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9

抑制剂 & 化合物

14

天然产物

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Cat. No. Product Name Target Signaling Pathways
T22243 Anserine

L-鹅肌肽,L-Anserine

Endogenous Metabolite Metabolism
Anserine (L-Anserine) 是 Carnosine 的甲基化形式,是口服具有活性的天然二肽,存在于脊椎动物的骨骼肌。它不会被血清肌肽酶裂解,能够作为生化缓冲液,螯合剂,抗糖化剂和抗氧化剂。它能够改善阿尔茨海默氏病模型小鼠的记忆功能。
T20097 Dilauryl thiodipropionate

NSC65494,NSC 65494,NSC-65494

Dilauryl Thiodipropionate is an agent of antioxidants.
T35689 MTP 131 acetate

Others Others
MTP 131 acetate 是一种小的线粒体靶向四肽。
T81880 MAGL-IN-11

MAGL Metabolism
MAGL-IN-11(化合物 29),一种选择性且可逆的MAGL抑制剂,具备研究炎症、癌症和抗氧化潜力。
T36616 DTUN

DTUN is a lipophilic hyponitrite radical initiator.1It initiates co-autoxidation of STY-BODIPY-embedded egg phosphatidylcholine liposomes when used at a concentration of 0.2 mM. DTUN has been used in fluorescence-enabled inhibited autoxidation (FENIX) assays for the development of ferroptosis inhibitors and the study of antioxidants in lipid membranes.1,2 1.Shah, R., Farmer, L.A., Zilka, O., et al.Beyond DPPH: Use of fluorescence-enabled inhibited autoxidation to predict oxidative cell death res...
T35957 PBD-BODIPY

PBD-BODIPY is a probe for the spectrophotometric measurement of autoxidation reactions. Co-autoxidation of the PBD-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring loss of absorbance at 591 nm. PBD-BODIPY has been used to measure the activity of radical-trapping antioxidants in cell-free assays. It has also been used as a fluorescent probe for the detection of epoxidation activity.
T68790 Shinorine

Shinorine, a mycosporine-like amino acid (MAA), is a small molecule sunscreen produced in some bacteria. Shinorine ameliorates chromium induced toxicity in zebrafish hepatocytes through the facultative activation of Nrf2-Keap1-ARE pathway. Shinorine is also an analogue of porphyra-344. Both porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding. Shinorine may be a useful agent to prevent or retard the progression of multiple degenerative disorders of ageing. S...
T36504 STY-BODIPY

STY-BODIPY,Styrene-BODIPY

STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the loss of absorbance at 571 nm. STY-BODIPY has been used to measure the activity of RTAs, as well as the kinetics and stoichiometry of RTA reactions in cell-free assays.1,2,3References1. Haidasz, E.A., Van Kessel, A.T.M., and Pratt, D.A. A continuous visible light spectrophotometric...
T36175 AAPH

AAPH is a water-soluble azo compound which is used extensively as a free radical generator, often in the study of lipid peroxidation and the characterization of antioxidants.[1],[2],[3],[4] Decomposition of AAPH produces molecular nitrogen and 2 carbon radicals. The carbon radicals may combine to produce stable products or react with molecular oxygen to give peroxyl radicals. The half-life of AAPH is about 175 hours (37°C at neutral pH), making the rate of free radical generation essentially con...

化合物

Anserine
Cat.No: T22243
Synonym: L-鹅肌肽,L-Anserine
Target: Endogenous Metabolite
Dilauryl thiodipropionate
Cat.No: T20097
Synonym: NSC65494,NSC 65494,NSC-65494
Target:
MTP 131 acetate
Cat.No: T35689
Synonym:
Target: Others
MAGL-IN-11
Cat.No: T81880
Synonym:
Target: MAGL
DTUN
Cat.No: T36616
Synonym:
Target:
PBD-BODIPY
Cat.No: T35957
Synonym:
Target:
Shinorine
Cat.No: T68790
Synonym:
Target:
STY-BODIPY
Cat.No: T36504
Synonym: STY-BODIPY,Styrene-BODIPY
Target:
AAPH
Cat.No: T36175
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T2902 Costunolide

Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯

Apoptosis; Endogenous Metabolite; Telomerase Apoptosis; DNA Damage/DNA Repair; Metabolism
Costunolide (Costus lactone) 是一种天然的倍半萜内酯,具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性,可诱导乳腺癌细胞周期阻滞和凋亡。
T3839 Cycloolivil

Isoolivil,环橄榄树脂素

Free radical scavengers; Others; Platelet aggregation Others; oxidation-reduction
Cycloolivil (Isoolivil) 是一种天然多酚化合物,在橄榄树中具有显着的自由基清除活性。 Cycloolivil 具有抗氧化活性,它可以预防与血小板过度聚集相关的血栓并发症,是开发抗聚集治疗策略的基础。
T3406 Kuromanin chloride

Glucocyanidin chloride,Chrysontemin,矢车菊素-3-O-葡萄糖苷,Chrysontemin chloride,Cyanidin 3-O-glucoside chloride

NF-κB NF-κB
Kuromanin chloride (Chrysontemin chloride) 是从桑叶中获得,能够提高血糖浓度、维持脂质代谢平衡,表现出降低肥胖的作用。
T0632 3,4,5-Trimethoxybenzoic acid

Gallic acid trimethyl ether,Eudesmic acid,3,4,5-三甲氧基苯甲酸,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid,没食子酸三甲醚

Antioxidant oxidation-reduction
3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) 是一种苯甲酸衍生物,可用作医药和有机合成中的砌块。
T3412 Hydroxytyrosol

