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Search Results for " antileishmanial "

34

抑制剂 & 化合物

16

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40117	Antileishmanial agent-1
	Antileishmanial agent-1 demonstrates activity against both L. amazonensis promastigotes (IC 50 = 15.52 μM) and intracellular amastigotes (IC 50 = 4.10 μM).
T61100	Antileishmanial agent-4
	Antileishmanial agent-4 是一种核糖核苷类似物，作为抗黑热病试剂。
T79471	Antileishmanial agent-20	Parasite	Microbiology/Virology
	Antileishmanial agent-20 显示对利什曼原虫的选择性抑制作用，其针对L. infantum和L. braziliensis的IC50值分别为2.8 μM 和0.2 μM，适用于寄生虫研究领域。
T83045	Antileishmanial agent-25	Parasite	Microbiology/Virology
	Antileishmanial agent-25（compound 24）展现了对胞内无尾线虫的选择性抗力士曼体活性，其半抑制浓度（IC50）为6.63 μM。
T79632	Antileishmanial agent-21	Parasite	Microbiology/Virology
	Antileishmanial agent-21 (compound 4e)，是靶向利什曼原虫蝶啶还原酶1 (Lm-PTR1) 的抗利什曼虫试剂。该化合物通过抗叶酸机制发挥作用，且其抗利什曼活性能被叶酸和亚叶酸逆转。Antileishmanial agent-21 还能抑制对 Chloroquine 抗性的恶性疟原虫菌株 (RKL9)，IC50 范围为0.0198-0.096 μM。
T60638	Antileishmanial agent-8
	Antileishmanial agent-8 (compound 18) 对杜氏利什曼原虫 (L. donovani) 显示出有效的和选择性的杀伤活性(IC50 = 5.64 μM)，并且对 L-6 细胞显示相对较低的细胞毒性 (IC50=73.9 μM)。
T79633	Antileishmanial agent-22	Parasite	Microbiology/Virology
	Antileishmanial agent-22 (compound 15b)是一种抗寄生虫和抗菌化合物，展示了对抗利什曼病、疟疾和结核病的活性。该化合物通过抗叶酸途径抑制利什曼原虫（IC50=0.408 μM）。在100 μM浓度时，Antileishmanial agent-22对叶酸和亚叶酸的抑制率分别达到88%和94%。在体内，以48.4 μM/kg/day剂量对伯氏疟原虫展示96.67%的抑制效果；在体外，其IC50值为0.038 μM。Antileishmanial agent-22还能抑制结核分枝杆菌，MIC值为28.44 μM。
T79419	Antileishmanial agent-24	Parasite	Microbiology/Virology
	Antileishmanial agent-24 (compound 33) Exhibiting an IC50 of 5.39 μM against the amastigote form.
T62210	Antileishmanial agent-10
	Antileishmanial agent-10 (Compound 7h) 是一种抗原虫 (antiprotozoal) 剂。
T78963	Antileishmanial agent-16	Parasite	Microbiology/Virology
	Antileishmanial agent-16 (化合物 14c) 是一种针对Leishmania的抗原虫剂，表现出针对Leishmaniamajor前鞭毛体的高效活性（IC50=0.59 µM）以及对Leishmaniamajor无鞭毛体的有效活性（IC50=0.81 µM）。此外，Antileishmanial agent-16对哺乳动物细胞（VERO 细胞）的毒性低，说明其具有较好的安全性。
T61416	Antileishmanial agent-9
	Antileishmanial agent-9 (compound 16c) exhibits potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. In addition, this compound demonstrates relatively low cytotoxicity in L-6 cells, with an IC50 value of 40.1 μM [1].
T61710	Antileishmanial agent-7
	Antileishmanial agent-7 (compound 23) exhibits strong antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively [1].
T61391	Antileishmanial agent-3
	Antileishmanial agent-3 (Compound 13) 是一种很有前景的Leishmania major 的生长抑制剂。
T63281	Antileishmanial agent-11
	Antileishmanial agent-11 是有效的抗利什曼原虫剂，能够作用于 Leishmania brazilensis (IC50: 28.3 μM)、Leishmania infantum (IC50: 24.8 μM) 和T. cruzi(IC50: 13.0 μM) 具有出抗原虫作用。
T62574	Antileishmanial agent-6
	Antileishmanial agent-6 是一种有效的抗利什曼虫剂。Antileishmanial agent-6 对Leishmania donovani 和 L-6 具有抗利什曼虫活性 (IC50: 0.54 μM) 和细胞毒性 (IC50: 10.2 μM) 作用。
T79390	Antileishmanial agent-23	Parasite	Microbiology/Virology
	Antileishmanial agent-23 (compound G1/9) 作为一种选择性trypanothione reductase (TR)抑制剂效力显著，展现了2.24 ± 0.52 μM的IC50值。该化合物有效抑制了利什曼原虫、克氏锥虫和布氏锥虫的生长。
T72260	Antileishmanial agent-13
	Antileishmanial agent-13 是一种喹啉-靛蓝杂交物，可作为抗利什曼病试剂，抑制L. MajorLeishmania 株系。Antileishmanial agent-13 通过抗叶酸机制获得其抗利什曼病活性。Antileishmanial agent-13 对前鞭毛体和无鞭毛体均具有较强的抑制作用，IC50分别为 0.604 μM 和 0.508 μM。
T61560	Antileishmanial agent-5
	Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L.infantum and T.cruzi, having EC 50 values of 0.68 μM and 0.83 μM, respectively [1].
