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Search Results for " atherogenic "

12

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4628	Seladelpar MBX 8025	PPAR	DNA Damage/DNA Repair; Metabolism
	Seladelpar (MBX 8025) 是一种有效的，具有口服活性的，特异性PPAR-δ激动剂，EC50为 2 nM。
T27706	K-111 BM170744,BM 170744,BM-170744,K111
	K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.
T35956	PAz-PC
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. PAz-PC is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL.
T36172	KOdiA-PC
	Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species. KOdiA-PC confers CD36 scave...
T36171	KDdiA-PC
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. KDdiA-PC is one of the most potent CD36 ligands among the oxLDL species. KDdiA-PC confers CD-36 scavenger receptor binding affinity to LDL at a frequency of only two...
T62598	Pitavastatin sodium
	Pitavastatin (NK-104) sodium 是一种有效的羟甲基戊二酰-CoA(HMG-CoA) 还原酶抑制剂，也是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。Pitavastatin sodium 在 HepG2 细胞中，能够抑制乙酸合成胆固醇 (IC50: 5.8 nM) 。Pitavastatin sodium 表现出抗动脉粥样硬化、抗哮喘、抗骨关节炎、神经保护、抗肿瘤、肝保护和肾保护作用。
T35580	POV-PC
	Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine, or POV-PC, is one of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC conf...
T35799	MBX-8025 (sodium salt)
	MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin...
T62974	Pactimibe sulfate
	Pactimibe sulfate (CS-505) 是一种双重的 ACAT1/2 抑制剂，能够作用于 ACAT1 (IC50: 4.9 μM)、ACAT2 (IC50: 3.0 μM)。Pactimibe sulfate 对 ACAT 表现出抑制作用，在肝细胞中 IC50=2.0 μM，在巨噬细胞中 IC50=2.7 μM，在 THP-1 细胞中 IC50=4.7 μM。Pactimibe sulfate 能够非竞争性地抑制 oleoyl-CoA (Ki: 5.6 μM)，显著抑制胆固醇酯的形成 (IC50: 6.7 μM)。Pactimibe sulfate 能够降低血浆胆固醇的活性，具有抗动脉粥样硬化的潜力。
T83710	Gastric Inhibitory Peptide (22-51) (human) TFA GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)
	胃抑制肽(GIP) (22-51) 是一种具有30个氨基酸的前动脉硬化肽，对应于GIP前体蛋白proGIP的第22至51个氨基酸残基，已在人类血浆中发现。在1 µM的浓度下使用，该肽能引起在巨峰细胞分化的THP-1细胞和分离的人类主动脉内皮细胞中IκB-α的降解和NF-κB的核转移。在体内，GIP (22-51) 增加了ApoE-/-小鼠的动脉粥样硬化病变面积和斑块形成。
T81900	LVGRQLEEFL (mouse) (TFA)
	LVGRQLEEFL (mouse) TFA，即G*肽，对应[113,122]apoJ中的第113至122位氨基酸序列，表现出抗炎与抗动脉粥样硬化的特性。该肽能够整合至apoJ模拟物，生成HM-10/10肽，一种新型嵌合高密度脂蛋白模拟肽。HM-10/10肽能够保护视网膜色素上皮(RPE)及光感受器，防止氧化剂引起的细胞死亡。
T81901	LVGRQLEEFL (mouse)
	LVGRQLEEFL（mouse）即G*肽，为[113,122]apoJ中113至122位氨基酸序列。该化合物展现抗炎与抗动脉粥样硬化功能。将LVGRQLEEFL（mouse）整合至apoJ模拟物，可生成HM-10/10肽，此为一种模拟肽及新型嵌合高密度脂蛋白。HM-10/10肽能守护视网膜色素上皮（RPE）及光感受器，防止氧化剂诱导下的细胞死亡。

化合物

Cat.No: T4628

Synonym: MBX 8025

Target: PPAR

Cat.No: T27706

Synonym: BM170744,BM 170744,BM-170744,K111

Cat.No: T35956

Cat.No: T36172

Cat.No: T36171

Pitavastatin sodium

Cat.No: T62598

Cat.No: T35580

MBX-8025 (sodium salt)

Cat.No: T35799

Pactimibe sulfate

Cat.No: T62974

Gastric Inhibitory Peptide (22-51) (human) TFA

Cat.No: T83710

Synonym: GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)

LVGRQLEEFL (mouse) (TFA)

Cat.No: T81900

LVGRQLEEFL (mouse)

Cat.No: T81901

Cat. No.	Product Name	Target	Signaling Pathways
T6917	Oleuropein 洋橄榄苦甙,橄榄苦苷	Apoptosis; Aromatase; ROS; PPAR	Apoptosis; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism
	Oleuropein 在橄榄叶和油中发现的天然产物，通过 p53 依赖性途径以及 Bax 和 Bcl2基因的调控来诱导乳腺癌细胞凋亡，还抑制芳香化酶。它可通过直接抑制 PPARγ转录活性来发挥抗氧化，抗炎和抗动脉粥样硬化作用。
TN2883	3',4'-Dimethoxyflavone	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准，类黄酮化合物具有多种药用活性。
TQ0188	Miquelianin 槲皮素-3-O-葡萄糖醛酸苷,Quercetin 3-glucuronide,Quercetin 3-O-glucuronide	stilbene oxidase; Endogenous Metabolite	Metabolism
	Miquelianin (Quercetin 3-glucuronide) 是槲皮素的代谢产物，属于类黄酮化合物。
TN1118	Tormentic acid 2Α,19Α-二羟基熊果酸,委陵菜酸	Immunology/Inflammation related	Immunology/Inflammation
	Tormentic acid 是一种分离自 Rosa rugosa 中的三萜，具有抗炎、降血脂和抗动脉粥样硬化活性。
TQ0165	Arglabin 阿格拉宾,(+)-Arglabin	NOD-like Receptor (NLR); Transferase; NOD; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Arglabin ((+)-Arglabin) 是从青蒿中分离出的一种天然产物，是一种 NLRP3 炎性体抑制剂，具有抗动脉粥样硬化和抗癌作用。
TN1943	Momordicoside G	Others	Others
	Momordicosides K and L, the main bitter taste triterpene glycosides in Bitter melon; and bitter melon has been reported to have hypoglycemic, anti atherogenic and anti HIV activities.

天然产物

Cat.No: T6917

Synonym: 洋橄榄苦甙,橄榄苦苷

Target: Apoptosis, Aromatase, ROS, PPAR

3',4'-Dimethoxyflavone

Cat.No: TN2883

Target: Others, PARP

Cat.No: TQ0188

Synonym: 槲皮素-3-O-葡萄糖醛酸苷,Quercetin 3-glucuronide,Quercetin 3-O-glucuronide

Target: stilbene oxidase, Endogenous Metabolite

Cat.No: TN1118

Synonym: 2Α,19Α-二羟基熊果酸,委陵菜酸

Target: Immunology/Inflammation related

Cat.No: TQ0165

Synonym: 阿格拉宾,(+)-Arglabin

Target: NOD-like Receptor (NLR), Transferase, NOD, Autophagy

Momordicoside G

Cat.No: TN1943

Target: Others

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