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27

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13920L	Terlipressin Acetate Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素	Vasopressin Receptor	GPCR/G Protein
	Terlipressin Acetate 是一种高度选择性的加压素 V1 受体激动剂，对氧和葡萄糖剥夺/再氧合 (OGD/R) 诱导的肠上皮细胞损伤 (IEC-6) 具有抗炎和抗氧化作用，可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。
T6991	Nitroprusside disodium dihydrate 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate	Guanylate cyclase; Autophagy	Autophagy; GPCR/G Protein
	Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) 是一种血管扩张剂，通过在血液中自发释放 NO 发挥作用。它可在谷胱甘肽耗竭的成骨细胞中诱导自噬，用于急性高血压和心力衰竭的研究。
T11918	Lysipressin Lysine vasopressin,[Lys8]-Vasopressin,赖氨加压素	Others	Others
	Lysipressin ([Lys8]-Vasopressin) 是一种抗利尿激素，从猪身上发现，能够诱发兔膀胱平滑肌的收缩，激活腺苷酸环化酶。
T7601L	Carbetocin acetate 醋酸卡贝缩宫素,Carbetocin acetate(37025-55-1 free base),卡贝缩宫素醋酸盐	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Carbetocin acetate 是催产素类似物，是催产素受体激动剂，Ki 是 7.1 nM。它对催产素受体的嵌合 N 末端具有高亲和力，Ki 为 1.17 μM。它能透过血脑屏障，可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性，具有用于产后出血的研究潜力。
T1514	Norethindrone Norethisterone,炔诺酮	Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Norethindrone (Norethisterone) 是孕激素，能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。
T11824LL	Lanraplenib GS-9876	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Lanraplenib (GS-9876) 是高效的、选择性的、口服具有活力的 SYK 抑制剂 (IC50=9.5 nM) ，能够用于炎症性疾病的研究。它通过糖蛋白 VI (GPVI) 受体抑制血小板中的 SYK 活性，而不会延长猴子或人类的出血时间 (BT)。
T3536	AZD1283	P2Y Receptor	GPCR/G Protein; Neuroscience
	AZD1283是P2Y12受体拮抗剂，EC50为3.0 ug/kg/min，结合的IC50为11 nM。它剂量依赖性地诱导血流量增加和抑制 ADP 诱导的血小板聚集，抗血栓形成的 ED50 值分别为 3.0 和 10 μg/kg/min。
T70349	DJT06001
	DJT06001 is a selective Factor Xa inhibitor, reducing thrombus formation with low risk of bleeding.
T20855	Gemeprost SC-37681,SC 37681,Carprost,Gemeprostum,Cervagem,Preglandin
	Gemeprost, an analog of prostaglandin E1, is used for the treatment of obstetric bleeding. It is used to terminate pregnancy up to 24 weeks gestation together with mifepristone.
T28237	Onapristone IVV-1001,ZK 98299,IVV 1001,ZK98299,ZK-98299,IVV1001
	Onapristone, a progesterone receptor antagonist, is used potentially for the treatment of breast cancer, advanced prostate cancer, and inducer of vaginal bleeding.
T11824	Lanraplenib succinate GS-9876 succinate	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib succinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
T11824L	Lanraplenib monosuccinate GS-9876 monosuccinate	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib monosuccinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
T28491	R-1663 R1663
	R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner without increasing bleeding time. Pharmac
T0171	Norethynodrel Lynestrol,异炔诺酮	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Norethynodrel (Lynestrol) 是一种合成的孕激素，其作用和用途类似于孕酮。它已被用于治疗功能性子宫出血和子宫内膜异位症。它作为避孕药，通常与 MESTRANOL 联合使用。