T78680	Antileishmanial agent-14	Parasite	Microbiology/Virology
	Antileishmanial agent-14，一种磺胺类类似物，展现了对Leishmaniadonovani promastigotes的潜在活性(IC50=4.1 μM)。该化合物同时对L. donovani amastigotes的感染也具有抑制作用(IC50=11.1 μM)。
T79449	Antileishmanial agent-19	Parasite	Microbiology/Virology
	Antileishmanial agent-19 (Compound F27)是一种有效的抗利什曼病试剂，其对L. donovani promastigotes的IC50值为3.39 μM。该化合物能够抑制L. donovani promastigotes中的脯氨酰-tRNA合成酶，并干预宿主PI3K/Akt/CREB轴，从而抑制IL-10的分泌。此外，Antileishmanial agent-19能诱导L. donovani promastigotes自噬介导的细胞凋亡(apoptosis)过程，并在感染的动物体内显著减少寄生虫负担。
T62330	Antileishmanial agent-12
	Antileishmanial agent-12 (compound 5a) 是一种有效的抗利什曼原虫剂，对 Leishmania brazilensis (IC50: 14.9 μM)、Leishmania infantum (IC50: 21.3 μM) 和 T. cruzi (IC50: 9.3 μM) 具有抗原虫作用。
T78964	Antileishmanial agent-17	Parasite	Microbiology/Virology
	Antileishmanial agent-17是香豆素杂化化合物，展现出优越的抗利什曼原虫活性(IC50<0.78 μM)，同时对VERO细胞具备安全性。该化合物通过抑制叶酸代谢途径发挥效用，且在对抗利什曼原虫不同生长阶段表现显著，其IC50值分别对前鞭毛体为0.40 μM，对无鞭毛体为0.68 μM。
T78962	Antileishmanial agent-15	Parasite	Microbiology/Virology
	Antileishmanial agent-15 (compound 13c) 是针对L. major前鞭毛体和无鞭毛体的高效抗利什曼原虫分子，展现出显著的抗原虫活性和细胞毒性，其IC50值分别为0.78 μM和0.99 μM。
T12137	N-(2-Hydroxypropyl)methacrylamide	Parasite	Microbiology/Virology
	N-(2-Hydroxypropyl)methacrylamide 用于合成共聚物，用于靶向递送内脏利什曼病中的抗寄生虫剂。
T15546	ICA N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine	Potassium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) 是有效的 SK 通道抑制剂。ICA 显示出抗利什曼原虫的活性，IC50为2.1 µM。
T9858	5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole	Parasite	Microbiology/Virology
	Antileishmanial agent-2 是一种基于 3-Br-isoxazoline 的疟原虫抑制剂恶性疟原虫（D10 和 W2 菌株）和利什曼原虫属。 (L. infantum 和 L.tropica) 前鞭毛体，IC50 为 0.035、0.058、3.5 和 7.5 μM。
T24011	DNDI-8219
	DNDI-8219 is an antitubercular agent. It has potent antileishmanial effects.
T35998	3,5-Dihydroxybenzaldehyde
	3,5-Dihydroxybenzaldehyde is a building block.1,2It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities. 1.Taha, M., Baharudin, M.S., Ismail, N.H., et al.Synthesis of 2-methoxybenzoylhydrazone and evaluation of their antileishmanial activityBioorg. Med. Chem. Lett.23(11)3463-3466(2013) 2.Taha, M., Ismail, N.H., Jamil, W., et al.Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazonesMolecules1...
T28609	Rohitukine NSC623611,NSC-623611,NSC 623611
	Rohitukine is an anti-cancer agent. It modulates apoptosis pathways through gastrin antagonism and H(+) K (+)-ATPase inhibition. Rohitukine ia an antiadipogenic, antidyslipidemic, gastroprotective, antifertility, and antileishmanial compound.
T80967	Topoisomerase I inhibitor 9	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseI inhibitor 9 (compound 3d) 是针对leishmanial topoisomerase IB的抑制剂，具有针对L. donovani promastigotes的抗利什曼原虫活性，其IC50值为34.81 μM。
T78620	Phylloflavan	Parasite	Microbiology/Virology
	Phylloflavan，一种抗利什曼病剂，在RAW 264.7细胞中显示出3.2 nM的EC50。此外，Phylloflavan能够抑制脑心肌炎病毒对L929成纤维细胞的细胞病变作用，其活性为38 U/mL。
T80968	Topoisomerase I inhibitor 10	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseI inhibitor 10 (compound 13)为一种抗利什曼原虫活性药物，特别针对L. donovani promastigotes的leishmanial topoisomerase IB表现出抑制作用，IC50值为27.91 μM。
T62328	Cabotegravir sodium
	Cabotegravir sodium 是一种 HIV 整合酶的高效抑制剂，能够作用于 HIVADA (IC50: 2.5 nM)。Cabotegravir sodium 主要由尿苷二磷酸葡萄糖醛酸转移酶 (UGT) 1A1 代谢，与其他抗逆转录病毒药物 (ARVs) 相互作用的可能性较小。
T37469	Sitamaquine tosylate
	Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin f...

