首页工具

登录

搜索结果

Search Results for " bifunctional "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T39710	ARV-471 Vepdegestrant	Estrogen Receptor/ERR	Endocrinology/Hormones
	ARV-471 (Vepdegestrant) 是一种高效的，口服有效的基于 Cereblon 配体的雌激素受体降解剂 PROTAC 。ARV-471 常用于研究乳腺癌。
T6798	Tretazicar 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	Tretazicar (NSC-115829) 是一种抗肿瘤前药，由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂，可以形成 DNA-DNA 链间交联。
T7750	N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]- Thiourea N-[3,5-双(三氟甲基)苯基]-N′-[(9R)-6′-甲氧基-9-金鸡宁]硫脲	Others	Others
	N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]- Thiourea 是金鸡纳生物碱衍生的双功能催化剂。
T11938L	Macropa-NH2	Others	Others
	Macropa-NH2 是 macropa 双功能类似物，是一种常与抗体偶联的载体分子，常作为螯合剂使用，参与癌症研究。
T17159	Treosulfan NSC 39069,曲奥舒凡,Treosulphan	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	Treosulfan (Treosulphan) 是一种双功能的烷化剂，对卵巢癌及其他的实体瘤都有抑制效果。
T15178	dTRIM24	Others	Others
	dTRIM24 是一种基于 PROTAC 技术的选择性双功能 TRIM24 降解剂，由von Hippel-Lindau 和TRIM24 两者配体构成。
T18728	Sulfo-SMCC sodium	Others	Others
	Sulfo-SMCC sodium 是一种异双功能、不可裂解的 ADC 交联剂，带有 N-羟基琥珀酰亚胺酯和马来酰亚胺基团，分别与伯胺和巯基反应。
T4382	Proguanil hydrochloride Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil	Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others
	Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。
T26803	Bibw 22 Bibw22,Bibw-22
	Bibw 22 is a bifunctional modulator of P-glycoprotein and nucleoside transport.
T19207	BFCAs-1	Others	Others
	BFCAs-1 is a polyamine polycarboxylic bifunctional chelating agent (BFCAs) with a broad range of applications in biology, chemistry, medicine and diagnostic imaging.
T16181	N-(Azido-PEG2)-N-Boc-PEG4-Boc	Others	Others
	N-(Azido-PEG2)-N-Boc-PEG4-Boc is a PEG-based bifunctional linker employed for the synthesis of PROTACs.
T18744	t-Boc-Aminooxy-PEG7-bromide	Others	Others
	t-Boc-Aminooxy-PEG7-bromide is a polyethylene glycol (PEG)-based bifunctional linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T19168	9-Azido-Neu5DAz	Others	Others
	9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent.
T28846	SR16835 AT-202,AT202,SR 16835,SR-16835
	SR16835 is a NOP receptor agonist, with low-affinity bifunctional activity at the μ opioid receptor.
T14267	Aminooxy-PEG3-C2-NH-Boc	Others	Others
	Aminooxy-PEG3-C2-NH-Boc is a PEGylated PROTAC linker utilized in the synthesis of PROTACs, an emerging class of bifunctional molecules for targeted protein degradation[1].
T25140	BCH 2763 BCH2763,BCH-2763
	BCH 2763 is an effective, selective bifunctional thrombin inhibitor that blocks both the anion binding exosite and the active catalytic site.
T17962	Fmoc-N-PEG36-acid	Others	Others
