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Cat. No. | Product Name | Target | Signaling Pathways |
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T7644 |
DPN
Diarylpropionitrile,2,3-双(4-羟苯基)丙腈 |
Apoptosis; Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones |
DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 ERβ选择性配体,其 EC50值为 0.85 nM。DPN 在许多神经系统疾病具有神经保护作用。 | |||
T23483 |
U 99194 maleate
U-99194A maleate,U-99194 maleate salt,U-99194 maleate |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
U 99194 maleate (U-99194A maleate) 是一种 D3 拮抗剂,可增加隔离诱导的攻击性雄性小鼠的社会行为。 | |||
T35707 |
3'-Sialyllactose sodium
3'-SL sodium |
NF-κB | NF-κB |
3'-Sialyllactose sodium 是一种益生元,具有抗炎活性,可维持免疫稳态。3'-Sialyllactose sodium 可减少压力源引起的焦虑样行为,可用于研究炎症和关节炎。 | |||
TP1981L |
Neuropeptide S (Mouse) acetate
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Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Neuropeptide S (Mouse) acetate 是一种生物活性肽。它作为 20 种氨基酸的神经递质/神经调节剂,可用于觉醒、焦虑、运动、摄食行为、记忆和药物成瘾的研究。 | |||
T28033 |
MGS0028
MGS 0028,MGS-0028 |
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MGS0028 is a selective agonist of metabotropic glutamate 2/3 receptor, it could reverse abnormal behaviors in mice induced by isolation rearing. | |||
T28713 |
Sch 32615
Sch-32615,Sch32615 |
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Sch 32615 is an enkephalinase inhibitor with inhibitory action on D-1 and D-2 dopamine receptor-mediated behaviors. | |||
T68633 |
Cinuperone
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Cinuperone is an antagonist of D2, alpha1 adrenergic and sigma receptors. The drug selectively inhibits dopamine agonists-dependent behaviors, mediated by the limbic system. The clinical development of the drug as an antipsychotic was terminated due to orthostasis. | |||
T21470 |
Davunetide
AL-208,AL 208,AL 108,AL-108 |
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Davunetide is an eight amino acid peptide (NAPVSIPQ) with potent neuroprotection in vitro and in vivo. Davunetide has been shown to enhance functional daily behaviors in schizophrenia patients and to increase memory scores in patients suffering from amnes | |||
T37920 |
7(Z),11(Z)-Heptacosadiene
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The mating and social behaviors of insects are largely orchestrated by a suite of volatile cuticular hydrocarbon pheromones. 7(Z),11(Z)-Heptacosadiene is the predominant female-specific courtship pheromone of the fruit fly D. melanogaster. At amounts above 100 ng, 7(Z),11(Z)-heptacosadiene elicits wing vibrations in male D. melanogaster flies in a dose-dependent manner. | |||
T71484 |
Utatrectinib
AZD-7451 |
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Utatrectinib (AZD-7451) 是一种有效的、选择性的和具有口服活性的Trk 抑制剂。Utatrectinib 可阻断TrkC 激活和相关的致瘤行为。 | |||
T12778 |
RTI-13951-33 hydrochloride
RTI-13951-33 hydrochloride (2244884-08-8 free base) |
Others | Others |