化合物

Antileishmanial agent-1

Cat.No: T40117

Antileishmanial agent-4

Cat.No: T61100

Antileishmanial agent-20

Cat.No: T79471

Target: Parasite

Antileishmanial agent-25

Cat.No: T83045

Target: Parasite

Antileishmanial agent-21

Cat.No: T79632

Target: Parasite

Antileishmanial agent-8

Cat.No: T60638

Antileishmanial agent-22

Cat.No: T79633

Target: Parasite

Antileishmanial agent-24

Cat.No: T79419

Target: Parasite

Antileishmanial agent-10

Cat.No: T62210

Antileishmanial agent-16

Cat.No: T78963

Target: Parasite

Antileishmanial agent-9

Cat.No: T61416

Antileishmanial agent-7

Cat.No: T61710

Antileishmanial agent-3

Cat.No: T61391

Antileishmanial agent-11

Cat.No: T63281

Antileishmanial agent-6

Cat.No: T62574

Antileishmanial agent-23

Cat.No: T79390

Target: Parasite

Antileishmanial agent-13

Cat.No: T72260

Antileishmanial agent-5

Cat.No: T61560

Antileishmanial agent-14

Cat.No: T78680

Target: Parasite

Antileishmanial agent-19

Cat.No: T79449

Target: Parasite

Antileishmanial agent-12

Cat.No: T62330

Antileishmanial agent-17

Cat.No: T78964

Target: Parasite

Antileishmanial agent-15

Cat.No: T78962

Target: Parasite

N-(2-Hydroxypropyl)methacrylamide

Cat.No: T12137

Target: Parasite

Cat.No: T15546

Synonym: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine

Target: Potassium Channel, Parasite

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Cat.No: T9858

Target: Parasite

Cat.No: T24011

3,5-Dihydroxybenzaldehyde

Cat.No: T35998

Cat.No: T28609

Synonym: NSC623611,NSC-623611,NSC 623611

Topoisomerase I inhibitor 9

Cat.No: T80967

Target: Topoisomerase

Cat.No: T78620

Target: Parasite

Topoisomerase I inhibitor 10

Cat.No: T80968

Target: Topoisomerase

Cabotegravir sodium

Cat.No: T62328

Sitamaquine tosylate

Cat.No: T37469

Cat. No.	Product Name	Target	Signaling Pathways
T5780	HYPOCRELLIN B	Apoptosis; Parasite; Antifungal	Apoptosis; Microbiology/Virology
	Hypocrellin B 是从真菌Hypocrella bambusae 和Shiraia bambusicola 中分离得到的一种感光颜料，可用于癌症光动力研究。它是一个凋亡诱导剂，还拥有抗菌和抗利什曼活性。
TN1117	Veraguensin	p38 MAPK; NF-κB; Antibiotic; Parasite; Antifection	MAPK; Microbiology/Virology; NF-κB
	Veraguensin 来源于 Magnolia sp.。 Veraguensin 抑制骨吸收并显示出高抗寄生虫活性。
T4593	ISOPIMPINELLIN 5,8-Dimethoxypsoralen,异茴芹内酯,4,9-Dimethoxypsoralen	Antiviral; DNA/RNA Synthesis; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology
	Isopimpinellin (4,9-Dimethoxypsoralen) 是从 Pimpinella saxifrage 根部分离得到的一种天然产物，具有抗病毒和抗利什曼病活性。
TN2058	Persicogenin	Anti-infection	Microbiology/Virology
	Persicogenin 是分离自 Rhus retinorrhoea 中，具有抗癌作用。
TN2293	Valechlorine	Antifection	Microbiology/Virology
	Valeranone shows antileishmanial and cytotoxic activity.
T11890	Ludaconitine	Others	Others
	Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC50 of 36.10 μg/mL.