T68681	Casuarinin
	Casuarinin is an ellagitannin. It is found in the pericarp of pomegranates. It is also found in Casuarina and Stachyurus species and in Alnus sieboldiana. It is an isomer of casuarictin. It is a highly active carbonic anhydrase inhibitor. It is a compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions.
T16377	Odiparcil SB-424323	Thrombin	Proteases/Proteasome
	Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events.
T36178	Aspalatone
	Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus.
T71980	Omeprazole acid
	Omeprazole acid is a medication used in the treatment of gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid.
T64257	FXIa-IN-8
	FXIa-IN-8 是一种有效的、选择性的 FXIa 抑制剂 (IC50: 14.2 nM)。FXIa-IN-8 表现出抗血栓形成效果，而且不会提高出血风险及明显的毒性 sup>[1]。
T7601	Carbetocin 卡贝缩宫素,醋酸卡贝缩宫素	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Carbetocin 是催产素类似物，是催产素受体激动剂，Ki 是 7.1 nM。它对催产素受体的嵌合 N 末端具有高亲和力，Ki 为 1.17 μM。它能透过血脑屏障，可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性，具有用于产后出血的研究潜力。
T79847	Frunexian EP-7041	Factor Xa	Metabolism
	Frunexian (EP-7041) 为针对 Factor XIa 的选择性有效凝血因子 XI/活化因子 XI 抑制剂，展现抗血栓活性，且在大鼠肠系膜动脉穿刺模型中显示出无出血倾向。此化合物亦可应用于体外膜氧合(ECMO)的研究领域。
T28099	MRS2179 MRS 2179,MRS-2179
	MRS2179 is a competitive P2Y1 receptor antagonist (Kb = 100 nM) with no appreciable activity at P2Y2, P2Y4, or P2Y6 at concentrations up to 30 µM, or at P2Y12 and P2Y13. It inhibits ADP-induced platelet shape change and aggregation (pA2 = 6.55) in vitro a
T36553	Thrombin Receptor Peptide Ligand (trifluoroacetate salt)
	Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 μM to inhibit platelet aggregation in vitro). It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating peptide in vitro when used at a concentration of 32 μM but does not affect platelet aggregation induced by ADP or collagen. It also inhibits thrombin- and TRAP-induced proliferation of vascular smooth muscle cells (VSMCs). Thrombin receptor peptide ligand (100 μmol/kg bolus, i.v...
T74647	BT5528
	BT5528 是一种双环肽毒素结合物，一种EphA2激活剂。BT5528 由双环肽和AuristatinE 组成，是 BCY6099 的衍生物。BT5528 在大鼠模型中显示出强大的抗肿瘤活性，不导致出血或引起凝血毒性。
T72113	6-Aminocaproic acid hydrochloride EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride
	6-Aminocaproic acid hydrochloride，一种单氨基羧酸，作为有效及口服活性的纤溶酶和纤溶酶原抑制剂，具备显著的抗纤溶能力。通过竞争性结合纤溶酶原上的赖氨酸残基，6-Aminocaproic acid hydrochloride 阻止血块溶解，抑制纤溶酶生成，减少纤维蛋白溶解，用于出血性疾病研究。
T38178	Ristocetin A (sulfate) Ristomycin III
	Ristocetin A, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism Nocardia lurida[1]. Ristocetin A is currently in clinical use to treat bacterial infections [1]. Ristocetin A is an antibiotic which can be used to treat staphylococcal infections. The side effects of ristocetin A include thrombocytopenia and platelet agglutination. Ristocetin A has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. These t...
T36660	Olsalazine-13C6 Olsalazine-13C6
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ...