	Fmoc-N-amido-PEG36-acid is a polyethylene glycol (PEG)-based linker utilized in PROTAC synthesis. It has been designed specifically for constructing PROTACs, which are bifunctional molecules capable of recruiting target proteins to an E3 ubiquitin ligase for degradation[1].
T70925	GS-5759
	GS-5759 is a bifunctional ß2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action.
T82537	D-MoDE-A (1)	LYTACs	PROTAC
	D-MoDE-A（1）是一种双功能小分子，它通过ASGPR（去唾液酸糖蛋白受体）介导外源蛋白的降解。
T14163	Ald-Ph-amido-C2-PEG3-NH-Boc	Others	Others
	Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
T68272	Batefenterol Succinate
	Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.
T41024	FmocNH-PEG4-t-butyl acetate FmocNH-PEG4-t-butyl acetate
	FmocNH-PEG4-t-butyl acetate is a polyethylene glycol (PEG)-derived PROTAC linker employed for the synthesis of PROTACs, bifunctional molecules designed to degrade target proteins.
T40648	NOTA
	NOTA, a bifunctional chelate, serves as a foundation for PET imaging tool construction, probe design, and signal amplification through the multivalent effect.
T34173	p-SCN-Bn-HOPO
	p-SCN-Bn-HOPO is an excellent bifunctional chelating agent for (89)Zr ImmunoPET, with low background, good tumor-organ contrast, and importantly, very low bone uptake for BT474 breast cancer imaging.
T18834	Thiol-PEG-CH2COOH (MW 5000)	Others	Others
	Thiol-PEG-CH2COOH (MW 5000) is a Polyethylene glycol (PEG) derived link molecule, commonly utilized in the construction of PROTACs, which are bifunctional compounds designed for targeted protein degradation [1].
T16234	N-Mal-N-bis(PEG4-NHS ester)	Others	Others
	N-Mal-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based bifunctional linker utilized for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].
T14449	Azido-PEG4-hydrazide-Boc	Others	Others
	Azido-PEG4-hydrazide-Boc is a polyethylene glycol (PEG)-based bifunctional linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
T81433	p-NH2-CHX-A"-DTPA
	p-NH2-CHX-A"-DTPA 是双功能螯合剂。
T18080	m-PEG-acrylate (MW 30000)	Others	Others
	m-PEG-acrylate (MW 30000) is a polyethylene glycol (PEG)-based bifunctional linker commonly employed in the chemical synthesis of proteolysis targeting chimeras (PROTACs)[1].
T17469	Azide-PEG3-Sulfone-PEG3-azide	Others	Others
	Azide-PEG3-Sulfone-PEG3-azide is a polyethylene glycol (PEG)-based bifunctional molecule, specifically designed as a PROTAC linker for the synthesis of PROTACs[1].
T81384	PROTAC BRD9 Degrader-3	PROTACs	PROTAC
	PROTACBRD9 Degrader-3为BRD9靶向的双功能降解剂，用于癌症研究。
T31584	DST Crosslinker DST Cross linker,DST Cross-linker
	DST crosslinker(disuccinimide tartarate) is an isotype bifunctional, cleavable crosslinker (cleavable by an oxidizer) for applications that require crosslinking cleavability and that do not interfere with protein disulfide bonds with reducing agents.
T77936	PROTAC BRD9 Degrader-4	PROTACs	PROTAC
	PROTACBRD9 Degrader-4 是一种针对BRD9的双功能降解剂，用于癌症研究。