T15258	Euphorbadienol alpha-Euphorbol	Others	Others
	Euphorbadienol is a triterpenic compound isolated from the latex of Euphorbia resinifera. It has antileishmanial and antitrypanosomal activity.
T38588	Amphotericin B trihydrate
	Amphotericin B trihydrate, a polyene antibiotic, is derived from Streptomyces nodosus fermenter cultures. It exhibits antileishmanial properties.
T3S0205	β-Hederin Beta-Hederin,β-常春藤素	Parasite	Microbiology/Virology
	β-Hederin 是从 Hedera helix L.(Araliaceae) 分离得到的一种皂苷，具有抗利什曼虫活性。它对乳腺癌细胞有凋亡作用，有望成为乳腺癌化疗的候选药物。
TN4653	Niazinin	Antifection	Microbiology/Virology
	Niazinin shows antileishmanial activity against promastigotes of Leishmania donavani, with an IC50 value of 5.25 microM.
TN4733	Pancixanthone A 胡桐，海棠木	Antifection	Microbiology/Virology
	Pancixanthone A may have antimalarial activity, it also shows a significant antileishmanial activity against the promastigote forms of Leishmania mexicana and L. infantum and against the amastigote forms of L. infantum.
TN3573	Camaric acid	Antifection	Microbiology/Virology
	Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity. Camar
TN2626	14-Norpseurotin A	Antifection	Microbiology/Virology
	14-Norpseurotin A shows good antileishmanial and moderate anticancer activities. It also displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM , r
TN4053	FD-838	Antifection	Microbiology/Virology
	FD-838 shows good antileishmanial and moderate anticancer activities, it can moderately inhibit the growth of cultured P388 and HL-60 cell lines. FD-838 has anti-fungal activity, it can significantly inhibit the growth of two plant fungal pathogens Botryt
TN4168	Grifolin	Others	Others
	Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precurs
TN4471	Lysicamine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the mini

天然产物

Cat.No: T5780

Target: Apoptosis, Parasite, Antifungal

Cat.No: TN1117

Target: p38 MAPK, NF-κB, Antibiotic, Parasite, Antifection

Cat.No: T4593

Synonym: 5,8-Dimethoxypsoralen,异茴芹内酯,4,9-Dimethoxypsoralen

Target: Antiviral, DNA/RNA Synthesis, Parasite

Cat.No: TN2058

Target: Anti-infection

Cat.No: TN2293

Target: Antifection

Cat.No: T11890

Target: Others

Cat.No: T15258

Synonym: alpha-Euphorbol

Target: Others

Amphotericin B trihydrate

Cat.No: T38588

Cat.No: T3S0205

Synonym: Beta-Hederin,β-常春藤素

Target: Parasite

Cat.No: TN4653

Target: Antifection

Pancixanthone A

Cat.No: TN4733

Synonym: 胡桐，海棠木

Target: Antifection

Cat.No: TN3573

Target: Antifection

14-Norpseurotin A

Cat.No: TN2626

Target: Antifection

Cat.No: TN4053

Target: Antifection

Cat.No: TN4168

Target: Others

Cat.No: TN4471

Target: IL Receptor, Antifection

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