化合物

Terlipressin Acetate

Cat.No: T13920L

Synonym: Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素

Target: Vasopressin Receptor

Nitroprusside disodium dihydrate

Cat.No: T6991

Synonym: 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate

Target: Guanylate cyclase, Autophagy

Cat.No: T11918

Synonym: Lysine vasopressin,[Lys8]-Vasopressin,赖氨加压素

Target: Others

Carbetocin acetate

Cat.No: T7601L

Synonym: 醋酸卡贝缩宫素,Carbetocin acetate(37025-55-1 free base),卡贝缩宫素醋酸盐

Target: Oxytocin Receptor

Cat.No: T1514

Synonym: Norethisterone,炔诺酮

Target: Estrogen/progestogen Receptor, Progesterone Receptor

Cat.No: T11824LL

Synonym: GS-9876

Target: Syk

Cat.No: T3536

Target: P2Y Receptor

Cat.No: T70349

Cat.No: T20855

Synonym: SC-37681,SC 37681,Carprost,Gemeprostum,Cervagem,Preglandin

Cat.No: T28237

Synonym: IVV-1001,ZK 98299,IVV 1001,ZK98299,ZK-98299,IVV1001

Lanraplenib succinate

Cat.No: T11824

Synonym: GS-9876 succinate

Target: Syk

Lanraplenib monosuccinate

Cat.No: T11824L

Synonym: GS-9876 monosuccinate

Target: Syk

Cat.No: T28491

Synonym: R1663

Cat.No: T0171

Synonym: Lynestrol,异炔诺酮

Target: Estrogen/progestogen Receptor

Cat.No: T68681

Cat.No: T16377

Synonym: SB-424323

Target: Thrombin

Cat.No: T36178

Omeprazole acid

Cat.No: T71980

Cat.No: T64257

Cat.No: T7601

Synonym: 卡贝缩宫素,醋酸卡贝缩宫素

Target: Oxytocin Receptor

Cat.No: T79847

Synonym: EP-7041

Target: Factor Xa

Cat.No: T28099

Synonym: MRS 2179,MRS-2179

Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

Cat.No: T36553

Cat.No: T74647

6-Aminocaproic acid hydrochloride

Cat.No: T72113

Synonym: EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride

Ristocetin A (sulfate)

Cat.No: T38178

Synonym: Ristomycin III

Olsalazine-13C6

Cat.No: T36660

Synonym: Olsalazine-13C6

Cat. No.	Product Name	Target	Signaling Pathways
T0881	6-Aminocaproic acid 氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid	Others	Others
	6-Aminocaproic acid (EACA) 是一种单氨基羧酸，是一种有效的、具有口服活性的纤溶酶和纤溶酶原的抑制剂。它是一种有效的抗纤维蛋白溶解剂，能够竞争性结合纤溶酶原上的赖氨酸残基，防止血块溶解，并抑制纤溶酶的形成，减少纤维蛋白溶解。它可用于出血性疾病的研究。
T13693	Fibrin	Others	Others
	Fibrin, the primary constituent of blood clots, is an insoluble protein essential for coagulation. Isolated from bovine blood, this protein is notably synthesized in response to bleeding.
T14865	Carboprost tromethamine	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Carboprost tromethamine 是合成的前列腺素 F2α的15-甲基类似物，能有效促进子宫的规律收缩，显着减少产中及产后出血量。
TN7238L	Sanguinarine citrate Sanguinarium citrate,Sanguinarin citrate,Pseudochelerythrine citrate	Antibiotic	Microbiology/Virology
	Sanguinarine citrate (Pseudochelerythrine chloride) 是一种来源于 Sanguinaria Canadensis 的生物碱，具有抗菌、抗炎和镇痛活性，可用于治疗口腔炎、牙龈出血和喉炎等口腔炎症疾病。
T80680	γ-Isofagarine Iso-γ-fagarine
	Isofagarine (Iso-γ-fagarine) 为一生物碱，源自Dictamnus angustifolius根皮。该化合物参与风湿、出血、瘙痒、黄疸、慢性肝炎和皮肤病等病态研究。

天然产物

6-Aminocaproic acid

Cat.No: T0881

Synonym: 氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid

Target: Others

Cat.No: T13693

Target: Others

Carboprost tromethamine

Cat.No: T14865

Target: Prostaglandin Receptor

Sanguinarine citrate

Cat.No: TN7238L

Synonym: Sanguinarium citrate,Sanguinarin citrate,Pseudochelerythrine citrate

Target: Antibiotic

Cat.No: T80680

Synonym: Iso-γ-fagarine

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