 抑制剂,与 BIR3 结构域 cIAP1、cIAP2 和 XIAP 结合,IC50 分别为 15、21 和 15 nM。 AZD5582 诱导细胞凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 594 | 现货 | ||
5 mg | ¥ 891 | 待询 | ||
10 mg | ¥ 1,627 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,870 | 现货 |
AZD5582 acetate (1258392-53-8 free base) 的其他形式现货产品:
产品描述 | AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis. |
靶点活性 | cIAP2:21 nM, XIAP:15 nM, cIAP1:15 nM |
体外活性 | AZD5582 (20 nM; 48 hours) inhibited cell viability by cooperation with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells[2]. AZD5582 (20 nM; 48 hours) involves in apoptosis due to induction of cell death and active caspase-3/ -8 activities by AZD5582 and IFNγ co-treatment in HCC827 NSCLC cells[2]. AZD5582 (20 nM; 17 or 25 hours) down-regulates cIAP-1, activates RIPK1( upstream regulator of caspase-8), and triggers the activation of extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, causing the cleavage of caspase-3 and caspase-7[2]. |
体内活性 | AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) causes degradation of cIAP1 and caspase 3 cleavage in tumor cells, and after a two-week treatment, the tumors largely resolved. When the mice are given a medium dose (0.5 mg/kg) of AZD5582, cIAP1 degrades after administration, but it takes a while time to reach apoptosis-inducing effect[1]. |
分子量 | 1075.36 |
分子式 | C60H82N8O10 |
CAS No. | T14378L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (51.15 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.9299 mL | 4.6496 mL | 9.2992 mL | 23.248 mL |
5 mM | 0.186 mL | 0.9299 mL | 1.8598 mL | 4.6496 mL | |
10 mM | 0.093 mL | 0.465 mL | 0.9299 mL | 2.3248 mL | |
20 mM | 0.0465 mL | 0.2325 mL | 0.465 mL | 1.1624 mL | |
50 mM | 0.0186 mL | 0.093 mL | 0.186 mL | 0.465 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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