RTI-13951-33 hydrochloride 是一种有效的、选择性的、可透过血脑屏障的GPR88激动剂。RTI-13951-33 hydrochloride 在 GPR88 cAMP 功能性测定中,EC50值为 25 nM。RTI-13951-33 hydrochloride 可以降低大鼠酒精强化和摄入行为。 | |||
T81033 |
TAT-P4-(DATC5)2
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TAT-P4-(DATC5)2 是PICK1 PDZ领域的高亲和性多肽抑制剂,具有 Ki 值为1.7 nM。在大鼠成瘾模型实验中,该化合物展现出抑制作用。 | |||
T80848 |
VUAA1
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VUAA1为昆虫气味辅助受体(Orco)激动剂,能够激活具Orco的异聚及同聚通道,进而干扰害虫的破坏性行为,适用于昆虫嗅觉方面的研究。 | |||
T81032 |
TAT-P4-(DATC5)2 TFA
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TAT-P4-(DATC5)2 TFA是一种针对蛋白激酶C相互作用蛋白1 PDZ结构域(PICK1 PDZ domain)具有高亲和力的多肽抑制剂,Ki值为1.7 nM。该化合物在大鼠成瘾模型实验中展示了抑制效果。 | |||
T37389 |
NS 383
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ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats. | |||
T76365 |
CART (1-39), Human, Rat
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CART (1-39), Human, Rat, 是一种由其1至39个残基构成的神经肽, 具有明显的减少食欲作用, 被认为是鼠类的饱腹因子, 并与瘦素及神经肽Y有着紧密的联系。它能有效抑制正常及饥饿状态下的摄食行为, 同时也能引发焦虑与压力相关的反应。 | |||
T23337 |
SCH772984 HCl
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ERK; Others | MAPK; Others |
SCH772984 HCl 是一种特异性的 ERK1/2 抑制剂,具有 I 型和 II 型激酶抑制剂的特性,其 IC50 分别为 4 和 1 nM。 SCH772984 HCl 在 BRAF、NRAS 或 KRAS 突变的肿瘤细胞中具有纳摩尔级细胞效力,并诱导肿瘤消退。 SCH772984 HCl 可用于 MAPK 抑制剂难治性肿瘤的研究。 | |||
T19652 |
IR-825
|
Others | Others |
IR-825 是一种近红外染料。 IR-825 纳米粒子显示出 pH 依赖性荧光发射和对体外靶向癌细胞的出色近红外辐射,以提供细胞毒性。 IR-825 纳米颗粒显示出有效的肿瘤归巢以及快速的肾脏排泄行为,如 MR 成像所揭示并通过生物分布测量得到证实。 | |||
T83894 |
4A7C-301-Nurr1 Agonist
4A7C-301-Nuclear Receptor-Related 1 |
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4A7C-301-Nurr1激动剂是一种核受体相关1(Nurr1)的激动剂。它通过与Nurr1配体结合域(LBD;IC50 = 48.22 nM)结合,增加了在使用SK-N-BE(2)C人神经母细胞瘤细胞进行的报告基因测定中Nurr1-LBD和全长Nurr1的转录活性(EC50s = 6.53 和 50-70 µM,分别)。每天5 mg/kg的4A7C-301-Nurr1激动剂能减少在经MPTP神经毒素或α-突触核蛋白过表达诱导的帕金森病鼠模型中纹状体和黑质compacta部分多巴胺能细胞的死亡,并减少运动和嗅觉缺陷,而不诱发类似运动障碍的行为。 | |||
T80242 |
TNO211
|
MMP | Proteases/Proteasome |
TNO211为具备生物活性的肽,主要研究对象是基质金属蛋白酶(MMP),一类能够降解多种细胞外基质蛋白并调控诸多生物活性分子的肽链内切酶家族。MMP在细胞表面受体裂解、凋亡配体释放及趋化因子/细胞因子失活等过程中起作用,同时与细胞增殖、迁移(粘附/分散)、分化、血管生成、细胞凋亡及宿主防御等生物行为密切相关。TNO211可靶向MMP-2、8、12、13和14,包含MMP特定可裂解的Gly-Leu键,并具有EDANS/DABCYL荧光标记,其荧光检测在监测内皮细胞培养基和患者滑液中的MMP活性方面表现出高灵敏度。吸光度/电磁场测量参数为340/490 nm。 | |||
T37201 |
CAY10787
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CAY10787 is an oxysterol and a negative allosteric modulator of GABAAreceptors.1,2It reduces GABA-induced currents in HEK cells expressing α1β1γ2or α4β3γ2subunit-containing GABAAreceptors (IC50s = 1.5 and 1 μM, respectively).2CAY10787 (500 nM) reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons.In vivo, CAY10787 (2, 10, and 50 mg/kg) increases latency to nocifensive behaviors in t... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4S1469 |
Cucurbitacin IIb
葫芦素IIB,雪胆素乙 |
Apoptosis; Others | Apoptosis; Others |
Cucurbitacin IIb 是一种雪胆中的活性成分。它阻碍 STAT3,JNK 和 Erk1/2 的磷酸化,提高 IκB 和 NF-κB (p65) 的磷酸化水平,抑制 NF-κB (p65) 的核转位,降低 IκBα 和 TNF-α 的 mRNA 水平。它能够诱导细胞凋亡,具有抗炎作用。 |