T18413	N-Desthiobiotin-N-bis(PEG4-t-butyl ester)	Others	Others
	N-Desthiobiotin-N-bis(PEG4-t-butyl ester) is a PEG-based linker compound employed for the synthesis of PROTACs, which are bifunctional molecules designed for targeted protein degradation[1].
T69149	L2-b
	L2-b is a bifunctional Aβ-interacting, metal-chelating molecule that modulates ROS production in, and improves survival of neuroblastoma cells incubated in the presence of Aβ along with Copper or Zinc. In cell-free aggregation studies, L2-b inhibits metal-induced Aβ aggregation, and also promotes the dissociation of Ab aggregates in homogenates of human AD brain samples.
T81385	PROTAC BRD9 Degrader-2	PROTACs	PROTAC
	PROTACBRD9 Degrader-2是针对癌症研究的BRD9双功能性降解剂。
T77155	Dalutrafusp alfa
	Dalutrafusp alfa (AGEN-1423; GS-1423) 为针对CD73与TGF-β的特异性双功能抗体，涉及免疫抑制路径。
T26049	RB 6145 RB6145,RB-6145
	RB 6145是一种双功能硝基咪唑，低氧细胞放射增敏剂RSU 1069的前药，它的毒性较RSU 1069降低。它具有缺氧细胞优先细胞毒性和抗肿瘤治疗活性。
T81779	M-MoDE-A (2)	LYTACs	PROTAC
	M-MoDE-A (2)为双功能小分子，其作用机理包括促进通过ASGPR (去唾液酸糖蛋白受体) 介导的细胞外蛋白质降解。
T32026	GYKI-13324 GYKI 13324,GYKI13324
	GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, b
T31588	Dynasylan 1161 Y 9138
	Dynasylan 1161 是一种双官能有机硅烷，可以与合适的聚合物反应。在水存在时，Dynasylan 1161可与各种无机基材结合。
T82560	di-Ellipticine-RIBOTAC	PROTACs	PROTAC
	Di-Ellipticine-RIBOTAC是一款双功能小分子，在体外和体内肌萎缩侧索硬化（ALS）模型中能够减少c9ALS/FTD r(G4C2)的重复扩增。
T81675	NICE-01 AP1867-PEG2-JQ1,AP-PEG2-JQ1
	NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1)是一款具有双功能的化合物，它通过特异性结合到细胞内特定亚细胞区室中的蛋白质，并以BRD4蛋白的核定位含溴结构域作为诱导，实现将胞浆中的货物输送至细胞核。
T68942	Caricotamide
	Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over...
T28464	p-SCN-Bn-TCMC HCl p-SCN-Bn-TCMC
	p-SCN-Bn-TCMC is a bifunctional chelator, it contains a powerful chelator TCMC and reactive tioisocyante linker. TCMC is a powerful chelator with capability to strongly bind radio-isotopic heavy metal ion, which are widely used for radio-diagnostic/imagin
T78879	CXCR4-IN-2	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	CXCR4-IN-2（compound A1）是一款具有抗癌活性的双功能氟化小分子，是CXCR4的强效抑制剂。它对小鼠结直肠癌(CRC)细胞展现出显著的细胞毒性（IC50：60 μg/mL；72小时）和抗增殖能力，能够引导细胞在G2/M期发生阻滞并诱导细胞凋亡(apoptosis)。
T78352	N-acetylglucosamine-1-P uridyltransferase (AGX1) GlcNAc1pUT
	N-acetylglucosamine-1-P uridyltransferase (AGX1) (GlcNAc1pUT) 是具有双功能乙酰转移酶/尿苷转移酶活性的原核生物专有酶。该酶能结合GlcNAc-1-P与UTP，催化合成UDP-GlcNAc的尿苷酰转移反应。
T82866	Biotin-PEG-Biotin (MW 20000)
	Biotin-PEG-azide (MW 2000) 为含有生物素标记的聚乙二醇 (PEG) 衍生物。该生物素（Biotin）作为酶辅因子，在蛋白质标记应用中具有重要作用，而PEG是低毒性且具亲水性的水溶性聚合物。
T81035	TAT-NSF222 Fusion Peptide
	TAT-NSF222 Fusion Peptide为包含TAT和NSF两个结构域的融合多肽，TAT负责通过巨胞饮促进细胞摄取，而NSF结构域则抑制N-乙基马来酰亚胺敏感因子(NSF)活性。该融合多肽是exocytosis的抑制剂。
T79618	M3/PDE4 modulator-1
	M3/PDE4 modulator-1 (10f) 为多功能化合物，具备M3mAChR拮抗和PDE4抑制作用。于OVA大鼠模型中，M3/PDE4 modulator-1 (10-1000 nM/kg；iv) 能降低半胱氨酸嗜酸性粒细胞内流。