2-(3,4-Di-hydroxyphenyl)-ethanol,3-Hydroxytyrosol,Dihydroxyphenylethanol,羟基酪醇,3,4-dihydroxyphenylethanol

Others; Endogenous Metabolite; Antibacterial; Antifungal Metabolism; Microbiology/Virology; Others
Hydroxytyrosol (2-(3,4-Di-hydroxyphenyl)-ethanol) 是从橄榄树及其叶子中提取的一种酚类化合物,具有抗氧化、抗动脉粥样硬化、抗血栓、抗菌、抗炎和抗肿瘤的作用,可用于研究心血管药物。
S00015 Tea polyphenol

Apoptosis; Others; Autophagy Apoptosis; Autophagy; Others
Tea polyphenol 也称为绿茶提取物,是茶中天然存在的酚类化合物,具有抗癌、抗氧化、抑制细胞增殖、诱导细胞凋亡、延缓细胞周期和调节致癌物代谢等生物活性。
T3415 Secoisolariciresinol diglucoside

亚麻木酚素,LGM2605

ROS Immunology/Inflammation
Secoisolariciresinol diglucoside (LGM2605) 在铁过载诱导的氧化还原炎症损伤的体外模型中具有细胞保护作用。 Secoisolariciresinol Diglucoside(25 mg/kg b.w.) 通过抑制 ROS 水平介导的酶和非酶抗氧化剂水平升高来防止肝脏受到过氧化损伤,从而发挥抗高血糖作用。
TCS2070 Homogentisic acid

高龙胆酸,2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid

Antioxidant; Endogenous Metabolite Metabolism; oxidation-reduction
Homogentisic acid (2,5-dihydroxyphenylacetic acid) 是一种尿液和血清代谢物中的特定代谢物,可用于尿黑酸尿症的诊断。
T3729 Ethyl gallate

Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

MMP; NF-κB; Akt; Antibacterial Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T5S1172 Tiliroside

银椴甙,Tribuloside,银椴苷;椴树苷

Antioxidant oxidation-reduction
Tiliroside (Tribuloside) 是糖苷类黄酮,是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收,具有抗糖尿病作用。
TN1551 Danshenxinkun B

Others Others
Danshenxinkun B has antioxIdant activity, it may have the potential of being used as natural antioxidants in foods and cosmetics.
T28122 Myrtenal

NSC-54384,NSC 54384,NSC54384,Benihinal

Myrtenal is a natural monoterpene. It is found to attenuate diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades. Myrtenal also inhibits acetylcholinesterase
TN3412 Andrographiside

Others Others
Andrographiside shows protective effects on hepatotoxicity induced in mice by carbon tetrachloride or tert-butylhydroperoxide (tBHP) intoxication, the effects could be due to its glucoside groups which may act as strong antioxidants.
TN1821 Kaempferol 3-O-arabinoside

山奈酚-3-O-α-L-吡喃阿拉伯糖苷,堪非醇 3-O-阿拉伯糖苷

ROS; Antifection Immunology/Inflammation; Microbiology/Virology
Kaempferol-3-O-α±-D-arabinoside displays cytotoxic and high antioxidant activity.Kaempferol-3-O-arabinoside and kaempferol-3-O-glucoside can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging ROS, and protect cellular membrane against ROS; they can be applicable to new cosmeceuticals for antioxidant, antiaging, and antibacterial activity.

天然产物

Costunolide
Cat.No: T2902
Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯
Target: Apoptosis, Endogenous Metabolite, Telomerase
Cycloolivil
Cat.No: T3839
Synonym: Isoolivil,环橄榄树脂素
Target: Free radical scavengers, Others, Platelet aggregation
Kuromanin chloride
Cat.No: T3406
Synonym: Glucocyanidin chloride,Chrysontemin,矢车菊素-3-O-葡萄糖苷,Chrysontemin chloride,Cyanidin 3-O-glucoside chloride
Target: NF-κB
3,4,5-Trimethoxybenzoic acid
Cat.No: T0632
Synonym: Gallic acid trimethyl ether,Eudesmic acid,3,4,5-三甲氧基苯甲酸,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid,没食子酸三甲醚
Target: Antioxidant
Hydroxytyrosol
Cat.No: T3412
Synonym: 2-(3,4-Di-hydroxyphenyl)-ethanol,3-Hydroxytyrosol,Dihydroxyphenylethanol,羟基酪醇,3,4-dihydroxyphenylethanol
Target: Others, Endogenous Metabolite, Antibacterial, Antifungal
Tea polyphenol
Cat.No: S00015
Synonym:
Target: Apoptosis, Others, Autophagy
Secoisolariciresinol diglucoside
Cat.No: T3415
Synonym: 亚麻木酚素,LGM2605
Target: ROS
Homogentisic acid
Cat.No: TCS2070
Synonym: 高龙胆酸,2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid
Target: Antioxidant, Endogenous Metabolite
Ethyl gallate
Cat.No: T3729
Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯
Target: MMP, NF-κB, Akt, Antibacterial
Tiliroside
Cat.No: T5S1172
Synonym: 银椴甙,Tribuloside,银椴苷;椴树苷
Target: Antioxidant
Danshenxinkun B
Cat.No: TN1551
Synonym:
Target: Others
Myrtenal
Cat.No: T28122
Synonym: NSC-54384,NSC 54384,NSC54384,Benihinal
Target:
Andrographiside
Cat.No: TN3412
Synonym:
Target: Others
Kaempferol 3-O-arabinoside
Cat.No: TN1821
Synonym: 山奈酚-3-O-α-L-吡喃阿拉伯糖苷,堪非醇 3-O-阿拉伯糖苷
Target: ROS, Antifection
TargetMol Loading
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