化合物

Cat.No: T39710

Synonym: Vepdegestrant

Target: Estrogen Receptor/ERR

Cat.No: T6798

Synonym: 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829

Target: DNA Alkylator/Crosslinker, DNA Alkylation

N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]- Thiourea

Cat.No: T7750

Synonym: N-[3,5-双(三氟甲基)苯基]-N′-[(9R)-6′-甲氧基-9-金鸡宁]硫脲

Target: Others

Cat.No: T11938L

Target: Others

Cat.No: T17159

Synonym: NSC 39069,曲奥舒凡,Treosulphan

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Cat.No: T15178

Target: Others

Sulfo-SMCC sodium

Cat.No: T18728

Target: Others

Proguanil hydrochloride

Cat.No: T4382

Synonym: Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil

Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite

Cat.No: T26803

Synonym: Bibw22,Bibw-22

Cat.No: T19207

Target: Others

N-(Azido-PEG2)-N-Boc-PEG4-Boc

Cat.No: T16181

Target: Others

t-Boc-Aminooxy-PEG7-bromide

Cat.No: T18744

Target: Others

9-Azido-Neu5DAz

Cat.No: T19168

Target: Others

Cat.No: T28846

Synonym: AT-202,AT202,SR 16835,SR-16835

Aminooxy-PEG3-C2-NH-Boc

Cat.No: T14267

Target: Others

Cat.No: T25140

Synonym: BCH2763,BCH-2763

Fmoc-N-PEG36-acid

Cat.No: T17962

Target: Others

Cat.No: T70925

Cat.No: T82537

Target: LYTACs

Ald-Ph-amido-C2-PEG3-NH-Boc

Cat.No: T14163

Target: Others

Batefenterol Succinate

Cat.No: T68272

FmocNH-PEG4-t-butyl acetate

Cat.No: T41024

Synonym: FmocNH-PEG4-t-butyl acetate

Cat.No: T40648

Cat.No: T34173

Thiol-PEG-CH2COOH (MW 5000)

Cat.No: T18834

Target: Others

N-Mal-N-bis(PEG4-NHS ester)

Cat.No: T16234

Target: Others

Azido-PEG4-hydrazide-Boc

Cat.No: T14449

Target: Others

p-NH2-CHX-A"-DTPA

Cat.No: T81433

m-PEG-acrylate (MW 30000)

Cat.No: T18080

Target: Others

Azide-PEG3-Sulfone-PEG3-azide

Cat.No: T17469

Target: Others

PROTAC BRD9 Degrader-3

Cat.No: T81384

Target: PROTACs

DST Crosslinker

Cat.No: T31584

Synonym: DST Cross linker,DST Cross-linker

PROTAC BRD9 Degrader-4

Cat.No: T77936

Target: PROTACs

N-Desthiobiotin-N-bis(PEG4-t-butyl ester)

Cat.No: T18413

Target: Others

Cat.No: T69149

PROTAC BRD9 Degrader-2

Cat.No: T81385

Target: PROTACs

Dalutrafusp alfa

Cat.No: T77155

Cat.No: T26049

Synonym: RB6145,RB-6145

Cat.No: T81779

Target: LYTACs

Cat.No: T32026

Synonym: GYKI 13324,GYKI13324

Cat.No: T31588

Synonym: Y 9138

di-Ellipticine-RIBOTAC

Cat.No: T82560

Target: PROTACs

Cat.No: T81675

Synonym: AP1867-PEG2-JQ1,AP-PEG2-JQ1

Cat.No: T68942

p-SCN-Bn-TCMC HCl

Cat.No: T28464

Synonym: p-SCN-Bn-TCMC

Cat.No: T78879

Target: CXCR

N-acetylglucosamine-1-P uridyltransferase (AGX1)

Cat.No: T78352

Synonym: GlcNAc1pUT

Biotin-PEG-Biotin (MW 20000)

Cat.No: T82866

TAT-NSF222 Fusion Peptide

Cat.No: T81035

M3/PDE4 modulator-1

Cat.No: T79618

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